Let's talk GLP1's downfall - MUSCLE LOSS

[tul9033]

That actually makes a lot of sense. thank you! I’ve definitely been guilty of stopping way before failure just because I felt tired or was bored I didn’t realize how important it was to push that far, especially with bands.

I’ve been debating whether to invest in a bench and dumbbells since space is kind of tight, but you’re right, it might be worth it long-term if I’m serious about building strength and keeping muscle on this journey. Appreciate the clear breakdown, especially for us newbies still figuring it out!

Don't be afraid to do do body weight exercises. Push ups alone are a great work out that work so many muscle groups when done with great attention to form. I would dedicate 30 minutes when I got home from work to doing as many body weight exercises I could with little rest time between sets, really focusing mostly on core. Planking with compound movement was another exercise I tried to do every day. Don't be discouraged if you can't do much for very long at first. 2 or 3 weeks 5 days a week and you'll start seeing big improvements.

 

[Calm Logic]

Anavar would be better at just preserving muscle and has fewer side effects, but I’ve been having trouble finding it.

A questionable vendor in the vendor forum just posted a picture of supposedly 1,000 bottles of it.

 

[syndet2x]

Bimagrumab has the potential to fix this issue, although Eli Lilly bought the company that developed it and will likely charge a huge premium for this when/if it becomes available.

But in human testing, Semaglutide + Gimagrumab led to a 22% weight loss, of which 100% was fat (so no muscle loss) and they gained 2.5% more lean muscle mass.

GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates - Nature Communications

Myostatin and activin A are the two primary negative regulators of muscle mass. Blocking these circulating ligands during GLP-1 therapy induces improved body composition through preservation of lean mass and enhanced fat mass loss in obese primates.

www.nature.com

https://www.sciencedirect.com/topics/medicine-and-dentistry/bimagrumab

Also of note, this sadly isn't a peptide or long chain protein that we may get access to, but a monoclonal antibody drug which will make it very difficult to manufacture.

Regeneron Pharmaceuticals

(i'm alive thanks to this firm)

Mibavademab (Leptin inhibitor) & Trevogrumab (Myostatin inhibitor) are in the pipeline.

In conjunction with Eli Lilly Tirz with Mibavademab, Semaglutide with Trevogrumab (with or without garetosmab (anti-activin A)

Heck, if i win a lotto, i'll invest in (NASDAQ: REGN)

 

[syndet2x]

wanted to add nuance as far as hGH

i wanted to give AOD a go, but heard too many horror stories

used same (176-191) frag AM with Tesa PM, knocked off 1% of visceral with slightly less than 1/2 to go on a 5mg recon

i blew out a hernia repair, but ready to stack a short run of anavar once exercise is viable again

 

[syndet2x]

Re: India shipment

100% received, so quite lucky given others' experiences. was going to setup with Ipostal1, but seems to be handled with USPS, so still looking

 

[Dagda]

Trevogrumab and Garetsomab are in stage 2 human trials. Both drugs work by reducing the activity of myostatin and activin-a, both of which reduce and cap skeletal muscle growth. Thus, these new drugs UNCAP that growth.

At least in monkeys, when these two drugs were coupled with a GLP-1, there was massive fat loss coupled with muscle GROWTH, and this was despite a caloric deficit (and the fact that monkeys don't do resistance training). Might be available to the public by, say, 2027.

 

[Calm Logic]

365 days a year is my plan.

Seems par for the course at Meso. (Why cycle when you can cruise?)

And I see on Meso that a few guys will get an echocardiogram just in case to check for early signs of LVH from long-term use of HGH and especially AAS.

https://thinksteroids.com/community...e-of-having-good-bp-and-blood-work.134426499/

https://www.thinksteroids.com/community/threads/usa-serostim-source-pharmaceutical-hgh.134381686/post-3518878

 

[syndet2x]

at traditional HRT/TRT protocols (compared to BB, might as well be microdosing ), the idea of mixed-esters has merit at similar ratio versus solo-depo/eth. IGF-1/HDL are the giveaway labs to set ceiling, keeping an eye open since heart healthy estradiol is somewhere ~75, but gyno avoidance at non-microdose test blasts adds risk with use of AI, so ekg/eeg is absolutely required ahead of hypertrophy/fibrosis heart probs.

Late last year some good news (re: non-supra-physiological regimens)

Research Finds Testosterone Therapy Safe for Heart Health | Cedars-Sinai

In the past, testosterone replacement therapy was believed to increase the risk of cardiovascular events. New research shows it?s safe for men aged 45-80.

www.cedars-sinai.org

 

[tangoecho311]

Last June I was 225lbs. I am 5'4, 31 year old female. I had twins in 2023. I started tirz in July. Highest dose I was on was 9mg every 5 days. I'm now on 3mg every 10 days for maintenance. I am 150lbs now, and need to have about 10lbs of skin removed. I lost some muscle, it's hard to keep up with weight training enough to combat losing the extra 75lbs I was carrying everyday. I would have to wear a weighted vest everyday to keep up. I priotorized protein in my diet and ate good carbs daily. No low carb bs for me. I did weight training (high weight, low rep) 2-3x per week, yoga daily, cardio 1-2x per week. I still can't lift as much as I could before the weight loss. I can do about 80%. But I can run now. My body hurts less. I FEEL 100x better. My back doesn't hurt, my knees don't crackle when I stand up. I'll happily accept being a year behind in my weight training goals to feel this good.

