[Progress][NSFW] 12 Months of GLP1's and Lifting ~30kg down

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Itankstuff

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I started my weight loss journey in 2025. I was depressed, anxious and recently started taking antidepressants for the first time. It started with Lexapro and eventually I added Bupropion. To make matters worse, I had recently been diagnosed with obstructive sleep apnoea. I felt so fatigued, lethargic and honestly was just letting life pass me by.

I am in my early 30's and previously had been a pretty fit guy around the time I was in college. I started lifting weights at around age 17 in my first year of college. I didn't go regularly or often, but around 2-3 times a week. The noob gains however were real, I tended to put on muscle fairly quickly and found that the gym was an excellent tool to help my mental health. Looking back it was so hard to understand how I had fallen so hard and ended up at my heaviest recorded weight (I stopped weighing myself out of embarassment, I'm sure some of you can relate) sitting at around 131-132kg, my height is 185.5cm.

Because I felt so empty and depressed whilst also managing a very stressful job, I would "reward" myself by imbibing wine. I used it as a reward to decompress on Friday and Saturday nights. Because I was drinking wine, it was classy, or so I thought. But there was nothing classy when over the course of 4 years the Friday and Saturday nights were accompanied by the Monday night bottle of wine "because it was a stressful day", then the Wednesday drinking session to "get through the mid week".... I'm sure you get the picture. By the end of it I have to estimate I would probably have 10-15 standard drinks of alcohol 3-4 nights a week (a standard drink being 10g of alcohol).

Image 1: March/April 2025

[Imported image pending local asset: attachments-screenshot-2026-03-21-at-1-39-36-pm-webp.18154]

Weighing around 131-132kg. Highest recorded.

I was always reluctant to use GLP1’s because I had read a lot about the side effects. I was afraid I’d get pancreatitis or gastroparesis. I was afraid I’d lose weight too quickly and end up with too much loose skin. I made all sorts of excuses. I got to a point where I felt like the way I was living was going to lead me to an early grave. So do you know what my rationale was for starting Tirzepatide? “Well, I’m going to die anyways, so why does it matter if it’s the Tirze that kills me”. It’s sad reflecting back on that mentality, but in many ways it kickstarted this whole journey. I came to this realisation in Jan/Feb, but looking at my Shotsy data, it turns out I didn’t muster the courage to start until April. I was too embarrassed to even speak to my Doctor, as our initial conversation was met with, “well, why don’t you just try doing it the normal way first.” I had explained that I had lost weight before and had been, up until this point, a regular gym goer. I understood macros, calories, fasting, you name it. But I didn’t understand how to do it with this black cloud hanging over me. After that experience I signed up to an online clinic. I had a phone call with a lovely Nurse Practitioner and for the first time she made me feel that I could maybe, just maybe, take control back of my life.

Image 2: The GLP1 Journey via Shotsy

[Imported image pending local asset: attachments-img_0584-webp.18155]

For those of you wondering what happened in January this year, don't worry, I can explain....

And so off I went, I started Tirzepatide, or Mounjaro as it's called around these parts. It was amazing. It was strange, I couldn't describe the feeling, but I just didn't thnk about food. It was weird, I didn't think or desire alcohol either. I mean, I still drank, because it was habit. The alcohol tasted funny, I enjoyed wine and I loved my gin and tonic, but they tasted funny. Despite this, I continued to drink, because I never thought I would never not drink, it's just what I did on a Friday. Without trying, it went down to 5 standard drinks 3-4 times a week. Sometimes I'd add a little chaos in to my life and thoroughly indulge myself when I could feel the Tirze wearing off, and let me tell you, I felt it the next morning. They say insanity is doing the same thing over and over again and expecting different results. I knew I was a little insane to begin with so it made sense for me to keep drinking despite not enjoying the taste, nor the feeling anymore.

