Immediate severe reaction

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bamagirl26 said:
is it possible that you and the other person who had a reaction last week (Im sorry, forget the name at the moment, but remember your hives/welts/bad reaction) both got a tainted batch? Has it been tested? maybe its not the CAG, just THAT cag. That said, I dont suggest you try it again! Glad you re ok
@spanky2026 .... ours were from different vendors. Mine from pgb so i paid premium for a tested/ recent batch. The itchiness and welts at injection site can be ph related or minor allergic reaction. I read alot of folks also add acetic acid to play with the ph. I never had an issue with 8 other peps, any meds, foods or insects bites so i just pinned it without consideration....
 
Airborne Daddy said:
@spanky2026 .... ours were from different vendors. Mine from pgb so i paid premium for a tested/ recent batch. The itchiness and welts at injection site can be ph related or minor allergic reaction. I read alot of folks also add acetic acid to play with the ph. I never had an issue with 8 other peps, any meds, foods or insects bites so i just pinned it without consideration....
Mine wasn't an injection site allergy, it was systemic. I've never had an injection site reaction of any kind. And to Bamagirls question, mine was JKL, OP was PGB, so different vendors. Possibly same source? But who knows.
 
Airborne Daddy said:
@spanky2026 .... ours were from different vendors. Mine from pgb so i paid premium for a tested/ recent batch. The itchiness and welts at injection site can be ph related or minor allergic reaction. I read alot of folks also add acetic acid to play with the ph. I never had an issue with 8 other peps, any meds, foods or insects bites so i just pinned it without consideration....
It is curious that your starting dose was much higher than many and aside from the allergic reaction you had no other results.

I read that the unknown marker in the recent no-peptide issues was said to be similar in all the cases of zero peptide.

Not sure it would be worth trying and I agree PGB seems to be thorough, but really weird no benefits at all from that large of a dose.
 
someone i know had same issue from tesa and then cjc, dose of antihistamine bought it back in check after about 30 mins and scared him to, wont take them anymore, i always have some antihistamine ready for a new peptide
 
pughster25 said:
someone i know had same issue from tesa and then cjc, dose of antihistamine bought it back in check after about 30 mins and scared him to, wont take them anymore, i always have some antihistamine ready for a new peptide
just like Benadryl or something stronger?
 
Skidude said:
It is curious that your starting dose was much higher than many and aside from the allergic reaction you had no other results.

I read that the unknown marker in the recent no-peptide issues was said to be similar in all the cases of zero peptide.

Not sure it would be worth trying and I agree PGB seems to be thorough, but really weird no benefits at all from that large of a dose.
Idk, i swear i got that PAM gene that lets you lose 3 or 4% body weight and thats it.... also i ran thyroid panels showing low t4, with free t4 almost low, so that has much ado with metabolism...

Everyone's saying it was an extreme start dose. I read initial is .6mg and the next titrate is 1.2mg..... you mean the glp1 forum titration schedule where everyone starts reta with .25 mg and stays there 6 months complete with the Reta not working threads?
 
Enyola said:
I don't think that a cross reaction with elora can be excluded though. They do have differences, but also similarities in their amino acid sequences. Nobody knows if the reaction came from a part of the sequence both share, or if the exchange does enough to the 3D-structure that it doesn't happen with it.

Position Cagrilintide Eloralintide

1 K –

2 C C

3 N N

4 T T

5 A A

6 T T

7 C C

8 A A

9 T T

10 Q G

11 R X*

12 L L

13 A A

14 E E

15 F F

16 L L

17 R V

18 H R

19 S S

20 S S

21 N N

22 N N

23 F F

24 G G

25 P P

26 I K

27 L L

28 P P

29 P P

30 T T

31 N E

32 V V

33 G G

34 S S

35 N N

36 T T

37 P-amid Y

+ – E (separate Glutaminsäure)
I spent way too much time researching allergic reactions to GLP's when I had weird rash that might have been due to a drug allergy a year or 2 ago. In general the opinion is cross reactions to GLP agonists are rare, despite the fact that they are going to share a lot of the same sequences as well. Does not prove that cross reactions to amylin agonists are equally uncommon, but is suggestive. There is at least one person on this forum who developed allergic responses to all three GLP drugs they tried so it is possible. Probably worth getting an epipen and having it on hand before trying elora just in case.
 
