Body stopped responding

[Voidnoodle]

Is it possible that my body has just stopped responding to any type of GLP1 medication?

I was on Wegovy for a while - over a year. Had amazing success then my insurance stopped covering it. Was off it for about 5 weeks then started compound semaglutide. Didn’t work so I switched to Tirz peptides. Still nothing so I just added (this week) 1 mg of Survoduride.

I do get sulfur burbs but literally no cessation of food noise or appetite. I’m ravenous and gaining weight. I worked SO hard to lose the weight (I lost over 100 before taking the wegovy) and I’m terrified of gaining it all back.

I did also try cagri but it just made me so exhausted,I was falling asleep at work.

I’d love any ideas. Thank you!

 

[indolent]

Have you tried a consistently low-carb diet?

I've found that in weeks when I have carbs, I stop losing weight or even gain quite a lot (probably water retention)?

 

[Skidude]

Not sure on your timelines for the Tirz or sema, but it may just be you are having to ramp up to a dose that is effective.

100% opinion only based on much I have read, but it is my understanding for many the first starting dosages do not help for many people and they need to get up to larger doses.

Need more information on your dosing to even comment really, but if you just started back at 2.5/5/7.5 or whatever you may need to slowly titrate up to a higher dose to have the effect you are looking for.

Also, I understand sema does more for food noise than Tirz so you may be getting benefits eventually that have not kicked in yet. I cannot speak towards the cagri

 

[Voidnoodle]

Not sure on your timelines for the Tirz or sema, but it may just be you are having to ramp up to a dose that is effective.

100% opinion only based on much I have read, but it is my understanding for many the first starting dosages do not help for many people and they need to get up to larger doses.

Need more information on your dosing to even comment really, but if you just started back at 2.5/5/7.5 or whatever you may need to slowly titrate up to a higher dose to have the effect you are looking for.

Also, I understand sema does more for food noise than Tirz so you may be getting benefits eventually that have not kicked in yet. I cannot speak towards the cagri

Thanks for responding!

Since switching to Tirz, I’ve done two weeks at 7.5 and then this week went up to 10mg.

 

[Skidude]

It is odd that you had so much success with sema name brand but not compound.

I am far from an expert on this, but some combine sema and tirz for the food noise.

I would suggest other diet based recommendations, but after losing 100lbs this is not your first rodeo.

I would love to see what others say.

 

[Calm Logic]

According to this article, you may want to ask your doctor to add phentermine or Qsymia (phentermine/topiramate):

Why Do GLP-1 Drugs Stop Working, and What to Do About It?

Everybody has a set point, and every weight loss intervention eventually leads to a plateau, so it helps to have a variety of tools to support patients.

www.medscape.com

Several strategies can be used to help patients break through a plateau. One is to try multiple weight loss agents with different targets — something often done in the real world, Stanford said. "You don't see this in the studies, which are focused on just one drug, but many of our patients are on combination therapy. They're on a GLP-1 drug plus phentermine/topiramate plus metformin , and more. They're usually on three, four, five drugs, similar to what we would see with resistant hypertension."

If a patient plateaus on a GLP-1 drug, Stanford might add phentermine . When the patient reaches a plateau on phentermine, she would switch again to another agent. "The goal is to use agents that treat different receptors in the brain," she said. "You would never use two GLP-1 agonists; you would use the GLP-1, and then something that treats norepinephrine, for example."

I have not tried Qsymia myself, but it seems very promising. It is a combination of phentermine and topiramate that can be taken long-term, unlike phentermine (which is given at a higher dose when taken by itself).

(There is also a savings program for Qsymia, including direct pricing for home delivery: "After benefits verification, if Qsymia is not covered, the cash price is $98 across all doses and product packs." "$98 home delivery pharmacy pricing includes 6-week New Patient Packs, 6-week Titration Packs and all 30-day prescriptions. Additional shipping and handling costs will apply.")

 

[Calm Logic]

Reta does come to mind since it can be stimulating (and raise heart rate) like phentermine. So that may be worth trying the next time there is money to burn

But a non-GLP I came across is teso (tablets), which is stimulating like phentermine but can be taken longer-term:

Tesofensine - Wikipedia

en.wikipedia.org

[archived internal link]

Teso is awesome (update: for a while...)

Sep 15, 2024

This is not medical advice:

If you have GLP1 fatigue and/or anhedonia, you should read up on tesofensine. It was originally aimed at neurodegenerarive disorders such as Alzheimer’s and Parkinson’s. Some benefits include:

— Mood enhancement/improvement

— Energy increase

— Appetite suppression

Warning: do not take while on SSRI medication. This can cause serotonin syndrome.

After 8 days of ~125mcg, my own personal research reflects those beneficial outcomes. It’s been a great week and I’m looking forward to the next one!

