CNCCurrency said:
3 total grams Epitalon every 4 months? How did you figure 3 grams? I don't follow?
Here is the actual science from my epitalon and thymalin protocol research.
Russian researchers historically used Epithalamin (a pineal gland extract) in many animal and c linical programs, while later work and commercial practice shifted to synthetic Epitalon (the isolated tetrapeptide Ala-Glu-Asp-Gly). These are related but not identical preparations, and there is no validated, universal conversion ratio between extract doses and pure-peptide
doses.
There is no reliable conversion ratio because Epithalamin (pineal extract) is
• Unknown and variable composition of extracts.
• Its biological effects may arise from several peptides acting together.
• Matrix effects in an extract (carrier peptides, salts, protease inhibitors) can alter absorption, proteolysis, and tissue exposure compared with a purified synthetic peptide.
Practitioner and forum discussions note that Epithalamin (pineal extract) protocols often used la rger nominal doses than later Epitalon (synthetic tetrapeptide) protocols, and some usersr eport different subjective effects when switching to pure Epitalon. This has driven the impression that the extract is “weaker” per mg. But mass-based comparisons are misleading. Because extract doses are expressed as crude mass of extract (not quantified active
tetrapeptide), a larger extract dose may still contain less of the specific active tetrapeptide than a small pure-peptide dose; apparent “weaker” effect can reflect dilution, different actives pecies, or different bioavailability rather than true lower intrinsic activity.
There is no validated, reliable mass-to-mass conversion between Epithalamin (pineal
extract) and Epitalon (synthetic tetrapeptide). Claims that the extract is simply “weaker” are plausible but unproven without analytical and bioassay bridging; responsible translation requires
quantification of active components and exposure-based PK/PD mapping.
