Update pertaining to this thread. My weight went up some then slingshotted down 7+ after my last post. These plateaus are about as understandable as a david lynch films plot. Guessing water mostly
Reta耐受性或退化？
- Thread starter RamCummins6.7
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Personally I was doing 3MG up from 2MG and it was doing pretty much nothing like the previous couple of weeks. This week i upped to 4.5 with a new vial and holy crap I'm having a hard week and going up 1.5mg seems like a stretch. Maybe I agitated the peptide too hard when I reconstituted the previous vial (this usually isnt a problem?) but it may be worth trying another vial.
Nah, don't toss the vial, and you didn't agitate it too hard.. Some of this stuff is just different. Yes, I mix based on the measured vial volume, not what it's marked as.Oreos69 said:
Thanks for the updatequicksilver80 said:
ive heard this and someone i believe on this thread said that at certain mgs the got nothing then they make a jump to 8mg and it smacked them again. My wife is visibly down weight and her waist is shrinking.Oreos69 said:
As far as agitated the peptide too much, what did you do when you reconned it? I just add the BAC and try to get it to squirt down the side of the vial then i roll the vial until it all dissolves.
Yes like stated here don’t toss it unless your well pst the 28-30 day mark on itBNLFL said:
Yep, I'll go 10 weeks reconstituted, but have never gone past 8 weeks. This current R50 is good for 7 doses at 8mg. 4 down, 3 to go. 7 weeks.RamCummins6.7 said:
A 2 to 4lb increase morning to night isn’t anything unusual. I have a 2 to 4lb decrease from night to morning as well.quicksilver80 said:
Well known occurrence in weight loss and recomp. No worriesquicksilver80 said:
“The "whoosh effect" is a popular weight loss theory describing a sudden, overnight drop in weight after a long, frustrating plateau. According to the concept, the body flushes out water that has temporarily accumulated in shrinking fat cells, resulting in a sudden, sharp decline on the scale”
This just happened to me recently. I had only lost 2 pounds in three weeks then all of a sudden, I lost 2 lbs in three days.Elgordoboy said:
Water is a huge part of it. I find it takes a lot of water when taking GLPs to get your urine clear. I assume it is working if the urine is cloudy. Yellow is different story IMO, I think you are dehydrated if you see bright colors.
Someone posted a video on the site put together by a couple of compounders who said the agitation is a myth. Your body would be a wreck if you went on a run and all the peptides in your body separated due to agitation.
I bring my peptides upstairs daily and they aren't packed in foam or bubble wrap, I also might get distracted and they might sit out for 20 minutes.
I think there is as much disinformation about peptides out there as there is about politics.
Before I found the grey, my peptides were shipped via UPS already reconstituted and maybe they had an ice pack in the box. But they would be delivered to the porch or mailbox in the middle of summer. They worked as well as me throwing powder in the freezer and reconning fresh and storing in the fridge.
Accelerated degradation happens at 40C/104F.
Surprisingly it does start to degrade in the fridge quicker than I thought
Practical stability window at 39°F (refrigerator): [archived internal link]
Chemically stable for ~7–14 days
Biologically active for ~2–3 weeks
Potency begins to decline meaningfully after ~28 days
Someone posted a video on the site put together by a couple of compounders who said the agitation is a myth. Your body would be a wreck if you went on a run and all the peptides in your body separated due to agitation.
I bring my peptides upstairs daily and they aren't packed in foam or bubble wrap, I also might get distracted and they might sit out for 20 minutes.
I think there is as much disinformation about peptides out there as there is about politics.
Before I found the grey, my peptides were shipped via UPS already reconstituted and maybe they had an ice pack in the box. But they would be delivered to the porch or mailbox in the middle of summer. They worked as well as me throwing powder in the freezer and reconning fresh and storing in the fridge.
Accelerated degradation happens at 40C/104F.
Surprisingly it does start to degrade in the fridge quicker than I thought
Practical stability window at 39°F (refrigerator): [archived internal link]
Chemically stable for ~7–14 days
Biologically active for ~2–3 weeks
Potency begins to decline meaningfully after ~28 days
Degrading Reta is a real thing. Mix up a new batch and you'll feel it pretty quickly. I did the same with too big of a vial and went 10 weeks on the same vial...the last 3 weeks were mostly discipline and determination. The next vial I mixed up was VERY noticeable in effect. Note mine was kept in the fridge...the 28 day limit is pretty real for Reta.
