Post-Mounjaro cut: Reta + Tesa + recovery peptides, looking for input

[guster]

Hey guys, looking for some input on my current plan and whether this stack makes sense.

Quick background:

I lost a significant amount of weight using Mounjaro (from 105 kg down to 79 kg). I tapered off properly, but after a month in Japan with a lot of eating, my appetite and food noise clearly came back and my weight started creeping up again. So I’ve decided to reintroduce a GLP-1, this time Retatrutide, mainly for appetite control and cutting back down.

My main goals right now are:

regain control over eating

continue cutting fat

preserve as much muscle as possible

improve recovery

address some loose skin around the stomach

protect an old knee injury (cartilage damage from an MCL injury)

Training-wise, I lift weights four times per week and also do swimming and squash for conditioning and cardio.

This is the stack I’m considering:

Retatrutide – for appetite control and cutting

Tesamorelin – to target visceral fat and support skin quality via GH/IGF-1 signaling

Ipamorelin – to support sleep and recovery through nightly GH pulses

Klow Blend (BPC-157 + TB-500 + GHK-Cu + KVP) – mainly for local tissue repair, knee health, collagen/skin support, and general recovery

Retatrutide is mainly there to manage intake and food noise. The other peptides are more about recovery, skin, and staying functional while cutting. I’m not trying to do anything extreme or stack heavy hormones, just looking for a balanced approach.

Does this combination make sense from a physiological point of view?

Anything you’d remove, pause, or reconsider while cutting with Reta?

Appreciate any feedback from people who’ve run similar setups or understand the mechanisms.

 

[Habibibi]

People coming from tirzepatide often complain about lack of appetite control on retatrutide. Be aware of that and decide how important that is to you.

 

[guster]

People coming from tirzepatide often complain about lack of appetite control on retatrutide. Be aware of that and decide how important that is to you.

Honestly i had the same with tirz. I think the glucose control did more for me.

 

[woundcarping]

Hey guys, looking for some input on my current plan and whether this stack makes sense.

Quick background:

I lost a significant amount of weight using Mounjaro (from 105 kg down to 79 kg). I tapered off properly, but after a month in Japan with a lot of eating, my appetite and food noise clearly came back and my weight started creeping up again. So I’ve decided to reintroduce a GLP-1, this time Retatrutide, mainly for appetite control and cutting back down.

So you lost 26kg on Tirz, but you're wanting to start back on Reta. How much weight did you gain back and what is your goal weight? Have you had a DEXA scan to see how much fat/lean mass you're working with? How long since your last dose of Tirz and what were you taking at what intervals (to calculate where your current Tirz level and where you needed to be before for compliance).

Retatrutide is mainly there to manage intake and food noise...

Of the big 3, Reta is the least effective per mg to control intake and food noise (GLP1). It absolutely can be effective, but the dose typically has to be high enough. I went from a 5.5mg collective peak (not steady state) on Tirz to somewhere around an 8mg cumulative peak on Reta to not have to reup my Tirz dose. GCGR is thought to be protective of lean mass, as well as a metabolic rate boost for additional calories burned so that could fit your other goals.

Retatrutide – for appetite control and cutting

Tesamorelin – to target visceral fat and support skin quality via GH/IGF-1 signaling

Ipamorelin – to support sleep and recovery through nightly GH pulses

Klow Blend (BPC-157 + TB-500 + GHK-Cu + KVP) – mainly for local tissue repair, knee health, collagen/skin support, and general recovery

Reta is great for cutting, but if you don't need the GCGR leg, Tirz could be fine.

Visceral fat is another metric from a DEXA scan. My forecast based on my understanding is my visceral fat will resolve below population norms before I hit my target weight, although I had the same idea of Tesa for targeting it if required.

Ipa... I take magnesium now.. at this point I'm generally hesitant to be dependent on anything to help with sleep. I'm borderline "good" in the sleep department now, would like to get there unadulterated as possible, if possible.

KLOW... I generally like the idea of not being stuck with fixed mixed vials, I'd rather have them separately. Right now I'm coming up on my 4th week of an 8 week cycle of BPC for rotator cuffs and acute tennis elbow, .5mg twice a day.

I don't plan on taking BPC or TB500 long term, unless angiogenesis risks become better understood. GHKcu I may cycle longer, but I'm not to that point in my journey yet. So not having to take everything to just take what I want was the route that I've picked as my baseline.

Does this combination make sense from a physiological point of view?

Anything you’d remove, pause, or reconsider while cutting with Reta?

Nothing jumps out to me as am issue, it does seem like you went from just Tirz to now wanting to stack 7 things for various reasons. After we know where you are vs where you want to be (how aggressive the cut will be), it may be easier to offer timing advice.

