Whiynot20026
GLP-1 Apprentice
Wholly crap. I’ve been on Tirz for 6 weeks and my carpal tunnel is almost totally gone. I had it nightly before. The inflammation is so deceased now.chewonmysac said:
Bill
Any Tesamorelin users in here.
- Thread starter Whiynot20026
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Bill
chewonmysac
GLP-1 Enthusiast
It is a know side effect for Tesamorelin. Even Tirz could not stop it.Whiynot20026 said:
Whiynot20026
GLP-1 Apprentice
Thanks for sharing.chewonmysac said:
Bill
Just because it's approved for daily use doesn't mean one has to use it daily. If your goal is to become Arnold, this isn't going to get you there. If your goal is to offset some muscle loss associated with GLP use (which is a complex and interesting topic to unpack all on its own), some amount of a *morelin could likely at least partially offset that.Whiynot20026 said:
Seems most who "get into" secretagogues like this move on to GH itself, but I suspect that's a selection bias kind of thing since most people are looking into in hopes of getting bigger (vs maintaining what they have). I think if I started experiencing water retention-style side effects (e.g. carpal tunnel or painful joints) I might question if my dosing and/or frequency is right from the POV that there could potentially be a different approach that balances the benefits of *morelins against the sides.
Are you proposing that's something unique to tesa VS peptides in general? I agree that refrigeration is generally preferred and most opposition to it is typically people who lack a chemistry background, know freezing can be harmful and reach the bizarre conclusion that if freezing is bad then maybe refrigerating is kind of bad.Airborne Daddy said:
I mean obviously there could be solubility/viscosity concerns (e.g. crystals coming out of solution and/or gelling), but that's more a function of the peptider not being aware that they could likely avoid that problem by simply reconstituting with a greater volume of water.
LongevitybroTX
GLP-1 Apprentice
egrifta does not = chinese tesa. It's formulation was specific to the way they formulated it. Tesa is a bit more touchy than other peptides (which is why you really need to stick to Hospira BAC water). But it's not magicalyl going to be contaminated and useless after a week. I wouldn't go past a month probably, but even a TSM20 kit is only going to last around 2-weeks and that's pretty commonly available.
Reconstitute with Hospira, chuck it in the fridge, and pin on!
Reconstitute with Hospira, chuck it in the fridge, and pin on!
LongevitybroTX
GLP-1 Apprentice
The serum half life is about 30 minutes (yes, the effect on the pituitary lasts much longer). This is just anecdotal but I wait around an hour, but that's just because I pin when I get up and I don't eat for at least an hour or so afterwards.DragonOfTheSea said:
Vbjeff13
Recently Joined 🚫No Source Discussion🚫
chewonmysac said:
Does the visceral / waist fat stay off after stoping if you stay active? I’m considering this but wouldn’t want to be in it long term.
Could you update us as you stay off it with what happens?
CNCCurrency
GLP-1 Specialist
Someone recently posted on the forum about fat cells having memory. So?Vbjeff13 said:
chewonmysac
GLP-1 Enthusiast
Cannot really answer that question. In the FDA trials the fat did return but that was expected because the AIDS medince that was causing the visceral fat build up and after Egrifta stopped the AIDS treatment continued. I plan on running few cycles a year.Vbjeff13 said:
Madkate
GLP-1 Apprentice
Been pinning 2mg Tesa and 150 mcg ipa 5days on and 2 off and results have been great so far
Diamondd817
GLP-1 Apprentice
I just started. I got the Tesa/Imp 10/3mg Blend. I am taking 2/.6 mg dose in the am when I wake up. Too early to see results but I have my fingers crossed.
Ticks
GLP-1 Apprentice
For those of you wondering about night or morning, especially with reta, here is the conclusion of my research.
1. IGF-1 output tracks GH pulse amplitude, and meal-induced insulin blunts that pulse at the pituitary — so protecting the fasted state outranks protecting circadian timing.
2. IGF-1 is timing-insensitive anyway (long half-life, integrates GH exposure across the day, builds to steady state over ~2 weeks), so the “lost nocturnal synergy” of a morning shot carries essentially no cost. That’s what makes the trade clearly favor morning fasted rather than being a close call.
