Interesting. I would assume that there are a lot more immune cells resident in the dermis under the skin than there are in the subcutaneous fat tissue, which would explain why a deeper injection causes a lesser reaction. The problem it causes is the immune reaction, I do not think tiny amounts of whatever your immune system is reacting to are going to be harmful, so I would not be concerned about bypassing the immune system. Compared with the amount of crap literally and bacterial metabolites and fragments that make it through the gut every day into the bloodstream, I doubt it would be significant. In theory it could be the benzyl alcohol in the bac you are reacting to, have you tried plain water for injections instead? Being allergic to all 3 peptides seems a bit unlikely.