
I'm up to 3mg/week after titrating up from 1mg/week 6 weeks ago. I've noticed with each dose increase an significant increase in my thirst - anyone else? Alot more thirst than prior to this GLP.


I wasn’t particularly thirsty but I didn’t drink enough water when I titrated too quickly at one point and became dehydrated (according to my scale) and just how I felt.tendency said:I'm up to 3mg/week after titrating up from 1mg/week 6 weeks ago. I've noticed with each dose increase a significant increase in my thirst - anyone else? Alot more thirst than prior to this GLP.


Seconded.fatty33 said:i'm thirsty om tirz

No I feel the opposite, I have to remember to drink. :-(tendency said:I'm up to 3mg/week after titrating up from 1mg/week 6 weeks ago. I've noticed with each dose increase an significant increase in my thirst - anyone else? Alot more thirst than prior to this GLP.


well, this only started after i began the reta.lessthanhalf said:GLP medications generally reduce thirst. I have seen scientific papers mention it. I used to drink too much fluid, about 8 litres a day , which dropped in half from semaglutide and is the same on tirzepatide 15mg plus 4mg of reta.
It might be worth getting your blood sugar checked.

Came here just to confirm haha. Just took first dose and thought I was oddly very thirsty all day lolfatty33 said:i'm thirsty om tirz





This is odd, you have to drink an awful lot of water to get measurably low sodium levels. Prior to starting GLPs I was drinking 8 litres / day, ( not deliberately, it just slowly crept up over years , partly due to a medication side effect dry mouth problem ) and no issues with low sodium. There are quite a few papers talking about how GLPs reduce fluid intake, and they are being considered as a treatment for excessive fluid intake - primary polydipsia. But GLPs dropped my intake to 3-4 litres.aRareUnicorn said:I have doubled the amount of water intake since starting Reta. This however diluted/washed out some of the electrolytes the body needs. My sodium dropped to dangerous levels. I now limit the amount of water at a cost of very dry mouth… but it seems to be working.
Also, this became a bigger problem with higher doses, eating less was not helping the situation… lowering the dose may help![]()



With tirz I didn't have it. But with reta well. It was regularly unexpected to much thirst.tendency said:I'm up to 3mg/week after titrating up from 1mg/week 6 weeks ago. I've noticed with each dose increase an significant increase in my thirst - anyone else? Alot more thirst than prior to this GLP.

To be honest, drinking 8L per day seems a lot! Could it be related to diabetes? Normal recommended intake is 2-3L for proper hydration.lessthanhalf said:This is odd, you have to drink an awful lot of water to get measurably low sodium levels. Prior to starting GLPs I was drinking 8 litres / day, ( not deliberately, it just slowly crept up over years , partly due to a medication side effect dry mouth problem ) and no issues with low sodium. There are quite a few papers talking about how GLPs reduce fluid intake, and they are being considered as a treatment for excessive fluid intake - primary polydipsia. But GLPs dropped my intake to 3-4 litres.
You can increase sodium intake rather than just reduce water intake, if dry mouth is an issue either by adding extra salt to food or using salt tablets, but probably a good idea to get blood sodium levels checked occasionally if it had been measurably abnormal. And there are sprays and mouthwashes that act as artificial saliva if dry mouth is a big issue.
Still think it is odd so many people saying it makes them drink more, when it is a possible treatment for the opposite problem, and it had the opposite effect on me.