New 5 Receptor Agonist

[lessthanhalf]

I don't think it will get close to passing trials, huge potential for big risks, Amylin brings an even slower digestion, removes cravings (positive) and keeps you full for extended periods, this brings higher risk of heart burn, eating much less than the desired amount to keep you healthy, then comes in Calcitonin, which completely shuts the off brain from the hunger signals, I'm a huge supporter of GLP-1's when it supports weight loss and mental health, but I'm a big believer of doing both GLP's while making a difference with a healthy lifestyle, this comes with meal planning, eating consistently, creating something that you could potentially keep the weight down choosing this healthy life style, completely shutting the mind from hunger and less food intake is a wrecking ball waiting to happen.

There are quite a few people on this forum who are already effectively taking something very similar, reta plus cagrilintide and having it work quite well.

The obvious case where GLP medications are less effective for weight loss is in diabetics, where despite excellent effects on blood sugar levels, weight loss is typically quite a bit less than in non diabetics, to the point where the studies on weight loss are done separately for diabetics and non diabetics. Another group that could benefit from better GLP drugs.

I would be interested to know how severe the obesity is that Beardboost is treating with GLP's plus lifestyle , diet and exercise. The attitude that GLP's are a relatively small part of the solution often seems to be from people who do not have severe obesity. Feel free to correct me if I am wrong in guessing that that is where this poster is coming from.

For those with more severe obesity who often have spent decades trying to lose and maintain weight with diet, exercise and lifestyle modifications, and having those methods succeed only temporarily at best, GLP medications are the solution. And subsequently make lifestyle and diet and exercise changes easier, and more likely to be persisted with. They are not irrelevant, but often decades of experience and a lot of scientific studies show that they are largely ineffective at achieving or maintaining large weight losses, except for a lucky or especially persistent few. Whereas GLP medications have very good rates of success, although not for every one, and maintain that weight loss long term if you stay on the medication.

 

[randompersonrandom]

His face was so fat, and his hands so puffy that I just

I'm sitting here with my cat in my lap, lol-ing and lol-ing and trying not disturb him. If somebody said "your face is so fat, and your hands so puffy" to me, I'd cry. I wish I knew more people I disliked because OMG.

 

[Neptide]

Saw this this morning, interesting, reta is going to be the dog in this fight.

View: https://www.youtube.com/watch?v=hZnjS9s6-JY

Perhaps more competitive medication and more options will drive prices down.

 

[Habibibi]

This is exciting for the intended audience but I think triple agonist should have a longer study on it before moving to five. This is marathon, not a sprint and sometimes I think medicine moves too fast for money/trademarks etc.

Just my two cents.

Dont' worry, there's at least a dozen studies coming from Lilly on retatrutide, which will help them prescribe it for a variety of metabolic issues.

 

[Mr. Blonde]

Can't wait til Costco starts selling this combo pack!

Make it happen RFK!

 

[Peotidethrowaway]

How long before this hits the grey market I wonder

 

[Lear00]

How long before this hits the grey market I wonder

I suspect once they start manufacturing for human trials, the compound will inevitably leak and be copied in a certain country.

 

[RubbaDubba1]

Honestly, what’s the point? Reta is already shown to cut 30% of peoples body weight. That’s ridiculous enough. Why would anyone need something more effective?

The former 600lb me, wouldn't mind so much and keeping most of the muscle mass would be good. Inching closer to things that help people in wheel chairs, elderly would be a good thing.

 

[jason370]

i'm holding out for a 30x agonist.

 

[Jfrick11]

There are quite a few people on this forum who are already effectively taking something very similar, reta plus cagrilintide and having it work quite well.

The obvious case where GLP medications are less effective for weight loss is in diabetics, where despite excellent effects on blood sugar levels, weight loss is typically quite a bit less than in non diabetics, to the point where the studies on weight loss are done separately for diabetics and non diabetics. Another group that could benefit from better GLP drugs.

I would be interested to know how severe the obesity is that Beardboost is treating with GLP's plus lifestyle , diet and exercise. The attitude that GLP's are a relatively small part of the solution often seems to be from people who do not have severe obesity. Feel free to correct me if I am wrong in guessing that that is where this poster is coming from.

For those with more severe obesity who often have spent decades trying to lose and maintain weight with diet, exercise and lifestyle modifications, and having those methods succeed only temporarily at best, GLP medications are the solution. And subsequently make lifestyle and diet and exercise changes easier, and more likely to be persisted with. They are not irrelevant, but often decades of experience and a lot of scientific studies show that they are largely ineffective at achieving or maintaining large weight losses, except for a lucky or especially persistent few. Whereas GLP medications have very good rates of success, although not for every one, and maintain that weight loss long term if you stay on the medication.

I actually agree with part of what you’re saying, especially around severe obesity. For a lot of people, meds are the first thing that actually works long term after years of trying everything else.

And yes, outcomes are different in diabetics vs non diabetics, that’s well established.

But I think it’s a stretch to say the meds are the solution and everything else is mostly ineffective for this population

Even with things like Retaor stacking with Cagri, the medication is changing appetite, satiety, and glucose handling. It’s not replacing the underlying physiology.

