Higher dose for higher weight

[cloratheshadow]

Been stalled at least 2-3 weeks with decent hunger. I’ve titrated up slowly faster than recommended but I’ve read the more you have to lose more likely the higher dose you need. I have another 75 lbs to lose after losing 60 naturally and 20 with Tirz. I’m also stacking a bit of Reta. So 5mg Tirz 1 mg Reta. Would it be stupid to continue titrating? I’m only on week 7 but I just don’t feel it like I did the first month.

 

[cloratheshadow]

Also i still have decent slow stomach emptying but i am definitely HUNGRY. Also got a single vial of Cagri coming so I can try that also.

 

[woundcarping]

Keep it simple, increase your Tirz.

Tirz primarily works by reducing consumption with less hunger and food noise. You’ve got plenty of runway left.

 

[cloratheshadow]

Keep it simple, increase your Tirz.

Tirz primarily works by reducing consumption with less hunger and food noise. You’ve got plenty of runway left.

I just get nervous because I hear about blowing out your receptors and people not feeling it anymore but honestly I already don’t so…my body definitely is telling me to increase. I am still losing a tiny amount but that’s from exercise and really struggling to eat in a calorie deficit. I will increase and hopefully that helps!

 

[5byfive]

I think the 5:1 Tirz:Reta ratio is probably pretty sound overall. A stall for a couple weeks is going to happen so I wouldn't suggest moving based on that. You are on a low dose, so bumping it is reasonable, but I wouldn ask first, is your diet dialed in? Are you getting a good amount of protien and enough calories? Ideally, 1g per lb of protien and around a 500-700 tops deficit. If you are hungry and you are not doing this, or you don't know if you are doing this, its probably a diet issue, not a med issue. If you can fix the issue with a diet adjustment, that is always the better option, if not, I would say bump it.

 

[cloratheshadow]

I think the 5:1 Tirz:Reta ratio is probably pretty sound overall. A stall for a couple weeks is going to happen so I wouldn't suggest moving based on that. You are on a low dose, so bumping it is reasonable, but I wouldn ask first, is your diet dialed in? Are you getting a good amount of protien and enough calories? Ideally, 1g per lb of protien and around a 500-700 tops deficit. If you are hungry and you are not doing this, or you don't know if you are doing this, its probably a diet issue, not a med issue. If you can fix the issue with a diet adjustment, that is always the better option, if not, I would say bump it.

Im definitely very dialed in with nutrition. Lowish carb, Whole Foods, no liquid calories, around 1700 cals a day (2300 is maintainance) tons of lean protein. I am still losing a tiny amount but it’s been really hard to maintain a calorie deficit. I feel like the Tirz wears off completely after a couple days and I’m back to tons of food noise and hunger.

 

[woundcarping]

I just get nervous because I hear about blowing out your receptors and people not feeling it anymore but honestly I already don’t so…my body definitely is telling me to increase. I am still losing a tiny amount but that’s from exercise and really struggling to eat in a calorie deficit. I will increase and hopefully that helps!

I’ve not heard any credible accounts of people blowing out receptors, including people taking 20+mg/week, some stacking with Sema for more GLP exposure.

I started split dosing my third week on Tirz, moved to Reta and kept splitting. Food noise returning on day 4-5 was my initial reason for splitting.

 

[birdwhacker]

Man I hear you big boy. I'm hungry as fuck too. Don't forget that you can always take more. You just can't always take less.

It took 2 weeks for the appetite suppression to start working properly for me. I started at 0.5mg reta and kept blasting until I hit 2mg for the week, then I dosed 1mg every 3 days. Now I'm up to 2mg every 3 days and considering stacking cagri or tirz as well.

Make sure you aren't dosing once a week. Split your dose in half and dose every three days. Alternate the reta with the tirz. Give it some time to work, but don't be afraid to blast some more if you need the appetite suppression. I sometimes do a little 0.5-1mg touchup between doses.

 

[5byfive]

Since your diet is good, sounds like it may be time to bump and/or split. The argument against splitting is that you may be more likely to build up a tolerance if the levels in your system are more constant vs the up and down of a weekly dose. Its theoretical, but it also makes sense. Personally, I would be in the bump the dose slightly camp over the split camp, but both are valid options.

 

[woundcarping]

In trials, weight loss percentages is dose dependent with decreasing returns at higher doses and generally limited by sides, if it’s limited.

Receptors aren’t a meaningful issue if you’re a big’un.

 

[cloratheshadow]

Man I hear you big boy. I'm hungry as fuck too. Don't forget that you can always take more. You just can't always take less.

It took 2 weeks for the appetite suppression to start working properly for me. I started at 0.5mg reta and kept blasting until I hit 2mg for the week, then I dosed 1mg every 3 days. Now I'm up to 2mg every 3 days and considering stacking cagri or tirz as well.