3. The one boundary condition: if you could get a clean fasted window at night, night might edge ahead via synergy — so “morning wins” is conditional on the night option being under-fasted, not an absolute.
4. Retatrutide doesn’t flip this. Slowed gastric emptying mildly reinforces morning-fasted as the cleanest window, and improved insulin sensitivity helps the pulse. The variable it introduces — deficit-driven hepatic GH resistance lowering IGF-1 — is independent of injection timing, so it doesn’t change the timing conclusion.
The caveat - Important one IMO
1. GHRH-receptor signaling directly promotes slow-wave sleep via the preoptic/anterior hypothalamus, independent of GH release.
2. That effect is time-locked — it needs the agonist centrally active around sleep, which a short-half-life peptide only achieves with an evening dose.
3. It’s GHRH-receptor-specific, not a GH/IGF-1 effect (the GHRP-2 dissociation), so the mechanism is consistent rather than just “more GH → better sleep.”
1. IGF-1 output tracks GH pulse amplitude, and meal-induced insulin blunts that pulse at the pituitary — so protecting the fasted state outranks protecting circadian timing.
2. IGF-1 is timing-insensitive anyway (long half-life, integrates GH exposure across the day, builds to steady state over ~2 weeks), so the “lost nocturnal synergy” of a morning shot carries essentially no cost. That’s what makes the trade clearly favor morning fasted rather than being a close call.
3. The one boundary condition: if you could get a clean fasted window at night, night might edge ahead via synergy — so “morning wins” is conditional on the night option being under-fasted, not an absolute.
4. Retatrutide doesn’t flip this. Slowed gastric emptying mildly reinforces morning-fasted as the cleanest window, and improved insulin sensitivity helps the pulse. The variable it introduces — deficit-driven hepatic GH resistance lowering IGF-1 — is independent of injection timing, so it doesn’t change the timing conclusion.
The caveat - Important one IMO
1. GHRH-receptor signaling directly promotes slow-wave sleep via the preoptic/anterior hypothalamus, independent of GH release.
2. That effect is time-locked — it needs the agonist centrally active around sleep, which a short-half-life peptide only achieves with an evening dose.
3. It’s GHRH-receptor-specific, not a GH/IGF-1 effect (the GHRP-2 dissociation), so the mechanism is consistent rather than just “more GH → better sleep.”
Yeah, the caveat matters to me. I care more about the sleep effect than the adipose tissue reduction, though that's also desirable.Hopefully there's enough of a gap between dinner and bedtime to get at least a partial benefit.Ticks said:
sheilarae74
GLP-1 Enthusiast
Thank you for sharing! I have 10lbs to go until I hit my goal weight on reta and I plan on starting tes/ipa soon after I do.Ticks said:
Dilbert4Life
GLP-1 Apprentice
So, you need to be fasted 3-4 hours before they pin and then a couple of hours fasting afterwards too? Like if you pin in morning, then how much gap required before you have breakfast?
rkbleddyn
GLP-1 Novice 🚫No Source Discussion🚫
I'm about ready to start it. I have noted that my Tirzepatide/diet combo is just not targeting that visceral fat, so an intervention needs to occur here. I'm thinking start at 500mcg. Maybe 250 is a better starting point?, not sure.
coach chickpea
GLP-1 Apprentice
2mg seems like a high dose and likely more side effects. 1mg is a typical dose.CNCCurrency said:
dondada109
GLP-1 Apprentice
2mg is the study dosage for relevant fat loss, 1mg is more for IGF-1 levelscoach chickpea said:
coach chickpea
GLP-1 Apprentice
That might be the study, as is 12mg for reta but there comes alot more side effects with doses. I lost 17lbs and alot of lean tissue using .6mg of tesa daily for only 2 monthsdondada109 said:
woundcarping
GLP-1 Specialist
coach chickpea said:
How did tesa cause you to lose "alot of lean tissue", how did you measure the lean tissue loss, and what is lean tissue?
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