Does Tirz just ghost everyone in the end?

[Mara_aa]

It seems like, for the vast majority of people, even when increasing the dose of Tirz, you eventually reach a point where after a while the effect drops off significantly or just seems to disappear.

My main concern is maintenance:

if someone already struggles with strong food noise or BED, how do you manage once Tirz stops helping?

Because realistically:

it’s not like we can just fast indefinitely if we can’t handle it…

and I can’t exactly quit my job to work out 8 hours a day (no one’s paying my bills).

So I’m wondering:

do you switch GLP-1?

do you add something (like an amylin receptor agonist)?

Or do you all just accept your fate and pretend the betrayal doesn’t hurt?

I’d really like to hear real experiences, especially from people who are further along.

How did you handle the “after”? How did you survive it?

 

[latviantower]

It seems like, for the vast majority of people, even when increasing the dose of Tirz, you eventually reach a point where after a while the effect drops off significantly or just seems to disappear.

My main concern is maintenance:

if someone already struggles with strong food noise or BED, how do you manage once Tirz stops helping?

Because realistically:

it’s not like we can just fast indefinitely if we can’t handle it…

and I can’t exactly quit my job to work out 8 hours a day (no one’s paying my bills).

So I’m wondering:

do you switch GLP-1?

do you add something (like an amylin receptor agonist)?

Or do you all just accept your fate and pretend the betrayal doesn’t hurt?

I’d really like to hear real experiences, especially from people who are further along.

How did you handle the “after”? How did you survive it?

I plateaued 10 pounds short of my goal on 15 mg tirz. Started pinning every six days, then five. Not much success. Then added midweek reta chaser - 2.5 mg. Boom! That did it. Am now on 10 mg tirz staggered with 5 mg reta for maintenance. Labs are even better - A1C went from 6.8 to 5.4 to 5.0.

 

[DrPEPr]

That's the risk of relying solely on medication; eventually, the body adapts. The beauty of these drugs (IMHO) is that they provide a window of opportunity to overhaul your lifestyle. Those habits are what make the difference in the long run - not an infinitely increasing dosage.

You don't necessarily need to fast, but you do need to make smarter food choices. If you eat the same foods that led to weight gain (just in smaller portions) you’re set up for a rebound the moment you stop the drug. It’s like taking aspirin daily for a headache caused by a loud noise instead of just turning down the volume.

You also don't need to work out for 8 hours a day. 3-4 (~1 hour) sessions a week is plenty. So no need to quit your job.

I have a full-time job, a family (couple of kids) and several hobbies and I even manage to lift 5 days a week (2-2.5 hour sessions).

 

[CallieKat]

I don’t think the effect disappears. I haven’t heard of anyone gaining significant weight back with consistent use. Stalling? Yes. But tirz losing effect and the user gaining back significant weight while consistently injecting every week? Not so much.

I’m thrilled I got the weight loss I wanted but I would still use it if it prevented me from gaining weight.

Success for some can be measured by just not gaining those 10 pounds every year.

 

[deluge]

It seems like, for the vast majority of people, even when increasing the dose of Tirz, you eventually reach a point where after a while the effect drops off significantly or just seems to disappear.

I've reached this point as well.

I read a good explanation on here from someone more experienced than I, who said it didn't disappear, or drop off. Think of it more like your body and the peptides have reached an equilibrium, at the new weight.

You didn't go back to your original weight, did you? This is the new weight, given the current food intake, calorie expenditure, and peptides. Make a further change, and see where that takes you.

I'm considering trying stacking Cagrilintide or Reta for my next step.

 

[chewonmysac]

I do not think it is a ghost so much as it is a shadow. When plateaus occur rather than stalls, it is because your body has fully accommodated to the given dose. Neither negative nor positive is usually seen, and we focus on the scale as the end-all be-all. As a society, we are wired to automatically increase intake for desired, speedy results. When we actually need to decrease intake to create a lower baseline for about a month. Then titrate back up. Sometimes, less is more.

 

[Jfrick11]

That's the risk of relying solely on medication; eventually, the body adapts. The beauty of these drugs (IMHO) is that they provide a window of opportunity to overhaul your lifestyle. Those habits are what make the difference in the long run - not an infinitely increasing dosage.

You don't necessarily need to fast, but you do need to make smarter food choices. If you eat the same foods that led to weight gain (just in smaller portions) you’re set up for a rebound the moment you stop the drug. It’s like taking aspirin daily for a headache caused by a loud noise instead of just turning down the volume.

You also don't need to work out for 8 hours a day. 3-4 (~1 hour) sessions a week is plenty. So no need to quit your job.

I have a full-time job, a family (couple of kids) and several hobbies and I even manage to lift 5 days a week (2-2.5 hour sessions).