I'm currently in an aggressive cut using Reta in combination with other tools and metrics. I'm 28% to my evaluation goal, so a ways to go so my perspective may be considerably different if I had a 5% cut, for example.

 

[guster]

So you lost 26kg on Tirz, but you're wanting to start back on Reta. How much weight did you gain back and what is your goal weight? Have you had a DEXA scan to see how much fat/lean mass you're working with? How long since your last dose of Tirz and what were you taking at what intervals (to calculate where your current Tirz level and where you needed to be before for compliance).

Of the big 3, Reta is the least effective per mg to control intake and food noise (GLP1). It absolutely can be effective, but the dose typically has to be high enough. I went from a 5.5mg collective peak (not steady state) on Tirz to somewhere around an 8mg cumulative peak on Reta to not have to reup my Tirz dose. GCGR is thought to be protective of lean mass, as well as a metabolic rate boost for additional calories burned so that could fit your other goals.

Reta is great for cutting, but if you don't need the GCGR leg, Tirz could be fine.

Visceral fat is another metric from a DEXA scan. My forecast based on my understanding is my visceral fat will resolve below population norms before I hit my target weight, although I had the same idea of Tesa for targeting it if required.

Ipa... I take magnesium now.. at this point I'm generally hesitant to be dependent on anything to help with sleep. I'm borderline "good" in the sleep department now, would like to get there unadulterated as possible, if possible.

KLOW... I generally like the idea of not being stuck with fixed mixed vials, I'd rather have them separately. Right now I'm coming up on my 4th week of an 8 week cycle of BPC for rotator cuffs and acute tennis elbow, .5mg twice a day.

I don't plan on taking BPC or TB500 long term, unless angiogenesis risks become better understood. GHKcu I may cycle longer, but I'm not to that point in my journey yet. So not having to take everything to just take what I want was the route that I've picked as my baseline.

Nothing jumps out to me as am issue, it does seem like you went from just Tirz to now wanting to stack 7 things for various reasons. After we know where you are vs where you want to be (how aggressive the cut will be), it may be easier to offer timing advice.

I'm currently in an aggressive cut using Reta in combination with other tools and metrics. I'm 28% to my evaluation goal, so a ways to go so my perspective may be considerably different if I had a 5% cut, for example.

I went from 105 kg down to my lowest point around 78 kg on mounjaro, After stopping and over the last months I’ve rebounded to 86 kg , largely due to lifestyle, not loss of control. December holidays, birthdays, and a month-long Japan trip with a lot of eating. I’m very confident most of that regain is glycogen, water, and some fat , not a full relapse.

Started at 32% bodyfat. Current body fat is likely ~19–21 At my leanest I was likely ~17–18% , not stage-lean. Goal now is sub-15% , ideally 12–14% , while restoring muscle fullness and tightening up skin after a long aggressive cut.

Goal weight is therefore dynamic , but realistically somewhere around 78–82 kg , depending on how recomp goes. I’m not chasing a number, I’m chasing composition.

I haven’t done a DEXA yet. I’m aware it’s cleaner data, but I have consistent longitudinal measurements showing:

fat mass dropped from ~32–33 kg → ~15 kg

lean mass loss across the entire cut was ~1.5–2 kg

Given the speed and duration of the cut, I’m comfortable with that trade-off.

Full Tirzepatide history​[archived internal link]

Start: April 22, 2024

2.5 mg: ~4 weeks

5 mg: longest phase , several months

7.5 mg: shorter period

10 mg: 3 weeks

Total run: ~9 months

Last dose: several weeks ago

So I’m not GLP-naïve, but I’m also not coming off a prolonged max-dose exposure.

Why Reta now​[archived internal link]

I agree that Reta is weaker per mg for food noise vs Tirz , and I’m not trying to replicate Tirz-level appetite suppression. My goal is not “eat nothing”, it’s controlled intake while cutting .

The reason Reta makes sense now :

I want to shred again and get under 15%

I want lean-mass protection after a long cut

I want some metabolic support (GCGR leg) instead of pushing GLP harder

I don’t want to restart Tirz and flatten out completely again

I’m fully aware Reta often needs a higher cumulative dose to match Tirz appetite effects. That’s fine. I’m okay titrating to where intake control is sufficient, not absolute.

Stack philosophy​[archived internal link]

This isn’t about stacking for fun. It’s about consolidation after a hard cut :

Reta as the primary cutting tool

Any GH-related support is there for recovery, tissue quality, and fullness , not rapid fat loss

I’m cautious about long-term repair peptides for the same angiogenesis reasons you mentioned

Nothing here is meant to be permanent

If I were still at 28–30% body fat, I’d be doing something much simpler and more aggressive. I’m not. This is a second-phase cut + recomp , not a crash diet.

Appreciate the pushback. I’m mostly sanity-checking direction and dosing strategy, not looking to overengineer things.