Appetite Suppression Ranking of the GLPs?

[dirtyharry]

I know right? Like I’m thinking about trying Reta but I’m nervous to take the plunge especially because Tirz is working for me. Like if it isn’t broken don’t fix it

Oh dude same here. Reta is incredible. I dont see myself ever trying anythign else. Even if they come out with the new 5 Agonist GLP, Ill still stay with Reta.

 

[dirtyharry]

I have been on Tirz since Feb 5. I am still on 2.5 mg and it has completely eliminated my hunger signals. I had to start counting calories again to make sure that I was getting enough calories in because I would go all day without eating and then eat a piece of cheese and have a bottle of water for dinner.

However, my inflammatory markers have not come down and have ticked up a few points. I also had a major flare up of (what I thought was) my Rheumatoid Arthritis but turned out to be Fibromyalgia (got the diagnosis a week ago) in April and completely stalled with weightloss. I added 1 mg of Reta last Monday with the hope that it wouldn't do more to reduce my appetite but it would start the weight loss again. And it worked. I'm now down 2 lbs and my appetite suppression is about the same.

So for me Tirz=10/10, Reta=1/10 but Reta was the lifesaver when it came to moving the scale.

This is very interesting.

 

[px1984]

So far only on Reta and only a very small dose as i want to fat burning element but dont want to completely wreck all enjoyment from eating/drinking from life.

I've found its dulled my hunger signals when it comes to eating snacks outside of meal time, generally not seeing massive differences generally with appetite but certainly seeing weight come off on the scales.

I have ordered a kit of Tirz for the freezer as a backup if things start to change and also interested in Tesa which sounds like it could help with muscle building whilst cutting (if that is even a thing)

A big component for me looking at GLPs was around how it effecting blood markets and inflammation, consistently had higher than normal cholesterol for years as well as recently flags for fatty liver so very interested to see how my next set of bloods look.

 

[PAPoots]

I've been on all 3. Tirz had the most appetite suppression. I would say sema and reta are a tie.

I've taken Sema, Reta, and Cagri.

I'd rank Cagri as #1, and I agree on Reta and Sema being tied.

I felt like I had to titrate Semaglutide and Retatrutide to the max trial levels to get results. But then the side effects kicked in. I found my happy spot at 8mg Reta and 1mg Cagri.

I think Reta and Sema works great for people who also focus on keeping their macros balanced towards slow weight loss in order to maintain their muscle growth. This group probably take low doses or micro dose.

For people with hunger control issues or who aren't responding to Reta and Sema, I think Tirz or a Cagri/Sema or Cagri/Reta might be best.

They'll all get you there, but their effectiveness comes down diet and exercise.

Fast weight loss, more than a couple pounds per week, without a good strength training program might lead to body composition results that make you feel worse than when you started.

Don't skip leg day.

 

[PAPoots]

So far only on Reta and only a very small dose as i want to fat burning element but dont want to completely wreck all enjoyment from eating/drinking from life.

I've found its dulled my hunger signals when it comes to eating snacks outside of meal time, generally not seeing massive differences generally with appetite but certainly seeing weight come off on the scales.

I have ordered a kit of Tirz for the freezer as a backup if things start to change and also interested in Tesa which sounds like it could help with muscle building whilst cutting (if that is even a thing)

A big component for me looking at GLPs was around how it effecting blood markets and inflammation, consistently had higher than normal cholesterol for years as well as recently flags for fatty liver so very interested to see how my next set of bloods look.

For muscle growth you need testosterone or hgh. Under forty, I'd recommend hgh since you might want children. after 40 get on test and tadalifil.

Tesamorelin is best for reducing visceral abdominal fat. It does very little for muscle and would be a waste of money. And the side effects suck, you'll look soft from the water gain and carpal tunnel syndrome is also a common side effect.

Keep reading the forums and you can actually search the forums using an AI tool to aggregate posts.

 

[Hawk_recon]

I've only been on reta, and I'm currently on 5mg, but I feel very little to no appetite suppression. 2/10, according to your scale. Been on it since beginning of the year and will go up to 6mg next week - if this also fails to deliver, I will quit reta. If it isn't working 6 months in, it just isn't for me. Before anyone says my reta isn't actually reta, my kit was independently tested and turned out to be significantly overfilled. I am going to try cagri or perhaps eloralintide in the near future when the prices calm down a bit.

I’ve had the same issue with Reta. Very little appetite suppression, so switching to tirz to see if that’s better.

 

[henzvwry]

I've taken sema and tirz. Sema was a 10/10 for me- but I think it was also partially because of how ill I constantly felt. Tirz is 7/10, but I prefer it much more. Haven't tried Reta.

 

[miameow]

I’ve had the same issue with Reta. Very little appetite suppression, so switching to tirz to see if that’s better.

It seems like there are quite a few of us non-responders here. I did titrate up to 6mg but again, absolutely no appetite suppression at all. I’m also curious about tirz. I’ll first try cagri then consider tirz if all else fails!

