积极的副作用

[Tidalwave]

What's crazy is that the stupid medical establishment still considers 130 systolic as too high.

When I took paramedic training back in a previous century, the common standard for "normal" systolic BP was 100+a persons age and 100. Then they lowered the hypertension threshold to 140 systolic, and when they couldn't get enough people paying for blood pressure meds they came up with this stage 1/stage 2 BS and lowered it again to 130.

You raise a really interesting point. It's true that the medical establishment has been slowly lowering the threshold for high blood pressure over the years, which has made more people eligible for blood pressure medication.

There's been a lot of controversy about this, with some people arguing that lowering the threshold too much can cause problems like over-diagnosis and overtreatment.

There's also been some discussion about whether the guidelines are based on the best evidence, or whether they're influenced by the financial interests of the pharmaceutical industry. What's your take on this?

 

[doughnutcat]

What's crazy is that the stupid medical establishment still considers 130 systolic as too high.

When I took paramedic training back in a previous century, the common standard for "normal" systolic BP was 100+a persons age and 100. Then they lowered the hypertension threshold to 140 systolic, and when they couldn't get enough people paying for blood pressure meds they came up with this stage 1/stage 2 BS and lowered it again to 130.

Yea I'm waiting to see if I drop another 20lbs how it does.

If I concentrate really hard and test myself a few times back to back and really really relax it's like 127 / 128.

 

[doughnutcat]

What's crazy is that the stupid medical establishment still considers 130 systolic as too high.

When I took paramedic training back in a previous century, the common standard for "normal" systolic BP was 100+a persons age and 100. Then they lowered the hypertension threshold to 140 systolic, and when they couldn't get enough people paying for blood pressure meds they came up with this stage 1/stage 2 BS and lowered it again to 130.

Also interesting I found out recently that 130 was still too high lol, after I googled and was happy about my new bp. This whole time I thought 130 was good and found out that yes it had indeed been lowered.

 

[Tidalwave]

Yea I'm waiting to see if I drop another 20lbs how it does.

If I concentrate really hard and test myself a few times back to back and really really relax it's like 127 / 128.

You raise a really interesting point. It's true that the medical establishment has been slowly lowering the threshold for high blood pressure over the years, which has made more people eligible for blood pressure medication.

There's been a lot of controversy about this, with some people arguing that lowering the threshold too much can cause problems like over-diagnosis and overtreatment.

There's also been some discussion about whether the guidelines are based on the best evidence, or whether they're influenced by the financial interests of the pharmaceutical industry. What's your take on this?

Also interesting I found out recently that 130 was still too high lol, after I googled and was happy about my new bp. This whole time I thought 130 was good and found out that yes it had indeed been lowered.

IMO there are actually several other factors that ‘’might’’ be contributing to the lowering of the high blood pressure threshold over time.

For example, there's been a rise in average body weight and an increase in the number of people with other risk factors for cardiovascular disease, like diabetes and high cholesterol.

And as medicine advances, we're able to more accurately measure blood pressure, so we're finding out that blood pressure levels that were once thought to be normal are actually more dangerous than we realized.

Click to expand...

 

[Snakez 97]

Interestingly the SURMOUNT-2 studies expressed some concerns about the effect of tirzepatide on blood pressure, including the potential for an unsafe drop in blood pressure for people with already low blood pressure, as well as dizziness and fainting.

Mine gets very low if I’m out doing yard work. I think it’s mostly/all dehydration. I try to drink enough, with serious electrolyte supplementation, but…Then I go to donate blood and it’s 140/105. I have terrible white coat syndrome. BUT it’s never been 105…

 

[TroubleTrouble]

I didn’t have an issue with drinking before, but now I just kind of never do. Unfortunately I’m a little sad about it- I’m a little weird sometimes socially and a drink was often…helpful. I hung out with friends at their place where tiki time is an afternoon tradition and I had to force the few sips I took to be polite.