By this time it was July, the 25th of July was a Friday, so you know what I did, Saturday was no different. I decided though on the 27th of July, why not continue the insanity for another day? It was on this day of insanity I said to my now fiance "I think I'm going to stop drinking next month" the expression on her face esentially read as "Oh, I'm sure you will, like the 15 other times you've said that." That expression sat with me. It may come as a surprise, but because July 27th was a Sunday, July 28th ended up being a Monday. On this auspicious Monday I poured out all the alcohol I had at home. I self excluded myself from Uber Eats and Doordash so I couldn't spontaneously order alcohol.

July 27th 2026 was the last time I had alcohol, hopefully for the rest of my life. At the time of writing this, my app says it’s been 7 months, 25 days and counting. I’ll be honest, I had tried plenty of “Sober Octobers” and “Dry Julys” before. But in all that time since quitting, there has only been a single moment where I had a genuine craving for alcohol.

For this to make sense, you have to understand that I’m on the spectrum and was recently diagnosed with ADHD, so I tend to become obsessed with obscure things. At that point in my life, it was North Korea. I was in bed watching this video on YouTube. It's essentially a video of a North Korean soldier describing how he used to dream of drinking whiskey, because it was something only royalty had access to. Watching him savour this cheap, bottom-shelf American whiskey, I suddenly wanted nothing more than to share a glass with him. Thankfully, my North Korea obsession has since taken a backseat, and for now, my sobriety is safe.

In a long-winded way, what I’m trying to say is that GLP1’s made it easy for me to abstain. It’s actually pretty funny looking at the Shotsy graph, because you can clearly see when I stopped alcohol, my sugar cravings briefly took over, and then the rapid weight loss followed. I’m starting to think the conspiracy theory that booze might be empty calories has some truth to it.

Anyways.... Mounjaro.... Not only did it make me not desire alcohol, a lot of dopamine seeking behviours reduced. I had been doing a lot of research and reading the literature and it turns out we don't quite understand the mechanism, but there's emerging evidence that the medication can help with ADHD. It all clicked. So, the alcohol, the binge eating, the risky behviours, the impulsivity... They aren't just weird quirks, but rather my dopamine starved brain looking for stimulation. I was diagnosed with ADHD, I now take Vyvanse and without a word of a lie, it's almost like I have been living life in black and white this entire time and now put on some colour vision glasses. Since starting I had reduced anxiety (though not zero, more on that later), reduced depression and I found it a bit easier to socialise. I used to get cripping social anxiety, but it was now tolerable.

Life was good. Work was good. I was going to the gym. I was trying to eat 200g of protein a day but usually hitting around 150g due to Mounjaro, but I was happy with how things progressed. I went for an overseas holiday in December, and because I wasn't working, rather than doing the normal things people do on a holiday, I read. I read and read and read, I educated myself. I spent about a month everyday reading more about peptides and peptide therapy, I read a lot about testosterone replacement therapy too. What prompted me to do so was though I felt really good, I noticed I wasn't holding on to my muscle like I used to. I had lost weight before, but this time was different. I felt flat, soft and weak. The gym was starting to become a struggle and.... I had noticed my balls started to shrink.

Image 3: January 2026. Before I went all in.

[Imported image pending local asset: attachments-img_0569-webp.18159]

Recently returned from my overseas trip and ready to execute on the knowledge I had acquired.

So the cool thing about this whole reflection on the journey thing is that I get to look at photos, timestamps and dates. January 3rd is apparently the date I signed up to this forum. I think I was still overseas then but returned home shortly. I started CJC 1295/Ipamorealin and Retatrutide sometime in mid January. I'll post the January Pre Peptide photo and a photo taken in the last few days side by side as I think the effects speak for themselves. I was afraid of TRT, even though my balls were shrinking, I was scared to take TRT because I didn't want my balls to shrink (do you see a pattern here?). But because Tirze, CJC/IPA and Reta had already given me confidence in making these changes I just did it. I'm now taking TRT at around 150-175mg per week. I am still playing around with the dosages to try "dial in" my dose, but it's been 6-8 weeks on TRT so far and remember how I said treating my ADHD made me have almost no anxiety and depression? Well, it turns out having small balls and lower testosterone tends to do this, with TRT I feel like it was the missing piece of the puzzle. I still am trying to stabilise the dosage so there are some ups and downs, but I feel like I am very close to there. I feel fantastic 90% of the time.

