Mixing Selank + Semax in one shot?

[cjdilan]

Quick question. I’ve already used Selank and Semax separately. No issues. I’m just trying to cut down on injections.

I see some online vendors sell them premixed, but I can’t find anyone here actually talking about mixing them themselves.

Has anyone here:

Mixed both into one syringe?

Reconstituted them into the same vial?

Run into stability or dosing issues doing it that way?

Not asking if they “work together” — I know how each feels on its own. Just want to know if there’s any real reason not to combine them or if it’s basically just draw both and pin once.

Looking for real-world experience, not vendor copy.

 

[Camlbacker]

Not vendor copy, most people find both Semax and Selank to be more efficacious administered intranasally. That also avoids needles altogether.

 

[Chili777]

Quick question. I’ve already used Selank and Semax separately. No issues. I’m just trying to cut down on injections.

I see some online vendors sell them premixed, but I can’t find anyone here actually talking about mixing them themselves.

Has anyone here:

Mixed both into one syringe?

Reconstituted them into the same vial?

Run into stability or dosing issues doing it that way?

Not asking if they “work together” — I know how each feels on its own. Just want to know if there’s any real reason not to combine them or if it’s basically just draw both and pin once.

Looking for real-world experience, not vendor copy.

Depends on what your goals are. I like Semax in the mornings and Selank later in the day and enjoy the separate effects. If you like them together, do it. Just be aware that a Semax cycle should be no more than 30 days and then a wash out of 30 days because it can overload BDNF receptors, whereas you can run Selank as long as you want although a break is recommended.

 

[94brian49]

I mixed them in the the same vial, no issue at all for me.

I used to mixed them with GLOW too, later found out its a big no no stopped doing that after that.

 

[desinr-gal]

Quick question. I’ve already used Selank and Semax separately. No issues. I’m just trying to cut down on injections.

I see some online vendors sell them premixed, but I can’t find anyone here actually talking about mixing them themselves.

Has anyone here:

Mixed both into one syringe?

Reconstituted them into the same vial?

Run into stability or dosing issues doing it that way?

Not asking if they “work together” — I know how each feels on its own. Just want to know if there’s any real reason not to combine them or if it’s basically just draw both and pin once.

Looking for real-world experience, not vendor copy.

Yes. I put them together into one vial, the first time I started using them.. It worked fine at first. But then the Selank started over powering the semax, inducing fatigue. I don't recommend doing it. Many people say keep the selank for afternoon/eve. Semax in the morning. Now I do semax in the am on days I feel I need that boost. I dont follow the protocals, because everyday started to feel like it created too much pressure in my head.

 

[Jfrick11]

Not vendor copy, most people find both Semax and Selank to be more efficacious administered intranasally. That also avoids needles altogether.

I mix them together in one intranasal bottle! Definitely prefer nose

 

[CNCCurrency]

I mixed them in the the same vial, no issue at all for me.

I used to mixed them with GLOW too, later found out its a big no no stopped doing that after that.

I mix selank, semax, pinealon and pe 22-28 in the same vial

 

[desinr-gal]

I mix selank, semax, pinealon and pe 22-28 in the same vial

Please tell me about pe 22-28, and what this blend is doing for you??

TIA

 

[CNCCurrency]

Please tell me about pe 22-28, and what this blend is doing for you??

TIA

PE-22-28 functions as a potent and selective antagonist of TREK-1 (KCNK2) two-pore domain potassium channels. By blocking TREK-1, it depolarizes neurons and enhances excitability, leading to increased firing of serotonergic neurons and elevated monoamine neurotransmission. This mechanism produces rapid antidepressant-like effects in preclinical models—within 4 days, PE-22-28 significantly increases hippocampal neurogenesis and synaptogenesis markers, changes typically requiring weeks with conventional antidepressants The peptide also activates CaMKII/CREB pathways that promote neuronal survival and plasticity. PE-22-28 represents a shortened, optimized analog of spadin with superior potency (IC50 ~0.12 nM versus 40–60 nM for spadin) and longer duration of action (~23 hours versus ~7 hours) Notably, research also demonstrates neuroprotective effects in stroke models through biphasic dosing that leverages both TREK-1 activation at ultra-low doses and inhibition at standard doses

20 mg semax

10 mg selank

10 mg pinealon

10 mg pe 22-28

 

[john_askins]

PE-22-28 functions as a potent and selective antagonist of TREK-1 (KCNK2) two-pore domain potassium channels. By blocking TREK-1, it depolarizes neurons and enhances excitability, leading to increased firing of serotonergic neurons and elevated monoamine neurotransmission. This mechanism produces rapid antidepressant-like effects in preclinical models—within 4 days, PE-22-28 significantly increases hippocampal neurogenesis and synaptogenesis markers, changes typically requiring weeks with conventional antidepressants The peptide also activates CaMKII/CREB pathways that promote neuronal survival and plasticity. PE-22-28 represents a shortened, optimized analog of spadin with superior potency (IC50 ~0.12 nM versus 40–60 nM for spadin) and longer duration of action (~23 hours versus ~7 hours) Notably, research also demonstrates neuroprotective effects in stroke models through biphasic dosing that leverages both TREK-1 activation at ultra-low doses and inhibition at standard doses

20 mg semax

10 mg selank

10 mg pinealon

10 mg pe 22-28

what dose of pe2228 did you start with? I was thinking 300mcg per day

 

[RubbaDubba1]

My Dr said it was completely fine to mix different peptides in the same syringe to cut down on pins, at the time of injection. (Except GLP-1's of course) I did recently come across this peptide interaction checker. https://thepeptidelist.com/interaction-checker

 

[Calm Logic]

My Dr said it was completely fine to mix different peptides in the same syringe to cut down on pins, at the time of injection. (Except GLP-1's of course) I did recently come across this peptide interaction checker. https://thepeptidelist.com/interaction-checker

Your doctor is acting like a quack to make such a blanket statement. But most docs overstep all the time, like in the pre-GLP days when they gave nutrition counseling for weight loss.

