Epi Pen resources?

[dont_wanna_be_fat]

Has anyone managed to buy some Epi Pens as a hedge against potential anaphylaxis? If so, what was your process? Is there a go-to telehealth that can issue a scrip?

 

[desinr-gal]

Has anyone managed to buy some Epi Pens as a hedge against potential anaphylaxis? If so, what was your process? Is there a go-to telehealth that can issue a scrip?

IDK but I would buy a pack of Benadryl in the meantime. It is what the ER docs try first.

 

[Labcat]

IDK but I would buy a pack of Benadryl in the meantime. It is what the ER docs try first.

No benadryl is ineffective against anaphylaxis. The ER Docs know what is anaphylaxis and what isn’t though. Cheap $15 telehealth services will prescribe epipen or neffy if you tell them you have had a peanut allergy and have been prescribed in the past.

 

[desinr-gal]

No benadryl is ineffective against anaphylaxis. The ER Docs know what is anaphylaxis and what isn’t though. Cheap $15 telehealth services will prescribe epipen or neffy if you tell them you have had a peanut allergy and have been prescribed in the past.

Well that's what they gave me when it happened to me and I went there. Only when they saw it didnt work they gave me the shot.

 

[Labcat]

Well that's what they gave me when it happened to me and I went there. Only when they saw it didnt work they gave me the shot.

Okay, maybe they couldn’t tell yikes . Benadryl is not in the treatment protocol for anaphylaxis, anyway, despite them giving it to you. Epi is pretty safe to give unless you’re nearly having a heart attack.

I’m just a random internet person, and this is not medical advice, but it’s not unreasonable that everyone should have epinephrine at hand if playing with mystery injections that have given other people anaphylaxis.

I know in children Benadryl can be given because they can get funny allergies that are not anaphylaxis. (I don’t know the difference, I just know a pediatrician lol).

 

[Calm Logic]

$110 for a 2-pack of generic Epipens:

https://www.cvs.com/content/epipen-alternative

Amazon telehealth (for using insurance):

Epinephrine and EpiPens | Online Prescription Renewal

Request epinephrine and EpiPen prescription renewal for you or your child at Amazon One Medical. Get treatment to prevent anaphylaxis with 24/7 telehealth care.

health.amazon.com

Nasal alternative, marketed as being more likely to be used:

https://visit.getneffy.com/about/

 

[Labcat]

$110 for a 2-pack of generic Epipens:

https://www.cvs.com/content/epipen-alternative

Amazon telehealth (for using insurance):

Epinephrine and EpiPens | Online Prescription Renewal

Request epinephrine and EpiPen prescription renewal for you or your child at Amazon One Medical. Get treatment to prevent anaphylaxis with 24/7 telehealth care.

health.amazon.com

Nasal alternative, marketed as being more likely to be used:

https://visit.getneffy.com/about/

Great resources!

Remember, too, that Neffy gets squirted inside the flappy part of the nostril that is outside the skull, aimed up toward the forehead. (Breathing not needed or wanted)

in contrast, our other semax, selank, epithalon nasal sprays are different — and meant to go inside the nasopharyx, so are pointed towards the back of the head.

 

[Calm Logic]

Two severe anaphylactic reactions in July of last year:

Two People Almost Died at RAADfest. We Went to the Experts.

Two people nearly died, and several more sought treatment, after receiving peptide injections at the last RAADfest in Las Vegas.

lifespan.io

Two people nearly died, and several more sought treatment, after receiving peptide injections at the last RAADfest in Las Vegas...

“The two women who were taken by ambulance to the hospital reported feeling as if their tongues were swelling and had trouble breathing and increased heart rates. By the time they reached the hospital, one was already intubated, and the other had lost muscle control in her neck and couldn’t open her eyes or communicate with doctors.”

Holtorf refused to clarify to ProPublica which peptides were administered at the conference. However, only three are listed on the IV price list on his clinic’s website: BPC-157, tymosine beta 4 (TB-4), and tymosine alpha 1 (Tα1).

I do not know if those injections were by IM or subq, and we don't know which peptides (or combinations) were used with the two women.

A table by Gemini that includes the peptides mentioned in the article--"BPC-157, tymosine beta 4 (TB-4), and tymosine alpha 1 (Tα1)"--along with other peptides for comparison:

