kpv for Crohn's

[RoundMan]

My daughter has Crohn's and it's mostly inflammation in the intestines.

She wants to try KPV but it's looking for cycle protocol.

She understands dosing but the only thing we can't find is a better guide to cycle length or if you cycle on and off at all.

I have seen one post that states 8-12 weeks but then it doesn't say, how long off for.

Any advice?

 

[lessthanhalf]

I have ulcerative colitis , so I looked into KPV. There are lots of cell and rat and mouse studies on it for colitis but no human studies, so any protocol or cycle you find is stuff someone just made up. Mouse models of colitis are fairly easy so research gets done on that , Chron's is much more complex and much harder to make a mouse or rat model of to test drugs on. There is good evidence it helps in mice models of colitis, when given orally but there is no real evidence it makes it very far in the gut, definitely not to the colon in humans if given orally. ( mouse GI systems are much shorter than human ones ) All the more recent research involves it being encapsulated or bound to another molecule to make it survive longer in the gut so it makes it through to where it is needed - mainly colon.

Injecting it might possibly work, but there are few animal studies done that way and no human ones so not much guidance. The fact that it is a peptide the body makes itself is a small indicator of safety but does not mean large doses given by injection are safe. My understanding is it is secreted in the gut as a antimicrobial peptide, presumably to help control microbiome bacteria.

 

[RoundMan]

Yes the dosage is small and then basically feel your way to the right levels for the individual is how I've read it.

I've seen a few Crohn's groups where people are using it and seem to have success.

The only reason I can see to cycle is to avoid desensitisation to it.

I'll ask amongst the Crohn's groups too.

 

[jordekorn]

I’ve read that it helps with inflammation with crohns and colitis and eczema, I had my colon removed in 2007 and no longer have ulcerative colitis, but I do have some pretty active/higher than needed immune responses and have developed terrible eczema at menopause, which kpv isn’t helping at all.

Join a crohns group like mentioned above, that sounds promising!

 

[wonttellyou]

I have CU and take it. Helps me not bleed out of my anus.

10 mg / 3 ml --> 10 units twice per week are enough for me to live a somewhat normal life with that illness.

 

[px1984]

I have ulcerative colitis , so I looked into KPV. There are lots of cell and rat and mouse studies on it for colitis but no human studies, so any protocol or cycle you find is stuff someone just made up. Mouse models of colitis are fairly easy so research gets done on that , Chron's is much more complex and much harder to make a mouse or rat model of to test drugs on. There is good evidence it helps in mice models of colitis, when given orally but there is no real evidence it makes it very far in the gut, definitely not to the colon in humans if given orally. ( mouse GI systems are much shorter than human ones ) All the more recent research involves it being encapsulated or bound to another molecule to make it survive longer in the gut so it makes it through to where it is needed - mainly colon.

Injecting it might possibly work, but there are few animal studies done that way and no human ones so not much guidance. The fact that it is a peptide the body makes itself is a small indicator of safety but does not mean large doses given by injection are safe. My understanding is it is secreted in the gut as a antimicrobial peptide, presumably to help control microbiome bacteria.

I’m also looking for potential aids with my UC, where did you get to with that research of KPV?

 

[RoundMan]

I’ve read that it helps with inflammation with crohns and colitis and eczema, I had my colon removed in 2007 and no longer have ulcerative colitis, but I do have some pretty active/higher than needed immune responses and have developed terrible eczema at menopause, which kpv isn’t helping at all.

Join a crohns group like mentioned above, that sounds promising!

Do you mind if I ask, do you have an ileostomy?

 

[Sir Chuck 13527]

I have CU and take it. Helps me not bleed out of my anus.

10 mg / 3 ml --> 10 units twice per week are enough for me to live a somewhat normal life with that illness.

That is definatly a win!

 

[jordekorn]

Do you mind if I ask, do you have an ileostomy?

I do. Almost 20 years, I opted for the bag instead of reattaching the small to my bootyhole, after having uc most of my life, pooping the “normal” way was not a concern, but possibly not having enough bowel control with all that liquid constantly coming out, was. The best decision I ever made was removing that thing, I should have done it at 18 instead of 34.

 

[jordekorn]

I’m also looking for potential aids with my UC, where did you get to with that research of KPV?

i had joined a ucsf study before removing my colon, it was going no where, my uc was not very responsive to treatments, the last “experimental” treatment I had was remicade, and it worked, but didn’t continue to work every time. There was no kpv around, I haven’t had my colon for 20 years ish. My dr also mentioned eating the paste food astronauts eat, and pin worms, I believe back then. But going to San Francisco for treatment became more stressful than it was worth, 5 hour drive each way, while in a flare up, since I was constantly flared up.

(I never got to try kpv for UC)

 

[lessthanhalf]

i had joined a ucsf study before removing my colon, it was going no where, my uc was not very responsive to treatments, the last “experimental” treatment I had was remicade, and it worked, but didn’t continue to work every time. There was no kpv around, I haven’t had my colon for 20 years ish. My dr also mentioned eating the paste food astronauts eat, and pin worms, I believe back then. But going to San Francisco for treatment became more stressful than it was worth, 5 hour drive each way, while in a flare up, since I was constantly flared up.

(I never got to try kpv for UC)

The information in those attatchments is not an accurate reflection on the science on KPV. It is AI generated, and it seems to be making the most common and standard mistakes, like making a coherent story over factual accuracy and not distinguishing between actual human clinical trials and animal or cell research. The places on the first page are wellness clinics optimised for extracting maximum amounts of money out of people regardless of the effectiveness of the treatments offered.

As far as I know there are no human studies on KPV as a therapy for inflammatory bowel disease, so by definition it is not proven to be safe or effective in humans. For every drug or drug like molecule that ends up working as a human treatment there might be 20 or 50 times as many molecules with interesting or promising sounding preclinical studies, which is exactly where KPV is currently.

 

[RoundMan]

I do. Almost 20 years, I opted for the bag instead of reattaching the small to my bootyhole, after having uc most of my life, pooping the “normal” way was not a concern, but possibly not having enough bowel control with all that liquid constantly coming out, was. The best decision I ever made was removing that thing, I should have done it at 18 instead of 34.

My wife had one around the same time.

She said it's the best thing she ever done, while she doesn't have UC any more she does still suffer with many other related issues.

I was contemplating weather kpv would be beneficial for her but I haven't found any info that would suggest it would be ok for ileostomy.

 

[jordekorn]

My wife had one around the same time.

She said it's the best thing she ever done, while she doesn't have UC any more she does still suffer with many other related issues.

I was contemplating weather kpv would be beneficial for her but I haven't found any info that would suggest it would be ok for ileostomy

What issues is she having?

Hands down the best iliostomy peptide for me is trizepatide. Slows stomach emptying, that helps with bag changes and not waking you up all night to burp it or rinse it. Helps with inflammation from all the uc meds from the 90s we had to take. My joints feel normal again.

Kpv hasn’t helped my menopausal skin inflammation I’ve developed in the last few years, but I am on Dupixant. I just have this wild inflammation response in my skin now, no dr has linked it to menopause, but no dr has looked into it either. In my mind puberty gave me ulcerative colitis and menopause gave me eczema. (Glad I never had kids, no telling what that hormone shift would have caused.)

All this to say, if she has a concern, if I’ve had the same problem, I’d be happy to offer my experiences.

 

[Skinnylegend95]

I’m also looking for potential aids with my UC, where did you get to with that research of KPV?

I also have uc and entyvio has pretty much worked great for me no flare ups in 2 years but i still want to try kpv also