Anyone suddenly become intolerant to Tirz overnight?

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Mara_aa

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After 5 weeks at 3 mg, everything happened all at once, as if I had injected 30 mg instead of 3 mg. Same vial, NO dosing mistake, no math crimes committed.

My stomach basically factory-reset itself. I got hit with nausea unlike anything I’ve ever experienced, extreme weakness, and a general feeling of absolute doom.

For the last 10 days I’ve barely been able to stand upright. Minimal movement gives me shortness of breath and tachycardia, like I’m training for the Olympics every time I walk to the kitchen. Blood sugar low-ish (not dangerously low), blood pressure also low.

To make things even weirder, I simultaneously caught a monster cold and ended up taking antivirals for suspected shingles/herpes zoster because I had this horrible “needles in the skin” sensation.

Except… no rash. No blisters. Nothing. So apparently even my possible shingles wanted to stay mysterious and dramatic.

Doctor basically shrugged and told me to skip last Thursday’s dose. Bloodwork results arrive May 20th.

Today Shotsy estimates my level at 1.48 mg and I’m slightly better, meaning I’ve upgraded from “barely functioning houseplant” to “weak but technically alive.” I still barely eat or drink though.

My current fear is that I somehow became suddenly and permanently intolerant to Tirz overnight. I can’t really find stories similar to this, so I’m wondering: has anyone experienced a sudden hypersensitivity/reaction like this after previously tolerating the dose just fine? Any theories, experiences, or reassuring stories welcome.

For context: I’ve always struggled a LOT with Tirz and was actually close to quitting completely. Then, thanks to you guys, I discovered microdosing, which made things much more manageable.

That said, it has never really been an “easy” medication for me, but the results were worth tolerating a bit of suffering.
 
The tingling, painful skin can be side effects of both Tirz and Reta.....but seems to be more prevalent with Reta. It almost sounds like a Reta OD. You say you are positive it is the same vial/dosing etc? You have not added anything else new?
 
Yes, this happened to me last summer while on regular prescription Mounjaro. The day after injektion, suddenly nausea like never before, and just very bad diarrhea. It was a struggle to even stay hydrated due to the nausea, forget trying to eat anything for a week. I was at a higher dose (7,5mg) but I had been at that dose for 5 weeks and it was the same pen as the 2 weeks prior.

Good news is that it is not permanent (only from personal experience), I did stop cold as I was very scared of it happening again, so I stayed off for about 4 months. Then got curious about grey and started again just on low dose (Tirz 2,5mg) for maintenance and help with food noise. After a while on low dose, I decided to increase as I never got to my goal weight and was still obese. I have now lost an additional 5kg since slowly tritating up.
 
I know you said no dosing mistake, but boy does it sound like a dosing mistake. You hear lots of stories about dosing mistakes and none about sudden intolerance issues. I've been absolutely sure of things in the past and been wrong befote. Plenty of people have talked about forgetting they had taken it and taking it again or just totally drawing the wrong amount. If it were me and it was working well, I'd probably wait till I was feeling better then start again at a slightly dose and see what happens.
 
I know you mentioned not a new vial, but maybe now its built up in your system? Is it a new kit from a different vendor you haven't used before? I heard some people have sides on some vs others.
 
I have been going through the exact same thing with reta over the past 10 days. I titrated up to 5mg 2 weeks ago and a few days later, I started feeling nauseous and haven't felt like doing anything all week. Malaise I guess they call it. I have had to force myself to eat. I have never felt this way the whole 17 weeks I have been on it. I ramped up my hydration because I thought it was that at first and and that is usually how I feel when I am dehydrated. So I loaded up on hydration drinks and ate so much damn salt my hands are puffy. I stopped taking all of my supplements except magnesium and potassium since last week, even stopping the GHK-cu this weekend and I still feel crappy.

I started my new kit a month ago and the first two weeks I felt almost nothing, so that is why I titrated up in the first place.

I feel slightly better today but I think once I stop feeling this way I am going to try to split up my dose and take 2.5mg every 3.5 days and see if that helps.
 
CandyCap said:
The tingling, painful skin can be side effects of both Tirz and Reta.....but seems to be more prevalent with Reta. It almost sounds like a Reta OD. You say you are positive it is the same vial/dosing etc? You have not added anything else new?
Yes, I’m positive: same vial, same concentration, same dosing routine, and I’m sure I didn’t make a dosing mistake.

