Reconstituting Powder ML Question.

[Whiynot20026]

So I’m pretty comfortable on mixing. Where I’m still not comfortable is what ML to use for a peptide. If I have a 500MG NAD I use 3ML. If I have a 10MG Reta I can use 1 ML. If I have a 40MG Reta or Tirzep this is where I go south. I know the more BAC the more diluted. So wouldn’t we want less BAC to be more concentrated. What would be the proper ML for a 40 gram mix?

Bill

 

[woundcarping]

Common logic is to reconstitute to make the injection volume where you want it to be.

There are limits to concentration, but they aren't very well defined. For GLP I use 30mg/ml as my general theory.

 

[Whiynot20026]

Common logic is to reconstitute to make the injection volume where you want it to be.

There are limits to concentration, but they aren't very well defined. For GLP I use 30mg/ml as my general theory.

Is that 3 MLs? The less BAC the better to me. But super confusing. I’m not a scientist. Yet.

Bill

 

[ultima thule]

Is that 3 MLs? The less BAC the better to me. But super confusing. I’m not a scientist. Yet.

Bill

My reconstituting concept is, to put such an amount of bac water, to have even unit of the shot on the syringe scale. I mean always try to aim to have 10u or 20u of the required dose. Just find it handy and easy to measure this way. Not always possible to do it that way, but when it's technically doable, I go for it.

 

[woundcarping]

Is that 3 MLs? The less BAC the better to me. But super confusing. I’m not a scientist. Yet.

Bill

30mg per mL as a general limit to how concentrated I'll make my GLP. I also prefer to keep my injection volume at or under .3ml when practical, since that uses my most common syringe.

At a 9mg dose, that's .3ml, which is fine for me.

Dose in mg divided by the mL you want the volume to be tells you the concentration.

9mg / .3ml= 30mg/ml (dimensional analysis is a fantastic tool)

Vial in mg divided by mg/ml gives you the reconstitution volume.

40mg vial / 30mg/ml= 1.33ml

 

[Whiynot20026]

30mg per mL as a general limit to how concentrated I'll make my GLP. I also prefer to keep my injection volume at or under .3ml when practical, since that uses my most common syringe.

At a 9mg dose, that's .3ml, which is fine for me.

Dose in mg divided by the mL you want the volume to be tells you the concentration.

9mg / .3ml= 30mg/ml (dimensional analysis is a fantastic tool)

Vial in mg divided by mg/ml gives you the reconstitution volume.

40mg vial / 30mg/ml= 1.33ml

This is so helpful. Thank you. So it looks like I want to take 2MG pep I’ll be mixing 2ML for a 40 MG vile which is 1 unit on syringe.

Bill

 

[woundcarping]

2mg dose divided by 20mg/ml is .10ml.

I'd practically never want a .01ml dose in an insulin syringe.

 

[skeptick]

Is that 3 MLs? The less BAC the better to me. But super confusing. I’m not a scientist. Yet.

Bill

https://calc.injectionshop.com/ This is my favorite dose calculator but there are many and also some reverse calculators that helped me understand the math involved with reconstituting and injection.

 

[sheilarae74]

Here is the reverse pep calculator https://reverse.peprecon.com/

 

[BNLFL]

Common logic is to reconstitute to make the injection volume where you want it to be.

There are limits to concentration, but they aren't very well defined. For GLP I use 30mg/ml as my general theory.

Currently on a R50, 56mg fill, reconned with 3ml and pinning 4.3mg/43units witch is 8mg.

 

[Whiynot20026]

Currently on a R50, 56mg fill, reconned with 3ml and pinning 4.3mg/43units witch is 8mg.

Those numbers check. Thanks. I’ve learned a shit ton the last few days. Thanks everyone.

Bill

 

[Whiynot20026]

BNFL could you have just gone 30ML. Why 28?

Bill

 

[BNLFL]

BNFL could you have just gone 30ML. Why 28?

Bill

Where's that?

 

[Whiynot20026]

Where's that?

I guess my question was ridiculous. I just thought the numbers were a little weird. But the mix was not.

Bill

 

[indolent]

Seriously, stop thinking in terms of concentration, and in terms of a nice round amount of bac to add to the vial.

For the extremes regarding fluid injection, know that tiny amounts will mean more variance from plan as you hit the top or bottom of your syringe mark; mostly that's de minimus unless you're at extreme concentration. At the other end of the spectrum, a study showed adverse effects from 2 ml (not unit) sq injection in a single pin; not sure if they're permanent (e.g. scar tissue), but presumably you're not going anywhere near that volume.

If you're titrating up, choose something that will manage your increases (typically 2.5 mg per step for tirzepatide) so that you hit the marked numbers on your particular syringe with each anticipated step.

Turn your math off, disregard the ordinary pep calculators, and master the reverse calculator, expecting a weird amount of bac to recon with.

If metric isn't your first language, get a very firm grip on it and measure twice, cut once.

 

[Oldguy]

Starting to sound like a math quiz.

 

[Whiynot20026]

Seriously, stop thinking in terms of concentration, and in terms of a nice round amount of bac to add to the vial.

For the extremes regarding fluid injection, know that tiny amounts will mean more variance from plan as you hit the top or bottom of your syringe mark; mostly that's de minimus unless you're at extreme concentration. At the other end of the spectrum, a study showed adverse effects from 2 ml (not unit) sq injection in a single pin; not sure if they're permanent (e.g. scar tissue), but presumably you're not going anywhere near that volume.

If you're titrating up, choose something that will manage your increases (typically 2.5 mg per step for tirzepatide) so that you hit the marked numbers on your particular syringe with each anticipated step.

Turn your math off, disregard the ordinary pep calculators, and master the reverse calculator, expecting a weird amount of bac to recon with.

If metric isn't your first language, get a very firm grip on it and measure twice, cut once.

I feel solid in most areas. I’m very new with being my own nurse for my wife and I. We have come along way in a short time. The two areas that concern me with all peptides is dosing and the amount of BAC to add to a vile. The question I keep asking everyone and never get a solid answer is always vague on the amount of BAC. Do some peptides benefit more with 10ML over 20 ML or vice versa. To me I’d like to put as little BAC into my body as possible. I like when the BAC pin is the same as the insulin syringe 1 mg per 10 on the needle. Although I have had 2mg per 10 units. But when is the BAC too little and when is the BAC too much?

Bill