Reta 的开始 - 博客

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UnusualLLama

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好了,开始吧……

先简单介绍一下背景,我是一个相对健康的四十多岁男性,十多年来一直坚持健身,但我一直以来都很难减脂。

我可以变得强壮有力,但就是减不掉脂肪。我觉得可能是基因决定了我身材比较丰满(目前体脂率在20-22%左右),所以我研究了一下GLP-12,看到Reta之后,我就下定决心了。

我的想法是——尽可能小的剂量,就能达到理想的效果。

我目前的体重和体脂率已经维持了一段时间,感觉还不错,但我真的很想减脂,希望Reta能在这方面帮上忙。所以我决定每周在这里记录一下我的观察结果,并更新一下进展情况。因为看过其他类似的帖子,我觉得了解其他人的经验很有帮助。

基本信息:

男性,

40多岁,身高

178厘米(5英尺10英寸)

,今早体重79公斤(174.165磅

),估计体脂率20-22%(我用的是Withings体重秤,我知道它不是很精确,但我只是在观察趋势),

平均静息心率44-46次/分,

平均血压110/71 mmHg。

开始注射1毫克利妥昔单抗。

初步想法和观察:

呼,第一次注射真是让人心跳加速。看了太多关于如何注射利妥昔单抗的视频,也读了很多关于注射之类的资料,我终于成功了。

愚蠢的是,我所有的注射器都是1毫升的,而我想要在装有20毫克利妥昔单抗的药瓶里注入2毫升的酒精溶液。所以,我得往瑞塔小瓶里注射两针苯氧乙酸(BAC),我当时觉得肯定搞砸了,因为我摇晃了几下小瓶后,里面还有几小块的瑞塔,不过最后它们都溶解了。

接下来就是量取正确的剂量。我从1毫克开始,不知怎么的,我之前一直觉得这针可能会装满注射器,我得花两分钟才能一次性全部注射进去,结果当我真正抽到想要的剂量时,却发现只有一点点。

真的非常非常非常少,只有10个单位。

我当时就想:“不会吧,这点儿液体能起什么作用呢?”

但不管怎样,我还是顺利地注射进去了。

我本来还期待着会有什么轰轰烈烈的反应,说不定有人会拿着喇叭和彩炮从壁橱里跳出来,结果什么也没有,就这么简单。注射完毕。

钉上别针后也没有什么明显的感觉,可能只有一点点发热?但我认为这更多是我的心理作用。

现在就只剩下等待了。我还在努力弄清楚这到底会是什么感觉。我觉得现在对我来说最难熬的就是不知道接下来会发生什么。也许是因为饥饿和渴望食物对我来说太自然了,所以想到以后可能不再那么强烈地感受到这些感觉反而会觉得很奇怪?

我也不知道,走着瞧吧。我主要希望减少零食摄入(尤其是在周末)加上稍微提高一下新陈代谢(我大部分时间都对着电脑,所以早上锻炼的那两个小时是我一天活动量最大的部分)能帮助我把这种长期的热量维持状态变成稳定的热量缺口。但我知道每个人的反应都不一样,所以时间会证明一切。

就先写到这里吧,我可能会在下一篇帖子(每周一次)里再更新,除非在那之前我发现了什么其他有趣的事情。
 
UnusualLLama said:
平均静息心率 - 44-46
老兄,你是这里第二个我见到的了……你们这些冷血的改造人是从哪儿冒出来的?
 
Smiter said:
老兄,你是这里第二个我见到的了……你们这些冷血的改造人是从哪儿冒出来的?
我是个红发,没灵魂,心脏像机器一样!