For people with severe obesity, those underlying issues are usually more pronounced, not less. Higher insulin levels, more metabolic adaptation, more resistance to weight loss. That doesn’t go away just because the medication is stronger.

Also, a lot of people have done diet and exercise before, but not in a way that preserves muscle, supports metabolism, or is actually sustainable. There’s a big difference between years of under eating and cardio versus adequately fueling, prioritizing protein, and doing consistent resistance training.

The meds make those things easier, 100%. But they still matter a lot for how far someone gets and whether they stall.

So I don’t see it as meds vs lifestyle.

It’s more that the meds finally make the lifestyle changes work the way they were supposed to in the first place.

 

[thorien]

Perhaps more competitive medication and more options will drive prices down.

That's unlikely to happen, especially if classed as biologic. This would mean lilly would be the only official supplier - no compounding pharmacies could manufacture it. Also it would extend the patent for many more years, thus locking in their profit margins for longer. Of course that won't stop the grey market.

 

[Pin&Play]

The more variety the better, especially if progress means less side effects (like from Sema to Tirz).

Reta for me is a downgrade because that damn glucagon spikes my adrenalin/anxiety or whatever, I don't know, but I just can't sleep.

Also 2 medications could be both triple or quintuple agonist but with a different "weight" on each one... resulting in a very different effect

 

[Waterheater]

Isn’t stacking peptides just a diy multi agonist?

 

[lessthanhalf]

I actually agree with part of what you’re saying, especially around severe obesity. For a lot of people, meds are the first thing that actually works long term after years of trying everything else.

And yes, outcomes are different in diabetics vs non diabetics, that’s well established.

But I think it’s a stretch to say the meds are the solution and everything else is mostly ineffective for this population

Even with things like Retaor stacking with Cagri, the medication is changing appetite, satiety, and glucose handling. It’s not replacing the underlying physiology.

For people with severe obesity, those underlying issues are usually more pronounced, not less. Higher insulin levels, more metabolic adaptation, more resistance to weight loss. That doesn’t go away just because the medication is stronger.

Also, a lot of people have done diet and exercise before, but not in a way that preserves muscle, supports metabolism, or is actually sustainable. There’s a big difference between years of under eating and cardio versus adequately fueling, prioritizing protein, and doing consistent resistance training.

The meds make those things easier, 100%. But they still matter a lot for how far someone gets and whether they stall.

So I don’t see it as meds vs lifestyle.

It’s more that the meds finally make the lifestyle changes work the way they were supposed to in the first place.

GLP drugs do actually fix a lot of the underlying metabolic problems , they reduce blood sugar, blood pressure, lipids and insulin resistance both as a direct action of the drugs themselves as well as secondary to the lost weight.

The problem with diet and exercise as a solution to obesity, however well optimised, is the long term. Maintaining that takes conscious cognitive effort or restraint, or at least nearly always, it is not impossible to turn those better health behaviors into new unconscious habits, but it is difficult and most people do not succeed. And the problem with cognitive effort as a strategy to fix a long term problem is that people just have limits on their resources of it, it just runs out eventually. It is mentally and physically tiring to maintain that effort, so sooner or later people revert to old patterns of behavior. And to be fair people with especially severe obesity are on average probably less good than average at maintaining healthy eating patterns and exercise, no doubt part of the reason they became obese. This is not a moral failing , it is just part of normal variation in people, plus an obesogenic environment, and once obesity sets in, it becomes harder to exercise, and the appetite regulation system starts to progressively malfunction as hormonal and neurotransmitter regulatory systems fail to function correctly under the metabolic stress of obesity.

Prior to the availability of GLP drugs long term weight loss of 5% or more rarely 10% was considered a great success in diet and exercise based therapy for obesity, as this small loss does significantly reduce long term health consequences. All the evidence I have ever seen is that any intervention short of surgery for weight loss, fails in the long term with nearly everyone putting the weight back on eventually after the intervention ceases, and maintaining any intervention in the long term runs into the cognitive effort or cognitive restraint problem .

GLP drugs completely bypass the cognitive effort issue as one injection a week is not exactly hard compared to sticking to a 1600 or 1800 calorie diet long term, and in the long term they just keep on working so long as you keep taking them. I think the evidence seen in the studies and on this forum provide good evidence of their effectiveness and that it is maintained long term. Better diet and exercise is important, but people taking GLP drugs for obesity without any special effort put into lifestyle changes lose weight anyway. And there is evidence that GLP drugs improve people's food choices, and just from personal experience it is much easier to exercise at normal or near normal weights than when severely obese.

My opinion is that diet and exercise are a largely ineffective therapy for obesity, based on long term results from thousands of studies over decades, not completely useless or pointless, but with very poor long term success rates. GLP drugs just work, except for a few who get bad side effects, or who respond poorly to them. But for the large majority they enable significant weight loss of 10-30% long term, with added bonus health benefits.

 

[cheaperseeker]

GLP drugs do actually fix a lot of the underlying metabolic problems , they reduce blood sugar, blood pressure, lipids and insulin resistance both as a direct action of the drugs themselves as well as secondary to the lost weight.

