Reta Hunger

[TeresaHip]

That’s a joke of a dose. How are you surprised it isn’t working…

How do you not know how much your taking?

 

[sheilarae74]

Wow it's crazy how differently people respond to Reta! It didn't make me want to sleep, I couldn't sleep right for a week lol. I was up 48 hrs straight after my first dose, and after that could only get 6 hrs a night every week that I took it. Which I honestly don't mind because I usually average 9-10 (occasionally up to 13) hours a night and have always wished I needed less.

I honestly felt like I had narcolepsy for a while. Especially in the afternoon. I work from home and it was so hard to stay awake, I would find myself nodding off as I was typing. What's really weird is that I normally only sleep like five hours a night and all I did was sleep the first few weeks I took reta.

 

[BNLFL]

I’m all for the absence of drama, especially over the internet- it’s most often adolescent and unnecessary. I don’t care to be one of those people.

The fact that you quoted my post to make your comment, it seemed quite direct. All good

It was about this guys" Estarossa19" comment that you quoted about being a joke of a dose or something like that.

 

[StanNorth]

so i bought 12 mg and i added 2 bac ml water and then i think i did 50 or 100 mcg ?

Lord Usopp, increase your dose by 10x.

sheilarae74's dosing is good ​[archived internal link]

 

[myboysherman]

This might actually be a joke of a dose. That is, one or two units is a crazy injection to attempt and I can't imagine he meant fifty or one hundred units, so is this just trolling? And if it isn't then OP should definitely step away from the vials and syringes and read a lot more. Or don't. I'm not the boss of you.

 

[PepDino]

I recently started taking Reta, and I’m noticing a significant increase in hunger, specifically intense cravings for sweets.

This is unusual for me because I also take Adderall, which typically suppresses my appetite.

Additionally, I am on Keppra and Lamotrigine. Does anyone have advice on managing these cravings or insight into how these medications might be interacting?

I also take Reta + Adderall and used to take Lamictal/Lamotrigine (never taken Keppara though).

I also experienced cravings with sweets and sometimes carbs the first few weeks of Reta but it’s mostly subsided now. I still get cravings, but it’s much less intense now.

Adderall has continued to be effective for me (although I take 20-30% of what’s prescribed to me) for mental focus and often times I still get appetite suppression for 4-8hrs depending on dose and if it’s IR vs XR.

Curious to know your dosages of these things and wishing you the best

 

[ussop]

What is your current dosage, and what does recently mean in length of time?

I don’t have any specific knowledge on any contraindications between Keppra and Lamotrigine, but I can say anecdotally that many experience an increase in hunger from lower dosages of Reta. This can often alleviate/resolve for those individuals as titration increases, but also remember that one of the functions of Reta is an increase in metabolic function with lower focus on appetite supression receptors, contrary to the other two main GLP meds with stronger focus on said receptors.. this is why it can often take higher dosages for the effect of supression to present itself. As such, instead of titrating up, many also add an additional peptide more specifically focused on supression such as Cagrilintide, Semaglutide, or Tirzepitide.

I normally fast for long periods or do OMAD, but now I’m eating daily just to keep up. Even after a high-protein dinner of two steaks, I woke up with intense sugar cravings

what is the recommended dosage that you would say in mcg?

I also take Reta + Adderall and used to take Lamictal/Lamotrigine (never taken Keppara though).

I also experienced cravings with sweets and sometimes carbs the first few weeks of Reta but it’s mostly subsided now. I still get cravings, but it’s much less intense now.

Adderall has continued to be effective for me (although I take 20-30% of what’s prescribed to me) for mental focus and often times I still get appetite suppression for 4-8hrs depending on dose and if it’s IR vs XR.

Curious to know your dosages of these things and wishing you the best

i am on 30 mg of addy ir (i take 2-3 a day) the cravings yes the sweet has subsidized i just wish i had something to be happy about

why do you take 20-30% less?

 

[PepDino]

I normally fast for long periods or do OMAD, but now I’m eating daily just to keep up. Even after a high-protein dinner of two steaks, I woke up with intense sugar cravings

what is the recommended dosage that you would say in mcg?

i am on 30 mg of addy ir (i take 2-3 a day) the cravings yes the sweet has subsidized i just wish i had something to be happy about

why do you take 20-30% less?

