您是否注意到随着时间的推移，您对Tirz产生了耐受性？

[GLP1Pharmacist]

I always thought it was the mixers which do add calories but even a 2oz serving of just vodka 200 calories .... pretty much every Oz of liquor is 100 to 120 calories or I'd be ordering 0 calorie booze by the case lol. Not ideal for liver and pancreas on glp1's also.

I know but you have to "live too". If a drink or two a week or on vacation is bad I can live with it. That said haven't had a drink in months.

 

[siouxstine]

I looked through some studies on this and it seems the topic hasn’t been researched well.

I’m curious about your personal experience, especially as a long-term users. Do you feel tirzepatide loses effectiveness over time?

I started 2.5mg in October of 2023. I increased every 4 weeks u til I reached 10mg and stayed on that for a few months as long as I kept losing. Eventually I increased up to 15mg and in about 8 months I’d lost 70 pounds and reached my goal weight. I have continued to take 15mg every week since but my body stopped losing weight. It’s like as soon as I got a good weight for me I just stabilized. I’m a female at 5’6 and fluctuate between 145 and 150 for the past year and a half. I don’t feel like it’s lost its effectiveness. I intend to take it for the rest of my life.

 

[DwightTheDelight]

I looked through some studies on this and it seems the topic hasn’t been researched well.

I’m curious about your personal experience, especially as a long-term users. Do you feel tirzepatide loses effectiveness over time?

I 100% believe tolerance develops over time, at least regarding appetite suppression. I also believe that positive changes we can't necessarily feel, like being more sensitive to insulin, continue as long as we are on the meds.

I've been on brand zepbound for close to two years now and well above the typical 15 mg/week dosing for a good portion of that. I feel no noticable appetite suppression anymore and can eat a lot, even on shot days. For instance, I've been very stressed lately due to costly house repairs and I ate 6k calories yesterday despite taking a shot in the morning. 450lb Dwight is still hiding in the 215lb Dwight and he will tear up your fridges.

 

[MsGizmo]

I looked through some studies on this and it seems the topic hasn’t been researched well.

I’m curious about your personal experience, especially as a long-term users. Do you feel tirzepatide loses effectiveness over time?

My completely unscientific opinion is that it might be tied to how heavy you are. I mean if you are approaching a healthy weight maybe the body just becomes more resistant to losing? Sure, it might SEEM like its a tolerance build up but you are already thinner.

I base this opinion solely on my husband, who has never been overweight let alone obese but he is a diabetic. He and I both took the same amount of sema over a 3 month period, starting dose up to 1mg per week. He didn't lose any weight. He didn't NEED to lose any weight. He has since upped his dose to 2mg because he was still having some blood sugar spikes and I have added reta. He has still not lost any weight and I am down 30 pounds.

I don't know, just a stray thought. In any case I'm only 4 months in and still need to lose over 100 pounds. What the heck do I know?

 

[keangkong]

I 100% believe tolerance develops over time, at least regarding appetite suppression. I also believe that positive changes we can't necessarily feel, like being more sensitive to insulin, continue as long as we are on the meds.

I've been on brand zepbound for close to two years now and well above the typical 15 mg/week dosing for a good portion of that. I feel no noticable appetite suppression anymore and can eat a lot, even on shot days. For instance, I've been very stressed lately due to costly house repairs and I ate 6k calories yesterday despite taking a shot in the morning. 450lb Dwight is still hiding in the 215lb Dwight and he will tear up your fridges.

That may be something else: The medicine won’t necessarily stop all overeating. Getting 450 pounds Dwight down to 215 is a huge accomplishment. Staying at 215 or neat there does the mrdici r works. But you may still struggle with current meds to get below 215.

 

[DwightTheDelight]

That may be something else: The medicine won’t necessarily stop all overeating. Getting 450 pounds Dwight down to 215 is a huge accomplishment. Staying at 215 or neat there does the mrdici r works. But you may still struggle with current meds to get below 215.

I bet it's tolerance, but it doesn't really matter what word we use to describe it. It's something. I have a feeling that just about everyone will have that early, crazy appetite suppression, regardless of current weight, that I, my wife, and Mom felt with it.

From what I felt and what I saw in family members who still need to lose substantial weight, I think you get about 3ish crazy months of suppression, and another 6-9 months of solid suppression. After the first year, most of the super noticeable effects will be done and it's just working in the background, making your body healthier in a myriad of ways that are harder to feel than crazy appetite suppression.

Anyways, I'm not upset about the 6k calorie day or anything and already back on today. I've just learned to let that shit go and never have two bad eating days in a row. If I break that rule then it becomes - never have three bad eating days in a row and so on.