Image 4: Before an after CJC/IPA for around 10-12 weeks and TRT for 6 weeks.

[Imported image pending local asset: attachments-12-weeks-cjc-ipa-webp.18160]

Image 5: DEXA Scan Results before and after CJC/IPA for around 10-12 weeks and TRT for 6 weeks.

[Imported image pending local asset: attachments-dexa_reddit_report_fixed-webp.18161]
 
So the administrators of the website have wisely placed a 10,000 character limit so my summary was cut off....

Summary

So, now here we are, it's the 24th of March 2026. I've now been 1 month free of Lexapro and Bupropion. I'm not depressed, I'm not anxious, I don't want nor do I care for alcohol. I am down to around 105kg and hoping to slowly lose another 10kg, but over the course of many months with no rush. I feel like my life has changed all because of a little (or long) sequence of amino acids which created a cascading effect to start taking care of myself. It's not just about weight loss, it's not just about fitting in those jeans we always wanted to wear. It's not just about feeling more comfortable in our own skin, it's about the fact that this medication, and these medications are all tools which allow us to finally have agency in our lives in a world and a society that at times makes us feel like we have no control at all. The ironic thing about this whole journey is, now I don't think or want to die, so with the way I feel now, I don't think I would have stuck that little needle in to my belly to start this journey. And to make it a bitter irony, my balls are still small, but for now, I think I'm okay with that..... Unless you know of a peptide for it.

Thanks for reading!
 
Great progress. You're not alone in your struggles. Did you know you can use HCG (from many china peptide dealers) to help with your balls and produce a little testosterone too. It tells your body to put the testicles to work which will prevent atrophy.
 
good for you! sounds like quite the journey to health and I'm always happy to hear when people are happier in their lives. Keep on, man.
 
Itankstuff said:
I started my weight loss journey in 2025. I was depressed, anxious and recently started taking antidepressants for the first time. It started with Lexapro and eventually I added Bupropion. To make matters worse, I had recently been diagnosed with obstructive sleep apnoea. I felt so fatigued, lethargic and honestly was just letting life pass me by.

I am in my early 30's and previously had been a pretty fit guy around the time I was in college. I started lifting weights at around age 17 in my first year of college. I didn't go regularly or often, but around 2-3 times a week. The noob gains however were real, I tended to put on muscle fairly quickly and found that the gym was an excellent tool to help my mental health. Looking back it was so hard to understand how I had fallen so hard and ended up at my heaviest recorded weight (I stopped weighing myself out of embarassment, I'm sure some of you can relate) sitting at around 131-132kg, my height is 185.5cm.

Because I felt so empty and depressed whilst also managing a very stressful job, I would "reward" myself by imbibing wine. I used it as a reward to decompress on Friday and Saturday nights. Because I was drinking wine, it was classy, or so I thought. But there was nothing classy when over the course of 4 years the Friday and Saturday nights were accompanied by the Monday night bottle of wine "because it was a stressful day", then the Wednesday drinking session to "get through the mid week".... I'm sure you get the picture. By the end of it I have to estimate I would probably have 10-15 standard drinks of alcohol 3-4 nights a week (a standard drink being 10g of alcohol).

Image 1: March/April 2025

View attachment 18154

Weighing around 131-132kg. Highest recorded.

I was always reluctant to use GLP1’s because I had read a lot about the side effects. I was afraid I’d get pancreatitis or gastroparesis. I was afraid I’d lose weight too quickly and end up with too much loose skin. I made all sorts of excuses. I got to a point where I felt like the way I was living was going to lead me to an early grave. So do you know what my rationale was for starting Tirzepatide? “Well, I’m going to die anyways, so why does it matter if it’s the Tirze that kills me”. It’s sad reflecting back on that mentality, but in many ways it kickstarted this whole journey. I came to this realisation in Jan/Feb, but looking at my Shotsy data, it turns out I didn’t muster the courage to start until April. I was too embarrassed to even speak to my Doctor, as our initial conversation was met with, “well, why don’t you just try doing it the normal way first.” I had explained that I had lost weight before and had been, up until this point, a regular gym goer. I understood macros, calories, fasting, you name it. But I didn’t understand how to do it with this black cloud hanging over me. After that experience I signed up to an online clinic. I had a phone call with a lovely Nurse Practitioner and for the first time she made me feel that I could maybe, just maybe, take control back of my life.

