Immediate severe reaction

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Airborne Daddy said:
I took less than a mg.... .75 is less than 1
My bad. It should be 0.1mg, to test first. Then go up to 0.25mg. 0.5 tops
 
lessthanhalf said:
It is interesting you got this response on the first dose, typically allergic reactions require repeated exposures before the allergy develops. Not sure it means anything , just a bit odd.
Former vol. medic here. This is correct. The body needs learn about a compound first, before it can decide to freak out about that particular compound.

The reaction is consistent with anaphylaxis, which could be:

- The reaction is to something else in the solution

or

- What was in the vial was not cagri

or

- You have, perhaps unintentionally, been exposed to cagri before, perhaps from cross-contamination in manufacturing.

Because these are injectables, the amount needed to develop an allergy can be very, very small. Small enough to where poor industrial hygiene can account for it.

Anaphylaxis is a serious thing and not knowing when it will strike next introduces additional threat vectors. Consider keeping epinephrine on hand.
 
Airborne Daddy said:
All my research says its likely an excipient or preservative. Hope its not the new norm. Got it through pgb so somewhat more assuring for the price mark up.
Holy hell, AD! That sounds terrifying. I'm really glad you're ok. I hope it's just the batch or combo of the cag with its inerts.

I'm so sorry it happened to you.

How do you feel today?
 
HereKittyKitty said:
Holy hell, AD! That sounds terrifying. I'm really glad you're ok. I hope it's just the batch or combo of the cag with its inerts.

I'm so sorry it happened to you.

How do you feel today?
Great. I now have a dozen epenepherine amps on hand.
 
4StrandKnot said:
Former vol. medic here. This is correct. The body needs learn about a compound first, before it can decide to freak out about that particular compound.

The reaction is consistent with anaphylaxis, which could be:

- The reaction is to something else in the solution

or

- What was in the vial was not cagri

or

- You have, perhaps unintentionally, been exposed to cagri before, perhaps from cross-contamination in manufacturing.

Because these are injectables, the amount needed to develop an allergy can be very, very small. Small enough to where poor industrial hygiene can account for it.

Anaphylaxis is a serious thing and not knowing when it will strike next introduces additional threat vectors. Consider keeping epinephrine on hand.
I have amps on hand. Cag was from pgb who test everything. Wondering if it was a different filler than mannitol.
 
Despite the fact that it was the first dose, peptides are just way more allergenic than anything else that might have been in the injection. Mannitol or any other sugar is not going to cause an allergic response. Bac is a possible but unlikely cause.

It is easy to test, just use a small dose of the bac water you used to see if you react to it. If not it is the peptide or much less likely a contaminant or a peptide fragment from degradation, but generally bigger peptides are more allergenic than small ones, making the drug as the biggest and most common peptide in there the most likely cause. And in general allergic reactions and non neutralising antibodies to GLP or amylin agonists are very common, about 5% and up to 50% respectively, though most are localised injection site reactions not generalised.
 
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