The problem with diet and exercise as a solution to obesity, however well optimised, is the long term. Maintaining that takes conscious cognitive effort or restraint, or at least nearly always, it is not impossible to turn those better health behaviors into new unconscious habits, but it is difficult and most people do not succeed. And the problem with cognitive effort as a strategy to fix a long term problem is that people just have limits on their resources of it, it just runs out eventually. It is mentally and physically tiring to maintain that effort, so sooner or later people revert to old patterns of behavior. And to be fair people with especially severe obesity are on average probably less good than average at maintaining healthy eating patterns and exercise, no doubt part of the reason they became obese. This is not a moral failing , it is just part of normal variation in people, plus an obesogenic environment, and once obesity sets in, it becomes harder to exercise, and the appetite regulation system starts to progressively malfunction as hormonal and neurotransmitter regulatory systems fail to function correctly under the metabolic stress of obesity.

Prior to the availability of GLP drugs long term weight loss of 5% or more rarely 10% was considered a great success in diet and exercise based therapy for obesity, as this small loss does significantly reduce long term health consequences. All the evidence I have ever seen is that any intervention short of surgery for weight loss, fails in the long term with nearly everyone putting the weight back on eventually after the intervention ceases, and maintaining any intervention in the long term runs into the cognitive effort or cognitive restraint problem .

GLP drugs completely bypass the cognitive effort issue as one injection a week is not exactly hard compared to sticking to a 1600 or 1800 calorie diet long term, and in the long term they just keep on working so long as you keep taking them. I think the evidence seen in the studies and on this forum provide good evidence of their effectiveness and that it is maintained long term. Better diet and exercise is important, but people taking GLP drugs for obesity without any special effort put into lifestyle changes lose weight anyway. And there is evidence that GLP drugs improve people's food choices, and just from personal experience it is much easier to exercise at normal or near normal weights than when severely obese.

My opinion is that diet and exercise are a largely ineffective therapy for obesity, based on long term results from thousands of studies over decades, not completely useless or pointless, but with very poor long term success rates. GLP drugs just work, except for a few who get bad side effects, or who respond poorly to them. But for the large majority they enable significant weight loss of 10-30% long term, with added bonus health benefits.

100% agree. Thinking about food all day, everyday - what you're eating, what you're going to eat, what strategies are you going to use at holiday gatherings, tracking, trying to keep yourself from eating after you've hit your limit and your body's telling you you're still hungry, how are you going to keep from eating the donuts someone brought to work when you're stressed and hungry, etc. - is a massive mental load that, for most people, is impossible to maintain for the rest of their lives.

I've also met a few people who have had the surgery, and still gained the weight back.

 

[FlowerFairy]

I've also met a few people who have had the surgery, and still gained the weight back.

I had a surgeon who modified the surgery I was approved for. Didn’t document what he did, essentially falsified my operative report of what he did. Only admitted it to me when my weight loss stopped after I’d lost around 110 lbs and stalled, and had worked with his office to determine why I was stalled. When he admitted what he had done, I asked when I was getting a revision to what I had paid for. His response was that he didn’t believe in revisions and I was a statistical success because I’d lost more than 100 lbs. I was stuck. Still morbidly obese. Couldn’t prove what he had done because he said it over the phone, not in print. Nothing worked until GLPs. I will take them until I die.

 

[cheaperseeker]

I had a surgeon who modified the surgery I was approved for. Didn’t document what he did, essentially falsified my operative report of what he did. Only admitted it to me when my weight loss stopped after I’d lost around 110 lbs and stalled, and had worked with his office to determine why I was stalled. When he admitted what he had done, I asked when I was getting a revision to what I had paid for. His response was that he didn’t believe in revisions and I was a statistical success because I’d lost more than 100 lbs. I was stuck. Still morbidly obese. Couldn’t prove what he had done because he said it over the phone, not in print. Nothing worked until GLPs. I will take them until I die.

Did you talk to a lawyer? An MRI or something might be able to prove what he did.

 

[Smiter]

I agree 100% that mere diet and exercise will not cure the obesity pandemic, but I don't think the cognitive load is the issue. I posit that it has to do with the endocrine malfunction. Food noise as folks put it, is quite likely a result of ghrelin overload due to leptin resistance. If test can cause roid rage, other hormones can affect behavior too.

 

[cheaperseeker]

I agree 100% that mere diet and exercise will not cure the obesity pandemic, but I don't think the cognitive load is the issue. I posit that it has to do with the endocrine malfunction. Food noise as folks put it, is quite likely a result of ghrelin overload due to leptin resistance. If test can cause roid rage, other hormones can affect behavior too.

I think it's both. The cognitive load is the symptom and endocrine dysfunction is the underlying cause. The hormones were telling us we were starving, even when we already had more than enough nutrition. GLPs hit what diet and exercise can't.

 

[Raidenfat2fit]

Take me for example. I started at 334 .. losing 30% would put me at 234. Still obese. I need to lose about 50% of my starting weight.

Also not everyone reacts the same to each receptor ... having options is always a good thing.

Exactly couldn't agree more