Migraines and tension headaches
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Pupsikas
Recently Joined 🚫No Source Discussion🚫
I was interested in your question so I searched it up. Seems like the main legit peptide-related option for migraines is CGRP-targeting meds. (CGRP itself is a peptide involved in migraine signaling.)
Research:
https://americanmigrainefoundation.org/resource-library/anti-cgrp-treatment-options/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11861264/
For actual peptide compounds people might look into, possibly oxytocin, Selank, or BPC-157, but they don’t seem nearly as evidence-backed for migraines or tension headaches.
Research:
https://americanmigrainefoundation.org/resource-library/anti-cgrp-treatment-options/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11861264/
For actual peptide compounds people might look into, possibly oxytocin, Selank, or BPC-157, but they don’t seem nearly as evidence-backed for migraines or tension headaches.
RubbaDubba1
GLP-1 Enthusiast
I only found about this through my Dr, who I do telehealth a couple times a year (and order a couple things) with a Dr who prescribes peptides, works in Regenerative medicine etc. He mentioned that the Secretagogues, Tesamorelin, Ipamorelin and Sermorelin help some (not all) of his patients with headaches. He doesn't know how, only that some happened to find relief, like it was a happy accident on my part. There's my medical disclaimer, for disclaiming.teetee07 said:
I've been to the ER with a headache before after 9 days, Med Spa many times to get an IV with all the good stuff to break it, Had 6 rounds of Trigger point injections, Dry needling, Cupping, Graston technique, 30-40 back/neck spasms a day, enough Physical Therapy I should qualify for the Olympics, take way to many pills everyday, I have a Neurologist and Dentist referenced to start Botox if & when I get there. This has really tested me of late, as I had a shoulder surgery 8 weeks ago, where the Trigger points are the worst for me on my right side. My references, for reference.
Now for your ? (I almost forgot) The Ipamorelin for me is the one that works best, it doesn't cure it, it kinda at times seems to help it go away or lessen in severity after I have a headache, but it is a hell of a preventative. If dosed before bed on an empty stomach or take it when I get up in the morning, I wanna say I can get 14-18 hours of coverage on average. I still get 100% of the pain, that kicks off my tension headaches and can feel my head pounding with the Gorilla wanting out of the cage, but no Headache or a dull one. I've used the Sermorelin, which didn't seem to help much, but want to try again for a longer period of time. I have not used Tesamorelin by itself, I have used Tesamorelin/Ipamorelin blend and it works fairly well, but not better than Ipamorelin by itself. The CJC-1295 no dac/Ipamorelin blend works best, best headache suppression if there is such a term and sleep is a little better.
Do your own do diligence of course, I only dose 5 days a week or do 3 on 1 off. Dosing has been as high as 500mcg daily on the Ipamorelin, but more didn't always help. I have found in other forums, mentions of this as well, it's all anecdotal of course. But I'd rather take this stuff than start on some abortive and all the ones I see advertised on TV. I've read of some people that have had migraines for like 30 years. I hope you find some relief.
lessthanhalf
GLP-1 Specialist
Migraines are something that have quite a lot of effective therapies in the more conventional medical therapy area.
Are you asking about treating acute migraines ? or trying to prevent ones that recur frequently?
You may well have already tried many different treatments or you may not but if you have not had expert advice from a good general practitioner or a neurologist if more frequent or severe or not responding to first line treatments, then it is likely worth pursuing and is more likely overall to result in less headaches than a bunch of peptides , none of which have been tested in humans as effective migraine therapies.
Unfortunately both for treating acute migraine and preventing recurrent ones there is no single treatment that always works for everyone, but there are a lot of different ones, all of which have pretty good success rates, so it is usually a case of trying a few different medications over time to find what works for you.
Tension type headaches are another story, but the same competent treatment has a good chance of finding effective therapies.
Analgesic overuse headaches are also very common, and may need a neurologist opinion on best treatment options.
Are you asking about treating acute migraines ? or trying to prevent ones that recur frequently?
You may well have already tried many different treatments or you may not but if you have not had expert advice from a good general practitioner or a neurologist if more frequent or severe or not responding to first line treatments, then it is likely worth pursuing and is more likely overall to result in less headaches than a bunch of peptides , none of which have been tested in humans as effective migraine therapies.