 

[Hawk_recon]

It seems like there are quite a few of us non-responders here. I did titrate up to 6mg but again, absolutely no appetite suppression at all. I’m also curious about tirz. I’ll first try cagri then consider tirz if all else fails!

Good to know there are others like me. It’s strange. I wonder what makes the difference. I thought about cagri too, but will see how tirz goes first. Thanks for the reply

 

[DrPEPr]

Sema: no experience

Tirz: 8/10

Reta: 6.5/10

Cagri: 9/10

Both tirz and cagri are a bit too much for me when it comes to hunger supression.

Reta provides just the right balance between being able to eat and resisting cravings.

 

[BNLFL]

I'm only curious about information that actually matters. I'm asking if the information is actually useful or important for anything related to what these drugs are designed for.

Thanks for the input Doctor.

Oh dude same here. Reta is incredible. I dont see myself ever trying anythign else. Even if they come out with the new 5 Agonist GLP, Ill still stay with Reta.

I agree, and have enough to back it up.

 

[Omxxl]

Good question, and honestly the answer is more interesting than people expect because these three compounds don't suppress appetite the same way at all, even if the end result on the scale looks similar.

My personal ratings, 1-10:

Semaglutide: 6/10. Solid, steady, kind of a "background" suppression. You notice you're just not thinking about food as much, but if food is in front of you, you'll still want it. Cravings stay mostly intact.

Tirzepatide: 8/10. This one is on another level for pure appetite shutdown. The GIP component seems to amplify the satiety signal hard. I'd get full from half a plate and the thought of eating more felt almost physically off-putting. Strongest hunger killer of the three by a clear margin in my experience.

Retatrutide: 5/10. And this is where it gets interesting, because on paper you'd expect reta to suppress the most, given it's a triple agonist. But the appetite suppression itself is actually milder than tirze for me, and a notch below sema too.

So why is reta still working so well if the hunger suppression is the weakest of the three? This is where the glucagon agonism completely changes the game, and I think a lot of people miss this when they compare compounds purely on "how much does it kill hunger."

What I notice on reta that I didn't get on the other two:

No alcohol cravings at all. Like, zero pull. Sema and tirze reduced it a bit, but with reta the desire just isn't there. There's actually emerging literature on GLP-1s and reward pathways (a lot of the addiction/alcohol use disorder trials are running on sema and tirze right now), but anecdotally reta hits this harder for me. Might be the glucagon component amplifying the dopaminergic effects, might be something else, but the effect is real.

Sweet cravings are way down. Sema and tirze killed hunger but I still wanted sweets specifically. On reta the actual desire for sugar isn't there. Big difference between "I'm not hungry" and "I genuinely don't want that donut." Reta does the second one.

Energy is noticeably higher. This is the glucagon receptor agonism doing its thing. Glucagon increases hepatic glucose output and bumps up resting energy expenditure, basically your body is running a bit hotter. You feel it. On sema and tirze in a deficit I'd get the typical lethargic, cold-hands, low-energy diet feeling. On reta I'm in a deficit and I still feel like training, still warm, still sharp. That's a huge quality-of-life difference when you're cutting.

So the way I'd frame it for anyone choosing between them:

If your problem is pure volume of food / can't stop eating, tirze is the strongest tool.

If you want steady, sustainable, mild suppression with a good safety record, sema.

If your problem is cravings (alcohol, sweets, reward-driven eating) and you want to actually feel good while losing fat, reta is in a different category.

The appetite number doesn't tell the whole story with reta. It's working on the metabolic side as much as the appetite side, and that's why people are getting these crazy recomp results even at modest doses.

 

[Imfrijole]

Been on Retatrutide for the last few months and the results have been amazing. I've seen people mention here before that the appetite supression effects of Reta are lower than that of Tirzepitide or Semuglutide. Either way, it's certainly enough for me. So this got me thinking. How would members of this community rank the supression of appetite effects from each of the GLPs? Semuglutide, Tirzepitide, Retatrutide, Cagrilintide, and maybe even other ones.

On a scale of 1 to 10. 1 being normal appetite (not on any GLP), and 10 being you could litteraly go the entire day without eating, how would you guys rank these GLPs? Could maybe even include the appetite supression effects of Melanotan-2 in there honestly.

Since my only experience is with Retarutide, I'd rank it a 8.5/10.

Been on Reta for 10 weeks, up to 4mg. I started feeling slight appetite suppression at 2mg but never really felt much until 4mg. It still doesn’t really suppress my appetite, it just makes me feel kinda full already and makes me get fuller faster.

 

[Calm Logic]

Tirz can increase thermogenesis (energy use) using GIP-based "futile calcium cycling." But probably at least 10x less energy use than reta's glucagon-based thermogenesis. And reta does futile calcium cycling too.

 

[Smiter]

Good question, and honestly the answer is more interesting than people expect because these three compounds don't suppress appetite the same way at all, even if the end result on the scale looks similar.

My personal ratings, 1-10:

Semaglutide: 6/10. Solid, steady, kind of a "background" suppression. You notice you're just not thinking about food as much, but if food is in front of you, you'll still want it. Cravings stay mostly intact.