Make sure you aren't dosing once a week. Split your dose in half and dose every three days. Alternate the reta with the tirz. Give it some time to work, but don't be afraid to blast some more if you need the appetite suppression. I sometimes do a little 0.5-1mg touchup between doses.

I’m a big lady excuse me..

 

[cloratheshadow]

Since your diet is good, sounds like it may be time to bump and/or split. The argument against splitting is that you may be more likely to build up a tolerance if the levels in your system are more constant vs the up and down of a weekly dose. Its theoretical, but it also makes sense. Personally, I would be in the bump the dose slightly camp over the split camp, but both are valid options.

I was splitting it but noticed better suppression every 5/6 days instead of 3! But adding a touch of Reta hopefully will help more

 

[cloratheshadow]

In trials, weight loss percentages is dose dependent with decreasing returns at higher doses and generally limited by sides, if it’s limited.

Receptors aren’t a meaningful issue if you’re a big’un.

Big un is hilarious I can’t help it I’m like a dog — food motivated

 

[hoobz]

Make sure you aren't dosing once a week. Split your dose in half and dose every three days.

I was listening to a podcast with a doctor the other day, where he said it's much better to dose once a week, cause we give time for the body to flush some of the peptide out and resensitize the receptors, which results in being able to use the peptide for a longer time on lower doses more effectively. Can't remember which doc that was, though it sounds interesting and kind of logical to me. Have you noticed any difference going once a week vs. every 3-4 days?

 

[woundcarping]

Big un is hilarious I can’t help it I’m like a dog — food motivated

Food noise was my thing, rarely hungry, always down to eat.

My goal will have me losing ~33-35% of my starting weight on GLP or ~38-40% of my ATH weight back in 2018.

With 12mg/weekly of Reta, only 24% lost 35% or more. My dose is currently 16mg/week to tip the scales in my favor.

 

[birdwhacker]

I was listening to a podcast with a doctor the other day, where he said it's much better to dose once a week, cause we give time for the body to flush some of the peptide out and resensitize the receptors, which results in being able to use the peptide for a longer time on lower doses more effectively.

I've heard the same bit of wisdom passed around. I can't say if it's true or not, though it doesn't sound right to me.

I can't compare the two because I've never gone more than 5 days without a dose. The hunger is too much lol. I absolutely love eating. Hell the other day I dosed my 2mg early trying to get out of eating some brownies I made for my dad. Next day I was sick as a dog from having so much GLP in my system and I still ate a brownie the size of my head. Then pigged out after bed too.

I think I need cagri LOL

 

[Chili777]

I just get nervous because I hear about blowing out your receptors and people not feeling it anymore but honestly I already don’t so…my body definitely is telling me to increase. I am still losing a tiny amount but that’s from exercise and really struggling to eat in a calorie deficit. I will increase and hopefully that helps!

GLP1s and potential sensor desensitization is a misconception, at tested dosages. They've been proven to not to have that issue because they work systemically and don't focus on any single set of receptors, like many peptides do. So feel free to titrate up slowly until you feel like it's working.

 

[birdwhacker]

I was listening to a podcast with a doctor the other day

GLP1s and potential sensor desensitization is a misconception, at tested dosages.

Seems like every piece of information that comes from a podcast, content creator, or blog is false. Everybody is cashing in on the GLP craze trying to get clicks. Everybody has an affiliate link. I'd bet money that doctor on that podcast is selling peptides and wellness supplements.

The other day, my stepmom shared a video of someone talking about Reta and he was fabricating studies for his content. Literally, she commented for more information, and he sent her a PDF of a fake study with fabricated results claiming benefits to taking 0.25mg of reta for anti aging. Littered throughout were, you guessed it, affiliate links.

Don't trust anything that doesn't come from some random guy on this forum speaking with absolute confidence.

 

[rettta]

I’ve not heard any credible accounts of people blowing out receptors, including people taking 20+mg/week, some stacking with Sema for more GLP exposure.

I started split dosing my third week on Tirz, moved to Reta and kept splitting. Food noise returning on day 4-5 was my initial reason for splitting.

yeah, I think that is instragram influencers conflating running cycles of reta and testosterone. I see "influencers" talking about desensitizing sensors and cycling, those people already have low body fat and are trying to get shredded. Most of us are trying to get a healthy body weight and the studies are based on longer timeframes

not cycling.

 

[rettta]

Been stalled at least 2-3 weeks with decent hunger. I’ve titrated up slowly faster than recommended but I’ve read the more you have to lose more likely the higher dose you need. I have another 75 lbs to lose after losing 60 naturally and 20 with Tirz. I’m also stacking a bit of Reta. So 5mg Tirz 1 mg Reta. Would it be stupid to continue titrating? I’m only on week 7 but I just don’t feel it like I did the first month.

You may not be getting the glucagon agonism intensity at that low of a dose of reta. I am at 8 mgs but am considering some added triz or sema for hunger. Reta doesnt seem to curb my hunger that well but im still slowly losing fat. Maybe look into flip flopping your triz and reta stack.