Anyone suddenly become intolerant to Tirz overnight?

[Mara_aa]

I have, and to be honest I have no good reason for not trying it other than I had already purchased a few kits of Tirz. I will probably take another look once I run out or cant hit my goal weight.

Honestly, that is an extremely valid reason lol

And if Tirz is still working for you overall, it totally makes sense not to switch prematurely. That was exactly my plan too before my body decided to stage this dramatic protest.

 

[desinr-gal]

The Tirz reaction/symptoms definitely started first. The antivirals were started a few days later because of the suspected shingles/herpes zoster situation.

And yes, antivirals can also be rough, which honestly makes the whole thing even more confusing to untangle

Sounds awful! I am sorry you are having this experience

 

[BNLFL]

… out of my own lack of knowledge, I had only ever heard about the “needles/allodynia/sunburn skin” thing with Reta, not Tirz, so when it appeared only on one side I completely trusted the suspected shingles/herpes zoster diagnosis.

“I would pin it on the Tirz” deserves an award lol

Seriously, thank you so much I’m absolutely telling my doctor about this tomorrow morning… although I probably won’t be thanking him for the 7 days of antivirals that may have flattened me even more.

The reason I keep suspecting Tirz is because the symptoms accompanying the extreme fatigue are very specifically: severe nausea, acid reflux, extreme gastric slowing/fullness, inability to eat or drink normally, etc.

Those are basically the exact same symptoms I experienced when I first started Tirz, just amplified to an extreme level this time

Yes, I do suspect the antivirals may have made everything worse on top of what was already happening lol

Thank you so much I really hope this nightmare starts fading soon too

Honestly, that is an extremely valid reason lol

And if Tirz is still working for you overall, it totally makes sense not to switch prematurely. That was exactly my plan too before my body decided to stage this dramatic protest.

Not sure you know, but you can multi quote and reply to each separately.

 

[Mara_aa]

Sounds awful! I am sorry you are having this experience

Thank you so much

I’m very slowly improving, so I’m trying to stay hopeful!

 

[Mara_aa]

Not sure you know, but you can multi quote and reply to each separately.

I have to confess that I do know about that feature because I’ve seen other users use it, but on my phone I keep trying and somehow end up making a mess and then can’t find all the quotes I wanted to reply to anymore.

I don’t really have the same problem on PC, but outside of work hours I barely use it.

I hope I’m not becoming annoying by replying to individual posts one by one.

Still, thank you for the lesson.

 

[BNLFL]

I have to confess that I do know about that feature because I’ve seen other users use it, but on my phone I keep trying and somehow end up making a mess and then can’t find all the quotes I wanted to reply to anymore.

I don’t really have the same problem on PC, but outside of work hours I barely use it.

I hope I’m not becoming annoying by replying to individual posts one by one.

Still, thank you for the lesson.

Nah, just wasn't sure you knew.

 

[Mara_aa]

Nah, just wasn't sure you knew.

Got it! As long as I'm not being annoying, that's what matters ahah

Thanks for patience and for taking the time to explain anyway. I really appreciate it.

 

[lessthanhalf]

I also get skin sensitivity / abnormal sensations from tirz. I got it when increasing doses originally, and now I am on both tirz and reta, it gets obviously worse with tiny dose increases of either reta or tirz.

It is also weirdly patchy, often worse on my left shoulder, or both arms and occasionally it hits local leg nerves, thankfully it is pretty mild unless I accidentally have a slightly higher dose.

I have tried to research this and really cannot find much on it other than being mentioned as a side effect in some of the studies. It is interesting that it seems to be more likely from reta, and it was rare in the semaglutide studies, but in the high dose semaglutide studies of 7.2 and 16 mg, it was very common , up to 20%. So given that sema does not affect anything other than GLP-1, it more or less has to be a GLP-1 effect, which totally fails to explain why it seems to be more common with reta. I have discussed this with chatgpt , it does not seem to think there are any concerns about actual long term nerve damage occurring from it, and as far as I know there are no reports of nerve damage from GLP drugs, which is reassuring I guess.

There is no obvious pharmacology explanation for why you suddenly got much more severe side effects. Apart from some of them being made worse by having a virus at the same time. All you can really do is avoid dosing until the effects have settled down a lot, and restart a fair bit lower, and half the dose twice as often will make it easier to adjust doses up and down if needed.

 

[sheilarae74]

The malaise/apathy part is something I really relate to too. It’s not just nausea, it’s this strange full-body “I can barely function as a human being” feeling.

THIS IS EXACTLY HOW I FELT! I had to force myself to do everything for the last 10 days.