It is less sterile anyway, at least slightly.

Anyway, there certainly is disagreement. There was some peptide conference last year that said it is not safe to add peptides to the same syringe. I don't know which conference. But they were saying the exact opposite of your doctor since, for them, the safety data is just not there -- for any two peptides to be in the same syringe.

As many people that use KLOW mixed up in a vial, it would seem safe to add KPV and GHK-Cu together in a syringe (and helpful for the sting). But the theory isn't there as far as safety. And the data is limited to basic anecdotal observations. If I were to add anything together, it would be GHK-Cu and GHK, which has been done in mice studies.

If you don't want to feel like a pin cushion, I like the 6-mm insulin syringes.

At the very minimum, a peptide-friendly doctor should prescribe a couple EpiPens or something equivalent.

 

[RubbaDubba1]

Your doctor is acting like a quack to make such a blanket statement. But most docs overstep all the time, like in the pre-GLP days when they gave nutrition counseling for weight loss.

It is less sterile anyway, at least slightly.

If you don't want to feel like a pin cushion, I like the 6 mm insulin syringes.

At the very minimum, this doc should have prescribed a couple EpiPens or something equivalent.

I disagree, he does this himself and this is how he makes his living. He's a longevity Dr & actually certifies other clinicians in peptide protocols. I haven't schilled for him or his business on here. I don't have a problem passing something along, he told me. I do telehealth every 3-4 months, there are a couple things I do get via compound pharmacy and he knows I use grey market.

After countless rounds of PT, over a 100 shots of cortisone and 13 operations. Needles don't bug me, hell I use 29/30 gauge, 12 mm syringes. It helps get the last of the juice out of the vial and saves time and money. I've had 1 site reaction in 2.5 years, a little cortisone took care of that. I got Benadryl and chewable baby aspirin always at the ready, If I discover my shellfish or blood clot allergy again.

 

[Calm Logic]

If you want to say there is more art than science to medicine/doctoring, fine. But I really think it's unideal and sloppy (as in peptide soup) to be using the same syringe for anything, especially on a routine basis.

Even Dr. William Seeds is mostly quackery, but I like his book since it is a starting point.

Every time I see a primary care doctor, they usually say something stupid, if they talk long enough. The last time it was "Zepbound has less side effects than compounded (tirz)."

 

[RubbaDubba1]

If you want to say there is more art than science to medicine/doctoring, fine. But I really think it's unideal and sloppy to be using the same syringe for anything, especially on a routine basis. It's the exact opposite of sterile technique.

Even Dr. William Seeds is mostly quackery , but I like his book since it is a starting point.

Every time I see a primary care doctor, they usually say something stupid, if they talk long enough. The last time it was "Zepbound has less side effects than compounded (tirz)."

I don't disagree, with that. I'd still rather pin 1-2X, than 4 or 5. One whiff of anything weird, I would stop cold. Some people don't like buying peps already mixed in a vial, yet klow is very popular. I'm probably healthy enough, to handle if something goes wonky. I check blood work 3-4X a year, I could always be proven wrong.

Love me some Dr Seeds, (I got his book to) it's where my guy started.

Funny, my weight loss surgeon is the one who got me onto compounded Tirz through his med spa of course. After I lost the regain weight, he got me onto grey market peptides. But Peptide Sciences is no longer in business, which is what he 1st recommended to me. Full circle for me anyways. Yeah, my regular GP is very anti, anything different drives me up a wall.

 

[TeresaHip]

I've been seeing vendors selling mixed too. I'm scared to do that.

 

[SolidChick]

Wait I though semax and selank arent to be taken together since it will cause adverse effects

 

[RubbaDubba1]

Wait I though semax and selank arent to be taken together since it will cause adverse effects

The interaction checker Linky is fairly new to me, but so far jives with the below chart you can find on Reddit easy enough. https://thepeptidelist.com/interaction-checker

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[Chili777]

Wait I though semax and selank arent to be taken together since it will cause adverse effects

They use different pathways, so there is no receptor issue using them at the same time. What happened with me is that the effects of Semax overwhelmed the effects of the Selank, so I got the full effects of neither. I only did this for a few days before I bailed on it. I greatly preferred the use of Semax in the morning before work and Selank later in the day or evening. Some people like it though.

 

[Chili777]

The interaction checker Linky is fairly new to me, but so far jives with the below chart you can find on Reddit easy enough. https://thepeptidelist.com/interaction-checker

View attachment 18240

I first saw this chart about a year ago and it's meant to describe what peps you shouldn't mix in the same syringe or vial, not about stacking. It says that at the top, but people miss it. It's also anecdotal and based on what wellness clinics were doing. I like this site better. Thanks to the original RS who posted this on the forum: https://thepeptidelist.com/interaction-checker