Psoriatic Arthritis and Golimumab (biologic treatment)

[Phil5062]

Hi All,

I’m new to this site and peptides. I’ve been injecting Golimumab for 15 years now. Found this site and had a realisation that there may be something of an alternative. I’m in total remission and have completed triathlon at a high level. I’m now reducing my meds from monthly to every two months, let see what happens (at the advise/suggestion of my Rheumatologist)

Any one else got any ideas/suggestions/experience/opinons?

Many thanks

Phil (UK)

 

[CheesyPotato]

Hi, I don't know if an alternative exists to replace, but there are a few that have been noted as complementary. Wonderful that you are in remission! I wasn't so lucky, ended up having a bad reaction to Simponi. Check out TA-1, KPV and Thymulin(this is a bit expensive to run though).

 

[Neurogroot]

Hi All,

I’m new to this site and peptides. I’ve been injecting Golimumab for 15 years now. Found this site and had a realisation that there may be something of an alternative. I’m in total remission and have completed triathlon at a high level. I’m now reducing my meds from monthly to every two months, let see what happens (at the advise/suggestion of my Rheumatologist)

Any one else got any ideas/suggestions/experience/opinons?

Many thanks

Phil (UK)

Hi Phil! I went through the slog that was Otezla for awhile... For me, tirzepatide helped with the skin issues from my PsA. After way too much reading, I gave subcutaneous KPV a shot too. I had a brief, but expected moderate flareup for 2 weeks maximum. Then, my joints slowly felt better, noticeably after my first month, but really decent improvement now into my 3rd month.

I am considering trying KLOW, but keeping KPV around just in case. I've had a bit of hair thinning from tirzepatide and psoriasis so I am hoping that, with maybe AHK-CU topical will get me back on track over the next 3-4 months there. But honestly, the skin and joints are doing so much better than they were (not perfect though), that I'd accept the hair thinning for myself and just enjoy the added freedom of movement I have now.

Hope this helps!

 

[Phil5062]

Thanks for your replies. Interesting reading. Thankfully, almost immediately I was symptom fee as soon as I went in Golimumab (Simponi). I’m getting some GLOW to try (an d I’m also getting some good road bike miles in and some resistance training . No doubt it’ll help . I’ll see how extending the periods between taking my Golimumab to 8 weeks goes then try more. I’m reluctant to stop in case.

 

[Neurogroot]

Thanks for your replies. Interesting reading. Thankfully, almost immediately I was symptom fee as soon as I went in Golimumab (Simponi). I’m getting some GLOW to try (an d I’m also getting some good road bike miles in and some resistance training . No doubt it’ll help . I’ll see how extending the periods between taking my Golimumab to 8 weeks goes then try more. I’m reluctant to stop in case.

Being that you're from the UK, I'm curious... Would your healthcare provider be supportive of the peptide route, or not so much? In the US, it's a mixed bag. Personally, I'd never bring it up to my primary care, but my rheumatologist is ALL about me using them, responsibly if that is what works. So, he is filled in. Primary care, not so much.

Reason I bring it up is to make sure there are no interactions with the peptide (like copper specifically) with your current treatment.

 

[LabRatBarbie]

Hi, I don't know if an alternative exists to replace, but there are a few that have been noted as complementary. Wonderful that you are in remission! I wasn't so lucky, ended up having a bad reaction to Simponi. Check out TA-1, KPV and Thymulin(this is a bit expensive to run though).

I deal with Psoriasis and Psoriatic arthritis along with Fibromyalgia, i'm interested if you dont mind sharing details what reaction you had with Simponi? I was on IV drip of Simponi and after a few months it stopped working and now my body gets immuned to any of the shots they put me on, right around the 6 month mark. Ive taken every one you can name and have to keep changing shots. It might of been the Simponi, maybe its just me. Sorry if its to personal.

 

[Phil5062]

That is a very good point , tbh it never occurred to me . I’ll let my Rheumy know next time I see him. Glow seems to be proven, and in that case he’ll no doubt be supportive (unless there are conflicts with my simponi)

 

[Phil5062]

I deal with Psoriasis and Psoriatic arthritis along with Fibromyalgia, i'm interested if you dont mind sharing details what reaction you had with Simponi? I was on IV drip of Simponi and after a few months it stopped working and now my body gets immuned to any of the shots they put me on, right around the 6 month mark. Ive taken every one you can name and have to keep changing shots. It might have been the Simponi, maybe its just me. Sorry if its to personal.

No problem, it’s not too personal at all. The onset of symptoms was gradual over 6 months (right knee and whole foot) Went onto DMARDs. Then health service guidelines are try 2 dmards etc. then I qualified for biologics, was given Simponi (Golimumab) FOC . Not had a single flare up/swelling/reaction whatsoever in almost 15 years. Since starting I’ve competed Trathlon and bike time trialling at a UK level and continued in work. I’m a firefighter and ow the Fire Behaviour instructor.

Ive had no ill effects. So I’m wondering if I could maybe go the one injection every 2 months?this was pt to me by my Rheumy.

I really hope you find something that works for you. How many have you tried? Have you done much reading on this?

