Do GLP1 peptides interact with meds?

[RanHerOver]

Hi!

So, my girlfriend was considering starting Retatrutide after seeing my results.

So far so good, but here's the thing: she daily takes 100mg of zoloft, 5mg of aripiprazole and oral birth control.

As far as I've looked into it, it seems that the only problems she might have is that since the digestive system is slowed down, the assumption of her meds might take more time.

She will talk to her doctor, of course. But in the meantime I wanted to know if any of you had some direct experience with any of this.

Thanks!

 

[ultima thule]

Maybe not medication, but I found out it is not supposed to be use with Berberine. Mention that, cuz some people (including myself) use this supplement to support lowering the blood sugar levels. When started Reta I put Berberine aside.

 

[RanHerOver]

Maybe not medication, but I found out it is not supposed to be use with Berberine. Mention that, cuz some people (including myself) use this supplement to support lowering the blood sugar levels. When started Reta I put Berberine aside.

She doesn't use berbarine but thank you for the info!

 

[Grogu]

Oral birth control is definitely one of the things that can be affected by glp-1s due to the delayed gastric emptying.

https://www.drtahery.com/glp-1-medications-and-birth-control-pills-how-do-they-interact

Haven’t heard any issues about zoloft and aripiprazole specifically, but here is a link to a Women’s Health website that provides a few other interactions to avoid with Rx medications, herbals, etc.

How To Avoid Medication Interaction Problems When Dieting With Ozempic - Women's Health Practice

GLP-1s like Ozempic are potent medications that may potentially have interactions with the medicines you are on.

www.womenshealthpractice.com

 

[chode174]

My wife switched to the birth control patch because of this. It does cost more than the pill, but better then getting pregnant. The patch goes directly into your system so won't be effected by GLP1.

 

[Devilseye]

I use a variety of meds (bipolar) and never had an issue. That said i would check up on the oral birth control. That seems to be the only i have no experience with and could potentially be an issue.

 

[puree]

My GP said it'll reduce the effectiveness and told me to double down with another type of birth control just to be safe.

 

[Lear00]

Hi!

So, my girlfriend was considering starting Retatrutide after seeing my results.

So far so good, but here's the thing: she daily takes 100mg of zoloft, 5mg of aripiprazole and oral birth control.

As far as I've looked into it, it seems that the only problems she might have is that since the digestive system is slowed down, the assumption of her meds might take more time.

She will talk to her doctor, of course. But in the meantime I wanted to know if any of you had some direct experience with any of this.

Thanks!

As others have said delayed gastric emptying will absolutely change the pharmacokinetics of essentially all oral medications.

In terms of how much of an issue it is will depend on how crucial the timing of absorption is for whichever medication someone’s taking. Some medications are more time critical - analgesics, anti-emetics, oral hypoglycaemics, Parkinson’s medications etc.

Hard to know re. specific medications tbh and until there’s more research, I suspect it’ll just have to be guided by how people feel their medications are more/less effective once they are stable on a dose of GLP1.

Somewhat related, one thing I’d emphasise is if you ever are in a situation where you might need anaesthetic whether it be a planned surgery or in an emergency, please for the love of god don’t hide that you’re on a GLP from your doctors.

 

[Bellypearl]

Hi!

So, my girlfriend was considering starting Retatrutide after seeing my results.

So far so good, but here's the thing: she daily takes 100mg of zoloft, 5mg of aripiprazole and oral birth control.

As far as I've looked into it, it seems that the only problems she might have is that since the digestive system is slowed down, the assumption of her meds might take more time.

She will talk to her doctor, of course. But in the meantime I wanted to know if any of you had some direct experience with any of this.

Thanks!

I do. I haven't had any problems. I take 50mg zoloft in the morning as well as birth control pill.

 

[Gt3294a]

Maybe not medication, but I found out it is not supposed to be use with Berberine. Mention that, cuz some people (including myself) use this supplement to support lowering the blood sugar levels. When started Reta I put Berberine aside.

Thank you for this. Did not know and have berberine in case need. Just it stay in backup.

 

[Gt3294a]

I use a variety of meds (bipolar) and never had an issue. That said i would check up on the oral birth control. That seems to be the only i have no experience with and could potentially be an issue.

Same on Prozac.

 

[bbbilly]

i am on Synthroid and beta blockers and working with my PCP, it took some time to dial everything in with being on tirz then stopping and then starting again. but i am advised to not eat for 6 hours before (normally 4 hours) so i have to take it first thing in the morning but i do that allready. and to not eat or drink ANYTHING, not even my morning energy drink for atleast a full hour after (normally a 30 minute wait) and even then she advised to not eat a giant breakfast.. like i could anyway from the tirz lol. so just the energy drink untill lunch.

it may be different for everyone and dependent on the dose she is on, if she plans to increase the dose and how long she has been on her current dose. honestly its worth working directly with her PCP and going slow to keep from accidentally having any big swings in the effectiveness of her prescription drugs. i know it was kinda a pain in the ass for me with my Synthroid.

