📌难道🇷🇪🇹🇦就该是这样吗⁉️❓

[UnusualLLama]

I want it...hand it over

I need it, it's mine.

 

[Smiter]

I need it, it's mine.

Just my luck. Is my reta contraband or fake?

 

[UnusualLLama]

Just my luck. Is my reta contraband or fake?

It's a genuine question, there's risk in the grey market.

You'll never know for certain unless you get it tested yourself or start to notice the effects.

I did my research here before taking that first plunge, can't discuss sources but looked for one with no controversial issues mentions and good reviews but at the end of the day how do I know they slapped the right label on a vial?

It could be you having the flu is messing with things a bit but as others have said I'd stick it out a bit, give it a month at least.

You're sure you're dosing it correctly as well, right?

 

[Smiter]

It's a genuine question, there's risk in the grey market.

You'll never know for certain unless you get it tested yourself or start to notice the effects.

I did my research here before taking that first plunge, can't discuss sources but looked for one with no controversial issues mentions and good reviews but at the end of the day how do I know they slapped the right label on a vial?

It could be you having the flu is messing with things a bit but as others have said I'd stick it out a bit, give it a month at least.

You're sure you're dosing it correctly as well, right?

the prob is that this was a single vial from a us seller

 

[UnusualLLama]

the prob is that this was a single vial from a us seller

Ahhh, yeahhhh.. hard to say then. Hopefully you'll feel something from it as it builds up in your system, assuming, hopefully, it's not fake.

 

[longestyards]

Is the batch tested? Could be its not even reta?

 

[lessthanhalf]

The half-life math is what got me circumspect. Yes, the amount of the drug in the system reduces by half every 6 days. So, 1mg becomes 500mcg in 6 days, 250mcg in 12 and so forth. Dosing once every 7 days with 1 mg will mean that on day 30, there will be 1.41mg of drug in the body, using the formula Remaining=1 mg×(1/2)^days elapsed/6.

It's using this math that I thought of raising the dose to 1.5mg.

Drug levels do not go down in a linear fashion , trying to work it out without a graph is almost impossible. I had to hand draw graphs of ozempic levels to try to work it out before I knew places like this forum existed and other people had already worked it all out, so not sure that math is technically correct, but my pharmacology is pretty rusty, glp1plottter is much easier.

 

[BNLFL]

the prob is that this was a single vial from a us seller

I've got them early on, no issues. It seems you may be over thinking this and want results immediately. JMO

 

[Smiter]

If maths is not your forte GLP plotter is a really good idea, understanding this bit makes understanding what is going on with effects and side effects over time much easier.

GLP-1 Plotter - Semaglutide (Ozempic/Wegovy) & Tirzepatide (Mounjaro) Dose Calculator

Plot graphs and calculate levels for GLP-1 Receptor Agonists Semaglutide (Ozempic/Wegovy/Rybelsus) or Tirzepatide (Mounjaro) based on dose & half-life.

glp1plotter.com

GLPLOTTER 似乎也使用了相同的公式。6 月 1 日，当我输入与上述相同的数据时，它显示的预测值为 1.41 毫克。

 

[GLP1Pharmacist]

我才服用第一剂1毫克，今天是第四天，还没感觉到食欲抑制。

对于大多数人来说，第一剂的效果并不持久。服用任何GLP类药物的前几个月都是为了测试你的耐受性，并让身体逐渐适应。幸运的是，大多数人即使在早期也能获得一些临床益处。别想太多，按月来，慢慢增加剂量，大多数人花了数十年才长胖，减肥也需要时间。这是最健康、最安全的方法。

 

[birdwhacker]

先从每三天1毫克开始，以后你会感谢我的。2毫克是起始剂量，一旦开始剂量低，避免了副作用，就没必要一直保持低剂量。

我一开始是0.5毫克，也没有任何食欲抑制。所以每两天再加0.5毫克，直到一周达到2毫克。然后改为每三天1毫克。食欲抑制效果很好，前三周我每周减重四磅。现在我每周服用4.66毫克，每三天2毫克。事实上，今天是注射日！

 

[Smiter]

先从每三天1毫克开始，以后你会感谢我的。2毫克是起始剂量，一旦开始剂量低，避免了副作用，就没必要一直保持低剂量。

我一开始是0.5毫克，也没有任何食欲抑制。所以每两天再加0.5毫克，直到一周达到2毫克。然后改为每三天1毫克。食欲抑制效果很好，前三周我每周减重四磅。现在我每周服用4.66毫克，每三天2毫克。事实上，今天是注射日！

我当时正在考虑这样的方案……分次服用。

 

[birdwhacker]

我当时正在考虑这样的方案……分次服用。

我不明白为什么有人会每周只服用一次。药物的半衰期是六天。受体脱敏根本就是个谬论。对我来说，分次服用效果非常好。

 

[Smiter]

我不明白为什么有人会每周只服用一次。药物的半衰期是六天。受体脱敏根本就是个谬论。对我来说，分次服用效果非常好。

我认为这与对“半衰期”这个术语的误解有关，也与它和药物作用之间的区别有关。半衰期仅仅衡量药物在体内浓度的持续时间，并不能说明药物作用是如何显现的。如果许多关于服药后最初几天食欲抑制的说法属实，那么从逻辑上讲，分次服药是必要的。

 

[BNLFL]

我不明白为什么有人会每周只服用一次。药物的半衰期是六天。受体脱敏根本就是个谬论。对我来说，分次服用效果非常好。

我从1月9日开始，每周一次，已经减掉了40磅。早在开始服用之前，甚至在加入这个论坛之前，我就读过关于半衰期的文章。我会坚持每周一次。

I think it has to do with misunderstanding what the term, "half-life" means, and how it's different from drug effects. Half-life simply measures the existence of a quantity of drug in the vessel. There's no indication of how the drug's effects manifest. If many anecdotalclaims of having appetite suppression only on the first few days after dosing are true, then logically, split dosing is called for.

I totally understand the half life deal. See above. I’ll continue on my once a week.

 

[birdwhacker]

I started January 9 at once a week and have lost 40lbs. I read about the half life way back before starting and way before joining here. Staying with the once a week deal.

I totally understand the half life deal. See above. I’ll continue on my once a week.

No if it works for you I totally get it!

I didn't fully elaborate on my meaning... Once a week makes sense if you don't have appetite problems. I actually still struggle with overeating on 4.66mg a week, I could easily eat 3-4 brownies or a triple quarter pounder right now. I need so much appetite suppression that it's actually disgusting.

I fully expect to need cagri soon

 

[Troposphere]

1mg every 3 days here also. I started at 0.5mg with the intention of pinning weekly, hunger got the best of me and I did another 0.5mg after 3 days. I've stuck to the every 3 days since.

After a month I went up to 1mg/3 days

 

[GLP1Pharmacist]

I can't understand why anyone would dose once a week. The half life is six days. Receptor desensitization is a myth. Split dosing is super effective for me.

Lacking any true clinical evidence would be one good reason.

 

[birdwhacker]

Lacking any true clinical evidence would be one good reason.

You can certainly say those words in that order, and they are technically true! Beyond that, I'm not sure how they're helpful.

 

[Smiter]

Lacking any true clinical evidence would be one good reason.

Ah, the old argument from authority fallacy over logical empiricism-enabled synthesis again? I always wonder where the true root of the dogmatic belief in its efficacy and inviolability stems from. Certainly not from the scientific method.