Image 2: The GLP1 Journey via Shotsy

View attachment 18155

For those of you wondering what happened in January this year, don't worry, I can explain....

And so off I went, I started Tirzepatide, or Mounjaro as it's called around these parts. It was amazing. It was strange, I couldn't describe the feeling, but I just didn't thnk about food. It was weird, I didn't think or desire alcohol either. I mean, I still drank, because it was habit. The alcohol tasted funny, I enjoyed wine and I loved my gin and tonic, but they tasted funny. Despite this, I continued to drink, because I never thought I would never not drink, it's just what I did on a Friday. Without trying, it went down to 5 standard drinks 3-4 times a week. Sometimes I'd add a little chaos in to my life and thoroughly indulge myself when I could feel the Tirze wearing off, and let me tell you, I felt it the next morning. They say insanity is doing the same thing over and over again and expecting different results. I knew I was a little insane to begin with so it made sense for me to keep drinking despite not enjoying the taste, nor the feeling anymore.

By this time it was July, the 25th of July was a Friday, so you know what I did, Saturday was no different. I decided though on the 27th of July, why not continue the insanity for another day? It was on this day of insanity I said to my now fiance "I think I'm going to stop drinking next month" the expression on her face esentially read as "Oh, I'm sure you will, like the 15 other times you've said that." That expression sat with me. It may come as a surprise, but because July 27th was a Sunday, July 28th ended up being a Monday. On this auspicious Monday I poured out all the alcohol I had at home. I self excluded myself from Uber Eats and Doordash so I couldn't spontaneously order alcohol.

July 27th 2026 was the last time I had alcohol, hopefully for the rest of my life. At the time of writing this, my app says it’s been 7 months, 25 days and counting. I’ll be honest, I had tried plenty of “Sober Octobers” and “Dry Julys” before. But in all that time since quitting, there has only been a single moment where I had a genuine craving for alcohol.

For this to make sense, you have to understand that I’m on the spectrum and was recently diagnosed with ADHD, so I tend to become obsessed with obscure things. At that point in my life, it was North Korea. I was in bed watching this video on YouTube. It's essentially a video of a North Korean soldier describing how he used to dream of drinking whiskey, because it was something only royalty had access to. Watching him savour this cheap, bottom-shelf American whiskey, I suddenly wanted nothing more than to share a glass with him. Thankfully, my North Korea obsession has since taken a backseat, and for now, my sobriety is safe.

In a long-winded way, what I’m trying to say is that GLP1’s made it easy for me to abstain. It’s actually pretty funny looking at the Shotsy graph, because you can clearly see when I stopped alcohol, my sugar cravings briefly took over, and then the rapid weight loss followed. I’m starting to think the conspiracy theory that booze might be empty calories has some truth to it.

Anyways.... Mounjaro.... Not only did it make me not desire alcohol, a lot of dopamine seeking behviours reduced. I had been doing a lot of research and reading the literature and it turns out we don't quite understand the mechanism, but there's emerging evidence that the medication can help with ADHD. It all clicked. So, the alcohol, the binge eating, the risky behviours, the impulsivity... They aren't just weird quirks, but rather my dopamine starved brain looking for stimulation. I was diagnosed with ADHD, I now take Vyvanse and without a word of a lie, it's almost like I have been living life in black and white this entire time and now put on some colour vision glasses. Since starting I had reduced anxiety (though not zero, more on that later), reduced depression and I found it a bit easier to socialise. I used to get cripping social anxiety, but it was now tolerable.

