zpped
GLP-1 Specialist
All GLP1 have an increased RHR effect. Reta is only 1-2bpm more than Sema on average. There is no medical reason to be concerned as long as you're not tachycardic (rhr over 100bpm).Adavis3053 said:
Heart racing from Reta
- Thread starter Adavis3053
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woundcarping
GLP-1 Specialist
What specifically makes you nervous?Adavis3053 said:
Calm Logic
GLP-1 Specialist
The BP medication nebivolol (a beta blocker) can lower heart rate, but not sure about safety, interactions, etc:
Heart racing from Reta
So everyone has heard of the great Reta which will officially be available in 2026 or 2027. I am very interested as it uses a 3 prong approach (sema is 1 and tirz 2) however i have read some mixed reviews. Some say it is a super appetite suppressor and others have reported it actually made them...
glp1forum.com
If heart rate from reta becomes an issue and you are stuck with it for a while in your system, I'm sure a doc can prescribe something, if necessary. Just tell them the truth (or say you took compounded tirz, but the truth is usually the safest option medically).
As mentioned before, taurine, electrolytes, and hydration can be supportive. I got turned on to taurine at Meso, but most people make enough on their own. So not necessary usually. But some sides from GH peptides (like fluid retention) can stress the heart somewhat.
Heart racing from Reta
So everyone has heard of the great Reta which will officially be available in 2026 or 2027. I am very interested as it uses a 3 prong approach (sema is 1 and tirz 2) however i have read some mixed reviews. Some say it is a super appetite suppressor and others have reported it actually made them...
glp1forum.com
If heart rate from reta becomes an issue and you are stuck with it for a while in your system, I'm sure a doc can prescribe something, if necessary. Just tell them the truth (or say you took compounded tirz, but the truth is usually the safest option medically).
As mentioned before, taurine, electrolytes, and hydration can be supportive. I got turned on to taurine at Meso, but most people make enough on their own. So not necessary usually. But some sides from GH peptides (like fluid retention) can stress the heart somewhat.
Adavis3053
GLP-1 Apprentice
Mostly the side effects. I have heard it burns fat like crazy-not just supressing appetite......and i can handle slight nausea and bathroom issues.....but I don't play with the heart! the increase HR has me hesitant as does the restlessness and trouble sleeping but that could be fixed by some melatonin. mostly the HRwoundcarping said:
Calm Logic
GLP-1 Specialist
The titration schedule with reta should help, as can splitting the dose to twice a week. Or just use tirz. I like tirz just as much (since I have sides with every GLP).
I know some people have HR issues with reta and discontinue due to insomnia (or, rarely, tachycardia), but I think it is overblown. It's not like clenbuterol (clen), which is a banned/unapproved heart stimulant (the opposite of a beta blocker). Even with clen, my heart rate was higher but nothing crazy.
I know some people have HR issues with reta and discontinue due to insomnia (or, rarely, tachycardia), but I think it is overblown. It's not like clenbuterol (clen), which is a banned/unapproved heart stimulant (the opposite of a beta blocker). Even with clen, my heart rate was higher but nothing crazy.
woundcarping
GLP-1 Specialist
Adavis3053 said:
Do you have a reason to think your heart can’t handle beating ~5 times more per minute at rest?
My heart beats considerably more beats exercising than the extra 5 per minute at rest.
trojanpeptide
GLP-1 Enthusiast
that is not the same thing at all.woundcarping said:
Also, on heart rate, I watched a video yesterday about this.
Heart rate increases YT video.
Peptidesearch
GLP-1 Enthusiast
I get increased HR - around 10bpm right after my shot for a few hours then it goes back to base line.
woundcarping
GLP-1 Specialist
Exercise is a stressor to the sympathetic system in varying degrees. GLP and GCGR peptides are some variety of a stressor to the sympathetic system. Caffeine is another sympathetic stressor that raises RHR.trojanpeptide said:
An example of an extreme that came to mind is the increase in polyps/intestinal cancer in long distance runners, thought to be caused by blood flow repeatedly being directed away from digestion to support to “flight” endurance exercise causing repeated hypoxic injuries to the lining. A less extreme, shorter term example of the same is the diarrhea that can be caused by the same mechanics.
Regarding the link, it’s two guys sitting around saying heart rate goes up, HRV goes down… maybe it’s a risk, they don’t know.
"Again we don't have an enormous and overwhelming body of evidence on this you know we don't have that many patients in our practice and we frankly don't have that many that take it"
“I mean again, we’re really wildly speculating”
“Again our sample size is so small that I want to be very careful and note that you know everything I'm saying is you know again it could be nothing…”
My average resting heart rate decreased 7bpm after starting Tirz, peak to valley. Getting to therapeutic levels of Reta has increased my RHR to approximately the levels it was before starting Tirz. My RHR is still within the same +/- 5-7bpm averaged band it’s been in for the last 5 years.
Foggy-Hollow
GLP-1 Enthusiast
I got +8-10 bpm across the board. No racing, but everything else went up: rhr, exercise, sitting… slowly went back as Reta worked itself out.
I don’t recall what happened with my HRV. I’d have to check logs for dates then Garmin.
I don’t recall what happened with my HRV. I’d have to check logs for dates then Garmin.
Adavis3053
GLP-1 Apprentice
I agree. Exercise increasing HR is different that reta!
Weird me out a bit......plus, I've heard tirz is a better appetite suppressor ? So why do folks love reta more?