不过说真的,关键在于坚持训练。每周五次,每次60-70分钟快走/慢跑,外加60-75分钟的力量训练。

然后每周两次,每次60-70分钟快走,外加20-30分钟的高强度有氧运动(间歇训练、计时训练等等)。

我发现训练的规律性和静息心率之间有直接的关联。上次我受伤,有一段时间没去健身房,受伤一周多一点后,我的平均静息心率就开始慢慢上升到50次/分左右,等我恢复规律训练后,心率很快就回落了。
 
我的静息心率一直徘徊在40多次/分。我去做了睾酮检查(并非因为这个),结果发现睾酮水平非常低,于是开始接受睾酮替代疗法(TRT),之后心率飙升到了50多次/分。考虑到你减脂方面的问题,如果你还没考虑过睾酮替代疗法,或许可以考虑一下。
 
5byfive said:
My RHR was running in the mid to lower 40's. I got my testosterone checked (not becuse of that) and it was really low so started TRT and it jumped into the low 50's. With your issues getting lean, might be something to look at if you haven't already.
I get a big blood panel done every year, my T-levels are all decent, nothing to indicate any possible cause for issues getting lean. And nowhere near the low-levels needed to be considered for TRT in Sweden (mine are upper-mid range).

And believe me I've scoured those blood tests every time my results come through looking for anything that might be a possible cause of struggling to get leaner, to no avail. I think it's just a combination of stubborn genes and less-than-perfect willpower.
 
UnusualLLama said:
I get a big blood panel done every year, my T-levels are all decent, nothing to indicate any possible cause for issues getting lean. And nowhere near the low-levels needed to be considered for TRT in Sweden (mine are upper-mid range).

And believe me I've scoured those blood tests every time my results come through looking for anything that might be a possible cause of struggling to get leaner, to no avail. I think it's just a combination of stubborn genes and less-than-perfect willpower.
Yeah, it's clear now.. The answer is in the genes, specifically the race.. You're all heartless. There's no other explanation. But, for the fat burning, have you tried using a thermogenic fat burner? or Lipo-C?
 
Smiter said:
Yeah, it's clear now.. The answer is in the genes, specifically the race.. You're all heartless. There's no other explanation. But, for the fat burning, have you tried using a thermogenic fat burner? or Lipo-C?
I tried fat burners years ago, honestly didn't see much/any of an impact from them.

As for lipo-c, I've looked a bit (and at other peptides etc.) and if the reta experiment doesn't get me where I want I might consider it but for now, I'm all in on the reta road and going to see how that pans out.
 
I’m 41 and into long distance running - been on Reta now almost a month and I also had a naturally low BP and RHR.

Reta skyrocketed my resting heart rate to a level that triggered my already natural anxiety but my body is beginning to get used to it.

Been hard to impossible to stay in Z2 for my runs at the pace I prefer but hoping it eventually evens out.

You noticed anything with your heart rate?
 
Fusoya said:
I’m 41 and into long distance running - been on Reta now almost a month and I also had a naturally low BP and RHR.

Reta skyrocketed my resting heart rate to a level that triggered my already natural anxiety but my body is beginning to get used to it.

Been hard to impossible to stay in Z2 for my runs at the pace I prefer but hoping it eventually evens out.

You noticed anything with your heart rate?
It's funny you mention this because I was debating on if I was going to post an update today, or just wait until the next week's pinning as I originally planned.

Two of the main things that I was "concerned" (I use the term loosely, it's a case of something I knew I'd probably have to accept to a degree) about were the reported increase in RHR/HR and disruptions to sleep (I know the importance of enough good quality sleep, and have had issues in the past, so really didn't want to rock the boat too badly so to speak).

Firstly, and this is only a day after my first dose @ 1mg;

RHR was down 1 beat from yesterday (45 this morning, 46 yesterday) but still in my current reference range of 44-46 so can't really view that as any meaningful variance other than "it hasn't gone up". BP estimate was a tiny bit lower as well.

Sleep actually felt good. Really good, I even checked my whoop and it showed a bit more than usual deep sleep. Definitely one to watch (anecdotally, I've also heard reports about how reta can actually "fix" sleep for some people, curious regardless).

