GLP-1s and Muscle Loss: What the Evidence Actually Shows

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Grogu said:
…The real question…

I’m not interested GLP causing more muscle loss vs conventional calorie restriction dieting because “dieting and exercise” is ineffective at long-term weight management. GLP are singularly the best way to currently manage weight long term for the massive masses.

My interest is in how to practically minimize lean tissue loss and more specifically muscle fiber.
 
woundcarping said:
I’m not interested GLP causing more muscle loss vs conventional calorie restriction dieting because “dieting and exercise” is ineffective at long-term weight management. GLP are singularly the best way to currently manage weight long term for the massive masses.

My interest is in how to practically minimize lean tissue loss and more specifically muscle fiber.
focus on myofibrillar hypertrophy to increase myonuclei content so that the muscle mass lost is only sarcoplasmic fluid. Muscle memory will remain and allow you to bulk up rapidly, regaining muscle volume in no time.
 
Well, one this is for sure, there is money to be made.....

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https://ir.verupharma.com/news-events/press-releases/detail/225/veru-announces-positive-topline-data-from-phase-2b-quality
 

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Smiter said:
focus on myofibrillar hypertrophy to increase myonuclei content so that the muscle mass lost is only sarcoplasmic fluid. Muscle memory will remain and allow you to bulk up rapidly, regaining muscle volume in no time.

Eating your weight in protein and lift weights isn’t intellectually stimulating or specific. I’m more interested in the least required effort yielding meaningful benefits for sustained compliance.

Things like:

How fast should you lose weight?

How much protein is the practical minimum?

What’s the practical protein benefit ceiling?

What OTC supplements are anti-catabolic?

What Rx supplements are anti-catabolic?
 
woundcarping said:
Eating your weight in protein and lift weights isn’t intellectually stimulating or specific. I’m more interested in the least required effort yielding meaningful benefits for sustained compliance.

Things like:

How fast should you lose weight?

How much protein is the practical minimum?

What’s the practical protein benefit ceiling?

What OTC supplements are anti-catabolic?

What Rx supplements are anti-catabolic?
My earlier comment was about the type of resistance training regimen that would be most optimal when one is losing weight. The type of training done will determine the type of muscle adaptation caused.

Supplements include creatine, glutamine, HMB, ATP, Leucine, Velositol, Myotor, IGF-1 DES, PEG-MGF, Follistatin, Epicatechin, TB-500, and Collagen.
 
Smiter said:
focus on myofibrillar hypertrophy to increase myonuclei content so that the muscle mass lost is only sarcoplasmic fluid. Muscle memory will remain and allow you to bulk up rapidly, regaining muscle volume in no time.
Long response - asked Claude to clean it up, but I like my original text better, so it stayed long.

—————————————————————-

My personal experience here is that a good strong base of “true muscle” is key, ultimate body composition is incredibly important due to the active nature of muscle tissue.

This said, the line between muscle and fat growth during any muscle building phase is a tough one. The adage that your either bulking or cutting, choose one because you can’t have both is, in general true.

And as was mentioned before, minimizing muscle loss during weight loss is really important. And not all muscle mass loss during weight loss is equal (effectively the point of the article).

Intramuscular fat, organ fat, etc all registers as muscle on the DEXA, so when you lose muscle mass, it does not always mean lost muscle fiber.

IMO, this nuance is incredibly important. There is no real good way to pull the threads apart aside from measurement of strength.

In the past, as I have yo-yo’d up and down, not due to bulk or cut, but due to the nearly impossible discipline required for me to maintain a lean weight, I have always lost strength during weight loss. My 315 bench dropped to 265, my 500lb deadlift dropped to 400, and etc. but my performance in activities such as MTB had always improved because on a bike, lower body weight is a huge factor in performance.

With Reta, I not only dropped weight faster, but my dip in strength was much less, and now I am still losing weight slowly, while getting back to my pre-Reta strength.

NGL, I am highly motivated. I am also pinning Tesa, and on 120mg test c per week.

I have been on test c for 8 years, since I started I have found it nearly impossible to get truly lean. My appetite is just uncontrollable, and if I don’t eat, I get miserable. This and I have always lost strength when losing weight, even on test c.

Each experience is unique, so I am not suggesting my experience is the same for everyone, but in the 4 months I have been on Reta, the weight came off more quickly and effortlessly that I have ever experienced in my life.