I started taking less when I had start paying out of pocket for it + I spend a lot of time in Asia where it is highly restricted. I decided to just taper down and supplement with diet and exercise. But now a 3 month script will last me 10-12 months. I’ll usually take one 20mg IR or one 30mg XR. The XR’s are my favorite. I was worried with the slower digestion on Reta the XR would stay in my system too long but I haven’t noticed any affect on that so far.

 

[ussop]

Were you on Tirz or a Sema before starting Reta? Odd for your hunger to increase if not but everyone responds differently. Some people find the appetite suppression much less on Reta so will add Cagri (or sometimes Tirz) to help.

no but its not there that much anymore well it is its just less but before when i was on adderal only it was not even noticable i would work until 11 pm and say holy fuck what happen

 

[ussop]

A little aggressive, no? They obviously just need a little guidance.

@ussop with the current dilution of your single 12mg vial, I would suggest starting with a 25unit injection- this will give you a 1.5mg dose. It is a bit on the lower side, but will be a significantly larger impact than any mcg amount.

Also, you “think” you did 50-100mcg… how many units did you inject, we can tell you for sure the dosage so that you can properly understand what is and isn’t working.

its okay

I’m all for the absence of drama, especially over the internet- it’s most often adolescent and unnecessary. I don’t care to be one of those people.

The fact that you quoted my post to make your comment, it seemed quite direct. All good

All good.

So, I added 2 ml of bac water to 12 mg. I then did another dosage of 10 units (which I think is 150 mcg).

It’s a bit better, I guess. I’m still kind of hungry, which is the annoying part. Addy completely shut it off.

But interestingly, when I eat normally, I’m a person who continues eating even if I can’t eat longer.

Here, I’ve put food or saved it for later (something I’ve literally never done). But yeah, it’s not even like I’m a fat guy. I think the term would be skinny fat, but yeah, I’m hoping it helps. The main reason I wanted Reta vs the others is because of its mental effects.

 

[DragonOfTheSea]

its okay

All good.

So, I added 2 ml of bac water to 12 mg. I then did another dosage of 10 units (which I think is 150 mcg).

It’s a bit better, I guess. I’m still kind of hungry, which is the annoying part. Addy completely shut it off.

But interestingly, when I eat normally, I’m a person who continues eating even if I can’t eat longer.

Here, I’ve put food or saved it for later (something I’ve literally never done). But yeah, it’s not even like I’m a fat guy. I think the term would be skinny fat, but yeah, I’m hoping it helps. The main reason I wanted Reta vs the others is because of its mental effects.

So I have a few things to say, but before we go any further discussing units and dosage, I want to clarify we are on the same page- are you using 100U 1mL syringes? Also, no matter what, your perceived dosage of 150mcg is definitely not correct, but I can be more exact once we confirm what your unit volume is.

 

[ussop]

A little aggressive, no? They obviously just need a little guidance.

@ussop with the current dilution of your single 12mg vial, I would suggest starting with a 25unit injection- this will give you a 1.5mg dose. It is a bit on the lower side, but will be a significantly larger impact than any mcg amount.

Also, you “think” you did 50-100mcg… how many units did you inject, we can tell you for sure the dosage so that you can properly understand what is and isn’t working.

i used peptide calculator

12 MG

2 ML Water

[Imported image pending local asset: attachments-screenshot-2026-04-29-at-2-53-05-pm-webp.21578]

so here it shows 250 mcg

so that is why i was talking in mcg

now what i am wondering is the increase

or yeah is there a weight loss calculator for reta (im jk i know results vary)

 

[DragonOfTheSea]

i used peptide calculator

12 MG

2 ML Water View attachment 21578

so here it shows 250 mcg

so that is why i was talking in mcg

now what i am wondering is the increase

or yeah is there a weight loss calculator for reta (im jk i know results vary)

That calculator is correct, your previous calculations do not seem so. But either way we still need to know how many units are on your syringe. Are you using a 100U 1mL syringe? Like the 3rd one in the screen shot you posted?

 

[ussop]

That calculator is correct, your previous calculations do not seem so. But either way we still need to know how many units are on your syringe. Are you using a 100U 1mL syringe? Like the 3rd one in the screen shot you posted?