How long have you been on, Kongy and do you still feel the same levels of suppression? (Edit- just realizing this might come off a little mean and I'm not intending it to be that way. I am actually just curious.)

 

[Rootus346]

Talking out my ass, but my feeling on tolerance is that tirz counteracts the signals my body is normally giving with regards to hunger, and those signals increase with every pound I lose. So it seems like if I did not change weight, the effect would stay the same -- i.e. not tolerance per se, at least not the way it works with many other drugs.

So based on my unscientific theory, Dwight's body is giving such strong "FEED ME" signals due to the amazing weight loss that it is difficult to get enough effect from tirz to adequately counteract it.

Personally, I am not quite at a plateau yet but I think I'm close. I've gone from 284 to 201, and I've been sitting around at 201-204 for the past couple weeks. The trend still looks like it is headed down, but veeeeery slowly. I've been doing 5mg twice a week, until this morning when I ratcheted it up a little to 5.5mg. I feel like my appetite suppression has been basically okay, and if I overeat just a little I still pay dearly with nausea (pulling off a Dwight-style 6000 Calorie day would probably put me in the hospital right now), just not really losing like I was. Still have 25 lbs to lose, for sure, so I'd like to keep chipping away at it.

 

[MsGizmo]

我猜是耐受性，但用什么词来形容其实并不重要。重要的是它确实存在。我感觉几乎每个人都会经历早期那种强烈的食欲抑制，无论目前的体重如何，就像我、我妻子和我妈妈当时经历的那样。

再说说我那瘦弱的丈夫吧，他服用的赛玛剂量是我的两倍……他完全没有食欲抑制的症状。而我几乎得强迫自己吃东西才能摄入一些蛋白质。我承认这或许只是他个人的生理特点。但我认识的服用奥泽匹克的人，没有一个一开始体重就很健康的。

 

[DwightTheDelight]

再说说我那瘦弱的丈夫吧，他服用的赛玛剂量是我的两倍……他完全没有食欲抑制的症状。而我几乎得强迫自己吃东西才能摄入一些蛋白质。我承认这或许只是他个人的生理特点。但我认识的服用奥泽匹克的人，没有一个一开始体重就很健康的。

这真是个有用的信息！

他服用这种药只是为了控制血糖，还是为了达到其他效果？

 

[Superchicken1]

我之前在服用替拉西肽的同时加用了瑞他汀（Reta）。但现在我的ALT水平已经超过正常上限10倍。虽然医生认为瑞他汀可能不是导致ALT升高的原因，但我同意他的观点，并遵照他的建议停用瑞他汀，直到ALT水平恢复正常。我和我的肝病专家都认为立普妥（阿托伐他汀）很可能是导致我肝脏问题的罪魁祸首。我已经停用了立普妥。但考虑到我的肝脏问题，我不想继续冒险服用瑞他汀这种未经批准的药物。如果我的ALT水平恢复正常，我会重新开始服用瑞他汀，看看情况如何。

匹伐他汀最近推出了仿制药，与其他他汀类药物相比，副作用和肝脏负担都小得多。它之前价格昂贵，以至于一些医生还不熟悉它。我不确定有人说使用合成代谢类固醇的人会避免服用他汀类药物，因为我是从美索类固醇论坛上了解到这种药的。他们是推荐的。分享一下，也许对你来说也是个选择。

 

[AndyPanda]

有研究表明葡萄酒不健康，这让我非常失望。现在我把剩下的几瓶酒都用来做饭了。

就连白藜芦醇补充剂在公众眼中也失去了往日的魅力，一些与运动相关的研究也证实了这一点：“补充白藜芦醇实际上会削弱运动带来的一些积极影响，例如心血管功能的改善或肌肉蛋白质合成的增强”（谷歌Gemini研究）。

我喜欢酿造蜂蜜酒，也喜欢喝，感觉自己无所不能！ 不过我身上的一些疤痕可不这么认为。我已经大幅减少了饮用量，但有时我觉得酿造蜂蜜酒比喝它更有乐趣。据说蜂蜜酒富含抗氧化剂，但我怀疑它对肝脏的损害是否值得。

 

[Calm Logic]

匹伐他汀最近推出了仿制药，与其他他汀类药物相比，副作用和肝脏负担都小得多。它之前价格昂贵，以至于一些医生还不熟悉它。我不确定有人说使用合成代谢类固醇的人会避免服用他汀类药物，因为我是从美索类固醇论坛上了解到这种药的。他们是推荐的。分享一下，也许对你来说也是个选择。

我的印象是，很多服用口服合成代谢类固醇的人都会避免服用他汀类药物，尤其是作为预防用药，因为他们知道口服合成代谢类固醇可能对肝脏有害。他们会服用其他药物，比如利尿剂或补充剂来降低胆固醇。更何况，他汀类药物对肌肉健康也并非最佳选择。

 

[Lucas]

耐受性常常与平台期混淆：https://prohibited-data-mining-site...-the-medication-lose-its-efficiency-over-time

 

[Airborne Daddy]

My completely unscientific opinion is that it might be tied to how heavy you are. I mean if you are approaching a healthy weight maybe the body just becomes more resistant to losing? Sure, it might SEEM like its a tolerance build up but you are already thinner.