Now, this is where it gets interesting for me. You mentioned not being able to stay in Z2 and my gym session this morning was cardio, so time on the treadmill.

Two things I noted were firstly, it was hella easy to work up a sweat, even at lighter efforts. And secondly, my HR increased up into working zones a lot quicker than it typically does.

The thing is, I can't really use a single workout/day as a metric to judge what is down to the reta and what isn't. As you probably know, or anyone that's done consistent work in the gym or training in general, you can have 2 separate days where you feel perfectly fine and on one of those days you might be hitting PR's like it's nothing and the other you might be struggling even in warmups.

It's just one of those things, some days you smash it, other days not so much, even if you don't feel much different initially.

So yeah.. it's definitely one to watch.

What dose reta are you on?
 
Oh yeah one more thing, probably the most important one with regards to reta itself; Appetite/hunger etc.

I'm still definitely feeling hungry, my stomach rumbles when it's getting empty, and I know that I should eat (gotta hit those macros and targets) but I'm not getting the urge to go and snack.

It's not a super strong difference, and I can't help but wonder how much of it is some part of my mind thinking "You had reta, you don't need to think about that" and how much of it is down to the reta itself, but it's a weird feeling.

Not bad weird just.. different.

Now that being said, I'm usually quite going at staying disciplined during the week. It's the weekends when my willpower falters and the good work I've done during the week is undone, so this weekend is going to be the big test.
 
I'm now curious to see how Reta affects a few heartless people in this forum. They say that their hearts beat at around 40 per minute. Obviously, thats hogwash, it's clearly some cybernetic machine. I took my 2nd Reta dose today and my RHR is around 76 now, which has increased from the 68 before. The flu has hindered my exercise plans.
 
UnusualLLama said:
It's funny you mention this because I was debating on if I was going to post an update today, or just wait until the next week's pinning as I originally planned.

Two of the main things that I was "concerned" (I use the term loosely, it's a case of something I knew I'd probably have to accept to a degree) about were the reported increase in RHR/HR and disruptions to sleep (I know the importance of enough good quality sleep, and have had issues in the past, so really didn't want to rock the boat too badly so to speak).

Firstly, and this is only a day after my first dose @ 1mg;

RHR was down 1 beat from yesterday (45 this morning, 46 yesterday) but still in my current reference range of 44-46 so can't really view that as any meaningful variance other than "it hasn't gone up". BP estimate was a tiny bit lower as well.

Sleep actually felt good. Really good, I even checked my whoop and it showed a bit more than usual deep sleep. Definitely one to watch (anecdotally, I've also heard reports about how reta can actually "fix" sleep for some people, curious regardless).

Now, this is where it gets interesting for me. You mentioned not being able to stay in Z2 and my gym session this morning was cardio, so time on the treadmill.

Two things I noted were firstly, it was hella easy to work up a sweat, even at lighter efforts. And secondly, my HR increased up into working zones a lot quicker than it typically does.

The thing is, I can't really use a single workout/day as a metric to judge what is down to the reta and what isn't. As you probably know, or anyone that's done consistent work in the gym or training in general, you can have 2 separate days where you feel perfectly fine and on one of those days you might be hitting PR's like it's nothing and the other you might be struggling even in warmups.

It's just one of those things, some days you smash it, other days not so much, even if you don't feel much different initially.

So yeah.. it's definitely one to watch.

What dose reta are you on?

Currently on 2mg a week-ish.

Next Monday will be my 5th week and planning on jumping up to 4mg but debating on splitting or not.

Yea the one thing about this stuff is it has KILLED my desire to snack which has been such a huge thing for me. I normally have an issue with donuts and stopping all throughout my work day to constantly eat stuff.

I also still get hungry and think about food but it’s not as loud and food is not as exciting to me. That’s a plus and a minus - I am a EATER but nothing really sounds exciting to me like it normally does.

Plan on cutting and then hopefully getting to a small maintenance dose. Overall pleased.

