Reta Beginner- Titration Questions

[PorcShanc]

Hey community,

I just started Reta today. My plan is to do 6 weeks at 1mg per week and I plan on splitting that into two doses per week. 0.5mg on Monday and 0.5mg on Thursday. My reasoning behind this is simply because I feel it might work better if there’s a steady stream of it rather than just once a week doing a full 1mg. Please let me know if doing this makes no difference at all. Another reason I’m doing it is to more so ease into it than going full on straight away.

I’m also taking g BPC, TB and GHK. All of these are being injected into my belly just above where my boxers waistband is.

Wondering if this is where everyone else does it as well?

Finally, I’m wondering should I move onto 2mg (weekly) after 6 weeks? I’ve read that there’s no need to really ever go beyond 2mg weekly but I’ve also seen people go up to as much as 12mg per week so I wanted to hear some opinions about this also.

Thanks in advance guys

 

[Calm Logic]

Most people here will be at 2 mg within a month of starting reta. But there are some super responders who stay at 1 mg longer than most, just as there are many who start at 2 mg or titrate up ASAP.

It's generally a good idea to rotate injection sites.

[Imported image pending local asset: attachments-image0-webp.11300]

 

[MsGizmo]

Hey community,

I just started Reta today. My plan is to do 6 weeks at 1mg per week and I plan on splitting that into two doses per week. 0.5mg on Monday and 0.5mg on Thursday. My reasoning behind this is simply because I feel it might work better if there’s a steady stream of it rather than just once a week doing a full 1mg. Please let me know if doing this makes no difference at all. Another reason I’m doing it is to more so ease into it than going full on straight away.

I’m also taking g BPC, TB and GHK. All of these are being injected into my belly just above where my boxers waistband is.

Wondering if this is where everyone else does it as well?

Finally, I’m wondering should I move onto 2mg (weekly) after 6 weeks? I’ve read that there’s no need to really ever go beyond 2mg weekly but I’ve also seen people go up to as much as 12mg per week so I wanted to hear some opinions about this also.

Thanks in advance guys

I don't think you can fully plan dosage that far ahead. You don't know how your body reacts to it. I mean you just took your first shot and it hasn't even had a chance to get up and running just yet. You don't know if your current dosage will cause a side effect nor even if it works at all at a low dose.

The way I decide: I take a first shot or dosage increase and wait until just before my next dose to decide if I need to reduce due to side effects. (I have never had anything so bad to do this) After the 4th shot at any dose I decide if to stay at the same dose or increase based on how my body responded. I do eventually plan to increase to the dosages in the official studies that are most effective .. but I want to get there slowly.

 

[PAPoots]

Document date, dose, weight, and side effects at the least. I started with the published protocol and as I titrated up i started getting allodynia and cramps for the first couple days. So I backed off the dose until the pain went away. Then the weight loss stopped. So I switched to Monday and Thursday dosing and then titrated up until I started seeing affects. But the allodynia came back. So I then moved to Monday, Wednesday and Friday. That worked for a couple months. That was a 2,2,3mg dose. Now I'm at 3,3,4 for a total of 10mg per week and I'm back to losing about a pound a week. My issue is appetite control. I was about to look into Cagri because I was so frustrated. But 10mg is working well.

I don't know how some people get away with a maintenance dose of a couple mg a week. Unless they really didn't need it for health issues, but they are already lean and hit the gym daily. They must want to shave that last few percent off to show their abs on Instagram. I'm also 5'10" and 210lbs. I imagine a smaller person, closer to their goal weight needs a lot less.

 

[Not_Your_Dad]

I agree that you shouldn't try to plan out that far ahead. You never know how you will or won't respond, what sides you'll have, etc.

I am curious where you read there's no need to go above 2 mg / week. I'm not sure 2 mg is even considered a therapeutic dose. Not to say you should titrate beyond it if 2 mg is working, but that planning on stopping at or before 2 mg doesn't make much sense to me.

 

[yrrdead]

I started low @.5mg every 3 days because A.) I had never taken anything ever. B.) I had no idea what I'm doing (still the case most likely). Currently on 1mg every 3 days since I've had no stall in my weight loss. 5'9//44M//SW 216 CW 187.

I do follow the clock around the belly button for Reta.

I will say I really like the Shotsy app. I've been using the free version which is great imo. You enter the dose ,injection site, pain level, notes , weight. And can set reminders for next dose. Then you can take a look at a decent graph to see what your trendlines are.