Also, it’s such a random thing- but the little bumps on the back of my upper arms? Those little keratin bumps? They’ve been there as long as I can remember and on my right arm they’re completely gone and they’re almost gone on the left. It doesn’t even feel like my own arm when I touch it.

 

[BlackSwan 91]

Mine gets very low if I’m out doing yard work. I think it’s mostly/all dehydration. I try to drink enough, with serious electrolyte supplementation, but…Then I go to donate blood and it’s 140/105. I have terrible white coat syndrome. BUT it’s never been 105…

I have a problem with low blood pressure. I am glued to my huge water bottle because I am afraid if I don’t drink enough water I will have a syncope. It happened so many times in my life and ended up in ER. At least for higher blood pressure there is medication.

 

[doughnutcat]

你们都应该去做血液检查。

 

[Reimann]

K

我以前喝酒没什么问题，但现在几乎不喝了。说实话，我有点难过——我有时候社交能力比较弱，以前喝酒常常能……帮上忙。我去朋友家玩，下午喝点提基酒是他们的传统，但我为了礼貌，还是勉强抿了几口。还有

，虽然有点莫名其妙——我上臂后侧的小疙瘩？就是那些角蛋白小疙瘩？它们从我记事起就一直在，现在右臂上的完全消失了，左臂上的也几乎没了。摸起来都感觉不像自己的胳膊了。

KP与高血糖有关。我的KP也消失了。

 

[比西纳特]

我患有纤维肌痛，多年来尝试过很多方法来改善整体状况（包括干细胞治疗）。如果我压力过大，通常会出现病情发作。

2022年7月底，感恩节后的第二天，我女儿开始出现肌阵挛，接下来的几个月我们频繁出入医院。但我的病情却没有发作，一次也没有。通常情况下，在这种压力下，我早就卧床不起了。我还有

严重的贫血，需要输铁剂，但自从开始吸食大麻以来，我的病情一直很稳定，无需再输铁。我也听其他人说过类似的情况。此外，它还

缓解了我逐渐增加的体重（更年期后），并且成功减掉了65磅（约30公斤），这感觉也很棒。

 

[TroubleTrouble]

K

P 与高血糖有关。我的 K P 也消失了。

我听说过这种情况，虽然我的血糖一直都很好。

 

[SassyPants]

我很想知道有多少人服用替泽帕肽后体验到了积极的副作用？

自从开始服用以来，我几乎戒了酒，感觉自己也快要戒烟了，耳鸣似乎略有改善，而且我明显感觉我的注意力缺陷多动症（ADHD）症状也有所改善。

当然，体重减轻对很多方面都有积极的副作用，包括缓解疼痛、提高灵活性，以及​​让日常活动变得更加轻松。但这种药物的作用肯定不止于对血糖和体重的影响。

我注意到，刚开始服用（Arctic P）TZ时，我的炎症和疼痛几乎立刻就消退了。

通常情况下，我站不了几个小时，之后就会感觉很疼。（我在沙发上、房间里都放了加热垫，冰箱里还备着几个凝胶包。）能连续几周完全不疼，真是太棒了！后来

我从别的地方买了第二批（组合装）TZ（PSG）。结果疼痛比以前更严重了。

我一直告诉自己这只是巧合，但我也不确定。

所以，嗯，最初的副作用是积极的。

我很想看看这批药用完后，换回Arctic P会是什么感觉。

 

[VicBweets]

大概在我使用2.5毫克大麻笔的第三周左右，情况开始恶化。我每晚都会调制一杯超大杯鸡尾酒，结果只喝了几口就倒掉了，然后好几次都像被遗弃在桌子上一样放着；到了下一周，我就干脆不做了。

更糟糕的是，大概在我服用5毫克SAF的第三周，我在邻居家喝了两杯波旁威士忌，结果接下来的24小时我都恶心反胃（不是宿醉的恶心，比宿醉难受500倍！）。从那以后，我偶尔会喝一两杯啤酒，但即使这样，我的身体也不舒服。TZ肯定改变了我肝脏处理糖分的方式，所以我干脆不再冒险了。

Same experience! My extra large dirty martini got dumped then I stopped making them. Much more of an effect with sema. Gotta admit after switching to tirz, I miss my martinis, but after 3 months, I was excited not to want/need them? Thinking of stacking in general, but this is one of my reasons for considering.

