工作分解结构

[dgoldrich]

Check out the vendor connection section of this forum and you will see WBS.

 

[Airborne Daddy]

Yeah, but a lot of us are rightfully concerned now that we know about their association with JYC. I was practically stanning for WBS, but they’ve done a few things that are concerning, like having the same dark orange tops for t30 and t60. And now this. I saw that @Airborne Daddy asked them about their association JYC on their vendor page and I hope they respond.

I have the dark orange top t30 and I know others have the light orange top t30. They don’t put dates or batch numbers on their products, so we don’t know what is what. I was part of the testing group for the dark orange tops, and it tested well, but who knows what I really have. One small mistake/misstep could change everything. Now I'm wondering if I should randomly grab one of my vials (or two) from the freezer and get them tested.

I guess there are definitely benefits to ordering from a much more expensive place like PGB, because at least they have batch numbers and dates and fairly aggressive third party testing.

That's a great idea. Grab a vial or 2 out the freezer and I'll pin it. If I get up to 3 injections of 10mg, hungry all the time and gained 4lbs, I'll know.

 

[Eengineering]

That's a great idea. Grab a vial or 2 out the freezer and I'll pin it. If I get up to 3 injections of 10mg, hungry all the time and gained 4lbs, I'll know.

Come to think of it, I have felt pretty hungry on JYC's reta although I've heard that's not uncommon coming from tirz.

 

[Calm Logic]

Come to think of it, I have felt pretty hungry on JYC's reta although I've heard that's not uncommon coming from tirz.

The restaurant industry would love people on LDR (low dose reta) instead of sema and tirz.

 

[Eengineering]

The restaurant industry would love people on LDR (low dose reta) instead of sema and tirz.

I see you on here a lot so I figured I'd ask. I understand I can probably find a million different answers here on the forum but if Reta has the lowest affinity for GLP-1 receptors of the big 3, how is it still rivaling tirz in terms of weight loss?

I guess I don't understand, I get that the glucagon activation of Reta will help burn calories, but I wouldn't think it would offset the extra intake from (significantly in my opinion) less appetite suppression. Especially since the large majority of individuals in the trial suffer from some sort of food fixation.

 

[Calm Logic]

I guess it does offset it:

While Retatrutide might have a lower affinity for GLP-1 receptors compared to Tirzepatide, its triple agonism, particularly the inclusion of glucagon, introduces a significant fat-burning and energy expenditure component that Tirzepatide lacks. This broader metabolic impact allows Retatrutide to achieve comparable or even superior weight loss outcomes, even if its appetite suppression mechanism alone isn't "stronger" on paper. It's a testament to the idea that weight loss isn't solely about reducing food intake but also about optimizing the body's energy balance.

Reta also has more appetite-suppressing GIP than tirz. This table is on a log scale, with lower values reflecting stronger activation:



And based on the table above, tirz and reta are more similar with GLP compard to sema (and survo). What is amazing to me is how anyone loses a lot of weight on mazd, which has the least GLP.

Regarding appetite suppression by GIP :

While GIP historically wasn't seen as a primary appetite suppressant when given alone, current understanding, particularly with dual and triple agonists, suggests it plays a significant role.

GIP receptors are expressed in brain regions involved in appetite control (like the hypothalamus). Agonism of these receptors can directly reduce food intake and promote satiety.

 

[Airborne Daddy]

Come to think of it, I have felt pretty hungry on JYC's reta although I've heard that's not uncommon coming from tirz.

I was on reta ended up adding 1mg of sema and that worked...

 

[peptideusername]

I guess it does offset it:

Reta also has more appetite-suppressing GIP than tirz. This table is on a log scale, with lower values reflecting stronger activation:

View attachment 7860

And based on the table above, tirz and reta are more similar with GLP compard to sema (and survo). What is amazing to me is how anyone loses a lot of weight on madz, which has the least GLP.

Regarding appetite suppression by GIP:

I appreciate your trying to inform, but regurgitating AI results, and more specifically that "Ki Chart", is not terribly helpful.

That table has no sources or anything to link it to a legitimate source. Hell, I can go make a table on excel, take an screenshot of it, and start circulating it around right now.

 

[Calm Logic]

Except survo, all those affinity (Ki) values are correct and from research articles, e.g. for sema, tirz, reta, and mazdutide (LY3305677): "Binding affinity (Ki) to human and mouse GcgR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively)."