UPDATE

Day 9 (9/15)...

peptideusername

Replies: 142

Forum: Tesofensine

Tesomet, which apparently ran out of funding, combined teso with metoprolol:

Tesomet - Saniona

Tesomet is an investigational fixed-dose combination therapy of tesofensine (a triple monoamine reuptake inhibitor) and metoprolol (a beta-1 selective blocker). Saniona is advancing Tesomet for hypothalamic obesity and Prader-Willi syndrome, two severe rare disorders characterized by obesity and...

saniona.com

Another option is OTC continuous glucose monitoring. But the problem is still the cost, at about $100 a month:

1200 bucks a year? i'd rather spend that on shit i can inject.

Since I am responding well to tirz, the only tech I use is my Fitbit (which is good for monitoring resting heart rate if I ever try reta).

Regarding cost, phentermine (or metformin) may be the cheapest way to augment for now, at least with approved meds. But I would be

tempted to go with teso instead: "At the conclusion of phase II clinical trials, Saniona announced that tesofensine was well tolerated with low incidence of adverse events, low increase in heart rate and no significant effect on blood pressure."

(I would also get some new bloodwork done to check A1c, lipids, etc., such as to see if they are still responding to the GLP-1s.)

More info, including on teso, tesa, and other goodies:

[archived internal link]

Post in thread 'Ok, I’m bored. And semi addicted. What’s next?'

Dec 3, 2024

I've been using Tesofensine since July with 10mg/week of tirz. Tirz was great for losing my first 50 lbs., but then my weight loss pace slowed down by half. For 7 months, I was only losing 0-5 lbs even though I still had 90 lbs to lose. Even on tirz, my metabolism is still a good bit slower than average for my height and weight.

Tesofensine supposedly speeds up your metabolism. Sure seems like it! I lost 6 lbs the first month. Added 2mg/week of reta the second month, but that was the only vial I had to experiment with. I lost 8 lbs that month. I went back to just tirz/tesofensine...

NolaJen1120

[archived internal link]

Post in thread 'whats your weight loss stack?'

Oct 26, 2024

Currently on Tirz since June (Sema before that from March) with 37 pound loss so far.

Have stacked AOD (cycled off 3 weeks ago) and loved it.

Have been researching Tesa and Ipa for the past 3 weeks and have seen a great reduction in abdominal fat. Really phenomenal.

I added Tesofensine this past week and bam! The weight is melting off and there’s been great energy.

I also add a very low dose of Reta mid week for energy and appetite suppression - but from what I’ve seen from the Teso I will probably d/c the Reta.

stephaniemeador

[archived internal link]

Post in thread 'Non GLP1s for fat burning'

Mar 25, 2025

The guy who lead the trials for AOD for the company developing it says it does nothing.

Tesa/Ipa can help induce lipolysis and improve nutrient partitioning but you'll still need to be in a caloric deficit for it to cause you to burn fat.

hexagonal

 

[Calm Logic]

As many as 1 in 5 people won't lose weight with GLP-1 drugs, experts say

Most people taking popular drugs like Ozempic and Wegovy to lose weight have shed significant pounds.

apnews.com

Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It’s a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results...

Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives.

“This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient...

Trying a different version of the new class of drugs may help. Griffin, who didn’t respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds.

“I’m hoping it’s slow and steady,” she said.

Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted.

“Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.”

 

[Calm Logic]

(I lost over 100 before taking the wegovy)

This may be applicable then:

We took Ozempic thinking we’d lose weight — we didn’t, and here’s why

“It did not budge the needle,” one person revealed.

nypost.com

Those who have made healthy lifestyle changes and already lost weight likely don’t get that much added bonus from the medications.

A reminder:

7 Reasons You Aren't Losing Weight on Weight Loss Drugs

Obesity medications don't work for everyone. Eating and exercising well and adjusting your dose could help.

www.verywellhealth.com

Individuals who cannot tolerate the highest doses of semaglutide or tirzepatide may find it hard to achieve the substantial weight loss reported in the clinical trials by using those drugs alone.

Another alternative:

Add-On to GLP-1s Yields Greater Weight Loss

Combination therapy of bupropion/naltrexone and GLP-1 receptor agonists showed a synergistic weight loss effect in individuals with obesity who responded poorly to GLP-1 monotherapy.

www.medscape.com

The addition of bupropion/naltrexone to glucagon-like peptide 1 (GLP-1) receptor agonists leads to a further 4%-5% total body weight loss (TBWL) in patients with obesity, including those who show a poor response to initial GLP-1 monotherapy.

 

[nonyabizznez]

Is it possible that my body has just stopped responding to any type of GLP1 medication?

I was on Wegovy for a while - over a year. Had amazing success then my insurance stopped covering it. Was off it for about 5 weeks then started compound semaglutide. Didn’t work so I switched

I’d love any ideas. Thank you!