Substance Type / Route Primary Function Immunological Risk Level Safety Notes & Red Flags MOTS-c Mitochondrial / IM or SubQ Metabolism High Triggers "danger signals" (DAMPs). High risk for rapid throat swelling/anaphylaxis, especially via IM. TA-1 Thymic / IV or SubQ Immune Modulation High Directly stimulates T-cell production. Involved in RAADfest hospitalizations. Can trigger "cytokine-like" systemic storms. HGH (Somatropin) Full Protein / SubQ Growth / Repair High Large 191-AA protein. High risk for Anti-Drug Antibodies (ADAs) which can neutralize treatment. Cerebrolysin Porcine Derived / IM or IV Neuro-recovery High Contains foreign porcine proteins. Risk of "Cerebrolysin fever" or rare autoimmune responses to non-human peptides. Glutathione Antioxidant / IM, IV, or SubQ Detox / Brightening High Severe Anaphylaxis & SJS risk. Potent sulfur allergen; can cause Stevens-Johnson Syndrome. CJC-1295 (DAC) GHRH / SubQ GH Elevation High Long half-life increases immune sensitization. High rate of flushing and potential for antibody-mediated reactions. TB-4 Thymic / IV or IM Systemic Healing High Full 43-AA chain. Linked to RAADfest incident. High potential for antibody development over time. Tesamorelin GHRH / SubQ Visceral Fat Loss Moderate-High Significant immunogenicity (~50% develop antibodies). Systemic rashes/hives occur in ~12% of users. L-Carnitine Amino Acid / IM (High Vol) Fat Oxidation Moderate High-volume IM can cause "sterile abscesses." Rapid absorption often triggers systemic flushing/sweating. Melanotan II MSH Analog / SubQ Tanning / Libido Moderate Potent; affects multiple receptors. Known for systemic flushing, nausea, and potential for Mast Cell Activation. PT-141 MSH Analog / SubQ or Nasal Sexual Dysfunction Moderate Derivative of MT2. High incidence of severe nausea and systemic flushing. Can trigger blood pressure spikes. ARA-290 EPO Fragment / SubQ Neuropathic Pain Moderate Small 11-AA chain but targets complex Innate Repair Receptors. Can trigger unexpected immune-signaling shifts. Sermorelin GHRH / SubQ GH Elevation Moderate 29-AA fragment. Higher risk of localized site reactions (itching/welts) than Ipamorelin. GHK-Cu Copper Fragment / SubQ Tissue Repair Moderate Noted for intense "sting." Primarily localized irritation, but copper sensitivity can cause systemic hives. TB-500 Synthetic Fragment / SubQ Targeted Repair Moderate 7-AA snippet. Can cause tachycardia, "head rushes," or flushing. Lower ADA risk than full TB-4. Semax ACTH Analog / Nasal or SubQ Nootropic / Focus Moderate Nootropic favorite. Nasal is lower risk, but SubQ can cause "brain fog" or anxiety if immune system reacts to the fragment. Selank Tuftsin Analog / Nasal or SubQ Anxiolytic / Calm Moderate Modulates immune system as a Tuftsin analog. Generally safe but can cause fatigue or congestion. Melanotan I MSH Analog / SubQ Tanning / Photoprotection Moderate Linear 13-AA chain. More selective than MT2; fewer side effects, but still carries moderate risk of flushing. Ipamorelin GH Secretagogue / SubQ Muscle / Recovery Moderate Small chain reduces antibody risk, but common histamine-like flushing can mimic early-stage allergic reactions. Vitamin B12 Vitamin / IM or SubQ Energy / Methylation Low-Moderate Contains Cobalt. While rare, those with cobalt/nickel allergies can experience systemic dermatitis or anaphylaxis. Epithalon Pineal Peptide / SubQ Telomere / Longevity Low Short tetrapeptide (4-AA). Generally very well tolerated with very low reported immunogenicity. KPV MSH Fragment / SubQ or Oral Anti-inflammatory Low Tiny 3-AA sequence. Structurally too small to be easily "seen" by the immune system. SS-31 Mitochondrial / SubQ Anti-aging / ROS Low Small 4-AA chain. Extremely well-tolerated; primary side effect is localized skin irritation. GLP-1s Incretin / SubQ Metabolic / Weight Low Extensive clinical data. Anaphylaxis is extremely rare (

Click to expand...

After a "virtual friend" of mine (who used to be very active here) recently had throat swelling after injecting MOTS-c by IM (with no history of such allergic reactions), I am distancing myself from the "community" (including GB groups) and from buying most non-GLP peptides.

Taking a baby dose whenever starting a new kit can mitigate some risk factors, but with IM, there is always a risk of the injection going into a vessel.

For epinephrine options, the Neffy spray seems more likely to be used before symptoms get worse.

 

[Calm Logic]

Reddit case of a systemic reaction after injecting CJC-1295 and ipamorelin:

I have never had any food allergies in my life. Today I took a peptide, (CJC-1295 and ipamorelin after taking a long break and had a severe allergic reaction. Lips, eyes hands, arms, eyes all immediately got swollen and I got lightheaded with shortness of breath.

It’s been about 3 hours now and I feel mostly better, no lightheaded feeling or shortness of breath. But my hands still remain a bit swollen...

I went to the ER and it appears dozens of other people had a similar reaction.

I have been doing some research and here’s what I found:

Over time, your body builds antibodies against the modified peptide. Once antibody levels reach a threshold, the next dose can trigger mast-cell degranulation and histamine release → full-blown anaphylaxis.

To anyone who has experienced the same, avoid all DAC-linked or modified CJC analogs (CJC-1295 DAC, CJC-1295 non-DAC, Mod-GRF 1-29).

I am now investigating Sermorelin as it would be the only “pure” GHRH analog left that’s identical to human sequence. I’ll update this post again with my experience.