Life was good. Work was good. I was going to the gym. I was trying to eat 200g of protein a day but usually hitting around 150g due to Mounjaro, but I was happy with how things progressed. I went for an overseas holiday in December, and because I wasn't working, rather than doing the normal things people do on a holiday, I read. I read and read and read, I educated myself. I spent about a month everyday reading more about peptides and peptide therapy, I read a lot about testosterone replacement therapy too. What prompted me to do so was though I felt really good, I noticed I wasn't holding on to my muscle like I used to. I had lost weight before, but this time was different. I felt flat, soft and weak. The gym was starting to become a struggle and.... I had noticed my balls started to shrink.

Image 3: January 2026. Before I went all in.

View attachment 18159

Recently returned from my overseas trip and ready to execute on the knowledge I had acquired.

So the cool thing about this whole reflection on the journey thing is that I get to look at photos, timestamps and dates. January 3rd is apparently the date I signed up to this forum. I think I was still overseas then but returned home shortly. I started CJC 1295/Ipamorealin and Retatrutide sometime in mid January. I'll post the January Pre Peptide photo and a photo taken in the last few days side by side as I think the effects speak for themselves. I was afraid of TRT, even though my balls were shrinking, I was scared to take TRT because I didn't want my balls to shrink (do you see a pattern here?). But because Tirze, CJC/IPA and Reta had already given me confidence in making these changes I just did it. I'm now taking TRT at around 150-175mg per week. I am still playing around with the dosages to try "dial in" my dose, but it's been 6-8 weeks on TRT so far and remember how I said treating my ADHD made me have almost no anxiety and depression? Well, it turns out having small balls and lower testosterone tends to do this, with TRT I feel like it was the missing piece of the puzzle. I still am trying to stabilise the dosage so there are some ups and downs, but I feel like I am very close to there. I feel fantastic 90% of the time.

Image 4: Before an after CJC/IPA for around 10-12 weeks and TRT for 6 weeks.

View attachment 18160

Image 5: DEXA Scan Results before and after CJC/IPA for around 10-12 weeks and TRT for 6 weeks.
 
MFGamesta said:
Great progress. You're not alone in your struggles. Did you know you can use HCG (from many china peptide dealers) to help with your balls and produce a little testosterone too. It tells your body to put the testicles to work which will prevent atrophy.

Weight issues and ADHD go hand in hand so I wouldn't be surprised if a non insignificant portion of this forum are neurodiverse to some extent! Thanks for the advice, I do have some HCG and I was using it initially, for some reason it didn't really do much for the little guys but I think did raise my E2 so makes it harder to get my TRT dose just right, so for the next 3 months or so I think I may stop it or use much less. For example I only slept 4.5 hours last night because yesterday was TRT pinning day.

Volkswagen57 said:
Curious about your cjc ipa protocol

I was taking 250mcg/250mcg twice a day, before bed and upon waking and staying fasted until midday. After 4 weeks I tested my IGF which came back at 405 (82-243 ng/mL) I can't remember the Z-score but it was, in my opinion too high. I already have a neanderbrow and big hands so don't want to welcome anymore acromegaly like features haha! I am now taking 200mcg/200mcg before bed and am waiting for my latest IGF1 to come back, should be some time today.
 
Itankstuff said:
Weight issues and ADHD go hand in hand so I wouldn't be surprised if a non insignificant portion of this forum are neurodiverse to some extent! Thanks for the advice, I do have some HCG and I was using it initially, for some reason it didn't really do much for the little guys but I think did raise my E2 so makes it harder to get my TRT dose just right, so for the next 3 months or so I think I may stop it or use much less. For example I only slept 4.5 hours last night because yesterday was TRT pinning day.