It initially wrecked my sleep but it’s begun to even out. I normally wake up at 4am anyway so waking up at 3:30am hasn’t been the end of the world.

Done a 10 mile run and three 8 mile runs this week so far and my heart rate is beginning to normalize to what it normally is but still higher than when I normally am doing some easy miles.

I have noticed that I feel GOOD when I get out to go do it which is normal for me but the past couple months my runs had been way harder than usual - it happens but I’m PUMPED to be feeling good and my legs are good lately.
 
So my RHR this morning was 48. That's just out of my current reference range and something I only typically see if I've eaten too close to bed time, dehydrated or been slacking on the consistency of my morning workouts.

That being said, it's only a single day measurement so I can't say for certain it's the reta.

In addition to that, throughout the 2 hours of training this morning, my average heart-rate was a little bit higher than it has been over the last 30-days so there's definitely a possible impact happening.

The good thing is this is only a slight increase, very slight. If my RHR had shot up 10 beats instead of 2/3 and working HR was hitting much higher numbers I'd be more concerned but it's nothing crazy so if this is the price of a slight increase to my metabolism, so be it.

I'm going to increase my base-cardio work a little bit (not high intensity stuff, just the lower end). I typically find that when I increase the volume of that my RHR comes down a bit, so will be interesting to see the interaction.

Otherwise everything else is fine. Still easily notice when I'm legitimately hungry, but still not overly compelled to try and deal with that immediately. But the weekend begins now so this will be the real test.
 
domin8brix said:
TEAM SOULLESS MACHINE!
Here's one of those facts that sounds like it's fake but actually isn't, but did you know that redheads have a higher tolerance to anesthetics than everyone else? To the point where medical practitioners actually take it into account when deciding on the levels to give to a patient (something like 20% more generally being used)?

The reason I mention it is because it's also thought to be a similar situation for a lot of other drugs, and part of me is wondering if it has any impact on things like reta?
 
UnusualLLama said:
Here's one of those facts that sounds like it's fake but actually isn't, but did you know that redheads have a higher tolerance to anesthetics than everyone else? To the point where medical practitioners actually take it into account when deciding on the levels to give to a patient (something like 20% more generally being used)?

The reason I mention it is because it's also thought to be a similar situation for a lot of other drugs, and part of me is wondering if it has any impact on things like reta?
I am aware of that need for more local/general anesthesia! Every procedure I've had they're like "ope, need a gallon for this one!" and my dentist always has to double up. I have not noticed any impact on these GLPs though, as far as super or low responding.

I don't know if it's redhead related or just me but I also generally have a pretty high tolerance for pain and will only use the "hard stuff" if I absolutely have to.
 
Little bit of an update;

One of my biggest concerns was weekend snacking. For me, a 2000-calorie day could easily escalate into a 4000-5000 calorie day. Stack that onto 2 days and all of a sudden the discipline I'd shown during the week was reset.

Well, reta put a hard stop to that.

Even on this 1mg first dose, I had a fairly regular lunch on Saturday (Kinda like a fish soup/stew with some garlic bread, lot of protein) and I was stuffed for hours. Previously, I'd have been in the kitchen 30 minutes later looking for a protein bar or something else to snack on (which is a pattern that'd typically repeat for the whole day). But not this time.

So while I may not be feeling a crazy appetite suppression, I sure am feeling food taking longer to work through and being full for longer.
 
So that's the first week in the bag!

Basic stats

Male

Mid-40's

5'10/178cm

Weight as of this morning - 77.9kg/171.7401lbs (Down from 79kg/174.165lbs)

Rolling 7-day average is down 0.7kg/1.54324lbs

Estimated body fat - 18-20% (I'm using a withings scale, I know it's not super accurate, but I'm watching trends - currently trending down)

Average resting heart rate - 44-47 (was 44-46)

Average blood pressure - 110/72 (was 110/71)

Current dose - 1mg reta

Initial thoughts and observations

So that little sliver of fluid (10 units) really does work, huh?