I would disagree with the caveat that not all are created and handled the same.kj4otu said:
I'll disagree as well. I have a vial of R50 I just pinned #6 out of, and it feels the same. Pretty sure there's one more dose in there.kj4otu said:
我第一次订购的是一套R12套件作为入门，之后又订购了一套R30套件作为后续使用。kj4otu said:
提交订单后，我被告知R12缺货，需要比R30晚一到两周才能到货。几周以来，我们一直收到各种配件包裹，我们以为这些东西足够用好几年了。
所以我重新装填了一瓶R30，然后就用了。三天后R12就到了。
总之，长话短说，我们用了第一瓶R30至少三个月，平均每周减重超过2磅。理想情况下，最好不要这么做。我确信它不如30天内新鲜出炉的批次效果好，而且很容易出问题，但如果你非常小心地处理产品，也不是完全没问题。
我现在有一套R12，感觉重新装填和过滤的麻烦程度几乎超过了它的价值。
在相同剂量下，食欲抑制作用逐渐减弱，最终完全消失，而体重保持稳定，这并非耐药性，而是所有GLP类药物的作用机制。在特定剂量下，你的体重“恒温器”（即身体想要维持的稳态体重）被设定在一个特定值。当你的体重超过这个值时，你会感受到食欲抑制；一旦达到这个值，食欲抑制就会停止。如果你在相同剂量下体重反弹，食欲抑制作用会再次出现，直到你的体重再次回到设定值。为了减掉更多体重，你需要增加剂量，此时稳态体重设定值会降低，食欲抑制作用也会再次出现，直到你达到设定值。
如果出现了耐药性（在Sema和Tirz长达4年以上的临床试验中，数千名参与者从未观察到这种情况），体重应该会开始回落到基线水平。
越来越多的证据表明，中断治疗后再重新开始会导致疗效降低，这是一种耐药性，可能源于免疫原性（对药物产生免疫力）。其他肽类药物也观察到了同样的现象，有时会导致疗效永久性下降，而非人们所期望的“重置”。
更频繁的注射、污染物（尤其是降解形成的聚集体，或复溶时用水量过少）也会导致这种情况。
这与疫苗训练免疫系统识别并摧毁特定分子的过程本质上相同。
过滤有助于降低这种风险。
如果出现了耐药性（在Sema和Tirz长达4年以上的临床试验中，数千名参与者从未观察到这种情况），体重应该会开始回落到基线水平。
越来越多的证据表明，中断治疗后再重新开始会导致疗效降低，这是一种耐药性，可能源于免疫原性（对药物产生免疫力）。其他肽类药物也观察到了同样的现象，有时会导致疗效永久性下降，而非人们所期望的“重置”。
更频繁的注射、污染物（尤其是降解形成的聚集体，或复溶时用水量过少）也会导致这种情况。
这与疫苗训练免疫系统识别并摧毁特定分子的过程本质上相同。
过滤有助于降低这种风险。
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PAPoots said:
Why cloudy urine means "it's working"?
PAPoots said:
Clear urine is more likely to be over hydrated, although the risks from moderate over hydration are fairly minimal. Cloudy isn't usually a good thing. Bright colors make me think medications or supplements. Pale yellow is ideal or ok, darker is progressively dehydrated.
PAPoots said:
I don't know what that references, but it seems like a hallucination from AI. Only "biologically active" for 2-3 weeks, but potency doesn't decline until after 4 weeks...
I asked because yesterday was the pin day.woundcarping said:
Reta, early morning, 7mg, taking since February
At night I noticed that the color of the urine was OK, but very cloudy (in fact opaque)
I felt some very small pain / discomfort
Today the urine was already clear and normal.. No discomfort
I sure hope you mean mg and not ml, unless there's supposed to be a decimal in front of those.bluefootedboobie said:I ended up taking a 10 week break (74 days specifically), and restarted three days ago.
YES, the break has reset my body's tolerance to reta!I want to be a little cautious because it's only been three days, but as of this morning, my stomach feels MUCH more full and it's 100% clear the gastric emptying is again slowing.
Re: the mental side, it's not as stone-cold certain, but beginning yesterday it absolutely feels like the food noise and mental desire to eat has reduced. I pulled out a Ben and Jerry's last night, had about five bites ... and just felt like nah, that's enough, and I put it back away. That quite literally NEVER happens. NEVER. An hour later I took it out again, had a few more bites, and was still like ... nope, can't really say why but I just don't feel like having more.
To be clear, I could have forced myself to have more, I wasn't "full," but my brain was just like -- hey, I'm good here.
The real test is if this is sustained for a minimum of at least two more weeks and hopefully more. In my first go-around the reta worked for about three months before all effects stopped. I'll keep reporting here about what happens.
Oh, it's probably worth stating -- my re-intro dosage was 4 ml. Previously when reta was working for me I was taking 3 to 5 ml weekly. After it stopped working I titrated from 5 up to 12 (with no effect).
I def feel the GH is playing a roll but i also feel you do build a tolerance to it. I want to take a break but i still want the insulin sensitivity so I’m tornbluefootedboobie said:
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