 

[PAPoots]

I started low @.5mg every 3 days because A.) I had never taken anything ever. B.) I had no idea what I'm doing (still the case most likely). Currently on 1mg every 3 days since I've had no stall in my weight loss. 5'9//44M//SW 216 CW 187.

I do follow the clock around the belly button for Reta.

I will say I really like the Shotsy app. I've been using the free version which is great imo. You enter the dose ,injection site, pain level, notes , weight. And can set reminders for next dose. Then you can take a look at a decent graph to see what your trendlines are.

I'll check it out. Thanks

 

[Calm Logic]

RE: Planning your doses

Go nuts. Have contingency tables. Publish the results. Let your obsession shine, haha.

But there are so many options if you are in a clinical trial of one. Even in the case of tirz, I think the dosing schedules can be seen as too conservative with having to wait four weeks to increase the dose at all. OTOH, there are the microdosers who think a therapeutic dose is less milligrams than most people think.

In the case of reta, there are different dosing schedules in different trials.

A summary by Google Gemini (which overlooks some exceptions):

Phase of Treatment Typical Weekly Dose (mg) Escalation Rationale Starting Dose 1 mg or 2 mg A low introductory dose to ensure initial tolerability. Some trials started at 1 mg, others at 2 mg. Escalation Steps Increase every 4 weeks The dose is gradually increased in steps (e.g., 2 mg → 4 mg → 8 mg, etc.) typically every four weeks . This slow, stepwise increase is key to managing side effects. Maximum Studied Dose Up to 12 mg (or 16 mg in some early cohorts) The schedule continues until the participant reaches their assigned maintenance dose (4 mg, 8 mg, or 12 mg) or the maximum protocol dose. Maintenance Phase 4 mg, 8 mg, or 12 mg The dose is held steady for the remainder of the trial duration (e.g., 48 weeks) to assess long-term efficacy and safety.

 

[PorcShanc]

Most people here will be at 2 mg within a month of starting reta. But there are some super responders who stay at 1 mg longer than most, just as there are many who start at 2 mg or titrate up ASAP.

It's generally a good idea to rotate injection sites. View attachment 11300

Thank you so much for the reply.

Most people here will be at 2 mg within a month of starting reta. But there are some super responders who stay at 1 mg longer than most, just as there are many who start at 2 mg or titrate up ASAP.

It's generally a good idea to rotate injection si

Most people here will be at 2 mg within a month of starting reta. But there are some super responders who stay at 1 mg longer than most, just as there are many who start at 2 mg or titrate up ASAP.

It's generally a good idea to rotate injection sites. View attachment 11300

Thank you for your reply and for the info. I appreciate it a lot

 

[PorcShanc]

I don't think you can fully plan dosage that far ahead. You don't know how your body reacts to it. I mean you just took your first shot and it hasn't even had a chance to get up and running just yet. You don't know if your current dosage will cause a side effect nor even if it works at all at a low dose.

The way I decide: I take a first shot or dosage increase and wait until just before my next dose to decide if I need to reduce due to side effects. (I have never had anything so bad to do this) After the 4th shot at any dose I decide if to stay at the same dose or increase based on how my body responded. I do eventually plan to increase to the dosages in the official studies that are most effective .. but I want to get there slowly.

Thanks so much for taking the time to reply. Yeah I do agree, my plan was to just do 0.5mg for the first week, if there are no side effects to n 7 days I was gonna move up to 0.5mg twice weekly and stay at that for 4 weeks, if I see steady results and no side effects I’ll move up to 1mg twice weekly and stay there until results stall.

You think this is a good strategy?

 

[PorcShanc]

Document date, dose, weight, and side effects at the least. I started with the published protocol and as I titrated up i started getting allodynia and cramps for the first couple days. So I backed off the dose until the pain went away. Then the weight loss stopped. So I switched to Monday and Thursday dosing and then titrated up until I started seeing affects. But the allodynia came back. So I then moved to Monday, Wednesday and Friday. That worked for a couple months. That was a 2,2,3mg dose. Now I'm at 3,3,4 for a total of 10mg per week and I'm back to losing about a pound a week. My issue is appetite control. I was about to look into Cagri because I was so frustrated. But 10mg is working well.

I don't know how some people get away with a maintenance dose of a couple mg a week. Unless they really didn't need it for health issues, but they are already lean and hit the gym daily. They must want to shave that last few percent off to show their abs on Instagram. I'm also 5'10" and 210lbs. I imagine a smaller person, closer to their goal weight needs a lot less.