It's still kinda wild to me that it can do that, especially when you consider the actual tiny amount of peptides that are in that fluid as well, but here we are.

Scale weight is 1.1kg down from last week, but the roll 7-day is 0.7. There will have been a tiny little bit of water weight gone initially, but not a lot. I was more or less at maintenance previously and have a good sense of water retention in general so I know when there's a lot of water or not (example being the day after a heavy leg session in the gym, when my legs are suddenly stiffer than week-old bread and the muscles scream every time I move them. Those days I always hold extra water). So I think that 0.7 is more than likely fat. It looks like fat as well, I can already see a subtle difference in some places.

My concern about RHR/HR increases is, at present, less of a concern and more of an ongoing observation.

Roughly 34-48 hours after pinning there was a slight increase in RHR of 2-3bmp, and it was definitely easier to get my HR up into working zones during cardio. Thankfully, during my interval session, I didn't see an increase at the higher end (maxed out at the same numbers I typically do during those intense sessions).

Other than that there's really been no "side-effects". Sure, 1mg is a low dose, but it's working and some people have reported sides on lower doses. But my energy is fine, no nausea, I did have a bit of a headache one day but that was due to dehydration. I guess that's a side? I have noticed a bit of increased thirst, but nothing wild, and I'm usually on top of my hydration.

When it comes to appetite suppression and things like that, it's weird. I keep looking for that "one physical thing I can feel" to verify that this is working, but I've realised that's the wrong way. It's actually the absence of the physical thing that shows me it's working.

I still get hungry, I can still feel when my stomach is getting empty, still hear and feel a bit of a rumble at times. But that driving urge to immediately go and "fix" it isn't there.

As I've mentioned in previous comments, my weekdays are usually very consistent and it's the weekends where the hard work comes undone. And that was the breakthrough for me. This weekend came and went, I had regular meals and felt full for hours afterwards and didn't feel drawn to raiding the kitchen at all .

So yeah, heading in the right direction, and at a pace that I'm fine with as well. I want to retain as much muscle as possible, so slow and steady is the way (it's almost impossible to not lose "some" muscle-mass when you lose weight unless you're juiced to the gills, and I expect there will be a little).

On we go.

I'm curious how long this 1mg dose will hold out for. I've read a bunch of people saying they start to get "the noise" back around weeks 3-4 on their starting doses before upping them, and I'd really like to stay at the lowest effective dose for as long as possible.

Time will tell.
 
Im enjoying the journey as im basically on the exact same one, early 40s, very active in the gym just a bit taller and a bit heavier than you and certainly not got your RHR.. Mine usually around 60 but tbh cardio has never really been my friend.

Did my first jab on Sunday so around 4 days in now, during the week is pretty easy for me as i work away and i take all my food with me so its all set doing intermittent fasting. I certainly questioned if it was working early on as i was still getting pretty normal food noise but i do fast 16hrs so i put it down to Reta not literally taking away all hunger noise and i also only did 0.5mg for the first week with intention of cycling up to 1mg next week.

I noticed that i actually worked a bit harder in the gym and it was a lot easier to get the sweat up and was happening on lifts i would never usually. Not sure if the working harder part is placebo of "if you are injecting yourself you should probably put max effort in".

Starting weight was 92.2kg on our crappy bathroom scales on Monday morning before (after a weekend away with a lot of food/drink) and this morning on the scale 89.3kg. Legit the first time ive seen below 90kg in about 15 years and certainly looking different in the mirror however i know its going to be water loss etc but still even after days fasting ive not seen that weight and i have eaten more good calories this week per day than i normally would.

In terms of sides then i defo felt the hydration element and was getting itchy skin and dry eyes, had to up to two electrolyte sachets a day now where usually i would just do a morning one and those seems to have passed now. Food noise is dampening a bit but i havnt hit the weekend yet! Not seeing anything major in RHR yet either
 
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