Are reta and other weight loss drugs meant to be long term use? Whats it like coming off them?

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Smiter said:
Sea

??? Who took it negatively? It's an excellent thing. But, if a joke offended you, though I usually wouldn't give a damn, you caught me in a charitable mood today. So, I will make recompense. Okay, listen close. Get a nice black marker and paper. Save the following name, and don't tell anybody, okay. You be on the lookout for the guy when he comes out. So here it comes.....

Mibavademab.

I know..It's too much...But I can be overkind sometimes. No thanks needed.
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indolent said:
They're a medical workaround to an unsolved health problem. Like eyeglasses for myopia. Drive safely.
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You are so good at mild-toned, dry, pithy, remarks. Your posts make me smile so often.
 
Is anyone doing any type of on off cycling on Reta? I wonder when i reach my goal weight if i can come off and maintain better lifestyle and diet choices if i will only need to come back on if i slip? Also I worry will my body ever recover from Reta use or will it permanently be altered? so many questions 😵
 
DeeWizForever said:
Is anyone doing any type of on off cycling on Reta? I wonder when i reach my goal weight if i can come off and maintain better lifestyle and diet choices if i will only need to come back on if i slip? Also I worry will my body ever recover from Reta use or will it permanently be altered? so many questions 😵
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In terms of long term weight loss maintenance, how important staying on the drug is is mainly determined by how severe the problem is. If you have a BMI of 40+ and have struggled with weight forever, the the most realistic option is to stay on it long term. If you are younger and a bit over weight it is not so critical.

I think there is pretty good evidence that getting obese damages your body and worse damages the system that controls weight and appetite, and it is possible that staying at normal weights for quite a while might make it a bit better , I think in a lot of people it does not recover, so that staying in the normal weight range requires eating less calories than would be expected, plus putting up with extra hunger, which is hard to tolerate long term. I doubt very much that reta causes long term changes, but I think obesity itself does.

Given recent mouse research where weight cycling in between periods on semaglutide caused much less weight loss overall, I think, though this is very early research, it suggests that cycling on and off might not be a good idea. It is easy enough to slowly drop doses once you get to your target weight, and if you can maintain that weight on low doses great, just keep doing it, if not then you need to increase doses until weight is stable. At this point until further research is done on intermittent glp use , it would be safer to stay on low maintenance doses than stop and start. Overall , the evidence from the studies suggests that the dose needed to lose the weight is the dose needed to keep the weight off, but there is little harm in trying to reduce doses and see what happens.
 
DeeWizForever said:
Is anyone doing any type of on off cycling on Reta? I wonder when i reach my goal weight if i can come off and maintain better lifestyle and diet choices if i will only need to come back on if i slip? Also I worry will my body ever recover from Reta use or will it permanently be altered? so many questions 😵
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SURMOUNT-MAINTAIN: Continuing Tirzepatide Maintains Weight Loss - American College of Cardiology

SURMOUNT-MAINTAIN trial shows continued tirzepatide use sustains weight loss and cardiometabolic benefits, while lower doses remain effective vs placebo.

www.acc.org
 
bockscar said:
helllll yea! Thank you and gonna read those when i get off in a few 🙏 and apologies if you took any offense to my request. im just here trying to learn and I think to really get a decent understanding you should absorb material and not just parrot what folks who know more than you say. Im just like that with everything, so my apologies if it came off the wrong way which I didnt even think of until i read that reply that eluded to it
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No offense taken at all! @Smiter was just giving you shit.

If there's empirical evidence, that should be available for anyone, and since this is intended to be a learning avenue, it's something I hope others find and read through.

These things have been around in some form for decades, so while each particular medication/compound evolves and new forms come along in time, these types of meds have been working for diabetics and other metabolic issues for many many years. My sister is diabetic and has been on some form for probably 25-30 years. I know there was one or two prior to this but I know she was on Byetta since mid 2000s til probably about 5 years ago when she was switched to Trulicity then Mounjaro, which she's currently on the highest dose of. But every time she would have a hangup with insurance and lose access, every ounce of progress evaporated.
 
Eli Lilly just announced the results from 2 maintenance studies over a 2-year period. We now have some actual data from a placebo controlled study. Pretty stunning, actually.