Unfortunately both for treating acute migraine and preventing recurrent ones there is no single treatment that always works for everyone, but there are a lot of different ones, all of which have pretty good success rates, so it is usually a case of trying a few different medications over time to find what works for you.
Tension type headaches are another story, but the same competent treatment has a good chance of finding effective therapies.
Analgesic overuse headaches are also very common, and may need a neurologist opinion on best treatment options.
Pupsikas said:
I take an Ajovy injection once per month which is a CGRP med, it definitely reduces the frequency of my migraines. Nurtec is also one and it helped, but it was a hassle to remember because it was taken every other day.
I don't have much experience or interest in peptides for migraines, but I have taken BPC-157 in the past for other reasons, it didn't seem to have any impact on migraines for me.
DragonOfTheSea
GLP-1 Enthusiast
* Disclaimer that these are just breadcrumbs for you to look into. Search deeper to affirm your own feelings on these *
+1 to having heard that CJC-1295 no DAC + Ipamorelin which @RubbaDubba1 mentioned, can have positive impact.
Additionally I have heard of GHK-Cu having an almost immediate (15-20 minutes) effect on reducing headache/migraine symptoms.
That being said, since there are a plethora of causes for migraine/headaches, I highly doubt there is ever going to be a blanket solution for you to find. As @lessthanhalf mentioned, there are many practices and therapies out there alternative to peptides. I think there are a number of people who think "there must be a peptide for that!" for anything that ails us, but alas we aren't there yet, haha.
+1 to having heard that CJC-1295 no DAC + Ipamorelin which @RubbaDubba1 mentioned, can have positive impact.
Additionally I have heard of GHK-Cu having an almost immediate (15-20 minutes) effect on reducing headache/migraine symptoms.
That being said, since there are a plethora of causes for migraine/headaches, I highly doubt there is ever going to be a blanket solution for you to find. As @lessthanhalf mentioned, there are many practices and therapies out there alternative to peptides. I think there are a number of people who think "there must be a peptide for that!" for anything that ails us, but alas we aren't there yet, haha.
Pin&Play
GLP-1 Apprentice
I recently noticed that I haven't had a headache in at least two months. Used to suffer from tension headache every few week, and almost certainly during periods of stress or after 1-2 nights of poor sleep. And I had plenty of sleepless nights recently.
Things that I've been taking more or less regularly that could have made the difference:
- Tirzepatide. This is a major candidate
- multivatimin. Maybe... but I have to drop it so we'll see
- KPV. This might have helped with IBS/stress but I don't see a correlation with sleep deprivation headache, but then who knows
My blood pressure has been lower than usual recently so that might be a factor too
Things that I've been taking more or less regularly that could have made the difference:
- Tirzepatide. This is a major candidate
- multivatimin. Maybe... but I have to drop it so we'll see
- KPV. This might have helped with IBS/stress but I don't see a correlation with sleep deprivation headache, but then who knows
My blood pressure has been lower than usual recently so that might be a factor too
teetee07
Recently Joined 🚫No Source Discussion🚫
You guys are awesome. Thank you so much for your feedback. These are definitely some options I can look into. I've dealt with headaches on and off for years and my doc at one point was talking about using botox for migraines and I really don't want to use that.
Galapagosfit
GLP-1 Apprentice
est ce que ca t'a été prescrit par ton medecin?Rezwalker said:
my wife have aura migraine and in quebec you need to try at least 2 to 3 meds before the the doc can ask the public insurance to cover ajovy ( fremanezumab).
Her migraines happen randomly, with long breaks of several months in between. This makes it hard for the neurologist to monitor the treatment because he prescribes something, my wife doesn't get a migraine for four months, and then, oops, she gets four in the same week.
lessthanhalf
GLP-1 Specialist
GLP drugs most likely reduce migraines. Not a lot of studies, but liraglutide did reduce migraines, and there is a pile of evidence from both human and animal studies that glp medications modify pain pathways and could be very effective in treating many different pain problems including neuropathic pain and abdominal pain. I suspect that over time there will be some new studies on the newer glps for migraine.
It is also probably reasonable to assume that the overall benefits to health from GLP's and weight loss would benefit migraines, by improving metabolic state and reducing systemic low grade inflammation, and maybe even by better food choices.
It is also probably reasonable to assume that the overall benefits to health from GLP's and weight loss would benefit migraines, by improving metabolic state and reducing systemic low grade inflammation, and maybe even by better food choices.
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