 

[RanHerOver]

As others have said delayed gastric emptying will absolutely change the pharmacokinetics of essentially all oral medications.

In terms of how much of an issue it is will depend on how crucial the timing of absorption is for whichever medication someone’s taking. Some medications are more time critical - analgesics, anti-emetics, oral hypoglycaemics, Parkinson’s medications etc.

Hard to know re. specific medications tbh and until there’s more research, I suspect it’ll just have to be guided by how people feel their medications are more/less effective once they are stable on a dose of GLP1.

Somewhat related, one thing I’d emphasise is if you ever are in a situation where you might need anaesthetic whether it be a planned surgery or in an emergency, please for the love of god don’t hide that you’re on a GLP from your doctors.

Yeah I figured it depended on how crucial the timing of the medication is. The good news is that the birth control she takes can be taken within a 12 hours window to still maintain its effects. She now takes it at 3pm. If she keeps taking it at that time, even if her body takes more time to absorb it, she should still be covered.

We'll keep you guys posted thanks

 

[Sid the SeaGull]

I found out it is not supposed to be use with Berberine.

I'd be keen to read about this more if you could share the reference.

Berberine is in an added OEA supplement that I've found helpful towards the end of the week before next dose .

I've not had issues with it but certainly keen to learn how it may be a risk I don't know out .

Ciao

 

[ultima thule]

I'd be keen to read about this more if you could share the reference.

Berberine is in an added OEA supplement that I've found helpful towards the end of the week before next dose .

I've not had issues with it but certainly keen to learn how it may be a risk I don't know out .

Ciao

There's a lot of informations about this in the web basiacaly. I'm a simple guy, hence before starting Reta I made a simple way research "what not to mix up with Glp-1" thorough Google. Berberine showed up in many articles. The main thing is that herbal supplement has hypoglycaemic properties. Means it lowers blood sugar levels which may increase hypoglycaemia risk. Maybe it is not a biggie, but imo it is better to beware. If you want to research this issue in a more complex way, I can only suggest to do it the same way as I did it.

 

[Sid the SeaGull]

There's a lot of informations about this in the web basiacaly. I'm a simple guy, hence before starting Reta I made a simple way research "what not to mix up with Glp-1" thorough Google. Berberine showed up in many articles. The main thing is that herbal supplement has hypoglycaemic properties. Means it lowers blood sugar levels which may increase hypoglycaemia risk. Maybe it is not a biggie, but imo it is better to beware. If you want to research this issue in a more complex way, I can only suggest to do it the same way as I did it.

Thank you , I guess I'm pushing the envelope. targeting ketosis, however if not managed could end up with hypoglycaemic.

Taking on the final days before next pin is minimising risk. For me the OEA that the Berberine is mixed with helps with end of week food noise. I have also used it when traveling when I've not been able to bring my pen with me for a few weeks .

I really appreciate your insights thank you .

 

[lessthanhalf]

It is known to alter the absorption of a lot of medications and can reduce the effectiveness of the combined oral contraceptive pill, so doing some research on that or getting a doctors advice might be a good idea.

It reduces the effect of dexamphetamine that I am taking for ADHD/adjuvant antidepressant, which I found a bit annoying, and delays absorption of painkillers/tramadol, so my gut hurts for a few extra hours each morning until they start working, and I cannot take them at night as they cause insomnia.

First time I have seen anyone mention OEA, one of the few supplements with clinical trial evidence of effectiveness for weight loss, even if only 1-2kg and all the research is Iranian.

 

[Sid the SeaGull]

It is known to alter the absorption of a lot of medications and can reduce the effectiveness of the combined oral contraceptive pill, so doing some research on that or getting a doctors advice might be a good idea.

It reduces the effect of dexamphetamine that I am taking for ADHD/adjuvant antidepressant, which I found a bit annoying, and delays absorption of painkillers/tramadol, so my gut hurts for a few extra hours each morning until they start working, and I cannot take them at night as they cause insomnia.

First time I have seen anyone mention OEA, one of the few supplements with clinical trial evidence of effectiveness for weight loss, even if only 1-2kg and all the research is Iranian.

Yes, when taking OEA I take it with a tablespoon of 92%Oleic Acid ( safflower oil). From what I could tell this was the best way to ensure OEA was absorbed. I guess that is my personal research, and what this community is about . Works well for me on last days of the week before pin.