Part of me feels as though the speed of the weight loss helped mitigate the more typical loss in strength.

And now back to the article and the nuance, the key point that struck me was the inadequacies of the dexa measures in the study. And the lack of nuance between muscle, fat, bone, etc.

Reta is strongly believed to reduce organ fat, which on a dexa would show up as loss of lean mass. I believe the same is likely true for loss of intramuscular fat (marbled muscle).

So, what are we left with? Without assessment of strength, the belief that muscle loss is occurring at the same rate on Reta as it does with any other weight loss program, because the dexa isn’t looking at lean organ vs fatty organ, or lean muscle vs fatty muscle.

I hypothesize that there is more to the story and the only evidence we have at the moment is strength gain/maintenance/loss.

Full stack:

Reta 4mg split dose

Test c 120 mg split dose (true hypogonadism, tested near zero and led to therapy)

Tesa 2mg 5/2

Wolverine .3mg 5/2

Creatine 10mg/day
 
Cannonball72 said:
Yes, i absolutely used AI to summarize (Claude). It’s way better at summary than I am. But the key points are there.

I really don’t get the issue with using AI for a summary.
It is an issue. To many people it won't be, you can get away with it for sure, but you should be summarizing and putting the AI content into your own words. Nobody gives a damn about reading Claude's verbatim response to your prompt as a post header, we all have our own Claude.

AI is like masturbation. Everybody does it, but do that shit in private for the sake of civilized society.
 
AI takes away the interpersonal experience we are looking for in a forum. People want to hear first hand from other people.. But it is a pain to write everything out when you are already doing a favor by sharing information.

You don't deserve to be shamed for it.

Thank you for the information you provided.
 
desinr-gal said:
AI takes away the interpersonal experience we are looking for in a forum. People want to hear first hand from other people.. But it is a pain to write everything out when you are already doing a favor by sharing information.

You don't deserve to be shamed for it.

Thank you for the information you provided.
You tell 'em sis.
 
birdwhacker said:
It is an issue. To many people it won't be, you can get away with it for sure, but you should be summarizing and putting the AI content into your own words. Nobody gives a damn about reading Claude's verbatim response to your prompt as a post header, we all have our own Claude.

AI is like masturbation. Everybody does it, but do that shit in private for the sake of civilized society.
A lot of people feel the same way about GLP weight loss.

If I didn’t feel the post offered something of interest I wouldn’t have posted it.

Feel free to block me/ignore my posts.
 
Cannonball72 said:
Feel free to block me/ignore my posts.
To be honest, I'd just prefer that you don't contribute to society's rot and the fall of the internet. There's enough bot content on this website that doesn't have good intentions. We don't need you adding to it.

Feel free to block me/ignore my posts.
 
birdwhacker said:
To be honest, I'd just prefer that you don't contribute to society's rot and the fall of the internet. There's enough bot content on this website that doesn't have good intentions. We don't need you adding to it.

Feel free to block me/ignore my posts.
Don’t need to ask me twice. Was your choice to check the thread in the first place.

Good luck with your journey.
 
UpDownLeftRightAS* said:
Well, one this is for sure, there is money to be made.....

View attachment 22345

https://ir.verupharma.com/news-events/press-releases/detail/225/veru-announces-positive-topline-data-from-phase-2b-quality

So enobosarm is also known as ostarine, a SARM that has been used as a PED for years. SARMs basically have the same side effects as anabolic steroids, except they have much less research done on them, and since they're used orally more often than not they're generally hard on the liver. It's not really a surprise that something that functions similarly to steroids would help retain muscle mass lol. If you're a male it's still going to shut down your bodies natural hormone production, so if someone were to go that route, they might as well just supplement with actual testosterone and/or another steroid.
 
Tattoo85 said:
So enobosarm is also known as ostarine, a SARM that has been used as a PED for years. SARMs basically have the same side effects as anabolic steroids, except they have much less research done on them, and since they're used orally more often than not they're generally hard on the liver. It's not really a surprise that something that functions similarly to steroids would help retain muscle mass lol. If you're a male it's still going to shut down your bodies natural hormone production, so if someone were to go that route, they might as well just supplement with actual testosterone and/or another steroid.
Definitely thought provoking, Looks like the dose they are playing with in these trials is so low it's not shutting down natural production....That would seem like an unsustainable path to generation the type of $$$ they are looking to as a piggyback off of GLP-1s. It's a slippery slope, as you point out.
 
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