T.H.I.S.

 

[Sasquatch]

I go with 15mg, on Thurs. Then 4.5mg on Sat. Mainly because I have .5ml syringes. It works but I've always been able to override my signals just because we have a buffett culture here. Everyone is severely overweight. We just don't give a fuck. Doctors, God bless 'em, they try to increase your longevity and quality of life. I gotta say it worked pretty well. But you're not getting off this planet alive. Something's gonna get you. I never smoked. I figure it'll prolly be cancer, but with the weight loss a stroke is less a chance.

 

[Mara_aa]

I do not think it is a ghost so much as it is a shadow. When plateaus occur rather than stalls, it is because your body has fully accommodated to the given dose. Neither negative nor positive is usually seen, and we focus on the scale as the end-all be-all. As a society, we are wired to automatically increase intake for desired, speedy results. When we actually need to decrease intake to create a lower baseline for about a month. Then titrate back up. Sometimes, less is more.

That’s a really interesting way to look at it, I like the “shadow vs ghost” analogy.

The idea of lowering intake to reset baseline before titrating back up actually makes a lot of sense. I hadn’t thought about it that way.

Thanks for sharing, really appreciate the perspective!

 

[latviantower]

I think maybe my original post was too long, because your reply, while totally valid, feels a bit… obvious and doesn’t really address what I meant.

What you’re describing mostly applies to people who gained weight from overeating out of boredom or habit and being inactive. That’s not really the scenario I was referring to.

I was talking about long-term maintenance for people dealing with severe food noise or BED, cases where, even after years of therapy, the underlying drive to eat doesn’t just disappear. That’s a very different situation, and lifestyle changes alone don’t always “fix” it.

Also, on a lighter note… I’m genuinely impressed

5 days a week, 2–2.5 hour lifting sessions? Do you sleep at all?

Because my reality looks a bit different: I work a full-time (actually more like 10–12 hour) office job as a finance manager, spend ~2 hours a day commuting, try to get at least 6–7 hours of sleep, cook most of my meals (I don’t really eat processed food), and handle all the usual life stuff.

So yeah… I don’t exactly have all that extra time for hobbies + long gym sessions. Maybe life is just more efficient in the US

10-12 hours per day in the office?? You must live in Milano - in my 5 years working in Roma I never met anyone who worked like that - they seemed to be all government employees or academics and were always at lunch.

 

[Mara_aa]

I plateaued 10 pounds short of my goal on 15 mg tirz. Started pinning every six days, then five. Not much success. Then added midweek reta chaser - 2.5 mg. Boom! That did it. Am now on 10 mg tirz staggered with 5 mg reta for maintenance. Labs are even better - A1C went from 6.8 to 5.4 to 5.0.

That’s awesome! Congrats, especially on your A1C, that’s a huge improvement.

Thanks for sharing your experience

Really interesting to hear how adding reta helped break the plateau and transition into maintenance.

 

[Mara_aa]

10-12 hours per day in the office?? You must live in Milano - in my 5 years working in Roma I never met anyone who worked like that - they seemed to be all government employees or academics and were always at lunch.

I live near Turin, and yes, I believe you blindly. Clearly I was meant to be born in Southern Italy and, above all, to work in the public administration.

 

[Mara_aa]

I don’t think the effect disappears. I haven’t heard of anyone gaining significant weight back with consistent use. Stalling? Yes. But tirz losing effect and the user gaining back significant weight while consistently injecting every week? Not so much.

I’m thrilled I got the weight loss I wanted but I would still use it if it prevented me from gaining weight.

Success for some can be measured by just not gaining those 10 pounds every year.

I agree with you, building sustainable habits is definitely key in the long run, and these meds can really help create that window.

At the same time, I think for some people (especially those dealing with strong food noise or BED) it can be a bit more complex than just habits, which is why I’m trying to hear different experiences.

Really appreciate you sharing your perspective!

 

[Mara_aa]

That's the risk of relying solely on medication; eventually, the body adapts. The beauty of these drugs (IMHO) is that they provide a window of opportunity to overhaul your lifestyle. Those habits are what make the difference in the long run - not an infinitely increasing dosage.

You don't necessarily need to fast, but you do need to make smarter food choices. If you eat the same foods that led to weight gain (just in smaller portions) you’re set up for a rebound the moment you stop the drug. It’s like taking aspirin daily for a headache caused by a loud noise instead of just turning down the volume.

You also don't need to work out for 8 hours a day. 3-4 (~1 hour) sessions a week is plenty. So no need to quit your job.

I have a full-time job, a family (couple of kids) and several hobbies and I even manage to lift 5 days a week (2-2.5 hour sessions).

