Has someone switched from Retatrutide to Tirzepatide?

[ppwDE]

Hey everyone,

I’ve used Retatrutide for 2 months and it worked well with me. Unfortunately due to its costs (back then I bought overpriced single vials) I stopped taking it once the vial was empty and it caused me gaining most of the weight back as the food noise came back. Now I’d like to get back in shape and especially remove my food noise, making life less food focused, but Retatrutide in my area is out of stock, but Tirzepatide is available, so I would like to try it. My question is, did someone switch Reta and went back to Tirz so I understand the dose difference better? I know that most people take much more Tirz than Reta. For reference, my last dose of Reta was 5mg per week, in one shot. Looking forward for your replies!

 

[CranberryRocker]

Usual a weekly starting dose of Tirzepatide is 2.5mg. And it is advised to stay at each dose for at least 4 weeks each as it builds up in the body over time before reaching a steady state at 4 weeks as per GLP plotter. Then increases if needed are by 2.5mg increments unless you go ‘off piste’! I don’t increase unless I need to and then only by 1mg a week. I also split dose - half the weekly dose on a Thursday and then again on a Monday to keep a more steady state in my system. It evens out the peaks and troughs a bit. This has minimised my sides.

 

[Jerrey]

I've not had much exposure to Reta personally but I have loved my results on Tirz. Also from what I've seen here and pretty much every where on line if you want to quiet food noise Tirzepatide is the king of the mountain.

 

[CNCCurrency]

Stop? Ha, I stack mine with tirz.

 

[ppwDE]

I've not had much exposure to Reta personally but I have loved my results on Tirz. Also from what I've seen here and pretty much every where on line if you want to quiet food noise Tirzepatide is the king of the mountain.

Thanks for your experience. I think I’ll go for a higher dose of Tirz in the beginning as my food noise is quite bad and then just see from there on.

 

[oldrunnerguy]

I am experimenting with both, but not for weight loss. I'm in it for the metabolic markers (lipids, A1c). I was on 1.5mg of Reta from end of December '25 till mid February this year, then switched to current dose of Tirzepatide 1.5mg. My short experience with both: Reta lessened food noise and suppressed hunger. Tirzepatide not having much effect on food noise (not what I expected) but suppresses hunger about the same as Reta. But that is just me. I'll probably switch back and forth every 3 months or so, and 1mg/week is likely plenty for me.

 

[FartfulCodger]

I switched from Tirz to Reta then back to Tirz. I like Tirz for its appetite suppression and lost a lot of weight through calorie restriction. Reta didn't give me that appetite suppression, and I've continued losing weight on Tirz.

 

[msyntakz]

I'm using both, but I started on Tirz alone for the first 4 weeks. No complaints. Great food noise suppression, immediately too. I am just experimenting with adding Reta for the energy and other glucagon benefits, but if I had to pick one, I would probably pick Tirz because the food noise control is so good. Wouldn't want to risk that, personally.

 

[Rtrain]

Stop? Ha, I stack mine with tirz.

How are you dosing using both? I am at 5 Reta now. Do most people split the mg and go 2.5 of each pin in a few days apart?

 

[CNCCurrency]

How are you dosing using both? I am at 5 Reta now. Do most people split the mg and go 2.5 of each pin in a few days apart?

How are you dosing using both? I am at 5 Reta now. Do most people split the mg and go 2.5 of each pin in a few days apart?

How are you dosing using both? I am at 5 Reta now. Do most people split the mg and go 2.5 of each pin in a few days apart?

I pin 3 days apart

 

[MountainsoftheMoon]

Stop? Ha, I stack mine with tirz.

Curious why? Did one or the other alone lose its efficacy? Is there a synergistic effect?

 

[lessthanhalf]

Thanks for your experience. I think I’ll go for a higher dose of Tirz in the beginning as my food noise is quite bad and then just see from there on.

Starting at higher doses, unless you have recent prior experience of higher doses of that GLP or another is a good way to get very unpleasant side effects, and given the half life of a week or so, they can last a long time. So unless you want to risk puking for a week and needing a few days in hospital on a drip , it is much safer to start at low doses like 2.5mg to reduce the risks. Starting at 5mg I would guess the odds of a very bad week of nausea and or vomiting to be fairly high, at least 10%, but probably higher.

Both reta and tirz are excellent weight loss drugs, reta is a bit more effective so if you have 30% or more body weight to lose it might be preferable, or if you do not have lots to lose then people in that situation can often get away with low doses of reta with few side effects as 1mg of reta can cause 9% weight loss in a year, 1mg of tirz is not close to that effective. In a lot of people there is not going to be a huge difference between them, they are much more similar than different. Reta is slightly more effective and probably has slightly higher rates of side effects. Tirz is slightly less effective and probably has the lowest rate of side effects.

 

[domin8brix]

If you are off all of the GLPs right now, start below the usual starter dose either way. For Tirz, I split dose, and when I started, I did three pins a week, first week I started with .2mg (1 unit) for the first day, .4mg (2 units) the second, and then .6mg (3 units for the third.) I started noticing the food noise chill out right around the middle of the second week. The second week I did all three at 3 units each (.6mg each) and stayed there for about 3 weeks. I basically just added 1 unit for any titration up, only when the food noise started getting louder, because I felt sooo gross the next day every time I'd go up. It took me several months to get beyond about 3mg per week.

When I started Reta this week -- stacking both, alternating shots -- I should've started at .25 or .5 but like an idiot, did 1mg. No nausea but definitely some trots! Next one I might do .5 or .75 instead of 1mg.

 

[cujet]

My wife stopped Reta due to side effects. She started Tirz a few weeks later with fewer side effects, and slower/no weight loss over the last month. It will probably improve with dose adjustment.