Thanks for the reply. I bought myself a notebook for keeping notes. What do you mean when you say the published protocol?

10mg does seem like a lot but I guess if that’s what you need to see results then that’s what you need. I’m guessing I probably will need something similar as I’m 6ft 1 and 213lbs.

I’ll stick to my plan as stated in my reply to the above comment but judging by your response I’ll probably be titrating up quicker than expected providing I don’t get any horrible side effects.

 

[PorcShanc]

I agree that you shouldn't try to plan out that far ahead. You never know how you will or won't respond, what sides you'll have, etc.

I am curious where you read there's no need to go above 2 mg / week. I'm not sure 2 mg is even considered a therapeutic dose. Not to say you should titrate beyond it if 2 mg is working, but that planning on stopping at or before 2 mg doesn't make much sense to me.

It was somewhere on Reddit for sure but I agree that it seems like very little. Especially considering I’m 6ft1 and 213lbs

 

[PorcShanc]

I started low @.5mg every 3 days because A.) I had never taken anything ever. B.) I had no idea what I'm doing (still the case most likely). Currently on 1mg every 3 days since I've had no stall in my weight loss. 5'9//44M//SW 216 CW 187.

I do follow the clock around the belly button for Reta.

I will say I really like the Shotsy app. I've been using the free version which is great imo. You enter the dose ,injection site, pain level, notes , weight. And can set reminders for next dose. Then you can take a look at a decent graph to see what your trendlines are.

Thanks so much for replying. I’ve never heard of Shotsy so I’ll definitely check that out. Very eye opening to hear about how everyone is dosing and the time between shots etc. Until I posted this I hadn’t really heard of anyone dosing 3 times a week.

 

[miss-sanne]

Hey community,

I just started Reta today. My plan is to do 6 weeks at 1mg per week and I plan on splitting that into two doses per week. 0.5mg on Monday and 0.5mg on Thursday. My reasoning behind this is simply because I feel it might work better if there’s a steady stream of it rather than just once a week doing a full 1mg. Please let me know if doing this makes no difference at all. Another reason I’m doing it is to more so ease into it than going full on straight away.

I’m also taking g BPC, TB and GHK. All of these are being injected into my belly just above where my boxers waistband is.

Wondering if this is where everyone else does it as well?

Finally, I’m wondering should I move onto 2mg (weekly) after 6 weeks? I’ve read that there’s no need to really ever go beyond 2mg weekly but I’ve also seen people go up to as much as 12mg per week so I wanted to hear some opinions about this also.

Thanks in advance guys

If it works on a given dose, stay, if not, move up. After 4 weeks on the same dose.

 

[PAPoots]

I looked at Shotsy. It looks nice, but it only tracks glps. I need an app that tracks them all.

 

[MsGizmo]

Thanks so much for taking the time to reply. Yeah I do agree, my plan was to just do 0.5mg for the first week, if there are no side effects to n 7 days I was gonna move up to 0.5mg twice weekly and stay at that for 4 weeks, if I see steady results and no side effects I’ll move up to 1mg twice weekly and stay there until results stall.

You think this is a good strategy?

Its not a bad strategy. My comment was basically just about trying to plan out farther ahead than 4 weeks. Unfortunately we can't know ahead of time how our bodies are going to react. Maybe you'll get sick, maybe you won't lose weight .. and hey, it could be just right.

 

[Habibibi]

There is absolutely no need to dose more than once a week, if you can tolerate side effects. The drug was meant to be dosed every week, it will have better efficacy that way. Plan to stay at the same dose for a minimum of 4 weeks, to establish steady state.

 

[PAPoots]

There is absolutely no need to dose more than once a week, if you can tolerate side effects. The drug was meant to be dosed every week, it will have better efficacy that way. Plan to stay at the same dose for a minimum of 4 weeks, to establish steady state.

"if you can tolerate side effects."

Microdosing has enough interest to have a clinical trial.

ClinicalTrials.gov

clinicaltrials.gov

I'll probably look at weekly dosing now they i have gotten adjusted to the reta and the only side effect I have now, is a bit of allodynia.

 

[Calm Logic]

By the way, @Super Trips is known for higher, experimental dosing, the opposite of microdosing.

Now that short-term orfo is out (in the grey world), that may help with feelz-based daily dosing/boosts.