
我可以用石头把钉子钉进木板,然后再换个更好的工具继续钉,或者我也可以一开始就用锤子。总有一天会有人发明出更好的锤子。AndyPanda said:无论哪种方式,一旦其效果达到最大值,如果你已经作用于所有受体,就没有提升的空间了。

我可以用石头把钉子钉进木板,然后再换个更好的工具继续钉,或者我也可以一开始就用锤子。总有一天会有人发明出更好的锤子。AndyPanda said:无论哪种方式,一旦其效果达到最大值,如果你已经作用于所有受体,就没有提升的空间了。

你可以直接使用吗啡止痛,但如果布洛芬有效,为什么要用吗啡呢?zpped said:我可以用石头把钉子钉进木板,然后再换个更好的工具继续钉,或者我也可以一开始就用锤子。总有一天会有人发明出更好的锤子。

因为吗啡的副作用很严重?而且它属于少数会产生耐药性的药物。RetaAndyPanda said:你可以直接使用吗啡止痛,但如果布洛芬有效,为什么要用吗啡呢?

你想太多了,而且似乎有些情绪化。瑞他曲肽确实有效,但如果你已经用完了最大剂量,它不再有效,那么你的下一步选择是什么?如果你正在使用司美格鲁肽,但它失效了,你可以改用替拉帕肽。如果你正在使用替拉帕肽,但它失效了,你就只能改用瑞他曲肽了。我们也不能忘记,瑞他曲肽目前尚未获准用于人体。任何地方都没有。zpped said:因为吗啡的副作用很严重?而且它属于少数会产生耐药性的药物。Reta
的副作用比 Tirz 少。

AndyPanda said:你想太多了,而且似乎有些情绪化。瑞他曲肽确实有效,但如果你已经用完了最大剂量,它不再有效,那么你的下一步选择是什么?如果你正在使用司美格鲁肽,但它失效了,你可以改用替拉帕肽。如果你正在使用替拉帕肽,但它失效了,你就只能改用瑞他曲肽了。我们也不能忘记,瑞他曲肽目前尚未获准用于人体。任何地方都没有。

I'm definitely not emotional. And you're completely misunderstanding the point. There is no benefit to starting with semaglutide. The only thing you get is slower progress and more side effects.AndyPanda said:You are overthinking this and appear to be responding emotionally. Retatrutide works, but If you are maxed out on it, and it’s no longer effective, what is your next option? If you’re on Semaglutide and it stops working, you can go to Tirzepatide. If you are on Tirzepatide and it stops working, you go to Retatrutide. Let’s also not forget that Retatrutide is still not approved for human use. Anywhere.
It really doesn't make a difference.GLP1Pharmacist said:Makes a difference imho if you need to lose 30lbs vs 100+lbs.


I find the hunger cravings come from not having enough of a given macro. So I just figure out which one it is and try to satisfy that. Also eating more calorie dense foods that don't physically fill you up as fast. 4 lbs in a week is a lot.kaahhllll said:Week eleven:
Down another 4lbs this week, continuing on at 1.0mg, but I'm considering titrating up again next week. I haven't had shit for an appetite, but I have felt hungry more lately. I don't like the discomfort of feeling hungry, especially when nothing sounds good enough to change that.
My girlfriend has been on compound sema for almost a year now and has lost about 70lbs. I am 70 days in and have lost half that on extremely small doses of reta. I can't see any reason to worry about tolerances or effectiveness. But also, what about that chart that shows the "strength" of each pep in relation to one another? If tirz has significantly less GLP1 than sema, and reta has significantly less GLP1 and GIC than tirz, what would make someone believe that the former would be rendered ineffective due to use of the latter? They work on different agonists, that's the whole reason for having different compounds.

