FOXO4-DRI

[trojanpeptide]

I'm having a real rough time tracking down this peptide. I don't want FOXO4 ; I want FOXO4-DRI , and if you ask the vendors, they will say whatever you want, yes it's foxo4, or yes its foxo4-dri, but none of them have a CoA.

The thing is I see product code F410 being offered by several vendors, but I've asked some vendors and they say it is FOXO4-DRI and others say its just FOXO4. So now I don't trust any F410 code.

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One of the companies gave me this as their CoA wtf.

Does anyone know where to find FOXO4-DRI with a CoA? Or at least that it's verified? I don't want to waste money buying from one of these vendors, then spending money on testing, just to find out its just FOXO4.

and btw, this is a warning for others out there too, be careful with that product code. I'm not saying it is or isn't FOXO4-DRI, just that some vendors said it isn't.

 

[mainefungi]

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[Researcher6076]

To the best of my knowledge there is no FOX04 manufactured or available anywhere. If the vendor says FOX04 it really is FOX04-DRI.

To the best of my knowledge there is no FOX04 manufactured or available anywhere. If the vendor says FOX04 it really is FOX04-DRI.

Having said that, be really, really, thorough on your research before you use this on a human subject.

This was never intended to be used on a human subject. It was developed just to study senolytics.

There was no long-term tracking for the rodent subjects used in tests, 2 months after the tests they were destroyed. So we don’t even know if the mice acquired long term health issues.

We have no human PK data. Extrapolating from the mouse trials the dose would be 25 – 30 mg every other day for 5 – 11 rounds.

The data suggests FOX04-DRI wouldn’t make any sense at a low dose.

The data suggests this wouldn’t make any sense for a subject that wasn’t 65+ yo.

If you do it, please do lots of labs before and after and share the results.

The danger with FOXO4‑DRI is not “you might feel sick for a few days.”

The danger is:

You may disrupt p53‑mediated tumor suppression.

You may impair tissue repair.

You may accelerate a latent cancer.

You may trigger organ‑specific toxicity that has never been mapped.

You may cause irreversible long‑term effects that appear months or years later.

My complete summary of all the research I could find is available here: FOXO4-DRI.pdf

 

[Chili777]

To the best of my knowledge there is no FOX04 manufactured or available anywhere. If the vendor says FOX04 it really is FOX04-DRI.

To the best of my knowledge there is no FOX04 manufactured or available anywhere. If the vendor says FOX04 it really is FOX04-DRI.

Having said that, be really, really, thorough on your research before you use this on a human subject.

This was never intended to be used on a human subject. It was developed just to study senolytics.

There was no long-term tracking for the rodent subjects used in tests, 2 months after the tests they were destroyed. So we don’t even know if the mice acquired long term health issues.

We have no human PK data. Extrapolating from the mouse trials the dose would be 25 – 30 mg every other day for 5 – 11 rounds.

The data suggests FOX04-DRI wouldn’t make any sense at a low dose.

The data suggests this wouldn’t make any sense for a subject that wasn’t 65+ yo.

If you do it, please do lots of labs before and after and share the results.

The danger with FOXO4‑DRI is not “you might feel sick for a few days.”

The danger is:

You may disrupt p53‑mediated tumor suppression.

You may impair tissue repair.

You may accelerate a latent cancer.

You may trigger organ‑specific toxicity that has never been mapped.

You may cause irreversible long‑term effects that appear months or years later.

My complete summary of all the research I could find is available here: FOXO4-DRI.pdf

I looked long and hard at this one and came to the same conclusion. I'll pass. I could have saved many hours with the document you compiled. Nice job.

 

[Raidersilver]

Well shoot i wish i would

Have read this before. I bought some single

Vials but have not used them at all and after this i probably will not even use them on my lab rat. Good points

 

[Researcher6076]

Well shoot i wish i would

Have read this before. I bought some single

Vials but have not used them at all and after this i probably will not even use them on my lab rat. Good points

I've done the same thing. I've got vials of stuff I will never use. I saw it. I thought I wanted it. Didn't do my research. Now it's just sitting in the freezer.

 

[trojanpeptide]

Thank you @Researcher6076 for sharing your research. So F410 is FOXO4-DRI? Because homopeptide told me they only have plain foxo4, but that just makes no sense to me; who would use that and for what? I'll heed your warning and pause.

