您是否注意到随着时间的推移，您对Tirz产生了耐受性？
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加拿大有一项研究采用持续血糖监测和每日摄入枫糖浆的方法。
但说真的，对我来说，副作用恰恰表明Tirz在后期仍然有效。每有一个人服用15毫克Tirz，可能至少有20个人因为副作用或害怕副作用而只能服用5毫克。
如果没有副作用，像我这样的人就不会因为持续服用10-15毫克（或更多）Tirz而停滞不前，而是会选择叠加用药。
所以，如果Tirz用不下去了，总会有其他选择。比如逐渐换用Reta（同时服用Reta和Tirz一段时间）。或者，如果将Cagri与Reta一起服用（或者将Cagri与Tirz+Survo一起服用），你就能作用于五个受体（Cagri作用于两个，Reta作用于三个），而不仅仅是Tirz作用于两个受体。
但说真的，对我来说，副作用恰恰表明Tirz在后期仍然有效。每有一个人服用15毫克Tirz，可能至少有20个人因为副作用或害怕副作用而只能服用5毫克。
如果没有副作用，像我这样的人就不会因为持续服用10-15毫克（或更多）Tirz而停滞不前，而是会选择叠加用药。
所以，如果Tirz用不下去了，总会有其他选择。比如逐渐换用Reta（同时服用Reta和Tirz一段时间）。或者，如果将Cagri与Reta一起服用（或者将Cagri与Tirz+Survo一起服用），你就能作用于五个受体（Cagri作用于两个，Reta作用于三个），而不仅仅是Tirz作用于两个受体。
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服用替拉帕肽的患者最终会达到体重稳定期。大多数患者会在最初 18 个月内经历体重稳定期。Horn 等人 (2025)。SURMOUNT-1 和 SURMOUNT-4 临床试验中替拉帕肽治疗达到体重稳定期的时间，15(e) Clin. Obesity e12734 ， https://doi.org/10.1111/cob.12734 。
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I stacked by adding reta to my tirzepatide. But now my ALT levels are 10 times the upper limit of normal. While the doctor believes that reta is probably not the cause of my increased ALT levels, I agree and am following his recommendation to stop taking reta until my levels return to normal. My hepatologist and I both believe that Lipitor (atorvastatin) is the likely cause of my liver problems. I stopped taking Lipitor But considering my liver problems, I'm not going to continue risking things by taking reta, an unapproved drug. If my ALT levels return to normal, I will start start reta again and see what happens.Calm Logic said:
Geez. Makes sense about the Lipitor being the culprit, but it is a wake-up call since it is such a popular drug. (For a similar reason, guys on oral AAS seem to avoid statins.)
Calm Logic said:
Or even revert to sema.... I switch up every 4 months maybe.keangkong said:
The body overtime gets used to many things and will try to circumvent and repair itself,the so called plateau. We can only fool the body for so long that's why with most peptides you need to cycle them so they keep working, makes me wonder if it will be the same with GLP'S.
Airborne Daddy said:
Or liraglutide, haha. I still use a lira pen sometimes, like when I want to add something but don't want to regret it the next day.
For me, at around the 18-month mark I stopped losing weight, but I still felt a fair degree of appetite suppression along with things like having zero desire for alcohol, so while my body had definitely adapted in some way, it also was definitely still doing "something".
Like so many other things, I think our individual body chemistry has a lot to do with it. At least from my experience it seemed like aside from weight loss stopping that I was still experiencing the other beneficial effects.
There are reasons many people require ever-increasing doses of various medications in order to maintain the same efficacy, so it doesn't surprise me that GLP-1s would be similar in that regard.
Like so many other things, I think our individual body chemistry has a lot to do with it. At least from my experience it seemed like aside from weight loss stopping that I was still experiencing the other beneficial effects.
There are reasons many people require ever-increasing doses of various medications in order to maintain the same efficacy, so it doesn't surprise me that GLP-1s would be similar in that regard.
Wish I could get the 0 desire for alcohol. It costs me 1000 calories every time I drinkZippityDooDah said:
@Airborne Daddy Have you tried low-dose naltrexone (LDN) or whatever else they got now in India to lower cravings? I got LDN to boost weight loss, but I haven't tried it yet.
In theory, marijuana gummies may help too with cravings, except for food, haha.
In theory, marijuana gummies may help too with cravings, except for food, haha.
Believe my daughter gave me that a few years ago, didn't seem to help much. Maybe cuz I stopped after a few weeks. Thanks brother.Calm Logic said:
Semaglutide seems to work best in this category, plus look for low calorie options - Vodka, lemon juice, Splenda plus iceAirborne Daddy said:
I need to get some basil plants. I get mojito vibes even from lemonade if there is basil in it, namely the strawberry basil lemonade from Panera Bread. If they had a Splenda version, I would be there every day.
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My best friend, an alcoholic who stopped drinking over 10 years, marvels at the fact that I have no desire to drink alcohol. However, I didn't like drinking even before starting GLP-1 meds.Airborne Daddy said:
The research that wine was not healthy was a big buzzkill for me. Now I use my few remaining bottles for cooking.
Even resveratrol supplements lost their magic in the public eye and in some exercise-related research: "Resveratrol supplementation can actually blunt some of the positive adaptations to exercise, such as improvements in cardiovascular fitness or muscle protein synthesis" (Google Gemini).
Even resveratrol supplements lost their magic in the public eye and in some exercise-related research: "Resveratrol supplementation can actually blunt some of the positive adaptations to exercise, such as improvements in cardiovascular fitness or muscle protein synthesis" (Google Gemini).
I’m old, so I distinctly remember in the ‘90s we were told by the experts that red wine was healthy for the heart. In fact, the recommendations were two glasses of red wine daily for men and one glass daily for women. Since I loved red wine, I happily followed their advice for years.Calm Logic said:
Now they tell us that there is no safe level of alcohol consumption. Wtf.Fortunately, I can’t drink beyond two glasses so it never got out of control. But still irksome how studies change so wildly over the course of time. Thirty years from now they’ll tell us that kale is a silent killer and GLP-1s cause autism.
I’ve been on a fairly low dose of tirz (4mg) since April, so my desire for red wine has plummeted. But I still have a couple of glasses on weekends just for old times sake.
Unfortunately I've loved it 25 years but I did quit cigarettes over a year ago..keangkong said:
I always thought it was the mixers which do add calories but even a 2oz serving of just vodka 200 calories .... pretty much every Oz of liquor is 100 to 120 calories or I'd be ordering 0 calorie booze by the case lol. Not ideal for liver and pancreas on glp1's also.GLP1Pharmacist said:
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