I haven’t added Reta or any other new peptide. Nothing new at all, except the antivirals, but those were started only after the skin symptoms had already appeared because my doctor suspected shingles/herpes zoster.

I actually knew about the “needle skin” sensation with Reta, but not with Tirz. Now I’m starting to wonder whether that was Tirz too. The strange thing is that it only happened on my left side, which is why shingles/herpes zoster was suspected in the first place (because it wasn’t bilateral).

I was definitely dealing with a pretty bad cold and a period of intense stress, but the reaction still felt completely disproportionate.

That’s why I’m so confused, it really felt like an overdose, but I can’t find any practical explanation for one.
 
Ascojoerg said:
Yes, this happened to me last summer while on regular prescription Mounjaro. The day after injektion, suddenly nausea like never before, and just very bad diarrhea. It was a struggle to even stay hydrated due to the nausea, forget trying to eat anything for a week. I was at a higher dose (7,5mg) but I had been at that dose for 5 weeks and it was the same pen as the 2 weeks prior.

Good news is that it is not permanent (only from personal experience), I did stop cold as I was very scared of it happening again, so I stayed off for about 4 months. Then got curious about grey and started again just on low dose (Tirz 2,5mg) for maintenance and help with food noise. After a while on low dose, I decided to increase as I never got to my goal weight and was still obese. I have now lost an additional 5kg since slowly tritating up.
Thank you so much for this reply, this is incredibly reassuring to read right now.

What scared me the most was exactly the fact that it happened after weeks at the same stable dose.

Your description sounds VERY similar, except I got more nausea/weakness than diarrhea. The “can barely stay hydrated” part especially is exactly what I’ve been experiencing.

And thank you for mentioning that it was not permanent for you. Right now my brain is catastrophizing a bit and convincing me that my body has suddenly decided Tirz is poison forever…

Today is already day 12 for me and the improvements are still very mild, so at the moment the idea of taking another dose is absolutely not happening 😂

Have you ever considered trying Reta instead? I honestly can’t imagine going back to my old level of food noise long term.

I’m really happy you managed to restart successfully and even continue losing weight by titrating slowly again.
 
5byfive said:
I know you said no dosing mistake, but boy does it sound like a dosing mistake. You hear lots of stories about dosing mistakes and none about sudden intolerance issues. I've been absolutely sure of things in the past and been wrong befote. Plenty of people have talked about forgetting they had taken it and taking it again or just totally drawing the wrong amount. If it were me and it was working well, I'd probably wait till I was feeling better then start again at a slightly dose and see what happens.
Honestly, I completely understand why you’d think that, if I were reading this from the outside, I’d probably suspect a dosing mistake too 😅

That’s also why this whole situation has been so confusing for me: the symptoms felt almost like an overdose. And I keep wondering whether it could even be some kind of accumulation effect; at this point, I don’t know what to think anymore.

I checked the dose very carefully, I’ve always been extremely cautious with Tirz because I tend to react strongly to it. I’m almost overly careful with dosing because of the side effects I’ve had in the past; if I’m even one click unsure, I’d rather throw everything away than risk ending up with a much rougher week than usual.

Your suggestion does make sense. I genuinely want to continue, it has changed my life, and I really felt like I had finally found some balance with my food noise. So when I start again I’ll follow your advice and begin at a lower dose, taking things very slowly. I just hope I haven’t become intolerant to it.
 
desinr-gal said:
Anti virals are no picnic either.. which did you start first?
The Tirz reaction/symptoms definitely started first. The antivirals were started a few days later because of the suspected shingles/herpes zoster situation.

And yes, antivirals can also be rough, which honestly makes the whole thing even more confusing to untangle 😭
 
WLBLD said:
I know you mentioned not a new vial, but maybe now its built up in your system? Is it a new kit from a different vendor you haven't used before? I heard some people have sides on some vs others.
Honestly, the build-up/accumulation theory genuinely makes the most sense to me right now, especially combined with stress and being sick at the same time.

And no, it wasn’t a new vendor or a new batch. Same source I had already been using and tolerating before this happened.

What really threw me off is that the reaction felt so sudden and disproportionate compared to my “usual” Tirz side effects.
 
Mara_aa said:
Have you ever considered trying Reta instead? I honestly can’t imagine going back to my old level of food noise long term.
I have, and to be honest I have no good reason for not trying it other than I had already purchased a few kits of Tirz. I will probably take another look once I run out or cant hit my goal weight.
 
