I thought .6mg was starting dose....lilamae05111 said:
Immediate severe reaction
- Thread starter Airborne Daddy
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Yeah, I think that's a lot. I thought 250 mcg was the recommended starting dose, but in your case it might have not made a huge difference. If you're allergic, you're allergic. Time to offload that on a BST somewhere.
It could also mean that Elora is a no-go, too, but that hits a limited set of amylin receptors. Cagri hits all of them. I wouldn't try one again without a Neffy or EpiPen. Sorry man, that sucks.
It could also mean that Elora is a no-go, too, but that hits a limited set of amylin receptors. Cagri hits all of them. I wouldn't try one again without a Neffy or EpiPen. Sorry man, that sucks.
FWIW, ODing isn't the same as your allergic reaction.Airborne Daddy said:
Yeah, a Cag OD would likely be some nausea, possibly vomiting, with strong appetite suppression. What Airborne had really sounds like an allergic reaction. And I'd bet it's some impurity in the Cag that he's allergic to, not the Cag itself.RetCurious said:
Or it's not even Cag. They're trying to find out what is being put in those bogus peps flooding the market. One was a low dose of tirz in a reta kit but most are completely unknown substances at this point.FartfulCodger said:
All my research says its likely an excipient or preservative. Hope its not the new norm. Got it through pgb so somewhat more assuring for the price mark up.FartfulCodger said:
The cag I had an allergic reaction to last week was from JKL. Don't think there's any connection between these two sources ?Airborne Daddy said:
I’m so sorry this happened to you, that sounds terrifying.
As others have mentioned, the symptoms certainly sound more consistent with anaphylaxis rather than an ordinary side effect. It also doesn’t sound like a typical reaction from simply taking too much cagrilintide.
I wouldn’t assume, however, that it was necessarily the cagrilintide itself or that you would react to every amylin-receptor agonist. It could have been the peptide, an excipient, the bacteriostatic water, contamination, or even a misidentified product. Too many variables to know for sure.
I definitely would not use that vial again or give it to someone else without letting them know what happened. Another reaction could be serious, and its severity would be impossible to predict. I’d get some epinephrine to have on hand. I've been meaning to do same and just haven't gotten around to it.... going on Amazon right now.
Feel better, buddy!
As others have mentioned, the symptoms certainly sound more consistent with anaphylaxis rather than an ordinary side effect. It also doesn’t sound like a typical reaction from simply taking too much cagrilintide.
I wouldn’t assume, however, that it was necessarily the cagrilintide itself or that you would react to every amylin-receptor agonist. It could have been the peptide, an excipient, the bacteriostatic water, contamination, or even a misidentified product. Too many variables to know for sure.
I definitely would not use that vial again or give it to someone else without letting them know what happened. Another reaction could be serious, and its severity would be impossible to predict. I’d get some epinephrine to have on hand. I've been meaning to do same and just haven't gotten around to it.... going on Amazon right now.
Feel better, buddy!
Damn son, glad you're OK.
Jfc, SO glad you're ok. I need you healthy enough to marry my mom some day, god damnit!
I hope it's not too early to make a joke.Airborne Daddy said:
The question is, did you eat during those two hours? Maybe that's how it works.
End of joke.
Are you going to try it again at 1/3 of the dose you used?
That does sound suspiciously like anaphylaxis. Not sure from your post what you did, but it does not sound like you went to hospital. The only remotely safe option then , once there was any issues with breathing or facial swelling was to call an ambulance, there is no possible way to predict if it will get worse or better, but given worse could be dead in that situation not going straight to an emergency department is dangerous.
I would strongly suggest not to ever test it to see if it was a true allergic response , just assume it is and avoid it forever. If a doctor wanted to do a test dose to see if you were truly allergic they would only ever consider doing that in a controlled environment with resuscitation equipment close by, and use a 1/10 or 1/100th dose. Trying it again at home is too high risk, given how severe the possible outcomes could be, even if you had an epipen at hand. It is possible to get this done by an allergy specialist but given the drug is not released yet my guess is they would be very reluctant to do the test with a grey sourced unapproved peptide. And in general they will only test if the reaction was not anaphylaxis, but some less extreme reaction.
