Cagri Fibrils Group Test

[Grogu]

Just an FYI for anyone interested in Cargilintide and has been thinking about fibrils that there is currently a group forming in STG's Discord Testing Server looking to have Jano run some tests on the formation of fibrils in reconsititued solutions. No decisions have been made about the test parameters at this point, but if you're interested in Cargi and been wondering about fibrils I thought some might be interested in joining. There are about 50 people in the group so far, so I'm thinking that testing won't be too expensive.

 

[Gohengrin]

Thank you. I am very much interested. Now i have to find the discord

 

[Grogu]

Thank you. I am very much interested. Now i have to find the discord

Will send you some info by DM!

Thanks for your interest!

 

[woundcarping]

I too, am interested in such things.

 

[Raidenfat2fit]

I'm interested. I'm currently awaiting for my order of reta and cagri to arrive. I've bought some standard bac water from my vendor but there's a lot of different opinions on whether or not bac water is enough and the possible risks are SCARY to say the least.

 

[HereKittyKitty]

Holy seamonkeys! I never heard of fibrils until this moment. Is the testing for product from a specific vendor or the product in general? If general product, I have a vial to donate and am very interested for more information. Please.

 

[Grogu]

Holy seamonkeys! I never heard of fibrils until this moment. Is the testing for product from a specific vendor or the product in general? If general product, I have a vial to donate and am very interested for more information. Please.

Yeah, I hadn’t even heard about fibrils either [or the ph issue] until my first kit was well on its way to me. I haven’t done the deep dive into the research, so can’t say if fibrils are a real concern or smoke. So, the testing group should be interesting.

As far as donor vials, I think that the group in envisioning two vials, but the group is in the recruiting phase and testing parameters haven’t been determined. The people putting the group together appear to be very democratic at this point and I think the plan is to take polls about how the tests would be conducted.

I can DM some instructions on how to get to the testing server if you’re not familiar with Discord.

 

[Thedooman445]

Can I get a DM? I would love to participate

 

[HereKittyKitty]

Yeah, I hadn’t even heard about fibrils either [or the ph issue] until my first kit was well on its way to me. I haven’t done the deep dive into the research, so can’t say if fibrils are a real concern or smoke. So, the testing group should be interesting.

As far as donor vials, I think that the group in envisioning two vials, but the group is in the recruiting phase and testing parameters haven’t been determined. The people putting the group together appear to be very democratic at this point and I think the plan is to take polls about how the tests would be conducted.

I can DM some instructions on how to get to the testing server if you’re not familiar with Discord.

Sounds good. I am on Discord. Would you mind to please send me an invite via DM here?

 

[Grogu]

@Thedooman445 and @MeedzMoar sent a DM with the Discord invite and how to access the group once in the server. Hopefully I did it correctly. I’m new to discord.

 

[Goonwise]

How do you actually test for fibrils from test vials? Wont you require to inject and test it in your body?

Probably a noob question. I am interested in the result myself.

 

[Grogu]

How do you actually test for fibrils from test vials? Wont you require to inject and test it in your body?

Probably a noob question. I am interested in the result myself.

The StG testing server was nuked, but someone had posted a bunch of research, which I wish I had downloaded, but basically you use Thioflavin T, a chemical that turns fluorescent in the presence of fibrils.

Fluorescent Filter-Trap Assay for Amyloid Fibril Formation Kinetics in Complex Solutions - PMC

Amyloid fibrils are the most distinct components of the plaques associated with various neurodegenerative diseases. Kinetic studies of amyloid fibril formation shed light on the microscopic mechanisms that underlie this process as well as the ...

pmc.ncbi.nlm.nih.gov

https://www.tandfonline.com/doi/full/10.1080/13506129.2017.1304905#d1e333

 

[Goonwise]

Thank you. That makes sense.

 

[Grogu]

Thank you. That makes sense.

Also something that might be helpful in considering fibrils, is that from the research I read before the nuke, I think that the consensus is that these fibrils are too large to break the Brain Blood Barrier (BBB) in normal healthy adults. Some small aggregates might break the barrier.

I personally don't want any extra fibrils floating around, even if too large to break the barrier. I haven't had time to research the mechanism (if one even exists) that fibrils in a SQ injection travel from fat into the bloodstream or if the fibrils stay localized in the fat. Unfortunately, I think that there is a lot unknown about fibrils.

 

[Lyophilized]

people with T1D insulin dependent suffer the same problem over all the years of SQ injections

So they are a good study subject to start. Insuline creates also fibrils at injection site

You will find a lot of scientific articles about this. Maybe even one with migration study..

I don´t believe that those fibril or aggregates migrate to other areas...but that´s my opinion...

 

[Grogu]

people with T1D insulin dependent suffer the same problem over all the years of SQ injections

So they are a good study subject to start. Insuline creates also fibrils at injection site

You will find a lot of scientific articles about this. Maybe even one with migration study..

I don´t believe that those fibril or aggregates migrate to other areas...but that´s my opinion...

Thanks so much for this! I'll look into this stream of research as it definitely sounds related to what the group on Discord was trying to look at prior to it being nuked. Thanks again!

 

[Grogu]

So, the Cargilintide fibrils group had about 100 members and then the StG Discord Server got nuked and was never was restored.... What a bummer....

Tangentially related, not sure if anyone is interested, but I'm working with a couple of others on testing this cagri.

[Imported image pending local asset: attachments-1771197629756-webp.16118]

Group Test Recruiting

AMO/BFF Cagrilintide C10

Batch #107220 – 12/2/2025

 

[CNCCurrency]

I thought this, Unlike native human amylin, which is highly prone to forming amyloid fibrils, cagrilintide is specifically designed to minimize this, allowing for better formulation stability.

 

[Grogu]

I thought this, Unlike native human amylin, which is highly prone to forming amyloid fibrils, cagrilintide is specifically designed to minimize this, allowing for better formulation stability.

I've also been thinking that even if fibrils form in the vial, I'm not sure if they can travel from the SQ location to the brain and cross the BBB.

 

[philicibine]

Very interested to see the results of this. It might lay to rest some worries alot of people have.