Airborne Daddy said:
We have an er 3 blocks away, i was dressed and ready to go if breathing didnt improve. Im the 1 in 10,000 but cant win a 100dollar lotto ticket.
I still suggest if anything like that ever happens again the only safe response is to call an ambulance. Trying to get yourself there in that state by driving is very unsafe. If there is someone there who could drive you maybe not quite as risky, but not what I would call safe. Being ready or only a few blocks away won't help if things suddenly go sideways and all of a sudden you really cannot breathe, if that happened you are just not going to have the time to spare or the ability to do much, let alone get to a hospital or maybe even calling the ambulance might be impossible. The odds of that happening are maybe only a few percent in that situation, but even a few percent is a pretty high risk to take, when there is an unknowable risk of things deteriorating rapidly to the point where you cannot do anything to get help, and dying becomes a genuine possibility. I guarantee an ER would rather you played it safe rather than sorry even if all they did when you got there was watch you to make sure nothing happened.

After reading a comment on here about the sequence similarity of elora to cagri, getting an epipen and having it on hand before trying elora is probably sensible. In general cross reactions to different GLP's are rare, but who knows for amylin agonists, there is nowhere near enough data on them for anyone to have any idea.

It is interesting you got this response on the first dose, typically allergic reactions require repeated exposures before the allergy develops. Not sure it means anything , just a bit odd.
 
Airborne Daddy said:
Everyone's saying it was an extreme start dose. I read initial is .6mg and the next titrate is 1.2mg..... you mean the glp1 forum titration schedule where everyone starts reta with .25 mg and stays there 6 months complete with the Reta not working threads?
I watched a video tonight that said the starting dose should be .75 to 4mg. The comments under the video must have mostly been people from here with the .25mg starting dose. I haven't experienced any negative issues from GLPs and may have also started at your dose.

I'm glad you are ok.

I read everything I can on Cagri in case I hit a stall as I get closer to goal. I don't have any in the freezer yet but still reading and watching.
 
Airborne Daddy said:
Got some 5mg cag i was looking forward to trying because i no longer get any suppression whatsoever from max dose reta or tirz..

Added 1ml if bac and took .75 mg....within minutes every square inch of skin itched. Nose swelled, lips got numb, heart rate took off and had difficulty breathing for an hour or 2... scared the shit out of me. Guessing id get same reaction from any amyl receptor driven peptide? Thoughts on why this happened? Ive heard of it with mots, never cag. Thanks for any insight.
I’m really sorry you went through that. That must have been TERRIFYING.

As everyone is already telling you, the combination of widespread itching, swelling, lip numbness, rapid heart rate, and difficulty breathing sounds much more like a possible allergic or hypersensitivity reaction than a typical side effect of cagrilintide.

There’s no way to know from a single event whether it was the peptide itself, an excipient, the bacteriostatic water, or something else, so I wouldn’t automatically assume you’ll react the same way to every amylin receptor agonist.

Given the swelling and breathing difficulty, I would be very cautious about trying it again without first speaking with a physician or allergist.

I’m really glad you’re okay now 🫶

And honestly, reading your experience genuinely scared me. I have a Cagri kit myself, and after reading what happened to you, I seriously doubt I’ll have the courage to try it 😖
 
Darn. I wonder IF it would be worth doing an allergy skin scratch test, also known as a skin prick test before injecting a new vial?
 
Mara_aa said:
I’m really sorry you went through that. That must have been TERRIFYING.

As everyone is already telling you, the combination of widespread itching, swelling, lip numbness, rapid heart rate, and difficulty breathing sounds much more like a possible allergic or hypersensitivity reaction than a typical side effect of cagrilintide.