What you said about increasing because the previous weeks felt “too mild” is really interesting too. It honestly makes me wonder whether there really can be some kind of delayed accumulation/saturation effect with these peptides.

Maybe when I restart, I could even consider splitting my microdose at first.

Also: I kinda love you for sharing such a similar experience and I seriously admire you for surviving this without even skipping a dose, because right now I am far too traumatized to even LOOK at a syringe.

You might be right about the accumulation thing. The last dose of 5mg I took last sunday was from a new vial, as the last vial didn't even even last 4 weeks. I am thinking this new vial might be more than the 20mg it was supposed to be. Plus this time I reserved some of the BAC to prime the filter and flush the last bit of reta out of it after I filtered it. The COA some guy showed me of the vial he had tested from that same batch had 22mg in it. That's the only thing I can think of. I was supposed to take my dose last night but I figured I better wait until I'm well.

Since I feel a lot better today, I think I am going to pin 2mg tonight and then another 2mg on Friday morning if things go well.

I don't blame you for being apprehensive about starting back up. I never want to feel like that again and I'm sure you don't either. I guess that's risk we take doing these China peps. I'm 12lbs from my goal and I'm not in a big hurry so I am gonna split for a while and see how it goes.

 

[Mara_aa]

I also get skin sensitivity / abnormal sensations from tirz. I got it when increasing doses originally, and now I am on both tirz and reta, it gets obviously worse with tiny dose increases of either reta or tirz.

It is also weirdly patchy, often worse on my left shoulder, or both arms and occasionally it hits local leg nerves, thankfully it is pretty mild unless I accidentally have a slightly higher dose.

I have tried to research this and really cannot find much on it other than being mentioned as a side effect in some of the studies. It is interesting that it seems to be more likely from reta, and it was rare in the semaglutide studies, but in the high dose semaglutide studies of 7.2 and 16 mg, it was very common , up to 20%. So given that sema does not affect anything other than GLP-1, it more or less has to be a GLP-1 effect, which totally fails to explain why it seems to be more common with reta. I have discussed this with chatgpt , it does not seem to think there are any concerns about actual long term nerve damage occurring from it, and as far as I know there are no reports of nerve damage from GLP drugs, which is reassuring I guess.

There is no obvious pharmacology explanation for why you suddenly got much more severe side effects. Apart from some of them being made worse by having a virus at the same time. All you can really do is avoid dosing until the effects have settled down a lot, and restart a fair bit lower, and half the dose twice as often will make it easier to adjust doses up and down if needed.

Thank you so much for taking the time to write such a detailed reply. This is genuinely very helpful and reassuring to read.

What you describe about the skin sensitivity being patchy/random and clearly worsening with dose increases sounds incredibly similar to what several people in this thread are describing, and honestly I had no idea this side effect could be this “real” and still so poorly understood.

The fact that you looked into the studies and found that it appears even with high-dose semaglutide is also really interesting. Obviously none of us can fully explain the mechanism, but it does make me feel a bit less like I’m losing my mind

And thank you especially for mentioning the lack of evidence regarding long-term nerve damage. I know ChatGPT is not a medical authority, but hearing that there do not seem to be reports of permanent nerve injury from GLP drugs is still psychologically reassuring when your skin suddenly feels bizarre.

Your explanation about the virus potentially amplifying already-existing GLP side effects honestly makes a lot of sense too. Maybe my body just hit some kind of temporary “too much at once” threshold.

For now I am definitely not dosing again until things calm down substantially. And if I ever restart, I think smaller and more frequent split doses will probably be the safest approach for me too.

Seriously, thank you again for such a thoughtful and balanced response

 

[Mara_aa]

THIS IS EXACTLY HOW I FELT! I had to force myself to do everything for the last 10 days.

You might be right about the accumulation thing. The last dose of 5mg I took last sunday was from a new vial, as the last vial didn't even even last 4 weeks. I am thinking this new vial might be more than the 20mg it was supposed to be. Plus this time I reserved some of the BAC to prime the filter and flush the last bit of reta out of it after I filtered it. The COA some guy showed me of the vial he had tested from that same batch had 22mg in it. That's the only thing I can think of. I was supposed to take my dose last night but I figured I better wait until I'm well.

Since I feel a lot better today, I think I am going to pin 2mg tonight and then another 2mg on Friday morning if things go well.

I don't blame you for being apprehensive about starting back up. I never want to feel like that again and I'm sure you don't either. I guess that's risk we take doing these China peps. I'm 12lbs from my goal and I'm not in a big hurry so I am gonna split for a while and see how it goes.

The “I have to force myself to function like a normal human being” part has been one of the scariest aspects for me too. It’s such a strange kind of malaise because it feels way beyond ordinary nausea or fatigue.

