Post‑pin reaction after vacation eating: lower the dose?

[Mara_aa]

I took four days off and went on my first mini‑cruise ever to see if this kind of holiday could work for me (spoiler: ABSOLUTELY NOT, NEVER AGAIN). We boarded on Wednesday and came back on Sunday. Friday evening was my Tirz injection.

I tried to behave like a responsible adult: no excesses, almost no alcohol, just way more carbs than usual because every dessert on that ship seemed personally offended if I didn’t taste it. I was mentally prepared for the classic “post‑cruise weight‑gain souvenir”, but definitely not for what happened Saturday morning (about 12 hours after the injection).

My husband ended up calling the ship’s doctor because I fainted in the bathroom. Severe diarrhea, horrible cramps… the full cruise‑ship horror‑movie experience. After six months on treatment, this kind of reaction was absolutely not on my bingo card.

Now I’m terrified of two things: the next injection and… stepping on the scale.

So here’s my question for you all: in your experience, after something like this, is it usually better to lower the dose for the next pin, or can simply going back to my normal diet be enough to avoid another disaster?

 

[vale113]

This reaction is common with GLP, but by returning to the usual diet everything should return to normal.

 

[Mara_aa]

This reaction is common with GLP, but by returning to the usual diet everything should return to normal.

Oh yes, I know it’s common, but I honestly didn’t expect it after six months, for just two pastries and an Aperol Spritz. I’m starting to think I might be a bit too gastrointestinally reactive to even the tiniest diet change, or maybe it’s just karma from a previous life

Thank you so much for your explanation, let’s hope everything goes smoothly next Friday

 

[Rolltide61]

I took four days off and went on my first mini‑cruise ever to see if this kind of holiday could work for me (spoiler: ABSOLUTELY NOT, NEVER AGAIN). We boarded on Wednesday and came back on Sunday. Friday evening was my Tirz injection.

I tried to behave like a responsible adult: no excesses, almost no alcohol, just way more carbs than usual because every dessert on that ship seemed personally offended if I didn’t taste it. I was mentally prepared for the classic “post‑cruise weight‑gain souvenir”, but definitely not for what happened Saturday morning (about 12 hours after the injection).

My husband ended up calling the ship’s doctor because I fainted in the bathroom. Severe diarrhea, horrible cramps… the full cruise‑ship horror‑movie experience. After six months on treatment, this kind of reaction was absolutely not on my bingo card.

Now I’m terrified of two things: the next injection and… stepping on the scale.

So here’s my question for you all: in your experience, after something like this, is it usually better to lower the dose for the next pin, or can simply going back to my normal diet be enough to avoid another disaster?

Before we blame the food let me ask you something. Was this Jeep Cruise Lines by chance?

 

[Jfrick11]

Oh yes, I know it’s common, but I honestly didn’t expect it after six months, for just two pastries and an Aperol Spritz. I’m starting to think I might be a bit too gastrointestinally reactive to even the tiniest diet change, or maybe it’s just karma from a previous life

Thank you so much for your explanation, let’s hope everything goes smoothly next Friday

Honestly, that sounds more like a GI bug than just a Glp1 reaction. Especially with how sudden and intense it was, and the fainting. Cruises are notorious for that kind of thing... Floating petri dishes.

Tirz can definitely make you more sensitive to rich or sugary food, but after six months it usually doesn’t come out of nowhere like that from a couple pastries and one cocktail.

It may have just been bad timing, virus plus injection on top of it. I wouldn’t assume you’re suddenly “too sensitive” based on this one episode.

I’d just make sure you’re fully recovered, VERY well hydrated, and back to normal eating before your next dose. If it happens again, then it’s worth rethinking dose.

 

[5byfive]

Honestly, that sounds more like a GI bug than just a Glp1 reaction. Especially with how sudden and intense it was, and the fainting. Cruises are notorious for that kind of thing... Floating petri dishes.

Could be the Tirz but this seems like the most likely answer.

As for the scale. When you first enter a deficit, the first thing to go is the glycogen in your muscles and its the first thing to fill back if you enter a surplus. The thing about is that for every gram of you gain/lose you gain/lose 3-4 grams of water. Thats why pretty much everyone sees a big drop in weight week one of a diet. A five pound loss may be a pound of glycogen reserves and four pounds of water. The same thing happens in reverse when you enter a surplus. All that to say, you likely didn't put on any fat in that short a time unless you had an intense surplus, and it doesn't sound like you did, so anything the scale shows is going to come right back off.

 

[Mara_aa]

Before we blame the food let me ask you something. Was this Jeep Cruise Lines by chance?

Muahahahaha I almost coughed up a lung, thank you, it’s been a while since I laughed that hard! And no, luckily it wasn’t that cruise company.

 

[Mara_aa]

Honestly, that sounds more like a GI bug than just a Glp1 reaction. Especially with how sudden and intense it was, and the fainting. Cruises are notorious for that kind of thing... Floating petri dishes.

Tirz can definitely make you more sensitive to rich or sugary food, but after six months it usually doesn’t come out of nowhere like that from a couple pastries and one cocktail.

It may have just been bad timing, virus plus injection on top of it. I wouldn’t assume you’re suddenly “too sensitive” based on this one episode.

I’d just make sure you’re fully recovered, VERY well hydrated, and back to normal eating before your next dose. If it happens again, then it’s worth rethinking dose.

Fair point. Given the timing and intensity, a GI bug layered on top of the injection is actually plausible.

I’m taking it slow, hydration is a bit of a struggle right now, and I’ll wait to be fully recovered before the next dose.