There’s no way to know from a single event whether it was the peptide itself, an excipient, the bacteriostatic water, or something else, so I wouldn’t automatically assume you’ll react the same way to every amylin receptor agonist.

Given the swelling and breathing difficulty, I would be very cautious about trying it again without first speaking with a physician or allergist.

I’m really glad you’re okay now 🫶

And honestly, reading your experience genuinely scared me. I have a Cagri kit myself, and after reading what happened to you, I seriously doubt I’ll have the courage to try it 😖
Youll be fine.... i won the 1 in 10,000 reaction which should increase your odds to not be the next. But yeah, any new peptide gets the skin prick with a tenth of recommended starting dosage.
 
I tried that with a bunch of possible drugs , and a few foods, mostly crushed up pills when attempting to see if one was causing a drug reaction, no results, but being an immediate type 1 reaction it is actually viable, if not risk free. The scratch test can only really detect type 1 histamine mediated reactions but intradermal injections will detect that and delayed hypersensitivity reactions ( that will not show up for hours to days )

Scratch test is just a scratch, deep enough to draw a tiny bit of blood , then drip a bit of solution on the scratch, and watch it for the next hour or 2. Quite low risk of triggering anaphylaxis, but not quite zero. The other option is an intradermal injection ( which would be safer than a subcutaneous injection as it would be absorbed slower ) but not sure how easy it is to do with zero practice, and 1/100 would be safer than 1/10, and even then would not recommend with those drugs. If an allergist wanted to do the test they would only do it if not being able to use the drug was a major pain as there were not good alternatives and it was needed, and only do it somewhere with resuscitation gear available.
 
Airborne Daddy said:
Got some 5mg cag i was looking forward to trying because i no longer get any suppression whatsoever from max dose reta or tirz..

Added 1ml if bac and took .75 mg....within minutes every square inch of skin itched. Nose swelled, lips got numb, heart rate took off and had difficulty breathing for an hour or 2... scared the shit out of me. Guessing id get same reaction from any amyl receptor driven peptide? Thoughts on why this happened? Ive heard of it with mots, never cag. Thanks for any insight.
That is very high dose. Should have start at 1mg first
 
This happened to my subject with Mots-C as well as TESA, both were when coming back from a break. Both times the injection drew blood. Mots-c was instant anaphylaxis, eyes were red like tomatoes in seconds, almost passed out, pounding headache, HR through the roof. Tesa was just hives. It was only in places where previous subq injections had taken place. Weird AF, like a subq injection detector. Swollen patches everywhere around the belly button.

All I had on hand was Benadryl, subject chewed three and laid down both times. Won’t ever be researching those again.
 
Airborne Daddy said:
Got some 5mg cag i was looking forward to trying because i no longer get any suppression whatsoever from max dose reta or tirz..

Added 1ml if bac and took .75 mg....within minutes every square inch of skin itched. Nose swelled, lips got numb, heart rate took off and had difficulty breathing for an hour or 2... scared the shit out of me. Guessing id get same reaction from any amyl receptor driven peptide? Thoughts on why this happened? Ive heard of it with mots, never cag. Thanks for any insight.
Did you see a doctor for an allergy test ? Please do not ignore those symptoms as it could be fatal. Your doctor will prescribe you an epi pen if you have an allergy to the ingredient. Maybe try a different amyl pep?
 
Youarewhen said:
This happened to my subject with Mots-C as well as TESA, both were when coming back from a break. Both times the injection drew blood. Mots-c was instant anaphylaxis, eyes were red like tomatoes in seconds, almost passed out, pounding headache, HR through the roof. Tesa was just hives. It was only in places where previous subq injections had taken place. Weird AF, like a subq injection detector. Swollen patches everywhere around the belly button.

All I had on hand was Benadryl, subject chewed three and laid down both times. Won’t ever be researching those again.
Omg did you seek help ?
 
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