Reta with Tesamorelin
- Thread starter Phatmax
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GeraltRedhammer
GLP-1 Apprentice
The recommended dose of tesamorelin is 2 mg at night, 2–3 hours after the last meal. In studies, a 1 mg dose proved to be significantly less effective. Taking tesamorelin alongside ipamorelin has a synergistic effect and enhances its efficacy, which is how I dose it.
Tesamorelin is expensive, which is why I’m wondering whether to replace it next time with CJC (without DAC) combined with Ipamorelin – apparently they work in the same way.
Tesamorelin is expensive, which is why I’m wondering whether to replace it next time with CJC (without DAC) combined with Ipamorelin – apparently they work in the same way.
Zydeceltico
GLP-1爱好者
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Tesamorelin targets visceral fat specifically so you won't get the same results by replacing tesa with CJC. I stack tirz, tesamorelin, CJC(No DAC), and Ipamorelin and have had very, very positive results. ymmv.........and the very best results - for me - have come from letting that stack be a strong tool for me to replace poor lifestyle habits with positive healthy ones (i.e., food choices, exercise, and proper sleep).GeraltRedhammer said:
The peptides don't do the work for me. They give a great assist in doing the work to get and stay fit.
Volkswagen57
GLP-1 Apprentice
Very interesting. I currently use cjc (no DAC), and ipamorelin. Curious what protocol you're running/ where you found your protocol. Personally I've been doing 500mcg of each every night about a half hour before bed. Been doing this for 2-3 weeks. I've give I definitely sleep better.Zydeceltico said:
Phatmax said:
There is no time of day to run tesamorelin. I take it in the middle of the day, fasted and sometimes non-fasted. This has not impacted the rise in my IGF-1 levels. Note that there is no time-of-day indication for the pharma version of tesamorelin, you take it once a day and that's it. You also need to track your IGF1 levels when taking these medications for safety. Do a search here, there are many threads where GH and secretagogues are discussed.
Galapagosfit
GLP-1 Apprentice
i heard the samething. this is the best combo. but I did not tried yet. looking for more testimonies before making an order.Phatmax said:
Calm Logic
GLP-1 Specialist
Habibibi said:
Ideally with fasting insulin.
jmon1977
GLP-1 Apprentice
What dosages are you running the 3 secretagogues at?Zydeceltico said:
Zydeceltico
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tesa: 2mg/daily fasted before bedjmon1977 said:
ipa & cjc(no dac): .5mg ea/daily fasted before bed
osulawkid
Recently Joined 🚫No Source Discussion🚫
Phatmax said:
I have personally found that 1mg may be less effective, it was night and day with reduced side effects like GI issues and water retention at higher doses. This was combined with IPA which may change thingsGeraltRedhammer said:
Cannonball72
GLP-1 Apprentice
I am on Reta and Tesa. Reta 2x/week, 1.5mg per pin, and Tesa 1.5mg/pin 5 days on, 2 off. Have been titrating up to these levels since beginning of Feb. Have been very happy with the results when combined with disciplines exercise regimen.
Reduction in trunk size is noticible, I still have a spare tI’ve around the belly button, but the progress has been steady.
It seems the fat melts from top to bottom for me, I have seen this in the past as well.
The major difference in this protocol vs without Reta and Tesa is the speed and ease. Stress/emotional/boredom eating has gone away, no discipline or struggle at all.
Reduction in trunk size is noticible, I still have a spare tI’ve around the belly button, but the progress has been steady.
It seems the fat melts from top to bottom for me, I have seen this in the past as well.
The major difference in this protocol vs without Reta and Tesa is the speed and ease. Stress/emotional/boredom eating has gone away, no discipline or struggle at all.
latviantower
GLP-1 Enthusiast
Didn’t care for the ipa side effects of increased hunger and maybe water weight(?). Used to do “recommended” Tesa dosing of 2 mg before bed 5 & 2, then an astute member of this forum directed me to the Egrifta clinical study (BP’s $brand name$ tesa). 2 mg daily (no weekly pause), preferably fasted - time of day not specified. Duration? Closest I’ve seen to a definitive answer is six months - but you probably won’t need it that long! If you shop around you can pick up 20 mg kits for under $200 - a full six month run would require 2 kits of 20’s (or 4 of 10’s).
Calm Logic
GLP-1 Specialist
And, of course, very few of us will "need" six months, especially since blood results for IGF-1 seem more likely to be in range than for testosterone.latviantower said:
Those people in the tesa studies are deficient, so in theory may have less sides like carpal tunnel. If managing sides, I would agree 5/2 isn't necessarily the best approach, since you can lower daily dose anyway. 5/2 is good for me for HGH since I have a backlog of other peptides to inject anyway.
The Seeds book on tesa dosing:
quoted said:
UpDownLeftRightAS*
GLP-1 Apprentice
That used to be the case for egrifta, but they updated their tesamorelin guidance....1.28mg seems to be the sweet spot. https://www.egriftawr.com/about-egrifta-wrGeraltRedhammer said:
https://www.perplexity.ai/search/egrifta-tesamorelin-1mg-dosage-47os1pwURmSeZy0aBx.lxA
bogardbilla
GLP-1 Apprentice
Egrifta WR is a different compound though, hence why the dosage is smaller. From your Perplexity link:UpDownLeftRightAS* said:
quoted said:
RadicalCrimson
GLP-1 Apprentice
I think 3 different formulations were approved at different times: the original, WR, and SV.
I don't know how the newer formulations differ, but I know that the 2mg dose was chosen for the phase 3 trial because the phase 2 trial that compared it with 1mg showed that the VAT reduction with 1mg was not statistically different from placebo.
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022505Orig1s000CrossR.pdf
The phase 2 trial: https://www.natap.org/2007/HIV/020807_05.htm
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I don't know how the newer formulations differ, but I know that the 2mg dose was chosen for the phase 3 trial because the phase 2 trial that compared it with 1mg showed that the VAT reduction with 1mg was not statistically different from placebo.
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022505Orig1s000CrossR.pdf
The phase 2 trial: https://www.natap.org/2007/HIV/020807_05.htm
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Derbyshire
GLP-1 Apprentice
Hello all, I am torn with this. I have added a fair bit of research and keep coming back to Tesa not being a fit for the risk against rewards. It seems Tesa can lose fat and at a good % but this fat is under the stomach muscles and not your middle "tyre". Reta is reported to do a great job of this, but Tesa can also reverse quickly if underlying factors like diet, sleep, and hormones haven't changed. I see Tesa being mentioned a lot and being advertised by posters to support with belly fat but the link below and other studies confirm it is organ fat more than typical above the abs fat.
https://img.thebody.com/pinf/2010/tesamorelin.pdf
https://img.thebody.com/pinf/2010/tesamorelin.pdf
UpDownLeftRightAS*
GLP-1 Apprentice
I'm in aggressive agreement here, good eye! I love perplexity! The drug and amount of bioavailability stays the same though, correct? At the end of the day we are still talking about tesamorelin mg's and its bioavailability. I guess I should read up a bit more, and make a better link to the standard 10mg kits I've purchased as well.... (antidotal however, I've seen great results from resistance training and a stint of 1mg daily w/ Tesa)bogardbilla said:
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