I was taking 250mcg/250mcg twice a day, before bed and upon waking and staying fasted until midday. After 4 weeks I tested my IGF which came back at 405 (82-243 ng/mL) I can't remember the Z-score but it was, in my opinion too high. I already have a neanderbrow and big hands so don't want to welcome anymore acromegaly like features haha! I am now taking 200mcg/200mcg before bed and am waiting for my latest IGF1 to come back, should be some time today.
Haha thanks for the response. I wish I had tested mine before starting (250mcg/250mcg) once before bed. But I was only 3 weeks in when I just went and had my blood drawn. Waiting on those results
 
Volkswagen57 said:
Haha thanks for the response. I wish I had tested mine before starting (250mcg/250mcg) once before bed. But I was only 3 weeks in when I just went and had my blood drawn. Waiting on those results

Please keep me updated. I just got my second set of results back. Dropping from 250/250mcg twice a day to once a day took me from:

Serum IGF1: 405 ng/mL

To

Serum IGF1: 314 ng/mL

Reference range of approx (~84–245 ng/mL)

I asked ChatGPT to review the available assay data and lab reference ranges to estimate a Z score. Apparently my most recent Z score is 3.5 - 3.8! With my previous Z score being approx 5.9!

I’m not sure how accurate the ChatGPT calculations are and wish the lab published the data.

I think I want to aim for 3, so may even split the dose to 100/100mcg twice a day.
 
Itankstuff said:
Please keep me updated. I just got my second set of results back. Dropping from 250/250mcg twice a day to once a day took me from:

Serum IGF1: 405 ng/mL

To

Serum IGF1: 314 ng/mL

Reference range of approx (~84–245 ng/mL)

I asked ChatGPT to review the available assay data and lab reference ranges to estimate a Z score. Apparently my most recent Z score is 3.5 - 3.8! With my previous Z score being approx 5.9!

I’m not sure how accurate the ChatGPT calculations are and wish the lab published the data.

I think I want to aim for 3, so may even split the dose to 100/100mcg twice a day.
I will report back my igf-1 level for sure. Appreciate you sharing your data/results. I will also report my total and free test levels as well as estradiol if interested. Currently running 125mg test cyp 2x/ week. Probably need to bring the dose down but my blood work will tell the story.
 
Volkswagen57 said:
I will report back my igf-1 level for sure. Appreciate you sharing your data/results. I will also report my total and free test levels as well as estradiol if interested. Currently running 125mg test cyp 2x/ week. Probably need to bring the dose down but my blood work will tell the story.

How are you feeling on this dose? Sans labs I'd be interested to know how mood, libido and general wellbeing are.

I can’t believe the improvements with TRT. Things like public speaking, meeting new people, work stress are all so manageable. It makes me better able to sweat the small stuff and not worry so much.

I am in a very toxic job and I literally said to my boss “I’m taking 4 weeks off, I need a break. These are the dates and we can discuss the terms I want to return on.” Ordinarily there would have been pushback, excuses because I asked. But since I instead told him and was calm, confident and clear in my messaging I could tell he respected that I was standing firm in my positioning.

I value myself more and see the value I provide a lot easier rather than doubting myself.

From a philosophical standpoint it makes me somewhat understand why TRT in society is so frowned upon. People in general are much more complicit and malleable when they lack self confidence and value themselves.
 
Itankstuff said:
How are you feeling on this dose? Sans labs I'd be interested to know how mood, libido and general wellbeing are.

I can’t believe the improvements with TRT. Things like public speaking, meeting new people, work stress are all so manageable. It makes me better able to sweat the small stuff and not worry so much.

I am in a very toxic job and I literally said to my boss “I’m taking 4 weeks off, I need a break. These are the dates and we can discuss the terms I want to return on.” Ordinarily there would have been pushback, excuses because I asked. But since I instead told him and was calm, confident and clear in my messaging I could tell he respected that I was standing firm in my positioning.

I value myself more and see the value I provide a lot easier rather than doubting myself.

From a philosophical standpoint it makes me somewhat understand why TRT in society is so frowned upon. People in general are much more complicit and malleable when they lack self confidence and value themselves.
"Feels report" I feel great. Previously I struggled with depression, anxiety, constantly feeling sluggish and tired through the day, and never feeling rested no matter how many hours of sleep I got.

I was on ssri medication for depression which helped but I felt "without purpose". And I had zero motivation to do things I enjoyed.

Now I feel well rested after 7-8 hours of sleep. My anxiety and depression is gone. No more depression meds. I've been going to the gym 3x/week. With the help of tirzepatide I've lost 25lbs since January 10th.
 
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