I base this opinion solely on my husband, who has never been overweight let alone obese but he is a diabetic. He and I both took the same amount of sema over a 3 month period, starting dose up to 1mg per week. He didn't lose any weight. He didn't NEED to lose any weight. He has since upped his dose to 2mg because he was still having some blood sugar spikes and I have added reta. He has still not lost any weight and I am down 30 pounds.

I don't know, just a stray thought. In any case I'm only 4 months in and still need to lose over 100 pounds. What the heck do I know?

I agree. I'm 14 months in and go sema, then tirz, then reta and ultimately repeat. Went from 249 to to 225 but that's it. I'm only 5'8.....:told the Bride if nothing else Doc loved my a1c, cholesterol, triglycerides, liver values, glucose, etc.... he said see ya next year instead of we need to run ur labs again in 6-8 weeks.

 

[Batscout]

Wish I could get the 0 desire for alcohol. It costs me 1000 calories every time I drink

I have experienced a profound reduction in my desire to drink alcohol. I met my goal back in February and I am now on maintenance, using only about 10-15 mg a month, in a combination of Reta and Tirz. Even if I used only 5 mg within 10 days, I can still barely choke back a drink.

 

[keangkong]

Again referring to my skinny husband who is taking twice as much sema as me .. he has not had any appetite suppression at all. While I almost need to force myself to eat to get some protein in. I will concede that maybe that is just his personal biology. But I don't know anyone else who is taking ozempic who started out at a healthy weight.

It sounds like it's a good thing that your hubby isn't losing weight.

 

[keangkong]

Pitavastatin recently went generic and has far less side effects and liver impact, than all the other statins. It was so expensive oop that some drs aren’t familiar with it as an option yet. I’m not sure where the person saying people who use AAS avoid statins, because I learned of this one from the Meso steroid forum. It’s one they recommend. Sharing in case it’s an option for you.

Thanks. I looked it up at Drug Induced Liver Injury Rank (DILIrank 2.0) Dataset, https://www.fda.gov/science-researc...induced-liver-injury-rank-dilirank-20-dataset. You're right. The numbers (5 or 3) indicate the seriousness of the injury that might result.





To use another source, Livertox [https://www.ncbi.nlm.nih.gov/books/NBK548236/] ranks atorvastatin as an A:



Livertox [https://www.ncbi.nlm.nih.gov/books/NBK548065/] ranks pitavastatin as a D.



I have stopped taking the statin and told the cardiologist by an electronic, email-like message that I did so. Assuming the Lipitor turns out to be the cause, as I believe it will be, then I can discuss with the cardiologist whether with my reduced weight and a past history of having statin-induced liver injury, it's medically advisable to still take a statin. If he recommends taking a different statin, I'd likely do so.

 

[keangkong]

My impression was that many on oral AAS avoid statins, especially as a preventative, because they know oral AAS can be toxic to the liver. And they take other things like reta or supplements to help cholesterol instead. Not to mention that statins are not the best for muscle health.

Years ago, because I get bad DOMS, my primary care doctor took me off Lipitor for a few months. I still got DOMS worse than most people. We resumed the Lipitor. The solution when lifting weights is easy although a bit frustrating: I can increase weight without suffering bad DOMS but I can only do so slowly.

 

[ZippityDooDah]

Wish I could get the 0 desire for alcohol. It costs me 1000 calories every time I drink

Before tirz, for 20-something years I was the evening cocktail guy 3-4 nights a week after work, and that stopped very shortly after my first couple of doses without really even thinking about it; I just realized one day that a few weeks had gone by since I had a drink.

The big wake-up came when during our regular Friday night hangouts, one of the neighbors in the cul de sac brought out a bottle of Weller Full Proof he received as gift from a parent (he's the athletic director at the local catholic school) and two shots destroyed me - I literally lost a day. I was no lightweight, and hadn't had alcohol do that to me since my teens.

 

[keangkong]

Tolerance is often mixed up with a plateau: https://prohibited-data-mining-site...-the-medication-lose-its-efficiency-over-time

I 100% agree. A person who weighs 500 pounds and loses 200 pounds on a GLP-1 drug but has trouble losing anything more probably hasn't experienced tolerance to the drug. Rather, that drug may be only helped so much by the drug. The drug works although not quite as well as the user hopes.