 

[joseblo]

Also 5'4, and started tirz at 180 in oct after diet/exercising off 10lbs and got to my original GW around 135 at a consistent 7-8lbs/mo. I blend a 20oz protein/fiber shake every single day just to make sure I get enough nutrients, but still have had muscle and some hair loss. Not as strong as I was, but walking a few miles a day is a LOT easier, planks are doable. I hear about the weighted vests, and I kinda wonder, but there's no way I'd put on a 40lbs vest. Trying kettle bells now.

Got kicked off formulary in March and started titrating down and now trying to switch to reta (so I can enjoy food without noise?). I continued to lose on tirz down to 115 and I actually wouldn't mind going up 10lbs. So far reta has me sleeping hotter and eating more at stable weight (for a coupla weeks). Will it let me gain muscle? I hope so. The lack of soreness and inflamation kicked in the first month I started tirz, and I don't want to go back! I guess I'll find out if reta will still do that.

 

[Eengineering]

Monoclonal antibodies are massively more difficult to produce than peptides or steroids.

It's not impossible - China produces plenty of monoclonal antibodies in general - but they're a lot more expensive and the production capacity is more limited in general. I wouldn't expect to see these in the grey market anytime soon

Would follistatin344 produce some of the same effects? From what I recall it is a myostatin inhibitor and I have seen it offered from some vendors.

 

[hexagonal]

Would follistatin344 produce some of the same effects? From what I recall it is a myostatin inhibitor and I have seen it offered from some vendors.

None of the current myostatin inhibitors work particularly well. Effect size is too small.

 

[keangkong]

One can certainly lose fat and build muscle but there are specific circumstances to doing that. Ones which I believe, from the way people are talking and the reason they're here, would apply to the majority of people here.

This somewhat of a deep dive into the topic but those special circumstances are covered in the first few minutes.

On the subject of resistance training. It's a must imo, not just for GLP1 users, for everyone who wants a long healthy life.

No need for special supplements, eat enough protein 0.6-1g/lb, 0.3g fat per lb, the rest carbs eaten before you train. Start with walking if that's where you are at, add bands, then body weight, then dumbbells or kettlebells, trian 1-2 reps to failure, push a set every so often to failure. Once you feel like you've made some progress then look at getting more serious about resistance training. There are so many various ways to train and implements one can use, it's almost limitless, don't sweat the details, just find what you enjoy and benefit from.

I'm not a bodybuilder by any means. But I am aware of Mike Isratael and know he knows what he's talking about. He's also funny.

 

[AndyPanda]

Trevogrumab and Garetsomab are in stage 2 human trials. Both drugs work by reducing the activity of myostatin and activin-a, both of which reduce and cap skeletal muscle growth. Thus, these new drugs UNCAP that growth.

At least in monkeys, when these two drugs were coupled with a GLP-1, there was massive fat loss coupled with muscle GROWTH, and this was despite a caloric deficit (and the fact that monkeys don't do resistance training). Might be available to the public by, say, 2027.

Anyone seen vendors carrying Trevogrumab yet?

 

[keangkong]

At least in monkeys, when these two drugs were coupled with a GLP-1, there was massive fat loss coupled with muscle GROWTH, and this was despite a caloric deficit ( and the fact that monkeys don't do resistance training ). Might be available to the public by, say, 2027. (Emphasis added.)

 

[hexagonal]

Anyone seen vendors carrying Trevogrumab yet?

Unlikely we'll see monoclonal antibody stuff with vendors anytime soon. China can produce them, but the facilities that can have enough legit work for pharma that they're not going to be funneling any to the grey or black market.

 

[indolent]

View attachment 8294

Thank you for the irrefutable documentary evidence that this outlandish claim is 1000% false.

Also, monkeys are funny.

 

[conzopiriani]

16 weeks.

HGH: The Ultimate Guide (Dosage, Cycles, Stacks) - Inside Bodybuilding

This comprehensive HGH guide includes the typical bodybuilding dosage, benefits, side effects, cycles, stacking information, and more.

insidebodybuilding.com

Oooo an ex of mine worked at genentech on protopin research in the 80s. I may have an old rollout promo t shirt laying around somewhere. Everyone knew it was the body builders who were going to be the most excited about it.

 

[Sandman1972]

I started lifting more than usual. High intensity and also some heavy lifts. Did that for 6 -8 months.

I liked the results but was tired- then I added Semorelin.

Wow. Huge difference. I do the troches bc I didn’t feel like injecting myself more than once a week.

 

[desinr-gal]

I bought Calcium HMB after seeing articles about how it has successfully prevented muscle loss in studies. Has anyone here tried it? I got a bag from bulk supplements, and have no clue how much or when to consume it. haha