SURMOUNT-MAINTAIN Trial: Patients who lost weight over 60 weeks on maximum doses of tirzepatide (Zepbound/Mounjaro) maintained significantly more weight reduction after another year of treatment. Participants who stayed on the maximum dose were seven times more likely to maintain their weight loss, and those who stepped down to a 5mg maintenance dose were four times more likely to maintain it, compared to stopping the drug.

ATTAIN-MAINTAIN Trial: This study demonstrated that patients could successfully transition from injectable therapies (Wegovy or Zepbound) to Eli Lilly's once-daily oral pill, orforglipron . Patients transitioning from semaglutide (Wegovy) retained over 79% of their weight loss, regaining an average of only 0.9 kg. Patients transitions from tirzepatide regained an average of 5.0 kg over one year.

Here is a nice graphic summarizing the results:

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I ran it for 13 weeks at 2mg a week. The last 2 weeks I ran 1.5mg and the last week I ran 1mg then went to SE Asia for 2 weeks. I initially started the Reta journey as a jumpstart to help me out getting healthy again and planned to get off it around the 3 month mark. I’ve heard horror stories about coming off it and the weight would come back on etc so I was nervous. But my experience is this , my cravings started coming back for fast food and alcohol so since I was on vacation I indulged in both but mostly eat street food. I did however keep up my gym routine while away as well and I didn’t step on a scale at all on vacation so when I got home I was nervous to see my weight after having a few beers and fast food abroad. To my surprise I was down another 1 1/2lb from when I left. I’m going to try to keep up my new lifestyle eating healthy and gym and see how I do without the Reta. If I feel I’m getting out of control with my cravings or gaining weight back I will start again. But once again , I only started the Reta journey as a tool to help me get back on track of being healthy. Started at 230lbs and currently at 189lbs.
 
DeeWizForever said:
Is anyone doing any type of on off cycling on Reta? I wonder when i reach my goal weight if i can come off and maintain better lifestyle and diet choices if i will only need to come back on if i slip? Also I worry will my body ever recover from Reta use or will it permanently be altered? so many questions 😵
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The links I posted indicate why NOT to do that.
 
Smiter said:
Sea

??? Who took it negatively? It's an excellent thing. But, if a joke offended you, though I usually wouldn't give a damn, you caught me in a charitable mood today. So, I will make recompense. Okay, listen close. Get a nice black marker and paper. Save the following name, and don't tell anybody, okay. You be on the lookout for the guy when he comes out. So here it comes.....

Mibavademab.

I know..It's too much...But I can be overkind sometimes. No thanks needed.
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MABs are miraculous drugs even more so than glp1s but also orders of magnitude more difficult to manufacture than peptides. You aren't likely to find a quality MAB on the black market in the next decade.
 
zpped said:
MABs are miraculous drugs even more so than glp1s but also orders of magnitude more difficult to manufacture than peptides. You aren't likely to find a quality MAB on the black market in the next decade.
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Operation: Instill Despair Successful
 
zpped said:
Just feel lucky you can stock up on reta. Current prices are ~$150 for a years supply at a fairly high dose. Buy a decades worth and keep an eye out for something better in 5 years.
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This is my plan for tirz and reta both... 👍
 
zpped said:
MABs are miraculous drugs even more so than glp1s but also orders of magnitude more difficult to manufacture than peptides. You aren't likely to find a quality MAB on the black market in the next decade.
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Hey zpped, i wanted to message you this but dont think i can cuz how new my account is.

I understand my permissions are a bit limited but can i make a post asking about peoples opinions on endotoxin testing and how essential it is? and ask for peoples opinion on MZ biolabs and to see if they have other budget but reliable options?

I finally got my peptides a couple days away from me (from a board sponsor) and im hoping to send for testing pretty much immediately since the vial im currently using is already a month old and figure i got another 2-4 weeks on it before i need a new vial. So want to get this done asap so i can start using the new stuff asap too. im set on testing for ID/Purity and content but that endotoxin is not cheap....so wondering if folks see it as a must since from my understanding you wont IMMEDIATELY die (LOL) from endotoxins 🤔
 
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