 

[cthruit]

I have similar reduction in desire for alcohol as described above. Another weird one: I used to have a habit of biting my nails which has gone away. On the negative side, I used to get really excited about various things and now I feel like I'm faking excitement sometimes. Obviously this could be about food and cooking a meal but other things too. For example, going out to a concert or travel now seems like a hassle rather than something I'm really excited about. Not sure if this is just a cycle thing that will change or if it is the Tirzapatide.

Something to do with dopamine. Dopamine is the neurotransmitter responsible for "seeking" behavior. People are no longer "seeking" food, alcohol, gambling, etc. You are no longer seeking concerts or travel, apparently.

 

[cthruit]

I didn’t have an issue with drinking before, but now I just kind of never do. Unfortunately I’m a little sad about it- I’m a little weird sometimes socially and a drink was often…helpful. I hung out with friends at their place where tiki time is an afternoon tradition and I had to force the few sips I took to be polite.

Also, it’s such a random thing- but the little bumps on the back of my upper arms? Those little keratin bumps? They’ve been there as long as I can remember and on my right arm they’re completely gone and they’re almost gone on the left. It doesn’t even feel like my own arm when I touch it.

Wow! After reading your post, I reached down and felt the backs of my thighs. I've always had keratosis pilaris (the little bumps due to excess keratin) there and now they are almost completely gone.

 

[lasagnabeach]

I feel more emotionally even and less impulsive, I have little craving for alcohol at all (though mostly was good off it anyway), I don't love sweets normally but now i actively dislike them....I was repulsed by a lifesaver mint today which I found hilarious

 

[jipax13855]

-Felt a decrease in ADHD symptoms (not enough to be fully without meds--just more present generally)

-Have done less impulse-y online shopping

-Probably an indirect side effect, but I've gone to craving a more keto/paleo diet and basically went gluten free without thinking about it. This fixed some GI symptoms and there is a notable improvement in my lol

 

[Smurfsam]

I'm curious how many people have experienced positive side-effects on tirzepatide?

Since starting I have pretty much given up alcohol, I feel like I'm almost ready to quit smoking, my tinnitus seems to have improved slightly, and I definitely feel like it's improved my ADHD.

Obviously the weight loss has had a positive side-effect on many aspects including aches and pains, flexibility, and just being easier to do every day things, but there's definitely more to this med than the impacts on blood sugar and weight.

Hi @ZippityDooDah

I’m also adhd and about to start Tirz tomorrow. Am I allowed to ask a cpl of questions to you by PM? Thanks

 

[Goreandglitter]

I'm curious how many people have experienced positive side-effects on tirzepatide?

Since starting I have pretty much given up alcohol, I feel like I'm almost ready to quit smoking, my tinnitus seems to have improved slightly, and I definitely feel like it's improved my ADHD.

Obviously the weight loss has had a positive side-effect on many aspects including aches and pains, flexibility, and just being easier to do every day things, but there's definitely more to this med than the impacts on blood sugar and weight.

Let me know how the smoking goes I deff need to quit. I enjoy it less and usually smoke like half a cig at a time but the urge is still there lol

My sister in law has been on it for over a year and has chronic pain and inflammation from long covid and it’s the only thing that’s really helped her. I have horrible hips that actually get worse when I lose weight they’re on fire but as I’ve upped my dose the pain significantly decreased I’m assuming that’s due to less inflammation.

 

[Goreandglitter]

My mood has improved significantly and general anxiety seems to have dropped.

I’ve heard that a lot. I on the other hand have had nonstop panic attacks since starting. A few of us apparently go the opposite direction