您是否注意到随着时间的推移，您对Tirz产生了耐受性？

[keangkong]

Before tirz, for 20-something years I was the evening cocktail guy 3-4 nights a week after work, and that stopped very shortly after my first couple of doses without really even thinking about it; I just realized one day that a few weeks had gone by since I had a drink.

The big wake-up came when during our regular Friday night hangouts, one of the neighbors in the cul de sac brought out a bottle of Weller Full Proof he received as gift from a parent (he's the athletic director at the local catholic school) and two shots destroyed me - I literally lost a day. I was no lightweight, and hadn't had alcohol do that to me since my teens.

I'm sure you could build up your tolerance again. However, since you haven't been drinking much, I suspect you have not wanted to do so.

 

[ZippityDooDah]

I'm sure you could build up your tolerance again. However, since you haven't been drinking much, I suspect you have not wanted to do so.

That's the thing, I literally have zero desire for alcohol. I assumed that would change as I adapted to the side-effects of tirz and now reta, but it hasn't.

 

[keangkong]

That's the thing, I literally have zero desire for alcohol. I assumed that would change as I adapted to the side-effects of tirz and now reta, but it hasn't.

Does it bother you that you don't desire alcohol?

 

[MsGizmo]

That's good info!

Is he taking it just to control blood sugar or is he after some other effect?

Just for his diabetes. He isn't allowed to use insulin because he is a truck driver .. something about the possibility of his blood sugar dropping too low and that doesn't happen with ozempic.

 

[keangkong]

Pitavastatin recently went generic and has far less side effects and liver impact, than all the other statins. It was so expensive oop that some drs aren’t familiar with it as an option yet. I’m not sure where the person saying people who use AAS avoid statins, because I learned of this one from the Meso steroid forum. It’s one they recommend. Sharing in case it’s an option for you.

Thank you. I'll discuss this with my cardiologist. I don't use AAS.

 

[keangkong]

Just for his diabetes. He isn't allowed to use insulin because he is a truck driver .. something about the possibility of his blood sugar dropping too low and that doesn't happen with ozempic.

That makes sense: I don't want a truck driver on the road who can't pay attention because his sugar has fallen too much.

 

[ZippityDooDah]

Does it bother you that you don't desire alcohol?

Nope, I find it fascinating how GLPs can impact so many different parts of the body and mind.

 

[MsGizmo]

I have stopped taking the statin and told the cardiologist by an electronic, email-like message that I did so. Assuming the Lipitor turns out to be the cause, as I believe it will be, then I can discuss with the cardiologist whether with my reduced weight and a past history of having statin-induced liver injury, it's medically advisable to still take a statin. If he recommends taking a different statin, I'd likely do so.

Just a side note. My husband was not a diabetic before he was put on lipitor. He had his first heart attack 2 weeks after they gave him a prescription of 40mg. At that point they gave him crestor and upped his dose to 80mg of lipitor. (maximum dose) They kept him on that for about a year while jerking him around with other meds to try and counteract what lipitor was doing before I was able to convince him to stop it taking it. In that year had 2 more heart attacks a stroke and developed diabetes. Also of note when they did 2 cardiac caths on 2 different occasions he had no blockages and no plaque build up either. Ever since he stopped taking lipitor his health improved dramatically but the diabetes is permanent likely caused by undiagnosed pancreatitis. (the pancreatitis is officially just my opinion, but the diabetes had to come from something)

Also of note I AM NOT A DOCTOR . Do not start or stop a medicine based on one dude's case history told to you by his wife at one o'clock in the morning.

 

[keangkong]

Just a side note. My husband was not a diabetic before he was put on lipitor. He had his first heart attack 2 weeks after they gave him a prescription of 40mg. At that point they gave him crestor and upped his dose to 80mg of lipitor. (maximum dose) They kept him on that for about a year while jerking him around with other meds to try and counteract what lipitor was doing before I was able to convince him to stop it taking it. In that year had 2 more heart attacks a stroke and developed diabetes. Also of note when they did 2 cardiac caths on 2 different occasions he had no blockages and no plaque build up either. Ever since he stopped taking lipitor his health improved dramatically but the diabetes is permanent likely caused by undiagnosed pancreatitis. (the pancreatitis is officially just my opinion, but the diabetes had to come from something)

Also of note I AM NOT A DOCTOR . Do not start or stop a medicine based on one dude's case history told to you by his wife at one o'clock in the morning.

Thanks. There is some evidence that taking Lipitor increases the chances one will get diabetes. I do wonder whether it would be wise for me to take a statin now that I have lost weight. However, right now I have ceased taking Lipitor based solely upon concern for my liver.