I think maybe my original post was too long, because your reply, while totally valid, feels a bit… obvious and doesn’t really address what I meant.

What you’re describing mostly applies to people who gained weight from overeating out of boredom or habit and being inactive. That’s not really the scenario I was referring to.

I was talking about long-term maintenance for people dealing with severe food noise or BED, cases where, even after years of therapy, the underlying drive to eat doesn’t just disappear. That’s a very different situation, and lifestyle changes alone don’t always “fix” it.

Also, on a lighter note… I’m genuinely impressed

5 days a week, 2–2.5 hour lifting sessions? Do you sleep at all?

Because my reality looks a bit different: I work a full-time (actually more like 10–12 hour) office job as a finance manager, spend ~2 hours a day commuting, try to get at least 6–7 hours of sleep, cook most of my meals (I don’t really eat processed food), and handle all the usual life stuff.

So yeah… I don’t exactly have all that extra time for hobbies + long gym sessions. Maybe life is just more efficient in the US

 

[Mara_aa]

I've reached this point as well.

I read a good explanation on here from someone more experienced than I, who said it didn't disappear, or drop off. Think of it more like your body and the peptides have reached an equilibrium, at the new weight.

You didn't go back to your original weight, did you? This is the new weight, given the current food intake, calorie expenditure, and peptides. Make a further change, and see where that takes you.

I'm considering trying stacking Cagrilintide or Reta for my next step.

That’s a really helpful way to frame it, thinking of it as a new equilibrium rather than something “failing” actually makes a lot of sense.

And you’re right, maintaining a lower weight is already a big shift compared to where we started.

Curious to see how stacking works for you if you try it, would be great to hear an update. Thanks!

 

[CallieKat]

I plateaued 10 pounds short of my goal on 15 mg tirz. Started pinning every six days, then five. Not much success. Then added midweek reta chaser - 2.5 mg. Boom! That did it. Am now on 10 mg tirz staggered with 5 mg reta for maintenance. Labs are even better - A1C went from 6.8 to 5.4 to 5.0.

I get ya. Too much skim reading on my part. If you haven’t tried everything then yes…try them all. Combine. Max them out. You can’t say it doesn’t work if you haven’t tried everything.

I like choosing a base med that you plan on maxing out if you have to like tirz or Reta. I like combining microdosing with sema or cagri along the way while you slowly max out on your base. Tirz with micro reta is pretty cool too. I’m sure folks do Reta with micro tirz.

But there isn’t a right or wrong way imo. Technically it’s all the wrong way because none of what we are doing here is “recommended”. Those that tell you that there is a right or wrong way are usually trying to make money off giving you advice….

Good luck!

 

[Airborne Daddy]

I go with 15mg, on Thurs. Then 4.5mg on Sat. Mainly because I have .5ml syringes. It works but I've always been able to override my signals just because we have a buffett culture here. Everyone is severely overweight. We just don't give a fuck. Doctors, God bless 'em, they try to increase your longevity and quality of life. I gotta say it worked pretty well. But you're not getting off this planet alive. Something's gonna get you. I never smoked. I figure it'll prolly be cancer, but with the weight loss a stroke is less a chance.

Gained 2lbs this week and have been 232 for 6 weeks even after adding cardio and cutting more sugar. 10mg reta and 2mg sema every 6 days....like my body just said after 15 months "were not fallin for your bullshit" frickin glucose running over 100.... im disgusted. My supply is good as the wife lost 11lbs in her first month at a ridiculously low dose. Sqwatch, im shit responder, nice to meet you.

 

[YoYoFat]

I believe it’s the SURMOUNT study that showed Tirz stops weight loss around the a year to 72 weeks.

 

[Mara_aa]

I go with 15mg, on Thurs. Then 4.5mg on Sat. Mainly because I have .5ml syringes. It works but I've always been able to override my signals just because we have a buffett culture here. Everyone is severely overweight. We just don't give a fuck. Doctors, God bless 'em, they try to increase your longevity and quality of life. I gotta say it worked pretty well. But you're not getting off this planet alive. Something's gonna get you. I never smoked. I figure it'll prolly be cancer, but with the weight loss a stroke is less a chance.

Sounds like you’ve found a setup that works well for you, that’s what really matters.

I get what you’re saying about being able to override signals, that part can be tough regardless of the meds.

And yeah… none of us are getting out of here alive but improving quality of life along the way is still a pretty big win.

 

[Mara_aa]

I believe it’s the SURMOUNT study that showed Tirz stops weight loss around the a year to 72 weeks.

That’s really interesting, I’ve heard similar things about weight loss slowing or plateauing around that timeframe, sometimes even before the person reaches their goal… something to think about.