 

[LabRatBarbie]

No problem, it’s not too personal at all. The onset of symptoms was gradual over 6 months (right knee and whole foot) Went onto DMARDs. Then health service guidelines are try 2 dmards etc. then I qualified for biologics, was given Simponi (Golimumab) FOC . Not had a single flare up/swelling/reaction whatsoever in almost 15 years. Since starting I’ve competed Trathlon and bike time trialling at a UK level and continued in work. I’m a firefighter and ow the Fire Behaviour instructor.

Ive had no ill effects. So I’m wondering if I could maybe go the one injection every 2 months?this was pt to me by my Rheumy.

I really hope you find something that works for you. How many have you tried? Have you done much reading on this?

I have tried Humira, Enbrel, Cosentyx, Taltz, Stelara, Simponi and now I'm currently on Tremfya which hasn't cleared me all the way up yet, and starting to see it come back. So Tremfya is already losing effectiveness.

I have to honest I haven't done much reading on it because I trusted the dr.s know what they are doing. But now that I see what its all really about $$$ and not to much about the health of the patient, I am trying different avenues to better my overall health.

Started Sema and Nad+ last year and my arthritis improved drastically. I'm talking I saw improvement in mobility the very next day after pin.

The fact that the FDA wont approve peptides that have shown positive results for people suffering from so many illnesses tells me they care more about the $$$.

If everybody is healthy they would lose BILLIONS.

 

[CheesyPotato]

I deal with Psoriasis and Psoriatic arthritis along with Fibromyalgia, i'm interested if you dont mind sharing details what reaction you had with Simponi? I was on IV drip of Simponi and after a few months it stopped working and now my body gets immuned to any of the shots they put me on, right around the 6 month mark. Ive taken every one you can name and have to keep changing shots. It might of been the Simponi, maybe its just me. Sorry if its to personal.

Hi, I don't mind. I'm in a similar situation as you, I've tried so many drugs for RA they all end up not working or have bad reactions. I guess I'm one of those challenging patients. After a 4th dose of Simponi IV, I went into a full blown flare, migraine headaches, swollen lymph nodes, sore throat for weeks, I'm still going through flares. Basically I went from thinking I was in remission for the last year to a complete set back and worse. So I'm looking for alternatives. These diseases can suck the life right outta ya..sorry got a little ranty

 

[Devilseye]

Hi All,

I’m new to this site and peptides. I’ve been injecting Golimumab for 15 years now. Found this site and had a realisation that there may be something of an alternative. I’m in total remission and have completed triathlon at a high level. I’m now reducing my meds from monthly to every two months, let see what happens (at the advise/suggestion of my Rheumatologist)

Any one else got any ideas/suggestions/experience/opinons?

Many thanks

Phil (UK)

Well, I hate to be the bearer of bad news but Golimumab is an extremely potent inhibitor of inflammation which is why you have complete remission. I would bet that NO peptide has a chance of working as well. Like the odds are 99.999% that youll need Golimumab for life.

TB500, BPC, Etc are agents that promote healing but they are not immune suppressors which is what Golimumab is. Biologics like that are extremely effective at neutralizing their targets. Antibodies have binding affinities several orders of magnitude higher than small molecules and they just work extremely well. In your case it neutralizes TNF-alpha, an extremely potent Inducer of inflammation. Even if immune suppressor peptides existed, none will work as well. There is zero chance of that.

I get you are suppressing immune response and are at higher risk of infections but your quality of life has dramatically improved according to your own statement. You can try lower doses to find your minimum effecyive dose but youre unlikely to completely remove it from your life.

Keep in mind that because it has a long half life and because youve taken it for a long time, its been accumulating in your system. If you stop, its likely you wont experience symptoms for an extended time but chances are very high theyll come back eventually sadly.

Best of luck.

 

[Phil5062]

Well, I hate to be the bearer of bad news but Golimumab is an extremely potent inhibitor of inflammation which is why you have complete remission. I would bet that NO peptide has a chance of working as well. Like the odds are 99.999% that youll need Golimumab for life.

TB500, BPC, Etc are agents that promote healing but they are not immune suppressors which is what Golimumab is. Biologics like that are extremely effective at neutralizing their targets. Antibodies have binding affinities several orders of magnitude higher than small molecules and they just work extremely well. In your case it neutralizes TNF-alpha, an extremely potent Inducer of inflammation. Even if immune suppressor peptides existed, none will work as well. There is zero chance of that.

I get you are suppressing immune response and are at higher risk of infections but your quality of life has dramatically improved according to your own statement. You can try lower doses to find your minimum effecyive dose but youre unlikely to completely remove it from your life.

Keep in mind that because it has a long half life and because youve taken it for a long time, its been accumulating in your system. If you stop, its likely you wont experience symptoms for an extended time but chances are very high theyll come back eventually sadly.

Best of luck.

Good summary there cheeers. Interesting about the half life. I’ll monitoring dropping from 6 weeks to 8 weeks.

I have ben very fortunate that I have no issues with it and life is as before, totally asymptomatic. Another fortunate thing is I rarely get the common cold etc. My wife is a eacher and is exposed to everything going through her school (and brings it home) I hardly develop anything.