Interesting new sleep medication trial

[cygnus]

BMB-101

It drastically improved amount of REM sleep in phase 2 trials.

A new drug in the middle of clinical trials just increased REM sleep by 90% without making people sleep longer!

This is the first medication ever to specifically enhance REM only and the implications go far beyond seizure control.

Here's what just happened. pic.twitter.com/2Htew1CbcD
— drMAWZ (@TheDrMAWZ) January 9, 2026

View: https://x.com/TheDrMAWZ/status/2009622195358843260

for thread discussion on the drug. What's intriguing is it doesn't do anything to total sleep duration, but changes the overall quality of the sleep.

 

[BH_LOVER]

Sleep quality is more important than quantity for me. I have only recently gotten better sleep

 

[Liber_Pater]

I'm interested in increasing deep sleep but I don't see any deep sleep info in the graphic provided (BMB-101 side). Has anyone seen any info related to deep sleep?

 

[TexasHoneybadger]

Interesting

 

[Peotidethrowaway]

Hello china. Please start making this. Please?

 

[IshimaruKenta]

Not discounting it, but DSIP also claimed to significantly increase your deep sleep. Then Epitalon, magnesium L-threonate and now this. Color me skeptical.

 

[lessthanhalf]

The early phase 1 and 2 human trials are for using it for absence seizures. But wikipedia lists it as being developed for several other conditions including binge eating disorder. I wonder what effect it would have on mood? Most antidepressants reduce rem sleep and sleep deprivation is thought to improve mood by reducing rem sleep as well.

 

[cheaperseeker]

The early phase 1 and 2 human trials are for using it for absence seizures. But wikipedia lists it as being developed for several other conditions including binge eating disorder. I wonder what effect it would have on mood? Most antidepressants reduce rem sleep and sleep deprivation is thought to improve mood by reducing rem sleep as well.

Sleep deprivation improves mood? I can't say that has been my experience. I feel like shit if I get less than 7 hours.

 

[foxgirl]

Sleep deprivation improves mood? I can't say that has been my experience. I feel like shit if I get less than 7 hours.

Sleep deprivation is genuinely one of the most impactful changes when it comes to my mood

 

[lessthanhalf]

I doubt that normal "not enough sleep" helps with mood, I think just about everyone feels cranky when overtired, it has been studied quite a lot in severe depressive illness states, where minimal overnight sleep improves mood the next day, not really useful in practice.

Given the lack of useful treatments for binge eating disorder, only lisdexamphetamine is approved, and GLP's almost certainly help, but not sure if it is proven enough yet to be recommended by doctors. It might still be worth keeping an eye on what happens to BMB-101, anything that genuinely helps with eating control long term is extremely relevant to treating obesity, assuming it even gets to trials for that purpose.

 

[pavlovs]

Of peptides, I've tried epitalon, DSIP, and selank to try to improve sleep. Of OTC meds, I tried L-theanine, L-tryptophan, and HTP. Using my Oura ring and keeping sleep notes, I used each alone for one week.

I got no increase in REM or deep sleep with DSIP, epitalon, or selank. Epitalon did help me sleep longer.

L-theanine and L-tryptophan both helped me fall and stay asleep, but did not give me any meaningful change in REM or deep sleep.

What has worked ---- Trazadone. I'm getting around two hours of deep sleep, and three hours of REM a night, and for the first time in years, I am waking up feeling refreshed.

I'm waiting for this med you linked to make through the trials, thank you for linking. I believe that next to hydration and nutrition, good quality sleep is the best thing we can do to improve health outcomes. Thank you for linking