Survodutide was designed with a 1:8 ratio between GLP and GCGR (glucagon), but the table's GLP value of 1 for survo is a gross, relative guess as no Ki values for survo seem to be published anywhere, including for its previous designation of BI 456906. And so the other value for survo is also a gross estimate.

The Ki table was originally posted by @Lullabytreehugger in the survodutide forum.

But in my previous post, as I just edited to put in bold, what interests me the most is GIP being underrated for appetite suppression, which applies to reta and tirz. From a 2024 mouse study:

"The increase in GIP was associated with improved glucose tolerance, as expected, but also triggered an unexpected robust inhibition of food intake."

Reta is designed to have a stronger effect on GIP compared to GLP-1 and glucagon.

But when people switch from a therapeutic dose of tirz to a starting dose of reta, they are often disappointed, partly and arguably because they have already been used to benefiting from some appetite suppression from GIP.

 

[Jlykken]

No Worries about WBS I been taking TIRZ 15 from them and working really good.

Is it the red cap Triz?

 

[tracylynn]

Come to think of it, I have felt pretty hungry on JYC's reta although I've heard that's not uncommon coming from tirz.

I'm so close to going back to tirz but I have 9 vials of reta. ugh

 

[nonyabizznez]

I'm so close to going back to tirz but I have 9 vials of reta. ugh

I'd suggest doing what's best for your health and progress over freezer space and budget. I'm a firm believer that if you're doing it effectively any GLP you choose won't effect your budget when offset by funds saved in eating (groceries/restaurants).

In maintenance you can use up your freezer stock. If the status quo is "I'm not losing on Reta" that sentence fits nicely in maintenance where you want the scale to stay the same.

 

[joseblo]

That's a great idea. Grab a vial or 2 out the freezer and I'll pin it. If I get up to 3 injections of 10mg, hungry all the time and gained 4lbs, I'll know.

So newbie question here, how would the 2mg Sema look at all like 30mg Tirz?

I don't expect density to be constant esp between peptides, but I'd think a 15x difference is a bit crazy. At least if I had 10 bottles and 1 looked different/light, I'd send that one in to test.

Or does the vacuum sublimation / lyophilization process lead to hollow blobs that fill the bottle however much material is inside? My inquiring mind wants to know before I send stuff out to test.

 

[Eengineering]

So newbie question here, how would the 2mg Sema look at all like 30mg Tirz?

I don't expect density to be constant esp between peptides, but I'd think a 15x difference is a bit crazy. At least if I had 10 bottles and 1 looked different/light, I'd send that one in to test.

Or does the vacuum sublimation / lyophilization process lead to hollow blobs that fill the bottle however much material is inside? My inquiring mind wants to know before I send stuff out to test.

The mannitol is the white powder filler you are seeing. It's not discernable to the human eye whether you have 30mg or 3mg.

 

[joseblo]

Ahhh thanks, that makes sense! Makes the weighing and filling equipment a lot easier too, but obviously introduces another way to screw things up. And wow, that GHK-Cu must be REALLY BLUE!

Not a bad article on it:

https://jpharmsci.org/article/S0022-3549(22)00366-5/fulltext

 

[Airborne Daddy]

The mannitol is the white powder filler you are seeing. It's not discernable to the human eye whether you have 30mg or 3mg.

There was a peptide company maybe recon and it wasn't glp1's like a year ago that everyone thought they were scammed cuz they didn't use much filler. Folks would say wtf u can barely see anything in the vial like just some flakes.

 

[Bikechick]

我之前看过他们的资料，但他们的 Telegram 群组总共只有不到 1000 人，所以我直接就放弃了。谢谢你的反馈。

因为大家可能都在用WhatsApp。

 

[Soccerdude]

Discord 群组很活跃。我又买了 2 套 T60 套件，打算也测试一下。目前只是暂时存放起来。

 

[Soccerdude]

我今天收到了订单。我是6月29日下的单，7月1日拿到了追踪号码，今天（7月12日）就收到了，所以对这个速度还算满意。但我有点

担心的是，包裹里没有批号，因为我之前特意问过他们会不会提供批号，他们也说会。不知道该怎么想。盒子里也没有任何装箱单或说明书之类的东西。这种情况正常吗？

Reta粉末结块很硬，这也是正常的吗？我之前从Dep买的Reta粉末是散粉，这是我第一次在WBS下单。

你做过任何检测吗？

 

[FairyDusty2022 12846]

你做过任何检测吗？

我上个月买了RT20，想知道有没有其他人测试过？在我自己测试之前，想先了解一下。