Mara_aa said:
I actually knew about the “needle skin” sensation with Reta, but not with Tirz. Now I’m starting to wonder whether that was Tirz too. The strange thing is that it only happened on my left side, which is why shingles/herpes zoster was suspected in the first place (because it wasn’t bilateral).

The needles/sunburn "allodynia" definitely does not need to be bilateral for it to be from the Tirz (or from Reta). I've experienced it on both peptides, and presents wherever it wants- I've had it: around ankles, tops of the feet, upper thighs, glutes, back, stomach, even my cheek/face (only the right side). I would pin it (pun intended) on the Tirz before shingles.
 
sheilarae74 said:
I have been going through the exact same thing with reta over the past 10 days. I titrated up to 5mg 2 weeks ago and a few days later, I started feeling nauseous and haven't felt like doing anything all week. Malaise I guess they call it. I have had to force myself to eat. I have never felt this way the whole 17 weeks I have been on it. I ramped up my hydration because I thought it was that at first and and that is usually how I feel when I am dehydrated. So I loaded up on hydration drinks and ate so much damn salt my hands are puffy. I stopped taking all of my supplements except magnesium and potassium since last week, even stopping the GHK-cu this weekend and I still feel crappy.

I started my new kit a month ago and the first two weeks I felt almost nothing, so that is why I titrated up in the first place.

I feel slightly better today but I think once I stop feeling this way I am going to try to split up my dose and take 2.5mg every 3.5 days and see if that helps.
This actually sounds VERY similar to what I’m experiencing, especially the delayed “what the hell is happening to my body” aspect of it.

The malaise/apathy part is something I really relate to too. It’s not just nausea, it’s this strange full-body “I can barely function as a human being” feeling.

I also thought dehydration/electrolytes might be the main issue at first and started aggressively hydrating, but it never fully explained the severity of the symptoms.

What you said about increasing because the previous weeks felt “too mild” is really interesting too. It honestly makes me wonder whether there really can be some kind of delayed accumulation/saturation effect with these peptides.

Maybe when I restart, I could even consider splitting my microdose at first.

Also: I kinda love you for sharing such a similar experience and I seriously admire you for surviving this without even skipping a dose, because right now I am far too traumatized to even LOOK at a syringe.
 
Mara_aa said:
Honestly, the build-up/accumulation theory genuinely makes the most sense to me right now, especially combined with stress and being sick at the same time.

And no, it wasn’t a new vendor or a new batch. Same source I had already been using and tolerating before this happened.

What really threw me off is that the reaction felt so sudden and disproportionate compared to my “usual” Tirz side effects.
Maybe its also bc the antiviral combo. I hope you feel better soon!!
 
Mara_aa said:
To make things even weirder, I simultaneously caught a monster cold and ended up taking antivirals for suspected shingles/herpes zoster because I had this horrible “needles in the skin” sensation.

Except… no rash. No blisters. Nothing. So apparently even my possible shingles wanted to stay mysterious and dramatic.

Why are we to assume that the issue is actually the tirz and not the virus?
 
DragonOfTheSea said:
The needles/sunburn "allodynia" definitely does not need to be bilateral for it to be from the Tirz (or from Reta). I've experienced it on both peptides, and presents wherever it wants- I've had it: around ankles, tops of the feet, upper thighs, glutes, back, stomach, even my cheek/face (only the right side). I would pin it (pun intended) on the Tirz before shingles.
… out of my own lack of knowledge, I had only ever heard about the “needles/allodynia/sunburn skin” thing with Reta, not Tirz, so when it appeared only on one side I completely trusted the suspected shingles/herpes zoster diagnosis.

“I would pin it on the Tirz” deserves an award lol

Seriously, thank you so much 🫶 I’m absolutely telling my doctor about this tomorrow morning… although I probably won’t be thanking him for the 7 days of antivirals that may have flattened me even more.
 
MsGizmo said:
Why are we to assume that the issue is actually the tirz and not the virus?
The reason I keep suspecting Tirz is because the symptoms accompanying the extreme fatigue are very specifically: severe nausea, acid reflux, extreme gastric slowing/fullness, inability to eat or drink normally, etc.

Those are basically the exact same symptoms I experienced when I first started Tirz, just amplified to an extreme level this time
 
WLBLD said:
Maybe its also bc the antiviral combo. I hope you feel better soon!!
Yes, I do suspect the antivirals may have made everything worse on top of what was already happening lol

Thank you so much 🫶 I really hope this nightmare starts fading soon too
 
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