I actually have some Dasatinib otw now, this will probably be much safer to try. Even that could lead to deleterious results, but at least there's a lot more research on it.

On a side note though, there are some who have used foxo4-dri and have shared their experiences, but it's far and few.

 

[AlexSilver]

Thank you @Researcher6076 for sharing your research. So F410 is FOXO4-DRI? Because homopeptide told me they only have plain foxo4, but that just makes no sense to me; who would use that and for what? I'll heed your warning and pause.

I actually have some Dasatinib otw now, this will probably be much safer to try. Even that could lead to deleterious results, but at least there's a lot more research on it.

On a side note though, there are some who have used foxo4-dri and have shared their experiences, but it's far and few.

One of those new vendors that just popped up this week shows both FOX04 and FOX04-DRI on their price list. Now that’s just weird considering the OPPOSITE effect.

 

[trojanpeptide]

I've done the same thing. I've got vials of stuff I will never use. I saw it. I thought I wanted it. Didn't do my research. Now it's just sitting in the freezer.

I've been reading over the document, and agree, yes there are risks, but there are also many benefits. Everything I read here regarding (some of) the risks would also apply to other senolytics, such as D&Q and maybe fisetin. Also a matter of dosages; start small go slow, clear a little, not a lot, seems like a good strategy.

The biggest concern I have regarding FOXO4-DRI is that the peptide needs to cross two membranes and that this was achieved in the mouse studies by, iirc, fusing the peptide to an HIV vector. It was also delivered intravenously, which I won't be doing that lol.

Although, it's been difficult for me to acquire years, and the years have taught me to listen to the Universe. I will start slowly with D&Q. Maybe even D&Q&F(isetin).

 

[Rink123]

I've done the same thing. I've got vials of stuff I will never use. I saw it. I thought I wanted it. Didn't do my research. Now it's just sitting in the freezer.

First off, you are super epic for this FOX04-DRI research paper. Also saved a ton of time reading through this.

Two questions:

1. Do you have similar papers or a folder that you can share with me? Would love to see your other research compilations.

2. You mentioned other research supplies that you bought and decided to pass on after digging deeper. What were those?

 

[Researcher6076]

First off, you are super epic for this FOX04-DRI research paper. Also saved a ton of time reading through this.

Two questions:

1. Do you have similar papers or a folder that you can share with me? Would love to see your other research compilations.

2. You mentioned other research supplies that you bought and decided to pass on after digging deeper. What were those?

I've got about 20 or 25 other research summaries on different peptides. About a dozen made my stack, the others didn't.

If you want to see them I'm OK with sharing them. Give me a couple of days to be sure they all have the appropriate disclaimers added that they are not medical advice, etc. I'll give you access to the whole folder.

You can read them for yourself and decide what looks good and what looks iffy.

 

[Researcher6076]

I've got about 20 or 25 other research summaries on different peptides. About a dozen made my stack, the others didn't.

If you want to see them I'm OK with sharing them. Give me a couple of days to be sure they all have the appropriate disclaimers added that they are not medical advice, etc. I'll give you access to the whole folder.

You can read them for yourself and decide what looks good and what looks iffy.

I am sharing what I've got for research summaries for about two dozen different peptides. I'm not telling anyone what to do. Just sharing the information, I put together for myself. The perfect is the enemy of the good, these could be better, but instead of obsessing to clean them up I’m just sharing.

Please, if you find errors or missing information let me know. No ego here, I make mistakes.

Please read the full disclaimer in README.pdf . And here is the folder link Share containing these file:

5 Amino 1q.pdf

bpc-157.pdf

CJC 1295 NODAC + Ipamorelin.pdf

Epitalon for sleep.pdf

Epitalon plus Thymalin.pdf

Epitalon plus Vilon.pdf

FOXO4-DRI.pdf

GHK-cu.pdf

GLOW.pdf

Glutathione.pdf

kpv.pdf

MOTS-C.pdf

NAD+.pdf

Prostamax.pdf

retatrutide.pdf

Selank.pdf

Semax.pdf

SS-31.pdf

tb-500.pdf

Tesamorelin.pdf

Thymosin Alpha 1.pdf

tirzepatide.pdf

Vesugen.pdf

vilon.pdf

 

[CNCCurrency]

I am sharing what I've got for research summaries for about two dozen different peptides. I'm not telling anyone what to do. Just sharing the information, I put together for myself. The perfect is the enemy of the good, these could be better, but instead of obsessing to clean them up I’m just sharing.