 

[Calm Logic]

Rare case of an asthma patient needing CPR after a glutathione injection:

A case of glutathione-induced life-threatening asthma attack

Glutathione; Asthma; Attack

www.koreamed.org

On asking for an EpiPen:

View: https://www.reddit.com/r/Peptidesource/comments/1q5ofsr/comment/ny4n9yv/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button

 

[ltjltj]

You can get neffy via their telehealth partner easily enough, that's what I did.

 

[Labcat]

Rare case of an asthma patient needing CPR after a glutathione injection:

A case of glutathione-induced life-threatening asthma attack

Glutathione; Asthma; Attack

www.koreamed.org

On asking for an EpiPen:

Comment
by
u/Delecron from discussion

in
Peptidesource

View: https://www.reddit.com/r/Peptidesource/comments/1q5ofsr/comment/ny4n9yv/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button

Click to expand...

Wow great find! A great reminder to us to being more careful about ha ing someone rrady to help us call 911 just in case a life threatening extreme reaction occurs despite even epipen. Like, also head to the ER if you use epipen, if it works, it likely only works for 15 minutes.

So this korean woman was intubated for glutathione. And someone at RAADfest was intubated recently for a yet not revealed likely commonly used peptide.

CL, you should consider putting this on Peppy’s also!

Everyone note that this woman did not collapse from anaphylaxis - her negative tryptase tells us that.

They are theorizing that glutathione, which is in the pathway to make leukotriene, might have triggered an inflammatory pathway that is known to contribute to asthma, eczema, a particular kind of hives, and maybe whatever caused this woman to lose blood pressure.

 

[Dos-Dox]

I’m only about halfway through this thread on Peppy’s, but there are a lot of anecdotal reports of interest in it, which include reactions after many months or a year of use without problems. Interestingly, there are also plenty noting mast cell reactions with GLPs (tirz and reta were specifically mentioned) even after long-term usage.

https://chat.peppys.org/t/anaphylactic-reactions/

 

[IAmTheWalrus]

Jeezo, this isnt something I had thought about...I have a bit of asthma. Thanks for posting.

 

[desinr-gal]

Two severe anaphylactic reactions in July of last year:

Two People Almost Died at RAADfest. We Went to the Experts.

Two people nearly died, and several more sought treatment, after receiving peptide injections at the last RAADfest in Las Vegas.

lifespan.io

I do not know if those injections were by IM or subq, and we don't know which peptides (or combinations) were used with the two women.

A table by Gemini that includes the peptides mentioned in the article--"BPC-157, tymosine beta 4 (TB-4), and tymosine alpha 1 (Tα1)"--along with other peptides for comparison:

Regarding subq vs IM for gluta, MOTS-c, and GHK-Cu:

After a "virtual friend" of mine (who used to be very active here) recently had throat swelling after injecting MOTS-c by IM (with no history of such allergic reactions), I am distancing myself from the "community" (including GB groups) and from buying most non-GLP peptides.

Taking a baby dose whenever starting a new kit can mitigate some risk factors, but with IM, there is always a risk of the injection going into a vessel.

For epinephrine options, the Neffy spray seems more likely to be used before symptoms get worse.

Thank you for sharing this important information! I am editing my to do list now.

 

[Calm Logic]

Another systemic reaction to CJC with ipamorelin:

 

[Labcat]

Another systemic reaction:

View attachment 15171

Excellent data ferreting!

And, omg, friends, think about the big picture, do not make the same judgment call as these people!

With systemic reactions meeting anaphylaxis criteria, you should really not try again with the same thing without access to resuscitation. Ie in a doctor’s office. Or you know, go with a friend and park next to the door of your local ER for a few hours with your epipen, and pin it there if you want to risk your life a little less and have a few thousand dollars to pay for emergency care. (This is sarcasm btw, not recommended.)

 

[Calm Logic]

Always shoot up near a Taco Bell since they are usually near a hospital or should be.

 

[Labcat]

Always shoot up near a Taco Bell since they are usually near a hospital or should be.

Are we naming hospitals after corporate sponsors now? Taco Bell General?

 

[Phatmax]

Two severe anaphylactic reactions in July of last year:

Two People Almost Died at RAADfest. We Went to the Experts.

Two people nearly died, and several more sought treatment, after receiving peptide injections at the last RAADfest in Las Vegas.

lifespan.io

I do not know if those injections were by IM or subq, and we don't know which peptides (or combinations) were used with the two women.

A table by Gemini that includes the peptides mentioned in the article--"BPC-157, tymosine beta 4 (TB-4), and tymosine alpha 1 (Tα1)"--along with other peptides for comparison:

Regarding subq vs IM for gluta, MOTS-c, and GHK-Cu:

After a "virtual friend" of mine (who used to be very active here) recently had throat swelling after injecting MOTS-c by IM (with no history of such allergic reactions), I am distancing myself from the "community" (including GB groups) and from buying most non-GLP peptides.

Taking a baby dose whenever starting a new kit can mitigate some risk factors, but with IM, there is always a risk of the injection going into a vessel.

For epinephrine options, the Neffy spray seems more likely to be used before symptoms get worse.

this is intresting looking at that list ive added GHK-cu to my routine started last monday and noticed my uvula in throat is swollen im thinking it must be the GHK-cu?