RetCurious
GLP-1 Enthusiast
quoted said:
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.70137
Reduced-Frequency GLP1 Therapy Maintains Weight, Body Composition, and Metabolic Syndrome Improvements
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https://onlinelibrary.wiley.com/doi/full/10.1002/oby.70137
oldrunnerguy
GLP-1 Apprentice
"This study aimed to evaluate whether reduced-frequency dosing of GLP1 receptor agonists maintains weight loss, body composition, and metabolic syndrome improvements following successful initial treatment with standard weekly therapy."
The part about metabolic improvements is why I began a trial of Reta and am currently trialling Tirz. I was on1.5mg of Reta for 8 weeks and am currently on 1.5mg of Tirz for 8 weeks. I had my labs done after the Reta and will do the same after my Tirz trial. Blood work showed my A1C dropped, HDL went up to 96, LDL went down from 75 to 55, total cholesterol lowered from 176 to 162, and my triglycerides, already low at 52 went down to 39. Given these numbers, whichever one I decide to continue will likely be at 1mg/week and maybe lower and less than weekly. For many, the weight loss from these drugs is awesome. For me, it's about the other stuff.
The part about metabolic improvements is why I began a trial of Reta and am currently trialling Tirz. I was on1.5mg of Reta for 8 weeks and am currently on 1.5mg of Tirz for 8 weeks. I had my labs done after the Reta and will do the same after my Tirz trial. Blood work showed my A1C dropped, HDL went up to 96, LDL went down from 75 to 55, total cholesterol lowered from 176 to 162, and my triglycerides, already low at 52 went down to 39. Given these numbers, whichever one I decide to continue will likely be at 1mg/week and maybe lower and less than weekly. For many, the weight loss from these drugs is awesome. For me, it's about the other stuff.
I have been having the same results. I stopped Tirz about 2 months ago because I was going to be on planes and in airports for 24 or so hours at a time and be in a home with sttrangers for a couple of weeks. I didn't wnt the gastric issues I have to be an issue. I have been home now for several weeks and have still not started back because I am maintaining and even lost 3lbs while gone. I know this is not long term, and my results could absoutely change, but as of right now, I am happy.
lessthanhalf
GLP-1 Specialist
I have seen this study before, there are significant issues with it as far as I am concerned,
Swapping to lower doses or less frequent doses when weight loss has ceased , which takes about a year or a bit more, is different to doing it when weight loss is still ongoing. Their definition of weight loss stalling is less than 5% change in 3 months, which is equivalent to less than 20% over a year, which is very rapid weight loss not stalling. I think this error invalidates a lot of what the study is trying to prove. It may be that weight loss had actually ceased, but there is no way of knowing due to the very poorly defined stall point. Weight loss that was still ongoing at a given dose being maintained at that dose being given less often is what I would expect to happen. Weight loss that had truly ceased being maintained by less frequent dosing is not what I would expect and would be showing something different to all the other research. All the studies that had long tern follow up on ongoing therapy showed weight loss being maintained at the dose used to lose the weight in the first place. Given that this study is trying to show something that disagrees with many other large studies all showing the same thing, it needs to show extra high quality evidence to support it's argument. A study with few participants with not very well designed definitions, does not prove much at all, compared with multiple very large scale studies done to demonstrate the drugs effectiveness at maintaining weight loss had many hundreds of participants , and results were consistent for all the different GLP drugs, weight loss is maintained at the dose used to lose the weight. I do not think this study disproves that.
Swapping to lower doses or less frequent doses when weight loss has ceased , which takes about a year or a bit more, is different to doing it when weight loss is still ongoing. Their definition of weight loss stalling is less than 5% change in 3 months, which is equivalent to less than 20% over a year, which is very rapid weight loss not stalling. I think this error invalidates a lot of what the study is trying to prove. It may be that weight loss had actually ceased, but there is no way of knowing due to the very poorly defined stall point. Weight loss that was still ongoing at a given dose being maintained at that dose being given less often is what I would expect to happen. Weight loss that had truly ceased being maintained by less frequent dosing is not what I would expect and would be showing something different to all the other research. All the studies that had long tern follow up on ongoing therapy showed weight loss being maintained at the dose used to lose the weight in the first place. Given that this study is trying to show something that disagrees with many other large studies all showing the same thing, it needs to show extra high quality evidence to support it's argument. A study with few participants with not very well designed definitions, does not prove much at all, compared with multiple very large scale studies done to demonstrate the drugs effectiveness at maintaining weight loss had many hundreds of participants , and results were consistent for all the different GLP drugs, weight loss is maintained at the dose used to lose the weight. I do not think this study disproves that.
RetCurious
GLP-1 Enthusiast
lessthanhalf said:
Nice looking out as usual, thank you.
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