If it ever repeats, then I’ll reassess.

Thanks for the perspective, really appreciated.

 

[Mara_aa]

Could be the Tirz but this seems like the most likely answer.

As for the scale. When you first enter a deficit, the first thing to go is the glycogen in your muscles and its the first thing to fill back if you enter a surplus. The thing about is that for every gram of you gain/lose you gain/lose 3-4 grams of water. Thats why pretty much everyone sees a big drop in weight week one of a diet. A five pound loss may be a pound of glycogen reserves and four pounds of water. The same thing happens in reverse when you enter a surplus. All that to say, you likely didn't put on any fat in that short a time unless you had an intense surplus, and it doesn't sound like you did, so anything the scale shows is going to come right back off.

Yeah, that makes sense.

And the glycogen and water shift explains the scale perfectly. I definitely didn’t have anything close to a real surplus.

Thanks for breaking it down so clearly and for the reassurance: my relationship with the scale is definitely more hate than love, so I needed that.

 

[Waterheater]

Nothing wrong with skipping a dose if you plan to enjoy yourself. Fatty and high carb foods really upsets the stomach for me at least. Nothing bad happens with a weekend off. Filling up the glycogen stores might even be a good thing for your weight loss journey

 

[Mara_aa]

Nothing wrong with skipping a dose if you plan to enjoy yourself. Fatty and high carb foods really upsets the stomach for me at least. Nothing bad happens with a weekend off. Filling up the glycogen stores might even be a good thing for your weight loss journey

True, a short break happens and it’s not worth stressing over. Hopefully it’ll give me a little boost then.

 

[wildweasel]

I took four days off and went on my first mini‑cruise ever to see if this kind of holiday could work for me (spoiler: ABSOLUTELY NOT, NEVER AGAIN). We boarded on Wednesday and came back on Sunday. Friday evening was my Tirz injection.

I tried to behave like a responsible adult: no excesses, almost no alcohol, just way more carbs than usual because every dessert on that ship seemed personally offended if I didn’t taste it. I was mentally prepared for the classic “post‑cruise weight‑gain souvenir”, but definitely not for what happened Saturday morning (about 12 hours after the injection).

My husband ended up calling the ship’s doctor because I fainted in the bathroom. Severe diarrhea, horrible cramps… the full cruise‑ship horror‑movie experience. After six months on treatment, this kind of reaction was absolutely not on my bingo card.

Now I’m terrified of two things: the next injection and… stepping on the scale.

So here’s my question for you all: in your experience, after something like this, is it usually better to lower the dose for the next pin, or can simply going back to my normal diet be enough to avoid another disaster?

If you fainted you need to see your primary care. glp1forum.com is not the right place to ask why you are losing consciousness.

That being said, this sounds like GI infection, par-for-the-course on cruises. it sounds like you got it pretty bad.

But seriously, see your real doc.

 

[Mara_aa]

If you fainted you need to see your primary care. glp1forum.com is not the right place to ask why you are losing consciousness.

That being said, this sounds like GI infection, par-for-the-course on cruises. it sounds like you got it pretty bad.

But seriously, see your real doc.

Thanks, just to clarify, because my question seems to have been taken a bit too literally.

When I wrote “is it better”, I wasn’t asking the forum to manage my treatment.

Between the ship’s doctor and a quick call with my endocrinologist, the medical side was already covered.

What I was looking for here is something different and very much in the spirit of this forum:

from people who actually use GLP‑1 and have gone through something similar, what worked for you with the next dose?

User experience matters a lot to me, otherwise I’d just rely on the doctors, who are great, but they don’t exactly have GLP‑1 running through their veins.

If that nuance didn’t come across, it’s probably just one of those things that happens when people who don’t know each other read fast.

It happens.

 

[lessthanhalf]

I have always found my gut to be pretty sensitive to diet changes, but I have ulcerative colitis and ibs-d , But if I had been eating a healthy diet for months and suddenly ate fatty rich foods I would probably have a similar reaction, although hopefully without the fainting. Gut function can be state dependent, so sudden changes in diet can cause unexpected results, though much more likely in those with sensitive guts.

But food poisoning and gastro are notoriously common on cruise ships too.

 

[Mara_aa]

I have always found my gut to be pretty sensitive to diet changes, but I have ulcerative colitis and ibs-d , But if I had been eating a healthy diet for months and suddenly ate fatty rich foods I would probably have a similar reaction, although hopefully without the fainting. Gut function can be state dependent, so sudden changes in diet can cause unexpected results, though much more likely in those with sensitive guts.

But food poisoning and gastro are notoriously common on cruise ships too.

Thank you for sharing your experience, it really helps to hear from someone with a sensitive gut too.

I don’t have UC or IBS, but I am very reactive to even small changes in diet, so I can definitely relate to what you’re saying.

I’ve ruled out food poisoning or gastro, though, since it was a Costa cruise and everything was handled very carefully (although, never say never) .

In my case the timing felt a bit odd because I’d already been eating differently for a couple of days, and the crash happened about 12 hours after my injection.

And honestly, you might be right, maybe my gut coped for a couple of days and then just decided “okay, that’s enough now”.

Thank you again for your perspective

 

[Zydeceltico]

.....since it was a Costa cruise and everything was handled very carefully..........

......wondering how we can get this tested.....................



lol

 

[Mara_aa]

......wondering how we can get this tested.....................



lol

Fair point, my comment was wildly optimistic. Clearly we need a proper test. The only sensible approach is for Costa to invite us back so we can repeat the experiment, ideally with more cocktails and fewer dramatic episodes. All in the name of scientific integrity.