Bacteriostatic Saline (0.9% Sodium Chloride) vs. Bacteriostatic Water

[Jfrick11]

Does anyone know if these can be used interchangeably with GLP1s? Ph is roughly the same and I can't find anything that says sodium chloride degrades this specific peptide. The straight Hospira Bac seems harder and harder to get, where the Bac NS seem readily available.

 

[Calm Logic]

Not for reta:

Bacteriostatic vs Sodium Chloride with Retatrutide- pics included [archived internal link]

 

[Jfrick11]

Not for reta:

Bacteriostatic vs Sodium Chloride with Retatrutide- pics included [archived internal link]

But fine for Tirz correct?

 

[Calm Logic]

I think so. There is no clouding with tirz. And no one has reported any problems.

Even the clouding with reta is controversial since @scarywood75 reported no clouding with reta.

 

[scarywood75]

I think so. There is no clouding with tirz. And no one has reported any problems.

Even the clouding with reta is controversial since @scarywood75 reported no clouding with reta.

It doesn't work for Ipamorelin that I know so far.

Everything else I reconstituted with isn't cloudy but sometimes need to be adjusted with a buffer, like tesamorelin and cagri

 

[Calm Logic]

Do you adjust cagri to a pH of 4 anyway? Or do you have your own acceptable range?

From what I read, saline BAC has a pH of around 5.0, while regular BAC may be 5.7. So maybe a 0.7 difference for being more acidic than regular BAC.

 

[geoguy78]

I'm under the impression that in Europe it's almost impossible to get bacteriostatic water so they use saline for everything. But maybe I'm wrong?

 

[ZippityDooDah]

I'm under the impression that in Europe it's almost impossible to get bacteriostatic water so they use saline for everything. But maybe I'm wrong?

You are correct, although it does seem that demand for BAC is increasing in the EU as peptide fever grips the world and people start digging deeper into the potential downsides of multi-dose vials without any preservative.

 

[indolent]

I'm under the impression that in Europe it's almost impossible to get bacteriostatic water so they use saline for everything. But maybe I'm wrong?

@ZippityDooDah

In Europe, do they generally use bacteriostatic saline (0.9% benzyl alcohol included), or just sterile saline?

 

[Jfrick11]

I'm under the impression that in Europe it's almost impossible to get bacteriostatic water so they use saline for everything. But maybe I'm wrong?

Same in Mexico. Bac doesn't exist

 

[texmexpep]

I have a case of this to reconstitute sema and tirz. Works great but it's not for everything. I have some of the regular Hospira bac to but I'm not touching it until I have to! lol

 

[ZippityDooDah]

@ZippityDooDah

In Europe, do they generally use bacteriostatic saline (0.9% benzyl alcohol included), or just sterile saline?

Just sterile water. BAC water is mostly a North American thing since apparently people here are too careless and ignorant and like to prepare and inject their medications disturbingly close to where they poop.

I am not aware of any endless strings of death overseas from patients using sterile water for a multi-dose vial for several weeks instead of BAC water. I truly believe BAC water came about from a combination of the government taking their solemn oath to protect us from ourselves too seriously and big pharma enjoying the windfall of selling prescription water for $2000/gallon.

 

[Rejuvenateme000!]

so which is better? the one with 0.9%? or just sterile water.

 

[CookiesPlease]

so which is better? the one with 0.9%? or just sterile water.

Peter Magic of Janoshik (and the rest of Europe) says sterile water or saline are better because they have fewer injection site issues than bac water, and last just as long.

 

[HereKittyKitty]

Peter Magic of Janoshik (and the rest of Europe) says sterile water or saline are better because they have fewer injection site issues than bac water, and last just as long.

That's very interesting. Will you share with us where he's said that? Please.

 

[Calm Logic]

Peter Magic of Janoshik (and the rest of Europe) says sterile water or saline are better because they have fewer injection site issues than bac water, and last just as long.

See above comments by Zippity.

There are other things that can be done to prevent ISRs. Like drawing the reconned solution into the syringe and leaving the capped syringe out at room temperature for 15 minutes before injection. Rotating injection sites also helps, as can injecting slowly. It also helps to let the rubbing alcohol dry for at least 30 seconds after using the rubbing alcohol wipe on the skin.

If you want the sterile water experience, another option (for those with money to burn) could be to dilute the syringe with sterile water right before injection, but that would cost about $2 for each single-use sterile water vial.

While sterile water will feel smoother, reconning with sterile water is not going to prevent bacterial growth at all. Refrigeration would be helping, but it is more for preventing aggregation than preventing bacterial growth. The reconned solution would need to be used sooner than later. Even more than a few hours would not be ideal. Excipients are food for bacterial growth, like the mannitol that is often in the lyophilized pucks.

 

[domin8brix]

in this same vein—what peps is the sodium chloride mix “required” for? I swear I read some reconstituting guide for one that said to use that specific blend and I cannot recall what it was.

 

[tedvio]

...

While sterile water will feel smoother, reconning with sterile water is not going to prevent bacterial growth at all. Refrigeration would be helping, but it is more for preventing aggregation than preventing bacterial growth. The reconned solution would need to be used sooner than later. Even more than a few hours would not be ideal....

But will saline water be OK for say 3-4 weeks, to get through a full vial of tirz?