I have not seen numbers for drug allergies to cagri, but they happen for all the other GLP peptides, I would expect the drug itself is almost certainly the culprit rather than a contaminant or the bac, given that allergic reactions to peptides are fairly common, even if mostly they are just injection site reactions.
At least elora is now out so you have a better if a bit dearer option instead of cagri.
I would strongly suggest not to ever test it to see if it was a true allergic response , just assume it is and avoid it forever. If a doctor wanted to do a test dose to see if you were truly allergic they would only ever consider doing that in a controlled environment with resuscitation equipment close by, and use a 1/10 or 1/100th dose. Trying it again at home is too high risk, given how severe the possible outcomes could be, even if you had an epipen at hand. It is possible to get this done by an allergy specialist but given the drug is not released yet my guess is they would be very reluctant to do the test with a grey sourced unapproved peptide. And in general they will only test if the reaction was not anaphylaxis, but some less extreme reaction.
I have not seen numbers for drug allergies to cagri, but they happen for all the other GLP peptides, I would expect the drug itself is almost certainly the culprit rather than a contaminant or the bac, given that allergic reactions to peptides are fairly common, even if mostly they are just injection site reactions.
At least elora is now out so you have a better if a bit dearer option instead of cagri.
I don't think that a cross reaction with elora can be excluded though. They do have differences, but also similarities in their amino acid sequences. Nobody knows if the reaction came from a part of the sequence both share, or if the exchange does enough to the 3D-structure that it doesn't happen with it.quoted said:
Position Cagrilintide Eloralintide
1 K –
2 C C
3 N N
4 T T
5 A A
6 T T
7 C C
8 A A
9 T T
10 Q G
11 R X*
12 L L
13 A A
14 E E
15 F F
16 L L
17 R V
18 H R
19 S S
20 S S
21 N N
22 N N
23 F F
24 G G
25 P P
26 I K
27 L L
28 P P
29 P P
30 T T
31 N E
32 V V
33 G G
34 S S
35 N N
36 T T
37 P-amid Y
+ – E (separate Glutaminsäure)
Airborne Daddy said:
Yowser..... that would have scared me too. Honestly, with the itching, swelling, numb lips, racing heart, and trouble breathing that quickly after the injection, I would never mess with Cag again. That sounds much more like an hypersensitivity allergic reaction than any side effect. The lip, heart and breathing piece are hallmark tells in anaphylaxis rewctions..... So count your lucky stars it didn't progress and get some epi to have on hand asapAirborne Daddy said:
I don't know that it means you'll react to every amylin peptide, but I also wouldn't assume it's safe to find out by trying another one on your own.
I was using Motsc for some time and I had a sudden hypersensitivity reaction. Mine didn't progress as far as affecting my breathing, but it was an entire body, scarey experience. No more Mots for me
EVER.Glad you're okay..... that's definitely not something to brush off.
LIkely not it did shit for me. Hunger pangs the next 2 days with absolutely no suppression.Seasonal1 said:
We have an er 3 blocks away, i was dressed and ready to go if breathing didnt improve. Im the 1 in 10,000 but cant win a 100dollar lotto ticket.lessthanhalf said:
I’m so sorry you experienced this; I’m glad you’re okay. Did you bring it up in PGB’s group chat to see whether anyone else experienced anything similar? Even if nothing has been posted publicly, someone may reach out to you via DM with more information if you ask.Airborne Daddy said:
No, figured im gonna be the lone problem. The batch was only about 3 months old. Most my stash is from 2025. Im concerned maybe this year everyone switched mannitol filler to something else that i did read folks have local reaction to but not systematic like me.miameow said:
is it possible that you and the other person who had a reaction last week (Im sorry, forget the name at the moment, but remember your hives/welts/bad reaction) both got a tainted batch? Has it been tested? maybe its not the CAG, just THAT cag. That said, I dont suggest you try it again! Glad you re okAirborne Daddy said:
Even if someone only had a local reaction, it could still be worth asking around. At least then you might have some reassurance that it isn’t cagri itself, but something else in the pep you’re reacting to. That could leave other options like Elora open for future research.Airborne Daddy said:
I suggested asking because I’ve noticed that some people in that group prefer to DM rather than discuss these kinds of topics openly.
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