📌难道🇷🇪🇹🇦就该是这样吗⁉️❓

[Smiter]

我第二次服用了1.5毫克，第一次是1毫克。到目前为止，除了服药当天，体重没有明显减轻，食欲也没有明显抑制。我是不是哪里做错了？我唯一损失的就是睡眠。我在想是不是应该增加剂量。

 

[WLBLD]

这只是你的第二剂。可能需要一些时间才能起效。如果是R型，它对食欲的抑制作用不大。这还取决于这是否是你第一次服用GLP-10。2毫克通常是起始剂量，但对某些人来说，更低的剂量也可能有效。

 

[CharmanderInDisguise]

第二次服药，所以才服用了一周？我建议你再等等。药物才刚刚开始在你体内积累。对我来说，头几个月，食欲抑制的效果到周末就消失了。现在到了第五个月，效果比较稳定了。别着急，这不是立竿见影的。

 

[kobeanbry24]

但你的腰围变细了吗？我体重也没减，但裤子感觉宽松了。自从开始减肥以来，我每天都坚持锻炼，所以肌肉增长抵消了脂肪减少的影响。

 

[Smiter]

唉，我的腰还是那么粗。该死的流感让我没法锻炼。

 

[BNLFL]

服用1.5或2毫克，持续4周。需要逐渐增加剂量。帖子标题里那些都是些什么鬼话？

 

[Smiter]

服用1.5或2毫克，持续4周。需要逐渐增加剂量。帖子标题里那些都是些什么鬼话？

当我浏览论坛时，这个名称很容易辨认。

 

[thebonus]

唉，我的腰还是那么粗。该死的流感让我没法锻炼。

才第一周就得了流感？给身体一些时间休息吧。

 

[Smiter]

才第一周就得了流感？给身体一些时间休息吧。

好吧……之前我只有30毫克，今天买了之后，我有点心动了。是的，我得了流感。

 

[GLP1Pharmacist]

药物需要几周时间才能在体内积累到有效浓度，最好一个月内保持剂量不变。

 

[Gt3294a]

药物需要几周时间才能在体内积累到有效浓度，最好一个月内保持剂量不变。

Half life is 6 days if I recall correctly. So a given dose actually takes 4 weeks to fully build up. You can look at how test e builds up by comparison because it has a similar half life. Google search will show the graphs. When people rush it, some end up wrecking their sleep for a few weeks with a racing heart. And the only thing that works instantly is DNP which is poison so I would avoid that:::

 

[sheilarae74]

My advice is to titrate slowly. I have been at 5mg for 2 weeks and I feel like absolute SHIT now. I haven't been able to eat hardly at all this week. I thought it was a dehydration issue at first but the extra fluids and salt didn't help. I think I should have stayed at 4mg for longer. I'm so stupid.

 

[Smiter]

Half life is 6 days if I recall correctly. So a given dose actually takes 4 weeks to fully build up. You can look at how test e builds up by comparison because it has a similar half life. Google search will show the graphs. When people rush it, some end up wrecking their sleep for a few weeks with a racing heart. And the only thing that works instantly is DNP which is poison so I would avoid that:::

You'know that math always boggled my noggin.

 

[Gt3294a]

You'know that math always boggled my noggin.

Just err on the side of extra test to account for possible miscalculation and less on Reta for the same and life works out just great. That’s how I do my rounding.

 

[lessthanhalf]

Before even considering messing with the standard dosing arrangement, you need to be sure you understand the pharmacokinetics of the drug. GLP's are totally different to just about any other drugs. They take around 24h to be absorbed and get to peak drug levels in the blood and the half life is 6 days for reta, so it takes 6 days for that peak to drop by half. The amount in your system will continue to increase over 4 weeks, which is why it is recommended to increase doses every 4 weeks.

GLPplotter is a good way to understand what is going on as it shows you this in a graph of blood levels over time.

The issue with increasing doses more often or by a larger amount is side effects. Most people will get some , most common are nausea, vomiting , diarrhoea or constipation and with reta skin sensation weirdness. Side effects typically are worst at 2-4 months after starting with dose increases at around 4-8mg/w and usually very slowly improve.