Correct the 3rd one.

 

[txnj11]

I recently started taking Reta, and I’m noticing a significant increase in hunger, specifically intense cravings for sweets.

This is unusual for me because I also take Adderall, which typically suppresses my appetite.

Additionally, I am on Keppra and Lamotrigine. Does anyone have advice on managing these cravings or insight into how these medications might be interacting?

I had a similar experience. I was on tirzepatide (Mounjaro) for a year, then experimented with retatrutide for a month. During that time, I noticed a higher heart rate, minimal hunger suppression, and GI issues. After switching back to tirzepatide, everything returned to baseline.

 

[DragonOfTheSea]

Correct the 3rd one.

Ok thank you for the clarification. SO:

With you dilution- 2ml into a 12mg vial, your concentration is 6mg/ml.

When you said you injected 10 units, that means you took a .6mg (or 600mcg) dose, not 150mcg.

Think back to what the volume of your other doses were, up to now, and make these adjustments so that you can properly (both for yourself and for anyone wanting to help you) describe accurately what your dosage history has been.

 

[lessthanhalf]

I recently started taking Reta, and I’m noticing a significant increase in hunger, specifically intense cravings for sweets.

This is unusual for me because I also take Adderall, which typically suppresses my appetite.

Additionally, I am on Keppra and Lamotrigine. Does anyone have advice on managing these cravings or insight into how these medications might be interacting?

There is a known interaction between GLP drugs and adderall, although it may not be listed as an interaction , it has been seen in animal studies. In the same way that GLP's make food less rewarding , they can reduce the effect of stimulants by direct action on the relevant brain cells.

Most interactions with GLP drugs are caused by slowing down absorption of other drugs by slowed gastric emptying.

I have not seen it mentioned for reta, but it is a GLP-1 agonist effect so should apply.

I noticed that as soon as I started taking ozempic I could no longer feel I had taken my dose of dexamphetamine, and tirzepatide has the same effect, effectively lowers the dose.

You mention you are taking it for possible mental benefits so hopefully this effect is not a big issue.

That being said the doses of reta you describe taking are so microscopic they may not be enough to do anything much. And might be placebo effects, hard to say.

But if it is reducing the effect of adderall, that could explain the increased sweet hunger. And people do sometimes complain about this happening when starting reta, due to the glucagon agonism, but it usually goes away after a while.

Not familiar with Keppra so cannot comment on if it has interactions, never heard of there being issues with lamotrigine. But if you are not sure look it up , it is the kind of thing that must always be checked if starting a new drug, and usually gets done by your doctor or their computer program, there are plenty of online resources or ask chatgpt, it's pharmacology is pretty good.

 

[elevator13]

i used peptide calculator

12 MG

2 ML Water View attachment 21578

so here it shows 250 mcg

so that is why i was talking in mcg

now what i am wondering is the increase

or yeah is there a weight loss calculator for reta (im jk i know results vary)

I believe the example doses given by the calculator are arbitrary - those amounts are not relevant to retatrutide specifically.

1ml = 100 units

1mg = 1000mcg

So, 10 units at a dilution of 12mg/2ml:

1ml=6mg

0.1ml=0.6mg

You took 600mcg. That’s a fine test dose to see if you tolerate the drug. The next step is an earnest dose of 1mg or 1.5mg. I personally started at 2.5mg.

16 units will give you 960mcg.

25 units will give you 1.5mg.

33 units will give you ~2mg.

 

[ussop]

Ok thank you for the clarification. SO:

With you dilution- 2ml into a 12mg vial, your concentration is 6mg/ml.

When you said you injected 10 units, that means you took a .6mg (or 600mcg) dose, not 150mcg.

Think back to what the volume of your other doses were, up to now, and make these adjustments so that you can properly (both for yourself and for anyone wanting to help you) describe accurately what your dosage history has been.

so double to 500 mcg?

 

[DragonOfTheSea]

so double to 500 mcg?

I don't think we're on the same page..

From what you have said, you have already dosed 600mcg on your last dose, in addition to whatever other doses you have done before then.

Do you have any record at all of when you took each of your does, and how many units you took at each of those doses? If so, can you provide that info? Do not provide what you think you dosed in .mcg, please provide what you dosed in units.