Weird me out a bit......plus, I've heard tirz is a better appetite suppressor ? So why do folks love reta more?
trojanpeptide
GLP-1 Enthusiast
hey man, variable rise in exercise heart rate is not the same as a rise in resting heart rate , that's what I said. I'm not arguing about that. Exercise is good for you, high RHR is not.woundcarping said:
As far as sema, tirz, and reta, the research indicates , ah fk it, here:
[Imported image pending local asset: attachments-1770322605718-webp.15585]
You might ask why this matters to some, well, those of us with Aortic dilations/aneurysms (which increased quite a bit during/after the pandemic), we don't want to dissect or have a stroke, so minimizing the number of hammer hits to the aorta is important.
Good for you, but this is anecdotal. I don't know what else to add but that effects taper off although seldom reset to baseline (unless the drug is stopped).woundcarping said:
I'm not trying to sound polemic or dismissive, but again, I'm just relating what is reported by the scientific community.
trojanpeptide
GLP-1 Enthusiast
If I could, I would trade in these 3 kits of reta for tirz. My rhr is way too high (high 70s low 80s), especially for my condition.Adavis3053 said:
Calm Logic
GLP-1 Specialist
Adavis3053 said:
Of course, Big Pharma got somewhat better numbers with reta for the stock market. God bless Eli Lilly, haha. But it's all dose-dependent, and most people don't go to the max of tirz or reta.
Foggy-Hollow
GLP-1 Enthusiast
/raises hand - Discovered mine about 3 years ago. The diagnosis is … slightly terrifying I guess. Mines associated with a connective tissue disorder, I’m too flexible. Everywhere including my blood vessels, hence the aneurysm.trojanpeptide said:
To those unfamiliar, if the worst happens you’re on a 2-3 hour timer to get into surgery and get the aorta repaired, or you're done. The “good” news is that it can be monitored, and knowledge is power.
My +10 bpm was on half the clinical starting dose. I suspect it is not dose dependent but I have done zero research to find out.
trojanpeptide
GLP-1 Enthusiast
I believe it's dose dependent. At first it could be a little higher though.Foggy-Hollow said:
I've created a protocol designed for non-syndromic TAAs that I published here, and the drink is here, but I don't know how it would affect your specific condition (or mine tbh). You can always ask AI if the protocol would help or hurt you, but don't just ask one AI engine. I am currently using this protocol but haven't introduced SS-31/MOTS-C or KPV yet.
zpped
GLP-1 Specialist
Jesus christ, don't ask AI for medical advice.trojanpeptide said:
DunningKruger
GLP-1 Enthusiast
Mine jumped dangerously high as well, due to the increased sympathetic tone from the glucagon effect. I'm only at 21% body fat, so I'm not too concerned (yet) as I don't expect to be on it long, but my RHR has always been high.
That said, in an effort to reduce the stress of the compound, I've decided to drastically decrease the intensity/frequency of my workouts, reduce my coffee intake to only one in the am, fully eliminate cold plunge/hot sauna/baths, and not eat within 5 hours of bed. It's still high, but about 7-10 bpm less than shown here.
[Imported image pending local asset: attachments-reta-webp.15739]
That said, in an effort to reduce the stress of the compound, I've decided to drastically decrease the intensity/frequency of my workouts, reduce my coffee intake to only one in the am, fully eliminate cold plunge/hot sauna/baths, and not eat within 5 hours of bed. It's still high, but about 7-10 bpm less than shown here.
[Imported image pending local asset: attachments-reta-webp.15739]
trojanpeptide
GLP-1 Enthusiast
trojanpeptide said:
Who do you suggest to ask then?zpped said:
The protocol I designed took weeks/months. I'm not exaggerating, I've researched this for a long time. I used AI to help design it and then I pitted it against several other AIs for many iterations. Dosages, scheduled pulses, redundancy, dangers, etc. There is nothing inherently wrong with that. The alternative, I'm afraid, is watch and wait; to keep your blood pressure and heart rate down, to avoid lifting, don't hold your breath, do bs lightweight exercises, etc. Then you wait.. watch, sometimes they give you faulty readings from time to time, until you possibly burst or develop a bad anxiety. What I offer is something that could potentially alleviate the condition; but idk if it will, nobody does. I can only do the best I can, and given that I don't want open heart surgery, I will use the protocol.
As far as Foggy-Hollow, I don't think they are so daft as to just listen to error-prone AI, but nevertheless, it is a tool and sometimes, as I explained, it's the best we've got. Anyways, I kinda know what the Ai would tell him, it would lambast warnings regarding his condition, having already had surgery and now has a mechanical valve. It would say do not do this and this and this and etc.
But the dill extracts might be a good thing for Foggy-Hollow... that's an entire different matter.
To be clear, all I suggest is to run his particular details along with the given protocol to assess what it says; he definitely doesn't want to just run that protocol !
I will ask:
[Imported image pending local asset: attachments-1770604361752-webp.15744]
That is what I meant. They are free to modify the protocol for their condition, but that will take a while and requires research and (best to) have it reviewed by someone with experience.
Thus I don't really agree with your remark regarding trusting AI for medical support. Ultimately it's a tool that I personally believe is paving the way for personalized medicine. In fact, it was AI that recommended SS31 and MOTS-C, as well as to taper back my reta use; it suggested that I use tirzepatide instead ~ which I think is sound advice, except I've already purchased three kits of reta. It tells me to hold off on tesamorelin, because IGF1 could potentially cause further dilation.
The physician sure the f ain't gonna help me. Do you know why a surgeon gets paid?
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