Please, if you find errors or missing information let me know. No ego here, I make mistakes.

Please read the full disclaimer in README.pdf . And here is the folder link Share containing these file:

5 Amino 1q.pdf

bpc-157.pdf

CJC 1295 NODAC + Ipamorelin.pdf

Epitalon for sleep.pdf

Epitalon plus Thymalin.pdf

Epitalon plus Vilon.pdf

FOXO4-DRI.pdf

GHK-cu.pdf

GLOW.pdf

Glutathione.pdf

kpv.pdf

MOTS-C.pdf

NAD+.pdf

Prostamax.pdf

retatrutide.pdf

Selank.pdf

Semax.pdf

SS-31.pdf

tb-500.pdf

Tesamorelin.pdf

Thymosin Alpha 1.pdf

tirzepatide.pdf

Vesugen.pdf

vilon.pdf

I am a believer on these peps, Epitalon plus Thymalin

 

[ktg123]

I just ordered some from a vendor a week ago that now shows Out of Stock.

I've done 2 cycles of Fox (yes, DRI). Couldn't tell any difference with the first round.

I've had a very small tender point on my left temple for probably over 20 years. It would get a little rough spot the size of the tip of a pencil lead that hurt to the touch. I'd apply a mix of Vitamin D and a specific selenium supplement overnight. It would basically 'eat' the spot that would then heal over the next few days, then in a month or 2 would be back. (although the tenderness never went away fully)

About 2/3 of the way through my last round of Fox, that spot disappeared and hasn't been back. I can push on that spot as hard as I want and I feel nothing. That was a couple months ago. The Fox is the only thing I can think of that was different that time.

 

[5byfive]

I am sharing what I've got for research summaries for about two dozen different peptides. I'm not telling anyone what to do. Just sharing the information, I put together for myself. The perfect is the enemy of the good, these could be better, but instead of obsessing to clean them up I’m just sharing.

You should put this in its own thread. A lot of people would probably be interested that may not find it here.

 

[randompersonrandom]

I am sharing what I've got for research summaries for about two dozen different peptides. I'm not telling anyone what to do. Just sharing the information, I put together for myself. The perfect is the enemy of the good, these could be better, but instead of obsessing to clean them up I’m just sharing.

Please, if you find errors or missing information let me know. No ego here, I make mistakes.

Please read the full disclaimer in README.pdf . And here is the folder link Share containing these file:

5 Amino 1q.pdf

bpc-157.pdf

CJC 1295 NODAC + Ipamorelin.pdf

Epitalon for sleep.pdf

Epitalon plus Thymalin.pdf

Epitalon plus Vilon.pdf

FOXO4-DRI.pdf

GHK-cu.pdf

GLOW.pdf

Glutathione.pdf

kpv.pdf

MOTS-C.pdf

NAD+.pdf

Prostamax.pdf

retatrutide.pdf

Selank.pdf

Semax.pdf

SS-31.pdf

tb-500.pdf

Tesamorelin.pdf

Thymosin Alpha 1.pdf

tirzepatide.pdf

Vesugen.pdf

vilon.pdf

Thanks for sharing this!

 

[sheilarae74]

The danger is:

You may accelerate a latent cancer.

This right here would make it a hell no for me.

Thank you for sharing your research files, by the way.

 

[piccolo101]

I am sharing what I've got for research summaries for about two dozen different peptides.

This is amazing, thank you for sharing!

 

[Researcher6076]

This right here would make it a hell no for me.

Thank you for sharing your research files, by the way.

Well... Several popular peptides can accelerate latent cancer. All the gh secretagogues share that warning. Tb-500 absolutely too.

We want growth. We want healing. Generally things that promote growth and healing can theoretically accelerate latent cancers and micro tumors. They can't cause cancer de novo, but they can give any cancer that does exist a boost.

That creates a challenge for each of us to find our own risk tolerance.

 

[sheilarae74]

Well... Several popular peptides can accelerate latent cancer. All the gh secretagogues share that warning. Tb-500 absolutely too.

We want growth. We want healing. Generally things that promote growth and healing can theoretically accelerate latent cancers and micro tumors. They can't cause cancer de novo, but they can give any cancer that does exist a boost.

That creates a challenge for each of us to find our own risk tolerance.

The reward would have to be awfully high for me to take the risk.