Tirzepatide: 8/10. This one is on another level for pure appetite shutdown. The GIP component seems to amplify the satiety signal hard. I'd get full from half a plate and the thought of eating more felt almost physically off-putting. Strongest hunger killer of the three by a clear margin in my experience.

Retatrutide: 5/10. And this is where it gets interesting, because on paper you'd expect reta to suppress the most, given it's a triple agonist. But the appetite suppression itself is actually milder than tirze for me, and a notch below sema too.

So why is reta still working so well if the hunger suppression is the weakest of the three? This is where the glucagon agonism completely changes the game, and I think a lot of people miss this when they compare compounds purely on "how much does it kill hunger."

What I notice on reta that I didn't get on the other two:

No alcohol cravings at all. Like, zero pull. Sema and tirze reduced it a bit, but with reta the desire just isn't there. There's actually emerging literature on GLP-1s and reward pathways (a lot of the addiction/alcohol use disorder trials are running on sema and tirze right now), but anecdotally reta hits this harder for me. Might be the glucagon component amplifying the dopaminergic effects, might be something else, but the effect is real.

Sweet cravings are way down. Sema and tirze killed hunger but I still wanted sweets specifically. On reta the actual desire for sugar isn't there. Big difference between "I'm not hungry" and "I genuinely don't want that donut." Reta does the second one.

Energy is noticeably higher. This is the glucagon receptor agonism doing its thing. Glucagon increases hepatic glucose output and bumps up resting energy expenditure, basically your body is running a bit hotter. You feel it. On sema and tirze in a deficit I'd get the typical lethargic, cold-hands, low-energy diet feeling. On reta I'm in a deficit and I still feel like training, still warm, still sharp. That's a huge quality-of-life difference when you're cutting.

So the way I'd frame it for anyone choosing between them:

If your problem is pure volume of food / can't stop eating, tirze is the strongest tool.

If you want steady, sustainable, mild suppression with a good safety record, sema.

If your problem is cravings (alcohol, sweets, reward-driven eating) and you want to actually feel good while losing fat, reta is in a different category.

The appetite number doesn't tell the whole story with reta. It's working on the metabolic side as much as the appetite side, and that's why people are getting these crazy recomp results even at modest doses.

Fvck...beat me to it. I was just about to do the thermogenic effect rating. In my experience, I used sema back in 2020 and 2021. It did suppress my hunger for a day or two, but did nothing to curb the gargantuan sweet tooth possessing my body and soul. I give it a 5/10.

Reta is more like Agent 47, and its suppression is on ninja mode. It doesn't kick your ass when you see food. It's more subtle. It's like you have this dutiful, loyal friend who wears Predator-esque camouflage and when food is around, he is like, "Hey look at the ass on that chick. Now that's cake worth eating", and you dont notice the food anymore. I would rate the suppression a 6/10.

Modafinil suppression- I put at a pleasant 3/10.

But for Tesofensine, i would give a 2/10...weak sauce.

But on the Asia Black-25, I would give it a 7/10 on appetite suppression.

With Reta, Asia Black, modafinil, the trio gives me a 13/10 appetite suppression. I have to remove my glasses, roll my shirt sleeves and stuff food down my throat.

 

[BadguyPep]

I’ve honestly had better appetite suppression on Reta than any other GLP really dialed in my defecit

 

[longestyards]

I've only been on reta, and I'm currently on 5mg, but I feel very little to no appetite suppression. 2/10, according to your scale. Been on it since beginning of the year and will go up to 6mg next week - if this also fails to deliver, I will quit reta. If it isn't working 6 months in, it just isn't for me. Before anyone says my reta isn't actually reta, my kit was independently tested and turned out to be significantly overfilled. I am going to try cagri or perhaps eloralintide in the near future when the prices calm down a bit.

That’s insane that it doesn’t work for you! I can’t believe how depressing it must be to find out something that works awesome for everyone doesn’t work for you. How long have you been on reta now?

 

[miameow]

That’s insane that it doesn’t work for you! I can’t believe how depressing it must be to find out something that works awesome for everyone doesn’t work for you. How long have you been on reta now?

I don't find it depressing at all and in fact, I have found many non-responders like myself here on this forum. I take it more for insulin and longevity related issues, so it was a personal experiment more than anything else. I'm on month six, 6mg, hungrier than ever. I will be closing my reta experiment soon.

 

[longestyards]

I've only been on reta, and I'm currently on 5mg, but I feel very little to no appetite suppression. 2/10, according to your scale. Been on it since beginning of the year and will go up to 6mg next week - if this also fails to deliver, I will quit reta. If it isn't working 6 months in, it just isn't for me. Before anyone says my reta isn't actually reta, my kit was independently tested and turned out to be significantly overfilled. I am going to try cagri or perhaps eloralintide in the near future when the prices calm down a bit.

By the way, what do you mean your reta was independently tested? Did you send to a testing lab yourself?

 

[miameow]

By the way, what do you mean your reta was independently tested? Did you send to a testing lab yourself?

Yes, indeed I had it tested as I've noted in my post. It was overfilled with high purity. Also tested for endos, and I filter all of my peps.