Best weight loss peps that are not GLPs?

[JokeyJo]

After two years of trying, I need to never take GLPs again. They cause terrible anhedonia for me, and Reta causes actual panic and anxiety too. I’ve experimented endlessly and it’s definitely them causing it.

I’m almost resigned to staying slightly overweight (all my diet and exercise stuff is on point) which makes me sad, but GLPs are not worth it for me.

Are there other things I can try please? Things that don’t work on reward pathways.

 

[Chili777]

Cagri works via a different channel (amylin receptors) than GLP1s and may be worth checking out. Mots-c and Tesamorelin also are said to have weight loss benefits, although Tesa works primarily on visceral fat.

 

[JokeyJo]

Cagri works via a different channel (amylin receptors) than GLP1s and may be worth checking out. Mots-c and Tesamorelin also are said to have weight loss benefits, although Tesa works primarily on visceral fat.

Thank you. Maybe a stack of those will be a good thing for me to do.

 

[Chili777]

Thank you. Maybe a stack of those will be a good thing for me to do.

NP. I'd try Cagri first and then try them one at a time. Cagri is low dose anyway. Then figure out what you can tolerate together. With Mots-c, start low there too, 1 mg and go up from there. Some people have a reaction to it.

 

[Devilseye]

I think youd be the ideal target candidate for eloralintide when it hits the grey market. It has glp1-like efficacy for weight loss while cagri seems to only be half as potent.

Cagri is still better than nothing though so id try that for now. It would be your best bet. Tesa is great for visceral fat so maybe combining cagri and tesa might work for you. Never tried it though.

 

[JokeyJo]

I think youd be the ideal target candidate for eloralintide when it hits the grey market. It has glp1-like efficacy for weight loss while cagri seems to only be half as potent.

Cagri is still better than nothing though so id try that for now. It would be your best bet. Tesa is great for visceral fat so maybe combining cagri and tesa might work for you. Never tried it though.

Thank you for the advice.

 

[emptynester]

I think youd be the ideal target candidate for eloralintide when it hits the grey market. It has glp1-like efficacy for weight loss while cagri seems to only be half as potent.

Cagri is still better than nothing though so id try that for now. It would be your best bet. Tesa is great for visceral fat so maybe combining cagri and tesa might work for you. Never tried it though.

Eloralintide causes anhedonia as well.

 

[JCO79]

I’ve experienced unanticipated effects on mood including depression and the attendant anhedonia from weight loss before ever trying GLP1 drugs. It’s a well described consequence of weight loss. Maintaining leanness below a certain point just isn’t great for mental health. Obviously that may not be the issue for you and with the effects on reward pathways it could be a direct drug effect in your case.

 

[lastresort]

Most other peptides take WEEKS to se results.

 

[Habibibi]

Cagrilintide : so effective, they had to pair it with semaglutide to be able to sell it.

 

[Smiter]

Apart from Cagri, and if you don't want dopamine-connected stuff, try bronchodilators, and anhedonia-inverters like euphoria-inducing thermogenics. Cardarine, clenbuterol, salbutamol, epicatechin, carnitine, lipo-C, tesofensene, NO boosters, fat burners with ephedra, etc.

 

[lastresort]

Epicatechin is not a peptide. Its a plant polyphenolic extract

 

[Smiter]

Epicatechin is not a peptide. Its a plant polyphenolic extract

errr...never said it was..almost all of the ones I listed are orals. Nasal inhaler version for salbutamol. Carnitine is available in both oral and injection forms.

 

[mybodyisasewer]

Apart from Cagri, and if you don't want dopamine-connected stuff, try bronchodilators, and anhedonia-inverters like euphoria-inducing thermogenics. Cardarine, clenbuterol, salbutamol, epicatechin, carnitine, lipo-C, tesofensene, NO boosters, fat burners with ephedra, etc.

Oral salbutamol is the bees knees. Effective, safe, cheap, it's a versatile drug if you're trying to cut weight, can use it to blunt hunger, or give you energy when you're tired, it is also slighty muscle sparing, so taking it fasted is more efficient for body composition. Definitely a good drug to keep around just cuz. I've never used the nasal version and honestly that sounds scary.

 

[Smiter]

I've never used the nasal version and honestly that sounds scary.

Be Afraid, be very afraid.

 

[cloratheshadow]

I agree with Cagri! Or even Tesofensine

 

[Calm Logic]

Also Clenbuterol, pretty cheap also

Cheaper than the funeral:

[archived internal link]

Google Scholar

scholar.google.com

It's a controlled substance in New Mexico because of the risk. In some other states, it may be considered a dangerous drug, with stiffer penalties for simple possession. In the UK, up to 14 years of prison time for distribution.

The bro science is why I tried clen myself last year. Besides risking my heart health, I had the some of worst muscle pain/cramps with just "therapeutic" doses of clen, even taking a lot of taurine with it.

 

[Smiter]

Also Clenbuterol, pretty cheap also

In the early 2000's I had one of my most successful training/weight loss sessions on clen without any issues. I even competed in tournaments while under clen influence. The output difference is staggering. I know so many folks who have used clen without any issues, but I know one person who collapsed on the field after taking a 25mg dose. I used 40mg. He was 65kgs, while I was 120 then.

 

[cloratheshadow]

I removed my recommendation. I didn’t know it had such bad risks. Don’t take drugs, kids.

 

[lastresort]

I am on 250mcg CJC1295/Ipamorelin and 7.5mg reta.

I tried BAM 15 by injection just a few days ago....first day 25mg, then 5mg next day because 25mg gave me a such a bad heart palpitation. Supposdely it should not cause body thermal effect or palpitation unlike DNP, but then again there has not been any clinical study, IDK.

I had the worst fatigue yesterday, a day after pinning 5mg BAM 15. Now, I dno't know if it was BAM 15 that caused it because my mom just happend to be sick from cold but I ddn't have any cold symptoms, and my resting heartrate was 120 (!) from the morning until like 5PM.

I don't know if it was a coincidence, but this morning after a BM, I lost 2lb compared to yesterday. I know it's not water weight because I always weight myself in the morning after BM.