How are you all taking adamax?

[tendency]

From my research it appears preferred delivery of Adamax is nasal spray. SubQ can also be tried but less preferred. How does this backup to real life experiences?

 

[Jack brown]

I think the idea is that SubQ might not cross the blood brain barrier, whereas the nasal spray can travel to your brain via the olfactory nerve. So I prefer IN, though it may just be placebo.

 

[Chili777]

The Adamantine chain allows Adamax to penetrate the BBB via SQ or IN. Pep-pedia recommends SQ and doesn't even include a IN protocol, though i know some RSs do use it that way. I have some ready to go and I'm researching SQ first. If it's the rocket fuel I've heard it is, I may stick with that and never go IN.

 

[tendency]

The Adamantine chain allows Adamax to penetrate the BBB via SQ or IN. Pep-pedia recommends SQ and doesn't even include a IN protocol, though i know some RSs do use it that way. I have some ready to go and I'm researching SQ first. If it's the rocket fuel I've heard it is, I may stick with that and never go IN.

Cool - looking forward to trying some out when it arrives later this week. Hopefully will get a boost to my catecholamine/dopamine systems for depression and ADD support. Thanks for the info.

 

[CNCCurrency]

The Adamantine chain allows Adamax to penetrate the BBB via SQ or IN. Pep-pedia recommends SQ and doesn't even include a IN protocol, though i know some RSs do use it that way. I have some ready to go and I'm researching SQ first. If it's the rocket fuel I've heard it is, I may stick with that and never go IN.

Its weird they recommend nasal for semax though?

 

[sheilarae74]

Cool - looking forward to trying some out when it arrives later this week. Hopefully will get a boost to my catecholamine/dopamine systems for depression and ADD support. Thanks for the info.

Please keep us posted. I am thinking about trying Adamax myself.

 

[lessthanhalf]

I am skeptical about how well peptides get into the brain via the olfactory nerve. Most of the research is in rodents where the distances involved are a centimeter or two at most. In humans that distance is 10 times as far, and a very long way for any molecule to passively diffuse along a fairly narrow nerve path to get to the brain., and measuring concentrations of drugs in the brain is a bit more difficult in humans as they do not normally volunteer to have needles stuck in their brains for testing drug levels there. Some intranasal drug will be absorbed into the bloodstream via the nasal passages, which have quite high blood flow, presumably any that gets swallowed will be destroyed by gastric enzymes.

Adamax is specifically chemically modified to improve BBB penetration, and increase half life, compared to semax which it is based on. Unfortunately there is basically zero scientific research on adamax.

 

[Chili777]

I am skeptical about how well peptides get into the brain via the olfactory nerve. Most of the research is in rodents where the distances involved are a centimeter or two at most. In humans that distance is 10 times as far, and a very long way for any molecule to passively diffuse along a fairly narrow nerve path to get to the brain., and measuring concentrations of drugs in the brain is a bit more difficult in humans as they do not normally volunteer to have needles stuck in their brains for testing drug levels there. Some intranasal drug will be absorbed into the bloodstream via the nasal passages, which have quite high blood flow, presumably any that gets swallowed will be destroyed by gastric enzymes.

Adamax is specifically chemically modified to improve BBB penetration, and increase half life, compared to semax which it is based on. Unfortunately there is basically zero scientific research on adamax.

Adamax had a very different start than Semax, which might account for the lack of studies, unlike Semax.

From Gemini:

Adamax was first synthesized in 2016–2017 by the research and development team at Ceretropic , a specialized nootropics company led at the time by Paul Ruairi (commonly known in the community by his handle, MisterYouAreSoDumb ).

Unlike the original Semax, which emerged from the Institute of Molecular Genetics at the Russian Academy of Sciences in the 1980s, Adamax is a product of the private-sector "designer peptide" era.

### The Synthesis Context

The goal of the Ceretropic team was to solve two specific limitations of the Russian-designed

NA-Semax Amidate :

1. Metabolic Stability: They wanted a peptide that could resist enzymatic degradation for a longer period in the bloodstream.

2. Blood-Brain Barrier (BBB) Penetration: They sought a way to make the peptide more lipophilic (fat-soluble) to increase its efficiency in entering the brain.

### The "Adamantane" Innovation

The "Adamax" name comes from the addition of an Adamantane group to the N-Acetyl Semax base. Adamantane is a unique carbon structure (a "diamondoid") that was famously used in the development of the Alzheimer's drug

Memantine .

By tethering this bulky, lipophilic group to the peptide, the Ceretropic team created a version of Semax that:

* Passed through the BBB with significantly higher efficiency.

* Had a much longer half-life (which is why it feels more "potent" or "intense" than its predecessors).

### Key Players & Origin

* Company: Ceretropic (Arizona, USA).

* Timeline: Developmental discussions began in late 2015 on forums like Reddit’s r/nootropics, with the first stable batches synthesized and released to the research market in 2016 .

* Status: Because it was developed outside of the traditional pharmaceutical pipeline, it exists in a gray area—it is highly popular in the performance-enhancement community but lacks the formal peer-reviewed clinical history of the original Russian Semax.

Note: Since Ceretropic ceased operations several years ago, the "Adamax" currently available on the market is typically produced by independent peptide synthesis labs (mostly in China or the US) using the original chemical blueprint established by the Ceretropic team.

 

[Chili777]

Great article on Adamax on some lady's suspicious-link-removed today. Every potential buyer of it should understand the differences she's pointing out in the article.

 

[yeddie]

I assume you mean the two-part article by some lady & her AI ghostwriter.

The problem with Adamax

The Adamax Problem; Part 2

Interesting discussion of testing standards.

Edit: Haha, someone doesn't like her name being posted here.

 

[AlexSilver]

So where does NA Semax Amidate fit on this scale?

 

[Chili777]

So where does NA Semax Amidate fit on this scale?

Adamax> NA Semax> Semax, in order of strength. You'll likely only find NA Semax with the Amidate chain, although theoretically an NA Semax could be made without it, it would be pointless and I've never seen it. However, it may be out there and due diligence is key. The giveaway would be knowing the Dalton weight for each one to determine what you really have.

Da weight for each:

Semax (813.9\ Da)

N-Acetyl Semax (854.98\ Da) (no Adimate)

N-Acetyl Semax Amidate (855.96 Da)

Adamax 1032.2 Da (in the proper formulation)

 

[tendency]

Please keep us posted. I am thinking about trying Adamax myself.

Assuming my Adamax was legit I didn't find a compelling reason to use it over NA-Semax. Similar effects and the NA version is much cheaper. I did mine (NA-Semax) IN and that works much better for me than SubQ.

 

[Neurogroot]

Assuming my Adamax was legit I didn't find a compelling reason to use it over NA-Semax. Similar effects and the NA version is much cheaper. I did mine (NA-Semax) IN and that works much better for me than SubQ.

Similar experience as @tendency. I would say it “feels” mildly more energizing and increases focus more than NA Semax and Amidate. But really, I’m looking at a price point where I can buy a kit of NA Semax for the cost of 3 Adamax singles.

If the price ever comes down, even to 2x, I’ll be Team Adamax. Until then, NA all the way!