Your theory about the vial actually makes a lot of sense, especially combined with the accumulation possibility. A slightly overdosed vial + delayed build-up could absolutely explain why it suddenly felt so disproportionate after previously tolerating it.

Hearing that you already feel much better today gives me a lot of hope, because I’m also improving… just frustratingly slowly haha

Your split-dose plan sounds really reasonable and cautious to me. Please report back how it goes, because right now I feel emotionally betrayed by syringes and I need success stories…

Also congratulations on being only 12 lbs from goal, honestly at that point taking things slowly and carefully sounds very wise.

 

[sheilarae74]

The “I have to force myself to function like a normal human being” part has been one of the scariest aspects for me too. It’s such a strange kind of malaise because it feels way beyond ordinary nausea or fatigue.

Your theory about the vial actually makes a lot of sense, especially combined with the accumulation possibility. A slightly overdosed vial + delayed build-up could absolutely explain why it suddenly felt so disproportionate after previously tolerating it.

Hearing that you already feel much better today gives me a lot of hope, because I’m also improving… just frustratingly slowly haha

Your split-dose plan sounds really reasonable and cautious to me. Please report back how it goes, because right now I feel emotionally betrayed by syringes and I need success stories…

Also congratulations on being only 12 lbs from goal, honestly at that point taking things slowly and carefully sounds very wise.

I took 2mg last night and I still feel ok. I am going to pin that dose every 3.5 days for a while and see how it goes.

 

[chipsandsalsayall]

Yes, this has happened to me, one time. I had been on Zepbound for about 6 months, then had to change to compounded (not gr*y). About 2 month into the compounded (7.5 mg IIRC), I got really bad nausea, diarrhea, and all manner of gastric rumblings and burps. Bad, I mean really bad. I didn't eat anything rich or greasy. Nothing was different. Then after about 2 - 3 days it subsided and never happened again. I almost went to the doctor, but I'm stubborn. Never has happened again. Weird.

 

[lessthanhalf]

Malaise or an illness response is a GLP-1 effect, and often goes with nausea and or food aversion. Basically designed to get you to lie down and rest and recover, and feel like crap while you do it so you are not inclined to get up and do anything. I definitely had all of those on ozempic , even at low doses. The circuits in the brain for malaise and nausea are linked and get activated by illness or toxic substances, or by GLP-1 activation. Thankfully the malaise side effect does not seem to be very common, and is definitely dose dependent. The GIP agonism in tirz and reta act against this effect making it less of an issue.

 

[lil ghost]

After 5 weeks at 3 mg, everything happened all at once, as if I had injected 30 mg instead of 3 mg. Same vial, NO dosing mistake, no math crimes committed.

My stomach basically factory-reset itself. I got hit with nausea unlike anything I’ve ever experienced, extreme weakness, and a general feeling of absolute doom.

The same thing happened to me! On Friday, I took my standard dose of 2.5 mg of tirz and then woke up on Saturday with horrible nausea and I was unable to eat or drink anything. I vomited on Sunday after trying to eat something and I've been weak, shaky, and dead tired since. I'm definitely skipping my next dose and lowering it next time I take it.

 

[Mara_aa]

I took 2mg last night and I still feel ok. I am going to pin that dose every 3.5 days for a while and see how it goes.

Please keep updating if you can, because I am now emotionally invested in your nervous system lol

 

[Mara_aa]

Yes, this has happened to me, one time. I had been on Zepbound for about 6 months, then had to change to compounded (not gr*y). About 2 month into the compounded (7.5 mg IIRC), I got really bad nausea, diarrhea, and all manner of gastric rumblings and burps. Bad, I mean really bad. I didn't eat anything rich or greasy. Nothing was different. Then after about 2 - 3 days it subsided and never happened again. I almost went to the doctor, but I'm stubborn. Never has happened again. Weird.

The fact that it never happened again afterwards is incredibly reassuring to read right now.

What you describe sounds very similar to this strange “sudden hit by a truck after months of stability” pattern that several people in this thread seem to have experienced.

I’m really hoping mine ends up being just temporary GLP chaos too

 

[sheilarae74]

Please keep updating if you can, because I am now emotionally invested in your nervous system lol

I will next week, I promise.

 

[sheilarae74]

Please keep updating if you can, because I am now emotionally invested in your nervous system lol

Well, I been doing 2.5mg every 3.5 days since and it is working very well. The only time I feel any nausea is when I am not getting enough hydration and I don't ever get super exhausted if I eat enough protein. I also added Nicotinamide Riboside and methylene blue to my supplement regimen and my energy level is a lot better. I have been able to accomplish quite a bit around the house every weekend, so I think I made the right decision to split my dose 2x weekly.