I suppose if this were Reddit the down vote would come in handy here...

These peptides are not like wine. They don't have nuance or different notes. Wegovy is Semaglutide. If you have bonafide versions of both at the same dose they are interchangeable.

I check glucose daily and whether it's been Mounjaro, Amo, QSC, SRY, TUK, Nexaph and other's tirzepatide only one yielded better average glucose and when I checked the test sho'nuff it was overfilled.

I think you might be beating your GLP with your mind saying this gray can't be as good as the expensive stuff.

Or you are an exception. Going from "amazing success" to "didn't work" does not jive.

 

[Calm Logic]

I think it's more complicated than nocebo, e.g. "I lost over 100 before taking the wegovy."

 

[AndyPanda]

For the price, I would not buy tesofensine. I would just Clenbuterol or Modafinil or Armodafinil from India that’s actually produced by a reputable drug company.

Or, add some Metformin to the mix. It has several health benefits.

 

[Calm Logic]

The Clenbuterol looks interesting. One guy put it this way: "It sheds weight like a dog sheds fur."

 

[AndyPanda]

The Clenbuterol looks interesting. One guy put it this way: "It sheds weight like a dog sheds fur."

I get 40mcg tablets and only take half. It gives me insane mental clarity and endurance. I highly advise not taking it unless you have some physical activity planned though or you get the shakes.

The only peptide I’ve tried that’s even close is AICAR. Definitely doesn’t give the shakes but the endurance is pretty cool.

 

[Voidnoodle]

I suppose if this were Reddit the down vote would come in handy here...

These peptides are not like wine. They don't have nuance or different notes. Wegovy is Semaglutide. If you have bonafide versions of both at the same dose they are interchangeable.

I check glucose daily and whether it's been Mounjaro, Amo, QSC, SRY, TUK, Nexaph and other's tirzepatide only one yielded better average glucose and when I checked the test sho'nuff it was overfilled.

I think you might be beating your GLP with your mind saying this gray can't be as good as the expensive stuff.

Or you are an exception. Going from "amazing success" to "didn't work" does not jive.

Perhaps it is a mental thing. I’m not sure. I just know that I went from 232 to 170 on Wegovy, but since I stopped that back in August of 2024, I’m back up to 202.

 

[Calm Logic]

@Voidnoodle And it seems you already tried teso too? Did it help at all?

 

[Calm Logic]

For more hardcore solutions (though with more potential for side effects), like clenbuterol that AndyPanda mentioned:

Ways to quickly reduce body fat – BG pharmaceuticals

www.bgpharmadrugs.com

 

[Calm Logic]

Some other options include going to a 5-day schedule:

[archived internal link]

Post in thread 'If not tirz+cagri, then what?'

Dec 2, 2024

Having taken cagri and probably shouldnt have. I would do the following first, personally. Some the below do not follow recommended guidelines by EL, but I'd probably explore them before resulting to cag.

1. Higher dose of my main glp

2. Switch to a 5 day schedule

3. Explore doses above the current recommendation (tirz studies at 20/25 happening)

4. Stack with Sema

5. Explore a stack with other glp1s

6. Explore other peptides/options.

nccane

But hopefully the survo you added will do the trick sooner or later.

It makes sense that survo + tirz = reta:

Survodutide (Survo) + Tirzepatide (Tirz) = Retatrutide (Reta)

Survodutide (Survo) is a dual agonist of the GLP-1 and glucagon receptors .

Tirzepatide (Tirz) is a dual agonist of the GLP-1 and GIP receptors .

Retatrutide (Reta) is a triple agonist of the GLP-1, GIP, and glucagon receptors , essentially combining the actions of survodutide and tirzepatide in a single molecule.

 

[Ms_Ery]

Have you tried a consistently low-carb diet?

I've found that in weeks when I have carbs, I stop losing weight or even gain quite a lot (probably water retention)?

Same.

 

[Calm Logic]

Experience of a non-traditional responder:

To say that it’s super individualized is an understatement. I took brand name Ozempic for 5 months and lost no weight while feeling like complete garbage for the whole 5 months . Then I switched to grey market tirz for 4 months and felt better but didn’t lose any weight until I added phentermine for appetite suppression.

I stopped the tirz because it wasn’t working and switched to Contrave over some blood pressure concerns. I had crazy side effects to contrave AND gained weight on it so I decided to order some Reta and use up the last bottle of tirz that I ordered last year just to get back into the swing of things. For some bizarre reason, I’m having fantastic appetite suppression without phentermine on this bottle of tirz ; it only starts to wear off on day 6/7.

Now a month later I have 400mg of Reta in hand and I’m wishing I had ordered tirz instead because I’m down 5lbs this month. So here’s to hoping that Reta works well for me and I don’t need to keep my appointment with my doc next month to get more phentermine.