 

[MsGizmo]

Thanks. There is some evidence that taking Lipitor increases the chances one will get diabetes. I do wonder whether it would be wise for me to take a statin now that I have lost weight. However, right now I have ceased taking Lipitor based solely upon concern for my liver.

I just wish I would have been pushier about him stopping it sooner or at the vey least reduce the dose. I mean in 2 weeks time he went from no drug at all to the maximum dose. Just sitting here thinking about what that drug did to him makes me so angry.

 

[Calm Logic]

I'm 14 months in and go sema, then tirz, then reta and ultimately repeat.

Seems very zen.

 

[keangkong]

I just wish I would have been pushier about him stopping it sooner or at the vey least reduce the dose. I mean in 2 weeks time he went from no drug at all to the maximum dose. Just sitting here thinking about what that drug did to him makes me so angry.

Your frustration is understandable. Still taking statins is standard medical advice. There are risks in following standard medical advice, along with risks in ignoring standard medical advice. How does he feel now?

 

[keangkong]

I looked through some studies on this and it seems the topic hasn’t been researched well.

I’m curious about your personal experience, especially as a long-term users. Do you feel tirzepatide loses effectiveness over time?

I earlier provided an answer basically stating that folks do not generally develop GLP-1 tolerance over time. I basically meant what I wrote but I believe that someone with medical knowledge who spoke precisely would have answered differently. We do develop tolerance to GLP-1 drugs. That's why we start GLP-1 drugs on a dose that will eventually be insufficient for most people. If we started on a higher dose or the highest dose, there is a good chance we'd have terrible side effects. Our bodies adapt. Still the tolerance we develop doesn't keep the GLP-1 drugs from continuing to work. We know that for tirzepatide, for instance, that even after three years people continue to stay at about the same weight as they had earlier plateaued.

 

[Batscout]

Does it bother you that you don't desire alcohol?

I have wondered how people feel about this myself. If you have zero desire for something, why do you miss having a desire for it? There must be a feeling of missing the social relaxation and feeling of participation and inclusiveness.

 

[MsGizmo]

Your frustration is understandable. Still taking statins is standard medical advice. There are risks in following standard medical advice, along with risks in ignoring standard medical advice. How does he feel now?

All his medical issues happened while taking Lipitor. 3 heart attacks and a stroke in one year while taking that poison and he felt like garbage. That was 2003/2004. 21 years without a statin and his only problem is diabetes. He did the smart thing and weaned himself off of it slowly and didn't go cold turkey. He is currently 62.

 

[desinr-gal]

Wish I could get the 0 desire for alcohol. It costs me 1000 calories every time I drink

try subbing with a mocktail like HIYO. It has ashwaganda and mushroom extracts. almost instant chill out, like a drink, but no rush or buzz. Then with more, you get more relaxed and sleepy.

Also only 30 calories. other mocks are very sugary

 

[Airborne Daddy]

试试用HIYO这样的无酒精鸡尾酒代替。它含有南非醉茄和蘑菇提取物。几乎能立刻让人放松，就像喝了酒一样，但不会有兴奋或躁动。喝多了，你会感觉更放松，甚至犯困。

而且只有30卡路里。其他无酒精鸡尾酒都太甜了。

谢谢你，愿上帝保佑你。

 

[desinr-gal]

谢谢你，愿上帝保佑你。

我最喜欢的口味是黑莓柠檬味，它不太甜。

 

[latviantower]

我记得女儿几年前给我吃过，好像没什么用。可能是因为我吃了几个星期就停了吧。谢谢兄弟。

纳曲酮彻底改变了我的生活。酗酒数十年后，我住院治疗了28天。医生给我开了每天100毫克的纳曲酮（大多数人的正常剂量是50毫克？），我服用了12个月。期间我再也没有对酒精产生过任何渴望。而且我觉得它对控制食欲也有帮助（这是在我开始服用Tirz之前）。现在我已经戒酒快三年了，而且完全没有酒瘾——Tirz可能也在这方面起了作用！

 

[Airborne Daddy]

纳曲酮彻底改变了我的生活。酗酒数十年后，我住院治疗了28天。医生给我开了每天100毫克的纳曲酮（大多数人的正常剂量是50毫克？），我服用了12个月。期间我再也没有对酒精产生过任何渴望。而且我觉得它对控制食欲也有帮助（这是在我开始服用Tirz之前）。现在我已经戒酒快三年了，而且完全没有酒瘾——Tirz可能也在这方面起了作用！

谢谢。我大概吃了八九天的最低剂量，然后就觉得……嗯……可能得去找医生或者我的印度兄弟了。