Any similar experiences with Retatrutide?

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Competitive Bird

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I was on Retatrutide for about 5 months and in the beginning it was a Godsend. It took my sciatic pain away, 30 pounds melted off in literally weeks, my blood labs all got better, especially my ApoB and BUN levels. For whatever reasons I started having chronic dizziness and I could never keep up with hydration. I do not know if it was the drug's side effects catching up or endotoxins from a new bottle but even at 2mg the sides persisted.

I decided to let it wash out and give Tirz a shot. I wasn't super comfortable with the elevated heart rate thing, it wasn't that bad but until I got to 6mg but even so, I would be more comfortable after the trials wrap up and it is declared a safe side effect. I am waiting on my testing reports to come back before beginning but I have lost 80% of the weight I want to lose, I am looking to gain muscle but control food noise while keeping my insulin sensitivity good and it's more about health markers than losing weight though I have about 20 more pounds of fat to go.

Option 2 is restart Reta and remain at lower doses to avoid the heart rate increases, say 4mg max, titrating up from 1mg every 4 weeks. If the dizziness was actually endotoxins and not the medication itself then there won't be an issue. It got pretty bad though. I had my first ocular migraine ever. I was constantly dizzy. Not enough to fall but enough to feel like something is not normal. I've seen a small amount of reports of this but it doesn't seem widespread and it didn't happen to me for 5 months. That is why I am thinking endotoxins possibly.
 
Hello! Are tracking Your daily kcal intake? This happens to me regularly if I don't eat enough or on my fasting days.
 
dailychemicals said:
Hello! Are tracking Your daily kcal intake? This happens to me regularly if I don't eat enough or on my fasting days.
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It could be that as well. I was pretty low on calories. Probably around 700-800 below maintenance. I am 230lbs, 20% body fat and was eating 2000-2200 a day and very active. I didn't even think of that.
 
This is surely a case. You are constantly hypoglycemic. You have to eat enough to feel better. 25-30g of protein + healthy carbs with every meal should help with the dizziness.
 
My sodium and chloride levels have been low last two blood tests. Guess what, I was drinking TO much water and flushing it and other good stuff out of my system. I was getting up 5-6 times a night to pee. I was also sleeping like crap and waking up at 4am and just couldn't go back to sleep. Since Monday after the doctor, cut way back on water and drinking one sugar free Gatorade or half a Liquid IV a day. Gatorade, 250mg sodium and 50mg potassium. Liquid IV has 500mg sodium and 370mg potassium, that's why I mix half in two empty bottles. Both have other electrolytes. We had started a diet back first of the year and I figured all the water would help, nope. Sleep seemed better last night, but not great and got up 4 times to pee. Hopefully it gets better.
 
BNLFL said:
My sodium and chloride levels have been low last two blood tests. Guess what, I was drinking TO much water and flushing it and other good stuff out of my system. I was getting up 5-6 times a night to pee. I was also sleeping like crap and waking up at 4am and just couldn't go back to sleep. Since Monday after the doctor, cut way back on water and drinking one sugar free Gatorade or half a Liquid IV a day. Gatorade, 250mg sodium and 50mg potassium. Liquid IV has 500mg sodium and 370mg potassium, that's why I mix half in two empty bottles. Both have other electrolytes. We had started a diet back first of the year and I figured all the water would help, nope. Sleep seemed better last night, but not great and got up 4 times to pee. Hopefully it gets better.
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I was drinking Redmonds Relyte everyday and Gatorade Zero and it still wasn't enough. Carbs help hold water and my carbs may have been too low as well. I was always in ketosis, blood and urine, even on 70-80 grams of carbs a day. I got labs and my sodium and chloride were fine but as luck would have it that particular day I wasn't having symptoms so I don't know if that lab result was right or just right for that day.
 
I'll see my my normal doc Monday, and I'm sure he'll set up another BT in 4-6 months. My cardiologist explained the water and sodium deal Monday at my yearly deal. Little shit found my BT at the lab.
 