Because of the long half life if you do get unpleasant side effects like vomiting, it might improve over a few days, but if you are unlucky you could be puking for a week, and when that happens there is a good chance you will need medical treatment.

Side effects or having them get worse are always a risk with any dose increases, but you are more likely to get more severe or prolonged ones if you push dose increases faster, and because of the slow build up of levels over 4 weeks , it might become a problem weeks after a dose increase, which is not intuitively obvious. And individual responses to the hunger reducing effects and the side effects are very variable, which is the reason for the slow careful dose increases plan.

 

[lessthanhalf]

If maths is not your forte GLP plotter is a really good idea, understanding this bit makes understanding what is going on with effects and side effects over time much easier.

GLP-1 Plotter - Semaglutide (Ozempic/Wegovy) & Tirzepatide (Mounjaro) Dose Calculator

Plot graphs and calculate levels for GLP-1 Receptor Agonists Semaglutide (Ozempic/Wegovy/Rybelsus) or Tirzepatide (Mounjaro) based on dose & half-life.

glp1plotter.com

 

[Estarossa19]

It's time to go to 4mg

 

[Smiter]

Before even considering messing with the standard dosing arrangement, you need to be sure you understand the pharmacokinetics of the drug. GLP's are totally different to just about any other drugs. They take around 24h to be absorbed and get to peak drug levels in the blood and the half life is 6 days for reta, so it takes 6 days for that peak to drop by half. The amount in your system will continue to increase over 4 weeks, which is why it is recommended to increase doses every 4 weeks.

GLPplotter is a good way to understand what is going on as it shows you this in a graph of blood levels over time.

The issue with increasing doses more often or by a larger amount is side effects. Most people will get some , most common are nausea, vomiting , diarrhoea or constipation and with reta skin sensation weirdness. Side effects typically are worst at 2-4 months after starting with dose increases at around 4-8mg/w and usually very slowly improve.

Because of the long half life if you do get unpleasant side effects like vomiting, it might improve over a few days, but if you are unlucky you could be puking for a week, and when that happens there is a good chance you will need medical treatment.

Side effects or having them get worse are always a risk with any dose increases, but you are more likely to get more severe or prolonged ones if you push dose increases faster, and because of the slow build up of levels over 4 weeks , it might become a problem weeks after a dose increase, which is not intuitively obvious. And individual responses to the hunger reducing effects and the side effects are very variable, which is the reason for the slow careful dose increases plan.

The half-life math is what got me circumspect. Yes, the amount of the drug in the system reduces by half every 6 days. So, 1mg becomes 500mcg in 6 days, 250mcg in 12 and so forth. Dosing once every 7 days with 1 mg will mean that on day 30, there will be 1.41mg of drug in the body, using the formula Remaining=1 mg×(1/2)^days elapsed/6.

It's using this math that I thought of raising the dose to 1.5mg.

 

[UnusualLLama]

I took my 2nd dose at 1.5mg, first one was 1mg. So far, no real weight loss or substantial appetite suppression except on the day of dosing. Am I doing something wrong? The only thing I have lost is sleep. I'm wondering if I should increase the dosage.

I'm only on the 4th day of my first 1mg dose and I'm not feeling any appetite suppression.

But what I am experiencing is this weird ability to distinguish want from need.

I keep trying to debate with myself, how much of this is the Reta talking and how much of it is my mind talking, and then I remember that Reta can make you change the way you think like that and suddenly I don't know what's real anymore.

An exaggeration obviously, but something has definitely given me the ability to differentiate want from need and that has pretty much eliminated snacking.

 

[Smiter]

I'm only on the 4th day of my first 1mg dose and I'm not feeling any appetite suppression.

But what I am experiencing is this weird ability to distinguish want from need.

I keep trying to debate with myself, how much of this is the Reta talking and how much of it is my mind talking, and then I remember that Reta can make you change the way you think like that and suddenly I don't know what's real anymore.

An exaggeration obviously, but something has definitely given me the ability to differentiate want from need and that has pretty much eliminated snacking.

I want it...hand it over