It does seem like a lot, but that's about the average for me throughout this whole period. According to Samsung health, I've been in about a 1500cal defecit every day and I am retaining muscle mass, so I'm not concerned with the rate of loss. Still trying to stick to higher protein than anything for the satiety. And I've been making sure I get a fair amount of fiber and low net carbs. The keto bread world is fantastic by the way, I will buy burger patties from fast food places and throw them on keto buns for 50cal each at like 1g net carbs. Get the filling effect of the bread and still hit my macros pretty well. Only bad thing is that samsung health counts total carbs and doesnt adjust for net carbs offset by fiber, so my tracker looks more carb heavy than it actually is. But I'm averaging TDEE of about 2,900cal, consuming an average of 1700cal, and I have plenty of energy throughout the day.zpped said:I find the hunger cravings come from not having enough of a given macro. So I just figure out which one it is and try to satisfy that. Also eating more calorie dense foods that don't physically fill you up as fast. 4 lbs in a week is a lot.


I will agree with this x1,000zpped said:I think you might feel less hungry if you added an extra 200 calories of regular carbs. Reta does really well for a lot of people when you feed it carbs


What kind of carbs are you eating? I find rice pretty filling. Now that I'm trying to gain weight I eat more beef but I was definitely eating a lot of chicken in the beggining.kaahhllll said:I was a little put off by the fat amount. But majority of that is from beef, some times cheese and it really adds up. I'll definitely try to cut down on fat, and I'll give it a try to add in some more carbs. It's tough though, because there have been a few days that are higher on carbs and I'm certainly feeling way hungrier on those days, its such an empty macro

Typically rice or potatoes, sometimes protein pasta. Occasionally its sweets or "junk" like poptarts or a rice crispy treats, sometimes chips, but that's when I'm dying before lunch and hit the vending machine at work. I try to stay chicken heavy. But I am big on burgers and steak. I've always been more of a red meat guy.zpped said:What kind of carbs are you eating? I find rice pretty filling. Now that I'm trying to gain weight I eat more beef but I was definitely eating a lot of chicken in the beggining.

Chickens aren’t nearly as personable as cows. I think it’s because they don’t have eyelashes. I’m with you on the red meat.kaahhllll said:Typically rice or potatoes, sometimes protein pasta. Occasionally its sweets or "junk" like poptarts or a rice crispy treats, sometimes chips, but that's when I'm dying before lunch and hit the vending machine at work. I try to stay chicken heavy. But I am big on burgers and steak. I've always been more of a red meat guy.

Oh I love beef. But I switched to flap steak mostly for lower fats.kaahhllll said:Typically rice or potatoes, sometimes protein pasta. Occasionally its sweets or "junk" like poptarts or a rice crispy treats, sometimes chips, but that's when I'm dying before lunch and hit the vending machine at work. I try to stay chicken heavy. But I am big on burgers and steak. I've always been more of a red meat guy.


Travel and illness can definitely throw everything off for a bit.kaahhllll said:Week twelve:
I'm unsure if its these work trips out of town that are fucking me up, or if its that I need to titrate up. Gained back a net of 3lbs this week, and at one point I was back up to 270 during the week. I did 1mg again yesterday, but I am considering doing another 0.5mg on Friday and doing 1.5mg/week moving forward. I'll see how the next couple days go. I will say, I've been very fatigued over the last week or so, and had a pretty aggressive cold or viral URI/sinus infection 2 weeks ago. I'm holding onto a lot of water right now and haven't pooped much recently. I'm thinking my whole system is messed up from being sick and I'll bounce back pretty well soon.
I did try getting in some good carbs throughout the day and I dont see or feel much of a difference, but again, I haven't been feeling well. I also increased my intake a fair bit over the week as per suggestions, and that could be whats thrown everything off. I averaged 1950cal vs the 1650-1700 I had been consistent with. All and all, I think the higher defecit worked a lot better for me and I plan on returning to it.

Yeah I get that, so I am remaining very positive and staying encouraged. It does suck to see things go backward thoughzpped said:Travel and illness can definitely throw everything off for a bit.