Anecdotally, additional carbs often help a lot of people with a number of ill effects on Reta. The electrolyte thing is real also. I would absolutely try increasing the intake of both, back on the Reta, and see.

Touching back to the first part of your Reta experience being awesome, then not, did you in fact change product? You mentioned a new bottle- was this from a different kit or were you purchasing single vial? Did you reconstitute yourself and if so, filter?
 
Competitive Bird said:
I was on Retatrutide for about 5 months and in the beginning it was a Godsend. It took my sciatic pain away, 30 pounds melted off in literally weeks, my blood labs all got better, especially my ApoB and BUN levels. For whatever reasons I started having chronic dizziness and I could never keep up with hydration. I do not know if it was the drug's side effects catching up or endotoxins from a new bottle but even at 2mg the sides persisted.

I decided to let it wash out and give Tirz a shot. I wasn't super comfortable with the elevated heart rate thing, it wasn't that bad but until I got to 6mg but even so, I would be more comfortable after the trials wrap up and it is declared a safe side effect. I am waiting on my testing reports to come back before beginning but I have lost 80% of the weight I want to lose, I am looking to gain muscle but control food noise while keeping my insulin sensitivity good and it's more about health markers than losing weight though I have about 20 more pounds of fat to go.

Option 2 is restart Reta and remain at lower doses to avoid the heart rate increases, say 4mg max, titrating up from 1mg every 4 weeks. If the dizziness was actually endotoxins and not the medication itself then there won't be an issue. It got pretty bad though. I had my first ocular migraine ever. I was constantly dizzy. Not enough to fall but enough to feel like something is not normal. I've seen a small amount of reports of this but it doesn't seem widespread and it didn't happen to me for 5 months. That is why I am thinking endotoxins possibly.
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Yep. Hypoglycemic
 
dailychemicals said:
This is surely a case. You are constantly hypoglycemic. You have to eat enough to feel better. 25-30g of protein + healthy carbs with every meal should help with the dizziness.
Click to expand...
I checked blood sugar regularly and it was fine most of the time. I still think there was a non blood sugar carb related issue though. I think it was electrolytes and not enough total carbs/calories to make glycogen fast enough to help my body hold water.

I was always in low level ketosis once I got past 3mg of reta. The glucagon agonist is pushing for ketosis by nature. Ketosis is naturally diuretic and so is Retatrutide, and so is another drug I am on for blood pressure. When I tried actual ketosis to see how it would go all hell broke loose.

Long story but I'll never go ultra low carb on reta again lol. I thought I was going to die, no exaggeration. Like got in to my car and headed for the ER then as soon as I got on the highway there was a 12 mile bumper to bumper back up from a major accident that had just happened.

I got off the next exit about 40 minutes later and got a gatorade with sugar and felt better 2 minutes later. Pretty crappy experience sitting in traffic with a HR in the 150s. I had checked my blood sugar and it was actually high so I don't think it wasn't the sugar in the Gatorade that helped per se. Or maybe it was I don't know.

All of these symptoms stopped when I stopped reta, about a week later. I think it was not enough calories, carbs, electrolytes, just not enough of everything for the level of activity I was doing (weight training and cardio regularly plus 13000+ steps a day).
 
DragonOfTheSea said:
Anecdotally, additional carbs often help a lot of people with a number of ill effects on Reta. The electrolyte thing is real also. I would absolutely try increasing the intake of both, back on the Reta, and see.

Touching back to the first part of your Reta experience being awesome, then not, did you in fact change product? You mentioned a new bottle- was this from a different kit or were you purchasing single vial? Did you reconstitute yourself and if so, filter?
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Same company from the same original order. Just a new vial but I can't say with certainty the side effects began with that vial or not. I am pretty sure they did but that could be a coincidence. I also starting ramping up activity exponentially without adjusting caloric intake around the same time. I think it was more about that the more I discuss this on here getting different points of view.

I'm actually convinced of it now. Good news is I can get back on Reta. I hated having to come off of it. I just needed that dizziness to stop. I was having anxiety about dying or becoming terminally ill all of the time. Being dizzy from the time you wake up until you go to bed with only short periods of relief randomly isn't fun.
 
BNLFL said:
My sodium and chloride levels have been low last two blood tests. Guess what, I was drinking TO much water and flushing it and other good stuff out of my system. I was getting up 5-6 times a night to pee. I was also sleeping like crap and waking up at 4am and just couldn't go back to sleep. Since Monday after the doctor, cut way back on water and drinking one sugar free Gatorade or half a Liquid IV a day. Gatorade, 250mg sodium and 50mg potassium. Liquid IV has 500mg sodium and 370mg potassium, that's why I mix half in two empty bottles. Both have other electrolytes. We had started a diet back first of the year and I figured all the water would help, nope. Sleep seemed better last night, but not great and got up 4 times to pee. Hopefully it gets better.
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Just curious, what dose are you on?
 
Competitive Bird said:
Sorry for all of the questions but got one more. I made it up to 6mg and my bowels came to a halt. What was your titration schedule like?
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No problem. 2, 4, 6, all 4 weeks. Actually did 5 weeks of 4mg, but stalled and went to 6mg. Tomorrow morning will be #5 of 6mg. Seems to be good still. I'm losing 1.5-2lbs/week. Now, my wife had that lack of poop deal first week at 2mg, but went away. I honestly don't remember what she did to fix it. We still get some heart burn at bedtime when laying down once in a while.
 
BNLFL said:
No problem. 2, 4, 6, all 4 weeks. Actually did 5 weeks of 4mg, but stalled and went to 6mg. Tomorrow morning will be #5 of 6mg. Seems to be good still. I'm losing 1.5-2lbs/week. Now, my wife had that lack of poop deal first week at 2mg, but went away. I honestly don't remember what she did to fix it. We still get some heart burn at bedtime when laying down once in a while.
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That's weird. 4mg was exactly where I stalled. I believe the stall happens because the glucagon effect is pretty light until you get up to the 5-6+ doses. The binding affinity and agonism is very subtle until those higher doses. At the lower doses you are losing weight in the same manner you would on Tirzepatide. How did you do when you got to 6mg? Did you get through the stall?
 
Competitive Bird said:
That's weird. 4mg was exactly where I stalled. I believe the stall happens because the glucagon effect is pretty light until you get up to the 5-6+ doses. The binding affinity and agonism is very subtle until those higher doses. At the lower doses you are losing weight in the same manner you would on Tirzepatide. How did you do when you got to 6mg? Did you get through the stall?
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Yeah, right away. I froze weight wise a little over a week. I'd need to look at my spreadsheet for exact numbers. 6 has been a constant 1.5-2lbs/week, BMI and fat % goes down .1-.2 point a week too. My main weigh day, along with shot day is tomorrow morning. I do check weight on Tuesdays too.
 
DragonOfTheSea said:
Fiber+water, fiber+water, fiber+water.
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Maybe throw some magnesium in there too. I take it at night and am ready to go in the morning. Also, ground flaxseed in my shake.
 
Dizzyness is a vague symptom with so many possible causes in the context of weight loss.

Is the dizzyness related to posture? Does it go away if you sit or lie down? You mention you are on blood pressure pills. Do you have a BP measuring device? have you checked sitting and standing BP? It may not be postural hypotension but it is extremely common with weight loss from any cause and reta does reduce blood pressure a bit on its own as well.

What is your overall calorie intake per day? Are you trying to push the weight loss to fast for your tolerance?

Sounds like you have thought about electrolytes, fluid and blood sugar as causes, so just checking if you have considered BP and just not enough calories as well.
 
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